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The map label for this gene is glk

Identifier: 116688988

GI number: 116688988

Start: 1071245

End: 1073173

Strand: Reverse

Name: glk

Synonym: Bcen2424_0965

Alternate gene names: 116688988

Gene position: 1073173-1071245 (Counterclockwise)

Preceding gene: 116688989

Following gene: 116688986

Centisome position: 30.8

GC content: 68.22

Gene sequence:

>1929_bases
ATGTCTACTGGTGCGCAAAGTAAGGCGGTCGTCGCGGGTCAGCATGCCGACGGCCCGCGCCTGCTCGCGGACGTCGGCGG
CACCAACGCGCGCTTCGCGCTGGAAACCGGCCCCGGCGAGATCACGCAGATCCGCGTGTATCCCGGCGCCGACTATCCGA
CGATCACCGACGCGATCCGCAAGTATCTGAAGGATGTGAAGATCAGCCGCGTGAACCACGCGGCGATCGCGATCGCGAAC
CCGGTCGACGGCGACCAGGTCACGATGACCAACCACGACTGGAGTTTCTCGATCGAGGCGACGCGCCGCGCGCTCGGCTT
CGACACGCTGCTGGTCGTCAACGACTTCACCGCGCTCGCGATGGCGCTGCCGGGCCTGACCGATGCCCAGCGCGTGCAGG
TCGGCGGCGGCGCACGTCGCCAGAACAGCGTGATCGGCCTGCTCGGGCCCGGTACCGGGCTCGGCGTGTCGGGGCTGATT
CCGGCCGATGACCGCTGGATCGCGCTCGGCAGCGAAGGCGGCCACGCATCGTTCGCGCCGCAGGACGAGCGCGAGGACCT
GGTACTGCAGTACGCGCGCAAGAAGTTTCCGCACGTGTCGTTCGAACGCGTGTGCGCGGGCCCCGGCATGGAGATCATCT
ATCGCGCGCTCGCGGCGCGCGACAAGAAGCGCGTCGCCGCGACCGTCGACACGGTCGAGATCGTCGAGCGCGCGCATGCG
GGCGACGCGCTCGCGCTCGAGACGGTCGAATGCTTCTGCGGGATTCTCGGCGCGTTCGCGGGCAGCGTCGCGCTAACGCT
CGGCGCGCTAGGCGGCGTGTACATCGGCGGTGGCGTCGCGCTGAAGCTGGGCGAGCTGTTCACGCGCTCGTCGTTCCGCG
CGCGCTTCGAGGCGAAGGGCCGCTTCACGCACTACCTCGAAAACATCCCGACCTACCTGATCACCGCCGAATATCCGGCG
TTCCTCGGCGTATCGGCGATCCTCGCGGAGCAGTTGTCGAACCGTTCGGGCGGCGCGTCGTCGGCCGTGTTCGAGCGAAT
CCGCCAGATGCGCGACGCACTGACGCCGGCCGAGCGCCGCGTCGCCGATCTCGCGCTGAACCATCCGCGCTCGATCATCA
ACGATCCGATCGTCGACATCGCGCGCAAGGCCGACGTGAGCCAGCCGACCGTGATCCGCTTCTGCCGCTCGCTCGGCTGC
CAGGGGCTGTCGGACTTCAAGCTGAAGCTCGCCACCGGCCTCACCGGCACGATCCCGATGAGCCACAGCCAGGTGCATCT
CGGCGATACGGCCACCGACTTCGGCGCGAAGGTGCTCGACAACACGGTGTCCGCGATCCTGCAGCTGCGCGAGCACCTGA
ATTTCGAGCACGTCGAGAACGCGATCGAGATCCTGAACGGCGCGCGCCGCATCGAGTTCTACGGGCTCGGCAACTCGAAC
ATCGTCGCGCAGGACGCGCACTACAAGTTCTTCCGCTTCGGCATTCCGACGATCGCGTACGGCGACCTGTACATGCAGGC
CGCGTCGGCCGCGCTGCTCGGCAAGGGCGACGTGATCGTCGCGGTGTCGAAGTCGGGCCGCGCGCCCGAGCTGCTGCGCG
TGCTCGACGTCGCGATGCAGGCCGGCGCGAAGGTGATCGCGATCACGTCGAGCAACACGCCGCTCGCGAAGCGCGCGACC
GTCGCGCTCGAAACCGACCACATCGAGATGCGCGAGTCGCAGTTGTCGATGATCTCGCGAATTCTGCATCTGCTGATGAT
CGACATCCTCGCGGTCGGCGTCGCGATCCGTCGCGCGTCGACGAACGGCGAACTGCCCGAAGCCGTCGCGCAGGCGAAAG
CGCGCGCCAGCGACGACGAAACGGCCGACGTGCTCGACTGGCTGAGCCACGGCGCGTCGCCGGCGGCGAAGGACGTCGCG
CGGGACTAG

Upstream 100 bases:

>100_bases
ATCGCGGGCGCCCGCAAACGCGACGTGCTCGACGCCGCGGCCGCGTCGCTGCAGAAGAACGCGATTTCCCAACTGGCCAA
CGACAAGGGGACCCAGCTCG

Downstream 100 bases:

>100_bases
CGCATGGCGCGGCGTCAGCCGCTTCACGCGTCCCAACGAAAAACGCCACCGGCGCATCGCGCGCGGTGGCGTTTTTCATT
GTGCGACCCGGCGGGCGGCG

Product: bifunctional glucokinase/RpiR family transcriptional regulator

Products: NA

Alternate protein names: Glucokinase; Glucose kinase; Putative HTH-type transcriptional regulator

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MSTGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTITDAIRKYLKDVKISRVNHAAIAIAN
PVDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQVGGGARRQNSVIGLLGPGTGLGVSGLI
PADDRWIALGSEGGHASFAPQDEREDLVLQYARKKFPHVSFERVCAGPGMEIIYRALAARDKKRVAATVDTVEIVERAHA
GDALALETVECFCGILGAFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKGRFTHYLENIPTYLITAEYPA
FLGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGC
QGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSN
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRAT
VALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRASTNGELPEAVAQAKARASDDETADVLDWLSHGASPAAKDVA
RD

Sequences:

>Translated_642_residues
MSTGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTITDAIRKYLKDVKISRVNHAAIAIAN
PVDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQVGGGARRQNSVIGLLGPGTGLGVSGLI
PADDRWIALGSEGGHASFAPQDEREDLVLQYARKKFPHVSFERVCAGPGMEIIYRALAARDKKRVAATVDTVEIVERAHA
GDALALETVECFCGILGAFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKGRFTHYLENIPTYLITAEYPA
FLGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGC
QGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSN
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRAT
VALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRASTNGELPEAVAQAKARASDDETADVLDWLSHGASPAAKDVA
RD
>Mature_641_residues
STGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTITDAIRKYLKDVKISRVNHAAIAIANP
VDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQVGGGARRQNSVIGLLGPGTGLGVSGLIP
ADDRWIALGSEGGHASFAPQDEREDLVLQYARKKFPHVSFERVCAGPGMEIIYRALAARDKKRVAATVDTVEIVERAHAG
DALALETVECFCGILGAFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKGRFTHYLENIPTYLITAEYPAF
LGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQ
GLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSNI
VAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRATV
ALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRASTNGELPEAVAQAKARASDDETADVLDWLSHGASPAAKDVAR
D

Specific function: Not Highly Important In E.Coli As Glucose Is Transported Into The Cell By The Pts System Already As Glucose 6-Phosphate. [C]

COG id: COG0837

COG function: function code G; Glucokinase

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788732, Length=321, Percent_Identity=44.5482866043614, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1788159, Length=256, Percent_Identity=36.71875, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI87082369, Length=291, Percent_Identity=27.1477663230241, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788767, Length=249, Percent_Identity=26.9076305220884, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87082130, Length=226, Percent_Identity=28.7610619469027, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLK_BURCA (Q1BYA7)

Other databases:

- EMBL:   CP000378
- RefSeq:   YP_620371.1
- ProteinModelPortal:   Q1BYA7
- STRING:   Q1BYA7
- GeneID:   4092635
- GenomeReviews:   CP000378_GR
- KEGG:   bcn:Bcen_0486
- eggNOG:   COG0837
- HOGENOM:   HBG367942
- OMA:   HYLQNIP
- ProtClustDB:   PRK14101
- BioCyc:   BCEN331271:BCEN_0486-MONOMER
- GO:   GO:0005622
- GO:   GO:0006096
- HAMAP:   MF_00524
- InterPro:   IPR003836
- InterPro:   IPR000843
- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- TIGRFAMs:   TIGR00749

Pfam domain/function: PF02685 Glucokinase; PF01418 HTH_6; PF01380 SIS

EC number: =2.7.1.2

Molecular weight: Translated: 68522; Mature: 68391

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00356 HTH_LACI_1; PS51071 HTH_RPIR; PS51464 SIS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a84da48)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTITDAIR
CCCCCCCCEEEECCCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHH
KYLKDVKISRVNHAAIAIANPVDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALA
HHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCEEEEHHHHHHHHCCCEEEEHHHHHHHH
MALPGLTDAQRVQVGGGARRQNSVIGLLGPGTGLGVSGLIPADDRWIALGSEGGHASFAP
HHCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
QDEREDLVLQYARKKFPHVSFERVCAGPGMEIIYRALAARDKKRVAATVDTVEIVERAHA
CCCHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
GDALALETVECFCGILGAFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEHHHHHHHHHHHHHHHHCCC
RFTHYLENIPTYLITAEYPAFLGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERR
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHH
VADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPM
HHHHHHCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
SHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSN
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQ
EEEECCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRAS
CCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
TNGELPEAVAQAKARASDDETADVLDWLSHGASPAAKDVARD
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHCCH
>Mature Secondary Structure 
STGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTITDAIR
CCCCCCCEEEECCCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHH
KYLKDVKISRVNHAAIAIANPVDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALA
HHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCEEEEHHHHHHHHCCCEEEEHHHHHHHH
MALPGLTDAQRVQVGGGARRQNSVIGLLGPGTGLGVSGLIPADDRWIALGSEGGHASFAP
HHCCCCCCCCEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
QDEREDLVLQYARKKFPHVSFERVCAGPGMEIIYRALAARDKKRVAATVDTVEIVERAHA
CCCHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
GDALALETVECFCGILGAFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEHHHHHHHHHHHHHHHHCCC
RFTHYLENIPTYLITAEYPAFLGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERR
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHH
VADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPM
HHHHHHCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
SHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSN
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQ
EEEECCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRAS
CCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
TNGELPEAVAQAKARASDDETADVLDWLSHGASPAAKDVARD
CCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA