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The map label for this gene is holA [H]

Identifier: 116688679

GI number: 116688679

Start: 729519

End: 730613

Strand: Direct

Name: holA [H]

Synonym: Bcen2424_0656

Alternate gene names: 116688679

Gene position: 729519-730613 (Clockwise)

Preceding gene: 116688678

Following gene: 116688680

Centisome position: 20.94

GC content: 70.32

Gene sequence:

>1095_bases
ATGCAATTGCGACTTGATGCGCTGGAGCCGCACCTCGCGAAGGGGTTGGCCGGGCTCTATACCGTGTACGGCGACGAGCC
GCTGCTCGCGCAGGAAGCGTGCGACCGCATTCGTGCGGCCGCGCGCGCGGCCGGCTTTACCGAGCGTTCGGTGCATACGG
TCGAGCGCGGCTTCGACTGGAGCGTGCTGCTCGGCGCGACCCAGGCGATGTCGCTGTTCGGCGAACGTCAGCTGATCGAA
CTGCGCATTCCGTCGGGCAAGCCCGGCAAGGAAGGCGCCGACGCGTTGAAGACGCTTGCGGCCACACCCAATCCCGACGC
GCTGATGCTCGTCACGTTGCCGCGCCTCGACGCGGCCACGCAGAAATCCGCGTGGTTCACCGCGCTGCAGAACGGCGGCG
TCGCGCTGAAGATCGATCCGGTCGATCGCGCGCAACTGCCGAACTGGATCGGCCAGCGCCTGTCGATGCAGGGCCAGCGC
GTCGCACCCGGCGACGACGGGCGCCGCGCGCTGCAGTTCATCGCGGAGCGCGTCGAGGGCAACCTGCTCGCCGCGCACCA
GGAAATCCAGAAGCTCGGGCTGCTGTATCCGCAGGGCGCGCTGTCGTTCGAGCAGGTGCACGACGCGGTGCTGAACGTCG
CGCGCTACGACGTGTTCAAGCTGAACGAAGCGATGCTCGCCGGCGACGCCGCGCGGCTCGCGCGGATGATCGACGGGCTG
AAGGGCGAGGGCGAGGCGATCGTGCTCGTGATGTGGGCCGTCGTCGAGGAATTGCGCACGCTGCTGCGGATCAAGCGCGG
CACGACGGCCGGCAAGCCGCTCGCGACGCTGCTGCGCGAGAACCGCGTGTGGGGGCCGCGCGAGCGGCTGATCGCGCCCG
CGCTGAACCGCGTGTCGGAAGCGGTGCTCGAAAAGGCGCTCGCATTCGCCGCGAAGCTCGACCGGCAGGTCAAGGGCTTG
TCCGCCGTCACGCCGGGCCGCCGCACGCAGGACGAACCGCCACCCGACCCGTGGGACGGGCTGTTCCAGCTCGCGATGAC
GGTCGCGGGCGCCCGCGGCGAACGACCGCCGACCGCGGGTCGCGTGCGACGCTAA

Upstream 100 bases:

>100_bases
CGTCCACTCGCTGACGCCGGCGCCGGAGGACGTGGTGCCGGGCGTGGCGCCGCGCGCGCCGCTGCCGCCGCCGCCGCTCT
GATCGCGGGCGCACGCAGCG

Downstream 100 bases:

>100_bases
GTCCCGTTCGGGCCTTCAGCGCGCGCTGCGCAACCCGCTTACAATGTTTGGATGACCGGGGCGCCGCCCTGCGCGGCGCG
GTTTTGCGGCCGTTACCCCG

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MQLRLDALEPHLAKGLAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDWSVLLGATQAMSLFGERQLIE
LRIPSGKPGKEGADALKTLAATPNPDALMLVTLPRLDAATQKSAWFTALQNGGVALKIDPVDRAQLPNWIGQRLSMQGQR
VAPGDDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPQGALSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
KGEGEAIVLVMWAVVEELRTLLRIKRGTTAGKPLATLLRENRVWGPRERLIAPALNRVSEAVLEKALAFAAKLDRQVKGL
SAVTPGRRTQDEPPPDPWDGLFQLAMTVAGARGERPPTAGRVRR

Sequences:

>Translated_364_residues
MQLRLDALEPHLAKGLAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDWSVLLGATQAMSLFGERQLIE
LRIPSGKPGKEGADALKTLAATPNPDALMLVTLPRLDAATQKSAWFTALQNGGVALKIDPVDRAQLPNWIGQRLSMQGQR
VAPGDDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPQGALSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
KGEGEAIVLVMWAVVEELRTLLRIKRGTTAGKPLATLLRENRVWGPRERLIAPALNRVSEAVLEKALAFAAKLDRQVKGL
SAVTPGRRTQDEPPPDPWDGLFQLAMTVAGARGERPPTAGRVRR
>Mature_364_residues
MQLRLDALEPHLAKGLAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDWSVLLGATQAMSLFGERQLIE
LRIPSGKPGKEGADALKTLAATPNPDALMLVTLPRLDAATQKSAWFTALQNGGVALKIDPVDRAQLPNWIGQRLSMQGQR
VAPGDDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPQGALSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
KGEGEAIVLVMWAVVEELRTLLRIKRGTTAGKPLATLLRENRVWGPRERLIAPALNRVSEAVLEKALAFAAKLDRQVKGL
SAVTPGRRTQDEPPPDPWDGLFQLAMTVAGARGERPPTAGRVRR

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=313, Percent_Identity=33.2268370607029, Blast_Score=155, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39640; Mature: 39640

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLDALEPHLAKGLAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDW
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCH
SVLLGATQAMSLFGERQLIELRIPSGKPGKEGADALKTLAATPNPDALMLVTLPRLDAAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHH
QKSAWFTALQNGGVALKIDPVDRAQLPNWIGQRLSMQGQRVAPGDDGRRALQFIAERVEG
HHHHHHHHHCCCCEEEEECCCCHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPQGALSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
KGEGEAIVLVMWAVVEELRTLLRIKRGTTAGKPLATLLRENRVWGPRERLIAPALNRVSE
CCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AVLEKALAFAAKLDRQVKGLSAVTPGRRTQDEPPPDPWDGLFQLAMTVAGARGERPPTAG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
RVRR
CCCC
>Mature Secondary Structure
MQLRLDALEPHLAKGLAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDW
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCH
SVLLGATQAMSLFGERQLIELRIPSGKPGKEGADALKTLAATPNPDALMLVTLPRLDAAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHH
QKSAWFTALQNGGVALKIDPVDRAQLPNWIGQRLSMQGQRVAPGDDGRRALQFIAERVEG
HHHHHHHHHCCCCEEEEECCCCHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPQGALSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
KGEGEAIVLVMWAVVEELRTLLRIKRGTTAGKPLATLLRENRVWGPRERLIAPALNRVSE
CCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AVLEKALAFAAKLDRQVKGLSAVTPGRRTQDEPPPDPWDGLFQLAMTVAGARGERPPTAG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
RVRR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]