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The map label for this gene is hemN [H]

Identifier: 116688937

GI number: 116688937

Start: 1022962

End: 1024353

Strand: Reverse

Name: hemN [H]

Synonym: Bcen2424_0914

Alternate gene names: 116688937

Gene position: 1024353-1022962 (Counterclockwise)

Preceding gene: 116688941

Following gene: 116688936

Centisome position: 29.4

GC content: 68.18

Gene sequence:

>1392_bases
ATGCATTCTGGTTCTGCCGACACGATGTTCCGTCCCGATTTGCTCACGAAATACGGCGCGAACGGGCCGCGCTATACGTC
GTACCCTACCGCACTGCAATTCCGCGACGATTTCGATCCGGCCGATTACGTCCGCGCGGCGGGCGACCCCGGCGCGTCGT
CGAGCGACCTGTCGCTGTACTTCCATATCCCGTTCTGCAACACCGCGTGCTTCTACTGCGGCTGCAACAAGATCGCGACC
AACAACCGCCGCCGCGCGCGCCCGTATCTCGACCAGCTCAAGCGCGAGATGGCGCTGCAGGCCGCGCTGTTCGATCCGTC
CCGCCCCGTCACGCAACTGCACTGGGGCGGCGGCACGCCGACCTTCCTGTCCGACGACGAAACGGCCGAGCTGATGGCGG
CCACGCGCGAGCATTTCGCGCTCGCGCCGGACACCGACGCCGAGTTCTCGATCGAAATCGACCCGCGCACGGTCACGCCG
GCGACGCTCGTTCATCTGCGCACGATCGGCTTCAACCGGCTGAGCCTCGGCGTACAGGATTTCGACCCGGCCGTGCAGCA
GGCGATCAACCGCATCCAGCCGCTCTCGATGACCGCCGACCTGCTCGGCGCCGCGCGCGCGACGGGCTTCCATTCGGTGA
GCGTCGACCTGATCTACGGGCTGCCGCACCAGACGGTCGCGGTGTTCGCGCGCACGCTCGAAACGATCATCGAACTCGCG
CCCGATCGCCTGTCGGTGTTCGGCTACGCGCACATGCCGCACCTGTTCAAGATGCAGCGGCAGATCGACGATGCGGCGCT
GCCGCCGCCGGAAACGCGCATCGCGCTGCTCGGCCTCGCGATCGACATGCTGACGTCGGCCGGCTACGTGTACATCGGGA
TGGACCACTTCGCGCGGCCGTCCGACGAGCTGGTGCGCGCGCAGCGCAACGGCACGCTGCAGCGCAATTTCCAGGGCTAC
AGCACGCGCGCGGATACCGACCTGCTCGGCTTCGGCGTGTCGTCGATCAGCAAGGTCGGCGACGTCTACGCGCAGAACGC
GAAGGACCTGCCCGCGTACGGCGCCGCGCTCGACGCGGGCCGGCTGCCGATCGCGCGCGGCGTACGGCTCACGCCGGACG
ACCGGCTGCGCCGCGACGTGATCACGCAACTGATGTGCAACCTCGCACTGCCGTTCTCGCATGTCGAGGCCGCGCACGGC
ATCCGCTTCGCCGATCATTTCGCGCGCGAGCTCGATGCGCTGCGCCCGTTCGAGCGCGACGGGCTGCTGACGATCGCAGC
CGACCGGCTGACGATCCATCCGGCCGGCCGGATGGTCGTGCGCAACATCGCGATGGCGTTCGACGCGTACCTCGGCCAGA
CGCCGCGGCAGCGCTACTCGCGCACGGTCTAA

Upstream 100 bases:

>100_bases
CACCCCGCATTGTGCCATCGCCGGCTGCGACGTTATTACACAATGCGGCCCGATCGCGCGTTCATATACTCGAAAGCATC
TAAAAAAGCGCGAGACCGTC

Downstream 100 bases:

>100_bases
GGCCGGTTCGCACGGCAAGGGGCGGTCGCGGGCCGCACGCGGTCGGCCGGTTTGATAGAGTGTGAGGCTTACATCCGCTT
CGCCAGCCCCCCAAGATGCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MHSGSADTMFRPDLLTKYGANGPRYTSYPTALQFRDDFDPADYVRAAGDPGASSSDLSLYFHIPFCNTACFYCGCNKIAT
NNRRRARPYLDQLKREMALQAALFDPSRPVTQLHWGGGTPTFLSDDETAELMAATREHFALAPDTDAEFSIEIDPRTVTP
ATLVHLRTIGFNRLSLGVQDFDPAVQQAINRIQPLSMTADLLGAARATGFHSVSVDLIYGLPHQTVAVFARTLETIIELA
PDRLSVFGYAHMPHLFKMQRQIDDAALPPPETRIALLGLAIDMLTSAGYVYIGMDHFARPSDELVRAQRNGTLQRNFQGY
STRADTDLLGFGVSSISKVGDVYAQNAKDLPAYGAALDAGRLPIARGVRLTPDDRLRRDVITQLMCNLALPFSHVEAAHG
IRFADHFARELDALRPFERDGLLTIAADRLTIHPAGRMVVRNIAMAFDAYLGQTPRQRYSRTV

