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The map label for this gene is hemH [H]

Identifier: 116688769

GI number: 116688769

Start: 838365

End: 839429

Strand: Direct

Name: hemH [H]

Synonym: Bcen2424_0746

Alternate gene names: 116688769

Gene position: 838365-839429 (Clockwise)

Preceding gene: 116688768

Following gene: 116688770

Centisome position: 24.06

GC content: 67.61

Gene sequence:

>1065_bases
ATGCGTTTCGATCTTGAGCCGCCTTCGAGCGTCGCGGCCGCCCATCGCATCGGTGTGCTGCTGATCAATCTCGGCACACC
CGACGCGCCCACGCCGCGCGCGGTACGGCGCTATCTGGCCGAATTCCTGTCGGACCCGCGGGTCGTCGAAATCCCGCAGG
CCGTCTGGCAGGTGCTGCTGCGCACGCTGATCCTGCCGCTGCGCGGCCGCGCGTCCGCGAAGAAATACGCGGCTGTCTGG
ATGCCCGAGGGTTCGCCGCTGCGCGTGTACACCGAGCGCCAGACCGACAGCGTGCGCCATCTGCTCACGTCGAACGGCTA
TCACGTGATGGTGGACTACGCGATGCGCTACGGCAGCCCGAACATTTCGCATGCGCTCACGCAGTTCAAGCGCGCCGGCG
TCGAGCGCGTGCTGCTGATGCCGATGTATCCGCAATACTCGGCGTCGACCACGGCCACCACCTTCGATGCCGCGTTCGAC
GCGCTGGCGCGCATGCGCAATCAGCCGGAAGTGCGCACGGTGCGGCACTACGCCGACCATCCGGCCTATATCCATGCGCT
GGCCGAGCAGGTGCGCCAGTACTGGGCGCAGCACGGCCGGCCCGATTTCGCGGCCGGCGACAAACTCGTGCTGAGTTTCC
ATGGCGTGCCGAAGCGCACGCTCGATCTCGGCGACCCGTATCACGACCAGTGTCAGCAGACGGGCGCGTTGCTGATGGCC
GCGCTCGGGCTGTCGACCACCGAATGCCGCGTCACGTTCCAGTCACGCTTCGGCAAGGCCGAATGGCTGCAGCCGTACAC
CGCGCCGACGCTGCGCGAATTCGGCGAGGCCGGCGTGCGGCGCGCCGACGTGTTCTGTCCCGGCTTCACGGCCGATTGCC
TGGAGACGATCGAGGAAATCGGCATGGAGGTGCGCGACGAGTTCCTCGCCGGCGGCGGCACGACTTTCCACCGGATTCCG
TGCCTGAACGGCGCGTCCGCGTGGATCGGTGCGCTCAGCGAGATCGTCGCGGAGAATCTGCAGGGCTGGCCCGTCAAGGC
TGCGCAGCCCGAACCGGTCAACTGA

Upstream 100 bases:

>100_bases
TGCCGCGCCGCCGCTCGCGGCGACAGTCGGCCGAACGGCACGGGGCGGCCCGCTATAATCGAGGACCGTCCGGTCCCGTG
CCTCGAGCACGTTCTTGCCC

Downstream 100 bases:

>100_bases
GATGAAACGACTGCCGCGTCCACTGCACCCGCTGCCGCCCGAAGGCGCGGCCGGCCTTTGCAGGGCGGCCCGGCGGAGAC
TGACATGAACTACAAGATTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MRFDLEPPSSVAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSPNISHALTQFKRAGVERVLLMPMYPQYSASTTATTFDAAFD
ALARMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLAGGGTTFHRIP
CLNGASAWIGALSEIVAENLQGWPVKAAQPEPVN

Sequences:

>Translated_354_residues
MRFDLEPPSSVAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSPNISHALTQFKRAGVERVLLMPMYPQYSASTTATTFDAAFD
ALARMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLAGGGTTFHRIP
CLNGASAWIGALSEIVAENLQGWPVKAAQPEPVN
>Mature_354_residues
MRFDLEPPSSVAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSPNISHALTQFKRAGVERVLLMPMYPQYSASTTATTFDAAFD
ALARMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLAGGGTTFHRIP
CLNGASAWIGALSEIVAENLQGWPVKAAQPEPVN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=269, Percent_Identity=24.907063197026, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI60499025, Length=270, Percent_Identity=25.5555555555556, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=45.6521739130435, Blast_Score=279, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6324750, Length=335, Percent_Identity=24.7761194029851, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17864156, Length=341, Percent_Identity=24.633431085044, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24651774, Length=270, Percent_Identity=24.8148148148148, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39392; Mature: 39392

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDLEPPSSVAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLL
CCCCCCCCHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSP
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEHHHHCCCC
NISHALTQFKRAGVERVLLMPMYPQYSASTTATTFDAAFDALARMRNQPEVRTVRHYADH
CHHHHHHHHHHHCHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEI
HHCCCCHHHEEEHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
GMEVRDEFLAGGGTTFHRIPCLNGASAWIGALSEIVAENLQGWPVKAAQPEPVN
HHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFDLEPPSSVAAAHRIGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQAVWQVLL
CCCCCCCCHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTDSVRHLLTSNGYHVMVDYAMRYGSP
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEHHHHCCCC
NISHALTQFKRAGVERVLLMPMYPQYSASTTATTFDAAFDALARMRNQPEVRTVRHYADH
CHHHHHHHHHHHCHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIHALAEQVRQYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLSTTECRVTFQSRFGKAEWLQPYTAPTLREFGEAGVRRADVFCPGFTADCLETIEEI
HHCCCCHHHEEEHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
GMEVRDEFLAGGGTTFHRIPCLNGASAWIGALSEIVAENLQGWPVKAAQPEPVN
HHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA