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The map label for this gene is cynR [H]

Identifier: 116688667

GI number: 116688667

Start: 717678

End: 718568

Strand: Direct

Name: cynR [H]

Synonym: Bcen2424_0644

Alternate gene names: 116688667

Gene position: 717678-718568 (Clockwise)

Preceding gene: 116688665

Following gene: 116688669

Centisome position: 20.6

GC content: 71.04

Gene sequence:

>891_bases
ATGCTTCTCCGCCACATCCGCTATTTCCTTGCCGTCGCCGAACAGCGCAGCTTCACGCGCGCGGCCGACGCGCTGCACGT
ATCGCAGCCGACGCTGTCGCAGCAGATCCGTCAGCTCGAGGACACGCTCGGCGTGCAGCTGTTCGACCGCTCGGGCCGCA
CGGTGCAGCTCACCGAATTCGGCGAGGTCTATGCACGCCACGCGCGCGCCGCCCTGCACGCGCTCGATATCGGGCAGCGC
GCGCTGCACGACGTCGCCGAGCTTGGCAGCGGCTCGTTGCGGCTCGCGATGATGCCGACTTTCGCGGCCTACCTGAGCGG
CTCGCTGATCGACGCATTCCATGCCGACCATCCGAACGTCGCGCTGACGATCGACGCGATGCCGCAGGAGCGCATCGAGG
CGTTGCTCGCCGACGACCGGCTCGACGCCGGCTTCGCGTTCATGCCGCCGCGTGCGCCGGACATCGAAGCGCTGCCACTG
TGGGACGAGCCGCTCGCGCTGGTGACGGGCCGCACGCATCGTCTCGCGCGCCGTCGCCGTGCGCTCACGCCGGCCGAGCT
CGGCGGCGAGCCGCTGGTGCTGCTGAGCCGCGCGTTCGCGACGCGCGAGCGCATCGACCGGTATTTCGTCGAGCACGGCG
CGCGGCCGTTGGTCGCGATCGAGACGAATACGGTCACTTCGGTGCTGGAACTCGTGCGGCGCGGCCGGCTCGCGACGGTG
CTGCCCGACGCGGTCGCGCGCGAGAGCGGCGACCTGTGCGCGCTGGAGATCGATCCGCCGCTGCCGACGCGCACGGCCGC
GCTGCTCACGCGCAAGGGTGCGTACCGCAGCGTCGCGGCGCGCGCATTCATCGAGCGCGTGCTCGCATATCGCGATCCGT
CGGAACGGTGA

Upstream 100 bases:

>100_bases
TTGCACGGAAGCGGATGTGCGTATGATGCGGGCATCGACTCATAGCGTCCAAGACTGGATCGTTATGGTCTCAATTGGCA
AAACCAATACGTTGGCCGCG

Downstream 100 bases:

>100_bases
CCGGCACGGCCGGGCGGAAGGCCGGGCCGCGGCGCGGGAGGATTACGCGCCGGGCGTCGGGAAGAAGACGCCCGCGCGCT
GCGCCGCGTTCGTGATGTGC

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MLLRHIRYFLAVAEQRSFTRAADALHVSQPTLSQQIRQLEDTLGVQLFDRSGRTVQLTEFGEVYARHARAALHALDIGQR
ALHDVAELGSGSLRLAMMPTFAAYLSGSLIDAFHADHPNVALTIDAMPQERIEALLADDRLDAGFAFMPPRAPDIEALPL
WDEPLALVTGRTHRLARRRRALTPAELGGEPLVLLSRAFATRERIDRYFVEHGARPLVAIETNTVTSVLELVRRGRLATV
LPDAVARESGDLCALEIDPPLPTRTAALLTRKGAYRSVAARAFIERVLAYRDPSER

Sequences:

>Translated_296_residues
MLLRHIRYFLAVAEQRSFTRAADALHVSQPTLSQQIRQLEDTLGVQLFDRSGRTVQLTEFGEVYARHARAALHALDIGQR
ALHDVAELGSGSLRLAMMPTFAAYLSGSLIDAFHADHPNVALTIDAMPQERIEALLADDRLDAGFAFMPPRAPDIEALPL
WDEPLALVTGRTHRLARRRRALTPAELGGEPLVLLSRAFATRERIDRYFVEHGARPLVAIETNTVTSVLELVRRGRLATV
LPDAVARESGDLCALEIDPPLPTRTAALLTRKGAYRSVAARAFIERVLAYRDPSER
>Mature_296_residues
MLLRHIRYFLAVAEQRSFTRAADALHVSQPTLSQQIRQLEDTLGVQLFDRSGRTVQLTEFGEVYARHARAALHALDIGQR
ALHDVAELGSGSLRLAMMPTFAAYLSGSLIDAFHADHPNVALTIDAMPQERIEALLADDRLDAGFAFMPPRAPDIEALPL
WDEPLALVTGRTHRLARRRRALTPAELGGEPLVLLSRAFATRERIDRYFVEHGARPLVAIETNTVTSVLELVRRGRLATV
LPDAVARESGDLCALEIDPPLPTRTAALLTRKGAYRSVAARAFIERVLAYRDPSER

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=288, Percent_Identity=53.125, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI1790399, Length=277, Percent_Identity=31.0469314079422, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1788887, Length=289, Percent_Identity=31.4878892733564, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789204, Length=243, Percent_Identity=35.8024691358025, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI145693105, Length=284, Percent_Identity=26.7605633802817, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081904, Length=223, Percent_Identity=31.8385650224215, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788748, Length=289, Percent_Identity=27.3356401384083, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787879, Length=249, Percent_Identity=30.9236947791165, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788481, Length=297, Percent_Identity=26.9360269360269, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788297, Length=255, Percent_Identity=28.2352941176471, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787530, Length=238, Percent_Identity=29.4117647058824, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI2367136, Length=248, Percent_Identity=30.6451612903226, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789173, Length=163, Percent_Identity=33.7423312883436, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790208, Length=257, Percent_Identity=27.2373540856031, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787589, Length=173, Percent_Identity=32.9479768786127, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787601, Length=122, Percent_Identity=34.4262295081967, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=31.1475409836066, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787806, Length=242, Percent_Identity=23.5537190082645, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI145693193, Length=121, Percent_Identity=33.8842975206612, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32821; Mature: 32821

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRHIRYFLAVAEQRSFTRAADALHVSQPTLSQQIRQLEDTLGVQLFDRSGRTVQLTEF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEECCCCCEEEEHHH
GEVYARHARAALHALDIGQRALHDVAELGSGSLRLAMMPTFAAYLSGSLIDAFHADHPNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCHHHHHHCCCCCCE
ALTIDAMPQERIEALLADDRLDAGFAFMPPRAPDIEALPLWDEPLALVTGRTHRLARRRR
EEEEECCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHH
ALTPAELGGEPLVLLSRAFATRERIDRYFVEHGARPLVAIETNTVTSVLELVRRGRLATV
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCEEEC
LPDAVARESGDLCALEIDPPLPTRTAALLTRKGAYRSVAARAFIERVLAYRDPSER
CCHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLLRHIRYFLAVAEQRSFTRAADALHVSQPTLSQQIRQLEDTLGVQLFDRSGRTVQLTEF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEECCCCCEEEEHHH
GEVYARHARAALHALDIGQRALHDVAELGSGSLRLAMMPTFAAYLSGSLIDAFHADHPNV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCHHHHHHCCCCCCE
ALTIDAMPQERIEALLADDRLDAGFAFMPPRAPDIEALPLWDEPLALVTGRTHRLARRRR
EEEEECCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHH
ALTPAELGGEPLVLLSRAFATRERIDRYFVEHGARPLVAIETNTVTSVLELVRRGRLATV
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCEEEC
LPDAVARESGDLCALEIDPPLPTRTAALLTRKGAYRSVAARAFIERVLAYRDPSER
CCHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]