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The map label for this gene is cobB [H]

Identifier: 116688967

GI number: 116688967

Start: 1051075

End: 1051944

Strand: Direct

Name: cobB [H]

Synonym: Bcen2424_0944

Alternate gene names: 116688967

Gene position: 1051075-1051944 (Clockwise)

Preceding gene: 116688966

Following gene: 116688969

Centisome position: 30.17

GC content: 71.03

Gene sequence:

>870_bases
ATGCCTTTTTCCGATCCCGCTGGTTCCGCCGACTCCGCCGCCGCGCCGCTTCCCGCCGATCTCGTCGCGTCCGCCGTCGA
CGCACTCGCACGCGCCGACGCCTTGCTCGTCACGGCCGGTGCGGGCATCGGCGTCGATTCCGGACTGCCCGATTTTCGCG
GCACGGACGGTTTCTGGCGCGCGTATCCGGCGCTGCGCCACGAGCGTTTCGAATTCCACGAGATCGCGTCGCCGCACGCG
TTTCGTGCGCGTGCGCCGCTCGCATGGGGCTTCTACGGGCACCGTCTCGCGCTGTACCGTGCGACGGTGCCGCACGCGGG
TTTCGCGATCCTGCGCCGCTGGATCGACGCGATGCCGAACGGCGGCTTCGTGCTGACCAGCAACGTCGACGGCCAGTTCC
AGAAAGCCGGCTTCGATCCGGCGCGCATCGTCGAGATCCACGGCTCGATTCATGCGATGCAATGCCTGCGCCCGTGCACG
GACGACACGTGGGACGCGGCGCCGTTCGTGCCGGTGGTCGACGAAGCGACGTGCCGCCTGGTTGGCGACCTGCCGCGCTG
CCCGCACTGCGGCGGTCTCGCGCGGCCGAACATCCTGATGTTCGGCGACACCGGCTGGCTCGGTGCGCGTTACGACGCGC
AGGAGCGCGCGCTCGAAGACTGGATCGCGCAGGCCGGGCGCGTCGCCGTGGTCGAGATCGGCGCGGGCACGGCGATTCCG
ACCGTGCGCCTGCTGAGCGAACGGCTCGGCGCCGACGTGATCCGCATCAACGCGCGCGAAGCGCATGCGCGCCGGGCGGA
CGTGATCGGGCTGAAAGGCGGGGCGTTGACGACGCTGAACGCGCTCGACCGCGCGTGGCGCGGCGGCTGA

Upstream 100 bases:

>100_bases
TGCAGCACGCCGCGTTGCGTGGCCGATGCAGCGCAGCGTCCGAACCGGCGTATGATCGCGACGCCACTCGCGCAACGCTC
GACGCCACTGCTTCTCCATC

Downstream 100 bases:

>100_bases
ACCACGTGCCGCGAGTCCACCGGCCGAGGCCGCGCGATTACGGCCGCGTGACGAGCGCCTGCACGAGCGCCGGCGCGATC
GGCGAACCGAGGCCCGTCAC

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MPFSDPAGSADSAAAPLPADLVASAVDALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFEFHEIASPHA
FRARAPLAWGFYGHRLALYRATVPHAGFAILRRWIDAMPNGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHAMQCLRPCT
DDTWDAAPFVPVVDEATCRLVGDLPRCPHCGGLARPNILMFGDTGWLGARYDAQERALEDWIAQAGRVAVVEIGAGTAIP
TVRLLSERLGADVIRINAREAHARRADVIGLKGGALTTLNALDRAWRGG

Sequences:

>Translated_289_residues
MPFSDPAGSADSAAAPLPADLVASAVDALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFEFHEIASPHA
FRARAPLAWGFYGHRLALYRATVPHAGFAILRRWIDAMPNGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHAMQCLRPCT
DDTWDAAPFVPVVDEATCRLVGDLPRCPHCGGLARPNILMFGDTGWLGARYDAQERALEDWIAQAGRVAVVEIGAGTAIP
TVRLLSERLGADVIRINAREAHARRADVIGLKGGALTTLNALDRAWRGG
>Mature_288_residues
PFSDPAGSADSAAAPLPADLVASAVDALARADALLVTAGAGIGVDSGLPDFRGTDGFWRAYPALRHERFEFHEIASPHAF
RARAPLAWGFYGHRLALYRATVPHAGFAILRRWIDAMPNGGFVLTSNVDGQFQKAGFDPARIVEIHGSIHAMQCLRPCTD
DTWDAAPFVPVVDEATCRLVGDLPRCPHCGGLARPNILMFGDTGWLGARYDAQERALEDWIAQAGRVAVVEIGAGTAIPT
VRLLSERLGADVIRINAREAHARRADVIGLKGGALTTLNALDRAWRGG

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=190, Percent_Identity=28.4210526315789, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI13787215, Length=201, Percent_Identity=28.3582089552239, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI6912664, Length=201, Percent_Identity=28.3582089552239, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30920; Mature: 30789

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFSDPAGSADSAAAPLPADLVASAVDALARADALLVTAGAGIGVDSGLPDFRGTDGFWR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCHHH
AYPALRHERFEFHEIASPHAFRARAPLAWGFYGHRLALYRATVPHAGFAILRRWIDAMPN
HHHHHHHHCCHHHHHCCCCCHHCCCCEEECHHHHEEEEEEECCCCHHHHHHHHHHHHCCC
GGFVLTSNVDGQFQKAGFDPARIVEIHGSIHAMQCLRPCTDDTWDAAPFVPVVDEATCRL
CCEEEEECCCCCHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCEECCCHHHHH
VGDLPRCPHCGGLARPNILMFGDTGWLGARYDAQERALEDWIAQAGRVAVVEIGAGTAIP
HHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHH
TVRLLSERLGADVIRINAREAHARRADVIGLKGGALTTLNALDRAWRGG
HHHHHHHHHCCCEEEEECHHHHHHHHCEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PFSDPAGSADSAAAPLPADLVASAVDALARADALLVTAGAGIGVDSGLPDFRGTDGFWR
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCHHH
AYPALRHERFEFHEIASPHAFRARAPLAWGFYGHRLALYRATVPHAGFAILRRWIDAMPN
HHHHHHHHCCHHHHHCCCCCHHCCCCEEECHHHHEEEEEEECCCCHHHHHHHHHHHHCCC
GGFVLTSNVDGQFQKAGFDPARIVEIHGSIHAMQCLRPCTDDTWDAAPFVPVVDEATCRL
CCEEEEECCCCCHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCEECCCHHHHH
VGDLPRCPHCGGLARPNILMFGDTGWLGARYDAQERALEDWIAQAGRVAVVEIGAGTAIP
HHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHH
TVRLLSERLGADVIRINAREAHARRADVIGLKGGALTTLNALDRAWRGG
HHHHHHHHHCCCEEEEECHHHHHHHHCEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]