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The map label for this gene is ytpA [H]

Identifier: 116689081

GI number: 116689081

Start: 1172619

End: 1173527

Strand: Reverse

Name: ytpA [H]

Synonym: Bcen2424_1058

Alternate gene names: 116689081

Gene position: 1173527-1172619 (Counterclockwise)

Preceding gene: 116689087

Following gene: 116689079

Centisome position: 33.68

GC content: 73.16

Gene sequence:

>909_bases
ATGAGCGCCACCACCACACCGGCCGCCGTGCCCGCCACCGCCGGATCGGCGCCCGCGCCGCGGATGGGTCGGTTGCGTAC
CGCGGACGGGCTCGAACTGGCGTCGTACCGCTGGCCGGCAAGCGACGGCACCGTGCCGCCGCGCGCGACGATCGCGCTGG
TGCACGGCCTCGCCGAGCACGCGGGCCGCTATGCCACGCTCGCCGGCCGGCTGAACGCGGCCGGCATCGACGTGCTGGCG
GTCGACCTGCGCGGGCATGGCCAGTCGCCCGGCAAGCGCGTGTGGGTCGAGCGTTTCGGCGACTACCTGAACGATGCGGA
GGCGCTGGTCGCCGAAGCCGCGCGCGGCGCGGCGCCGCTCTTCCTGATGGGGCACAGCATGGGCGGCGCGGTCGCCGCGC
TCTACGCGATCGAACGCGCGCCGGCTCGCGGCCACGCGCTGGCGGGCCTCGTGCTGTCGAGCCCGGCGCTGGCACCCGGG
CGCGACGTGCCGCGCTGGATGCTTGCGCTCAGCCGCATCATCAGCCGTGTGTGGCCCACTTTCCCCGCGATCAGGATCGA
TGCGGCCCTGCTGTCGCGCGATCCAGCCATCGTCGCGGCCAATCGCGCCGATCCGCTCGTGCATCACGGCGCGGTGCCCG
CACGCACCGGCGCGGAGATTCTCGACGCGATGACGCGCATCGAAAACGGCCGCGGCGCGCTGCGCGTGCCGGTGCTCGTC
TATCACGGCACCGAGGACAAGCTCACCGAACCCGACGGCAGCCGCGCGTTCGGCGCGCGTGTCGGTTCGCCCGACCGTAC
GCTGACGCTGTACGAAGGCGGCTTCCATGAAACGATGAACGATCTCGAACGCGACCGCGTGATCGACGCGCTGATCGCGT
GGATTCACGCGCGCGTGCCGGCGCGCTGA

Upstream 100 bases:

>100_bases
TTTCATAACCAGACGAAATTAGAGGGGCGCTGCCGGGCCCGCGCGGGAGGGGCGCGACTATGATCGCGAAACGCAGACCA
ACGAACAGGAGACCCGCCAG

Downstream 100 bases:

>100_bases
GCGCGCCCGGCCCGGCCGGTCGAGCGGGAATCAGATCCCGGCCAGCACGCGCAGGTGCGCGACGACGCTGCGCCCGAGCG
CGGACAGGTTGTAGCCGCCC

Product: alpha/beta hydrolase fold

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSATTTPAAVPATAGSAPAPRMGRLRTADGLELASYRWPASDGTVPPRATIALVHGLAEHAGRYATLAGRLNAAGIDVLA
VDLRGHGQSPGKRVWVERFGDYLNDAEALVAEAARGAAPLFLMGHSMGGAVAALYAIERAPARGHALAGLVLSSPALAPG
RDVPRWMLALSRIISRVWPTFPAIRIDAALLSRDPAIVAANRADPLVHHGAVPARTGAEILDAMTRIENGRGALRVPVLV
YHGTEDKLTEPDGSRAFGARVGSPDRTLTLYEGGFHETMNDLERDRVIDALIAWIHARVPAR

Sequences:

>Translated_302_residues
MSATTTPAAVPATAGSAPAPRMGRLRTADGLELASYRWPASDGTVPPRATIALVHGLAEHAGRYATLAGRLNAAGIDVLA
VDLRGHGQSPGKRVWVERFGDYLNDAEALVAEAARGAAPLFLMGHSMGGAVAALYAIERAPARGHALAGLVLSSPALAPG
RDVPRWMLALSRIISRVWPTFPAIRIDAALLSRDPAIVAANRADPLVHHGAVPARTGAEILDAMTRIENGRGALRVPVLV
YHGTEDKLTEPDGSRAFGARVGSPDRTLTLYEGGFHETMNDLERDRVIDALIAWIHARVPAR
>Mature_301_residues
SATTTPAAVPATAGSAPAPRMGRLRTADGLELASYRWPASDGTVPPRATIALVHGLAEHAGRYATLAGRLNAAGIDVLAV
DLRGHGQSPGKRVWVERFGDYLNDAEALVAEAARGAAPLFLMGHSMGGAVAALYAIERAPARGHALAGLVLSSPALAPGR
DVPRWMLALSRIISRVWPTFPAIRIDAALLSRDPAIVAANRADPLVHHGAVPARTGAEILDAMTRIENGRGALRVPVLVY
HGTEDKLTEPDGSRAFGARVGSPDRTLTLYEGGFHETMNDLERDRVIDALIAWIHARVPAR

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI6005786, Length=291, Percent_Identity=34.020618556701, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI51242953, Length=291, Percent_Identity=34.020618556701, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1787678, Length=277, Percent_Identity=26.3537906137184, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322756, Length=291, Percent_Identity=28.5223367697594, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 31897; Mature: 31766

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATTTPAAVPATAGSAPAPRMGRLRTADGLELASYRWPASDGTVPPRATIALVHGLAEH
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
AGRYATLAGRLNAAGIDVLAVDLRGHGQSPGKRVWVERFGDYLNDAEALVAEAARGAAPL
CCCEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
FLMGHSMGGAVAALYAIERAPARGHALAGLVLSSPALAPGRDVPRWMLALSRIISRVWPT
EEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
FPAIRIDAALLSRDPAIVAANRADPLVHHGAVPARTGAEILDAMTRIENGRGALRVPVLV
CCHHHHHHHHHCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE
YHGTEDKLTEPDGSRAFGARVGSPDRTLTLYEGGFHETMNDLERDRVIDALIAWIHARVP
EECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
AR
CC
>Mature Secondary Structure 
SATTTPAAVPATAGSAPAPRMGRLRTADGLELASYRWPASDGTVPPRATIALVHGLAEH
CCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
AGRYATLAGRLNAAGIDVLAVDLRGHGQSPGKRVWVERFGDYLNDAEALVAEAARGAAPL
CCCEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
FLMGHSMGGAVAALYAIERAPARGHALAGLVLSSPALAPGRDVPRWMLALSRIISRVWPT
EEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
FPAIRIDAALLSRDPAIVAANRADPLVHHGAVPARTGAEILDAMTRIENGRGALRVPVLV
CCHHHHHHHHHCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEE
YHGTEDKLTEPDGSRAFGARVGSPDRTLTLYEGGFHETMNDLERDRVIDALIAWIHARVP
EECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
AR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]