Sequences:

>Translated_463_residues
MHSGSADTMFRPDLLTKYGANGPRYTSYPTALQFRDDFDPADYVRAAGDPGASSSDLSLYFHIPFCNTACFYCGCNKIAT
NNRRRARPYLDQLKREMALQAALFDPSRPVTQLHWGGGTPTFLSDDETAELMAATREHFALAPDTDAEFSIEIDPRTVTP
ATLVHLRTIGFNRLSLGVQDFDPAVQQAINRIQPLSMTADLLGAARATGFHSVSVDLIYGLPHQTVAVFARTLETIIELA
PDRLSVFGYAHMPHLFKMQRQIDDAALPPPETRIALLGLAIDMLTSAGYVYIGMDHFARPSDELVRAQRNGTLQRNFQGY
STRADTDLLGFGVSSISKVGDVYAQNAKDLPAYGAALDAGRLPIARGVRLTPDDRLRRDVITQLMCNLALPFSHVEAAHG
IRFADHFARELDALRPFERDGLLTIAADRLTIHPAGRMVVRNIAMAFDAYLGQTPRQRYSRTV
>Mature_463_residues
MHSGSADTMFRPDLLTKYGANGPRYTSYPTALQFRDDFDPADYVRAAGDPGASSSDLSLYFHIPFCNTACFYCGCNKIAT
NNRRRARPYLDQLKREMALQAALFDPSRPVTQLHWGGGTPTFLSDDETAELMAATREHFALAPDTDAEFSIEIDPRTVTP
ATLVHLRTIGFNRLSLGVQDFDPAVQQAINRIQPLSMTADLLGAARATGFHSVSVDLIYGLPHQTVAVFARTLETIIELA
PDRLSVFGYAHMPHLFKMQRQIDDAALPPPETRIALLGLAIDMLTSAGYVYIGMDHFARPSDELVRAQRNGTLQRNFQGY
STRADTDLLGFGVSSISKVGDVYAQNAKDLPAYGAALDAGRLPIARGVRLTPDDRLRRDVITQLMCNLALPFSHVEAAHG
IRFADHFARELDALRPFERDGLLTIAADRLTIHPAGRMVVRNIAMAFDAYLGQTPRQRYSRTV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=253, Percent_Identity=26.8774703557312, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87082341, Length=451, Percent_Identity=50.1108647450111, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1789325, Length=283, Percent_Identity=28.9752650176678, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51178; Mature: 51178

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSGSADTMFRPDLLTKYGANGPRYTSYPTALQFRDDFDPADYVRAAGDPGASSSDLSLY
CCCCCCCCEECCHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHCCCCCCCCCCCEEEE
FHIPFCNTACFYCGCNKIATNNRRRARPYLDQLKREMALQAALFDPSRPVTQLHWGGGTP
EECCCCCCEEHEECCCHHHCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
TFLSDDETAELMAATREHFALAPDTDAEFSIEIDPRTVTPATLVHLRTIGFNRLSLGVQD
CCCCCCHHHHHHHHHHHHEEECCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEECCHHH
FDPAVQQAINRIQPLSMTADLLGAARATGFHSVSVDLIYGLPHQTVAVFARTLETIIELA
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHC
PDRLSVFGYAHMPHLFKMQRQIDDAALPPPETRIALLGLAIDMLTSAGYVYIGMDHFARP
CCHHEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCC
SDELVRAQRNGTLQRNFQGYSTRADTDLLGFGVSSISKVGDVYAQNAKDLPAYGAALDAG
HHHHHHHHHCCCEEECCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RLPIARGVRLTPDDRLRRDVITQLMCNLALPFSHVEAAHGIRFADHFARELDALRPFERD
CCCHHCCCEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
GLLTIAADRLTIHPAGRMVVRNIAMAFDAYLGQTPRQRYSRTV
CEEEEEECEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure
MHSGSADTMFRPDLLTKYGANGPRYTSYPTALQFRDDFDPADYVRAAGDPGASSSDLSLY
CCCCCCCCEECCHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHCCCCCCCCCCCEEEE
FHIPFCNTACFYCGCNKIATNNRRRARPYLDQLKREMALQAALFDPSRPVTQLHWGGGTP
EECCCCCCEEHEECCCHHHCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCC
TFLSDDETAELMAATREHFALAPDTDAEFSIEIDPRTVTPATLVHLRTIGFNRLSLGVQD
CCCCCCHHHHHHHHHHHHEEECCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEECCHHH
FDPAVQQAINRIQPLSMTADLLGAARATGFHSVSVDLIYGLPHQTVAVFARTLETIIELA
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHC
PDRLSVFGYAHMPHLFKMQRQIDDAALPPPETRIALLGLAIDMLTSAGYVYIGMDHFARP
CCHHEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCC
SDELVRAQRNGTLQRNFQGYSTRADTDLLGFGVSSISKVGDVYAQNAKDLPAYGAALDAG
HHHHHHHHHCCCEEECCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RLPIARGVRLTPDDRLRRDVITQLMCNLALPFSHVEAAHGIRFADHFARELDALRPFERD
CCCHHCCCEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
GLLTIAADRLTIHPAGRMVVRNIAMAFDAYLGQTPRQRYSRTV
CEEEEEECEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]