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The map label for this gene is clcA [H]

Identifier: 116689011

GI number: 116689011

Start: 1095224

End: 1096780

Strand: Reverse

Name: clcA [H]

Synonym: Bcen2424_0988

Alternate gene names: 116689011

Gene position: 1096780-1095224 (Counterclockwise)

Preceding gene: 116689013

Following gene: 116689003

Centisome position: 31.48

GC content: 69.49

Gene sequence:

>1557_bases
ATGCCGCGCCCTGCCCTTCCCGCGCTGTTTCCCGCCCTCACCCGCCGCTCGCTGCGAATCTGGCGCCAATACGGAGTTTT
CTGGCTCGGTGCGATCGTCGTCGGCCTCGCGGCCGTACTCTACGCCCGGTTGATCGACTGGGGTTACGAGACTTTCCGCG
CGATGCGCGATCACGCCGTCTGGCTGCCGCTGCTGCTGACCCCGGCGATCGCCGCGTTGTCGGCATGGACGACACGTCGC
TTTTTCCGCGGCGCCGAGGGCAGCGGCATCCCGCAGGTGATCGCGACGCTGCATGCCAGCCCGAGCGCATTCGGCGCCCG
GCTGCTGACGCTGCGCATTCTGTTCGGCAAGGTGCTGATCTCGTTCCTCGGCATCCTCGGCGGCTTCACGATCGGCCGCG
AAGGGCCGACCGTGCAGGTCGGTGCGGCGCTGATGTTCAACCTGCGACGCTTCTACCCGCGCTCGAACGCGCAGATCGAA
CGCCAGCTCGTGCTGGCCGGCGCGGCGGCCGGGCTGTCGGCCGCATTCAACACGCCGCTCGCGGGCATCGTGTTCGCGAT
CGAGGAACTGACCCGCAGCTTCTCCGCGCGCGCCAGCGGCGTGCTGATCACCGCGATCATCCTCGCCGGCGTTGTCGCGC
TCGGGCTGAACGGCAACTACACGTATTTCGGCACGATCAACGCCGGGCTCCATTTCCCGAAGCTGCTGGCGGTCGCGGTG
CTGGTCACCGCGATCGTGACGGGCATCGCGGGCGGCCTGTTCTGCTGGTTGTTGCTGAATACGGGGCGCTGGCTGCCCGC
GCAACTGCTGGGCCTGTATCGCGAGCGGCCGGTCGCGTTCGCCGCGCTGTGCGGCTTCACGATCGCCGTCGTCGGGCTCG
TGTCCGGCGGCACGACGTTCGGCAGCGGCTATGCGGAGGCGCGCGGGCTGCTCGACGGCAGTCAGCAGTTGTCGGTGTTC
TATCCGCTCCTGAAGATGGTGTCGATGGTCGCGTCGTACCTGCCGGGCATCCCGGGCGGGATCTTCGCGCCGTCGCTGTC
GATCGGCGCCGGCTTCGGCAACGTGCTGCATGCCGTGTTCAGCAACATGAGCCTGCCGATGCTGATCGCGCTCGCGATGG
TCGGCTATCTGGCCGCCGTCACGCAGGCGCCGATCACGTCGTTCGTGATCGTGATGGAAATGATCAACGGTCATGCGCTC
GTGATTTCGCTGATGGCGACCGCGCTGGTATCGAGCCGGGTATCGCGCTTTTTCGCGCCGCCGCTCTACGAAACGCTCGC
GCAGCGCTATCTCGCGCCGCCCGTCGCGGCCGCCGCGCCGGCCGCGGCAACCGCAGCGGCCGCGGCGGACAACATGACCG
GCGTGACCGAACCCCAGGATGCAACCGCGGCCCCCGCCGATCCGCTCGACACGCTGCGCGACGAAAGCGGTAACGAGCCG
GCCGCTGCGGCGGCGGCCGACAGCGCCGCGGACACGGCGACGCCGCACGATGCCGGGCCGGCCGCGACCGACGCAAACGG
CCCGGCGCAACAGCACGGCCCGCGCGACGCTCAGTAG

Upstream 100 bases:

>100_bases
CATCTCTTTGTGGATTTTTGTCGCTCACTAAGAACGTTTGACGCCCCCGCTGGCATCCCGTTCTTTTTATAATCCACTCT
TTGCCCTCCGGCCCGAGCCA

Downstream 100 bases:

>100_bases
ATCACGACGGGCGCCGGCCGGTAGTAGACCGGCCGCGCGGGCACGACGGTGCATCCGGCCAGCGTGATCGCGACGAGCGC
GATGGCGATTGCGGTTCTTT

Product: Cl- channel, voltage-gated family protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MPRPALPALFPALTRRSLRIWRQYGVFWLGAIVVGLAAVLYARLIDWGYETFRAMRDHAVWLPLLLTPAIAALSAWTTRR
FFRGAEGSGIPQVIATLHASPSAFGARLLTLRILFGKVLISFLGILGGFTIGREGPTVQVGAALMFNLRRFYPRSNAQIE
RQLVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTINAGLHFPKLLAVAV
LVTAIVTGIAGGLFCWLLLNTGRWLPAQLLGLYRERPVAFAALCGFTIAVVGLVSGGTTFGSGYAEARGLLDGSQQLSVF
YPLLKMVSMVASYLPGIPGGIFAPSLSIGAGFGNVLHAVFSNMSLPMLIALAMVGYLAAVTQAPITSFVIVMEMINGHAL
VISLMATALVSSRVSRFFAPPLYETLAQRYLAPPVAAAAPAAATAAAAADNMTGVTEPQDATAAPADPLDTLRDESGNEP
AAAAAADSAADTATPHDAGPAATDANGPAQQHGPRDAQ

Sequences:

>Translated_518_residues
MPRPALPALFPALTRRSLRIWRQYGVFWLGAIVVGLAAVLYARLIDWGYETFRAMRDHAVWLPLLLTPAIAALSAWTTRR
FFRGAEGSGIPQVIATLHASPSAFGARLLTLRILFGKVLISFLGILGGFTIGREGPTVQVGAALMFNLRRFYPRSNAQIE
RQLVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTINAGLHFPKLLAVAV
LVTAIVTGIAGGLFCWLLLNTGRWLPAQLLGLYRERPVAFAALCGFTIAVVGLVSGGTTFGSGYAEARGLLDGSQQLSVF
YPLLKMVSMVASYLPGIPGGIFAPSLSIGAGFGNVLHAVFSNMSLPMLIALAMVGYLAAVTQAPITSFVIVMEMINGHAL
VISLMATALVSSRVSRFFAPPLYETLAQRYLAPPVAAAAPAAATAAAAADNMTGVTEPQDATAAPADPLDTLRDESGNEP
AAAAAADSAADTATPHDAGPAATDANGPAQQHGPRDAQ
>Mature_517_residues
PRPALPALFPALTRRSLRIWRQYGVFWLGAIVVGLAAVLYARLIDWGYETFRAMRDHAVWLPLLLTPAIAALSAWTTRRF
FRGAEGSGIPQVIATLHASPSAFGARLLTLRILFGKVLISFLGILGGFTIGREGPTVQVGAALMFNLRRFYPRSNAQIER
QLVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTINAGLHFPKLLAVAVL
VTAIVTGIAGGLFCWLLLNTGRWLPAQLLGLYRERPVAFAALCGFTIAVVGLVSGGTTFGSGYAEARGLLDGSQQLSVFY
PLLKMVSMVASYLPGIPGGIFAPSLSIGAGFGNVLHAVFSNMSLPMLIALAMVGYLAAVTQAPITSFVIVMEMINGHALV
ISLMATALVSSRVSRFFAPPLYETLAQRYLAPPVAAAAPAAATAAAAADNMTGVTEPQDATAAPADPLDTLRDESGNEPA
AAAAADSAADTATPHDAGPAATDANGPAQQHGPRDAQ

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=451, Percent_Identity=29.9334811529933, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24665008, Length=409, Percent_Identity=25.1833740831296, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 54000; Mature: 53868

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPALPALFPALTRRSLRIWRQYGVFWLGAIVVGLAAVLYARLIDWGYETFRAMRDHAV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPLLLTPAIAALSAWTTRRFFRGAEGSGIPQVIATLHASPSAFGARLLTLRILFGKVLI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SFLGILGGFTIGREGPTVQVGAALMFNLRRFYPRSNAQIERQLVLAGAAAGLSAAFNTPL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCH
AGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTINAGLHFPKLLAVAV
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH
LVTAIVTGIAGGLFCWLLLNTGRWLPAQLLGLYRERPVAFAALCGFTIAVVGLVSGGTTF
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
GSGYAEARGLLDGSQQLSVFYPLLKMVSMVASYLPGIPGGIFAPSLSIGAGFGNVLHAVF
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHCCCHHHHHHHHH
SNMSLPMLIALAMVGYLAAVTQAPITSFVIVMEMINGHALVISLMATALVSSRVSRFFAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
PLYETLAQRYLAPPVAAAAPAAATAAAAADNMTGVTEPQDATAAPADPLDTLRDESGNEP
HHHHHHHHHHCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC
AAAAAADSAADTATPHDAGPAATDANGPAQQHGPRDAQ
CHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
PRPALPALFPALTRRSLRIWRQYGVFWLGAIVVGLAAVLYARLIDWGYETFRAMRDHAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPLLLTPAIAALSAWTTRRFFRGAEGSGIPQVIATLHASPSAFGARLLTLRILFGKVLI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SFLGILGGFTIGREGPTVQVGAALMFNLRRFYPRSNAQIERQLVLAGAAAGLSAAFNTPL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCH
AGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTINAGLHFPKLLAVAV
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH
LVTAIVTGIAGGLFCWLLLNTGRWLPAQLLGLYRERPVAFAALCGFTIAVVGLVSGGTTF
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
GSGYAEARGLLDGSQQLSVFYPLLKMVSMVASYLPGIPGGIFAPSLSIGAGFGNVLHAVF
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHCCCHHHHHHHHH
SNMSLPMLIALAMVGYLAAVTQAPITSFVIVMEMINGHALVISLMATALVSSRVSRFFAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
PLYETLAQRYLAPPVAAAAPAAATAAAAADNMTGVTEPQDATAAPADPLDTLRDESGNEP
HHHHHHHHHHCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCC
AAAAAADSAADTATPHDAGPAATDANGPAQQHGPRDAQ
CHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA