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The map label for this gene is idnD [H]

Identifier: 116688665

GI number: 116688665

Start: 714973

End: 716031

Strand: Direct

Name: idnD [H]

Synonym: Bcen2424_0642

Alternate gene names: 116688665

Gene position: 714973-716031 (Clockwise)

Preceding gene: 116688664

Following gene: 116688667

Centisome position: 20.52

GC content: 71.2

Gene sequence:

>1059_bases
ATGCGGTTGCGTTGCATGTGTGTGGTGATCCACGGGCCGAACGACCTGCGGGTCGAGGAGCAGGACGCGGGCGAGATCGG
CCCGGGCCAGGTGCGCGTCGACGTCGCGATGGGCGGCATCTGCGGCTCCGACCTGCATTACTTCCGGCATGGCGGCTTCG
GCGCGATCCGCCTGCAGCAGCCGATGGTGCTCGGTCACGAGGTCGCCGGCACGGTCGCGGAAGTGGCGCCGGACGTGACG
TCGGTGAAGGTCGGCGATCGCGTCGCGGTCAATCCGAGCCGGCCGTGCGGCGCGTGCCGCTACTGTCTCGAAGGGCTGCC
GAACCAGTGTCTCGACATGCGCTTCTACGGCAGCGCGATGCGGATGCCGCACGTGCAGGGCGCGTTCCGCAACGCGCTCG
TGTGCGACGCGGTGCAGTGCGTGAAGGTCGCCGATCACGTGCCGCTGTCGCTCGCGGCGCTCGCCGAGCCGTTCGCGGTC
GGGCTGCATGCGGTGTCGCGCGCGGGCCCGCTGATCGGCAAGCGCGTGCTCGTGTCGGGGTGCGGGCCGATCGGCGTGCT
GGCGGTCGCGGCGGCGCGCGTGCACGGTGCCGCGGAGATCGTCGCGACCGACGTCGTCGAGGCGCCGCTGGAAGTGGCGA
GCGCGCTCGGCGCGGACCGCACGATCAATGCGGCGGCCGATGCCGGCTGGGTCGAGCGCTACGGCGCCGACAAGGGCACG
TTCGACGTGATGATCGAGTGTTCGGGCAATGCGCGCGCGCTGCGCGACGGGCTGGACGTGATGCGTCCGCGCGGCGTCGT
CGTGCAGCTCGGGCTGGGCGGCGACGTGAGCCTGCCGCAGAACGTGGTGGTCGCGAAGGAACTGTCGATCTGCGGCTCGT
TCCGGTTCCACGCGGAATTCGCGCTCGCGGTGCAGTTGATCAACGCGGGGCGCGTCGACCTGCGGCCGGCCGTCACGCGC
GTGTTCCCGATGCGCGACGCGAACCTCGCATTCGAACTGGCGGGCGACCGCCAGCGTGCGATGAAGGTGCTGATCGATTT
CGCGAACGAGGCCGCGTGA

Upstream 100 bases:

>100_bases
GCGGCGATCTTCCTCGCGTCGGCCGCGTCCGATTTCGTGAACGGCCAGACGCTGTTCGTCGACGGCGGGCTGACCAGTGC
CGTCTAACCAGGAGCGCGTC

Downstream 100 bases:

>100_bases
CGGTGCGGCGCTAGCGCGTCGAGACGGCAGCGACGCCCCCGGCAAAAAGGCACGCCCGCGATGCGCGGCGCGTGCCTTTT
TCGTCGTGCGGCGCAAACGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MRLRCMCVVIHGPNDLRVEEQDAGEIGPGQVRVDVAMGGICGSDLHYFRHGGFGAIRLQQPMVLGHEVAGTVAEVAPDVT
SVKVGDRVAVNPSRPCGACRYCLEGLPNQCLDMRFYGSAMRMPHVQGAFRNALVCDAVQCVKVADHVPLSLAALAEPFAV
GLHAVSRAGPLIGKRVLVSGCGPIGVLAVAAARVHGAAEIVATDVVEAPLEVASALGADRTINAAADAGWVERYGADKGT
FDVMIECSGNARALRDGLDVMRPRGVVVQLGLGGDVSLPQNVVVAKELSICGSFRFHAEFALAVQLINAGRVDLRPAVTR
VFPMRDANLAFELAGDRQRAMKVLIDFANEAA

Sequences:

>Translated_352_residues
MRLRCMCVVIHGPNDLRVEEQDAGEIGPGQVRVDVAMGGICGSDLHYFRHGGFGAIRLQQPMVLGHEVAGTVAEVAPDVT
SVKVGDRVAVNPSRPCGACRYCLEGLPNQCLDMRFYGSAMRMPHVQGAFRNALVCDAVQCVKVADHVPLSLAALAEPFAV
GLHAVSRAGPLIGKRVLVSGCGPIGVLAVAAARVHGAAEIVATDVVEAPLEVASALGADRTINAAADAGWVERYGADKGT
FDVMIECSGNARALRDGLDVMRPRGVVVQLGLGGDVSLPQNVVVAKELSICGSFRFHAEFALAVQLINAGRVDLRPAVTR
VFPMRDANLAFELAGDRQRAMKVLIDFANEAA
>Mature_352_residues
MRLRCMCVVIHGPNDLRVEEQDAGEIGPGQVRVDVAMGGICGSDLHYFRHGGFGAIRLQQPMVLGHEVAGTVAEVAPDVT
SVKVGDRVAVNPSRPCGACRYCLEGLPNQCLDMRFYGSAMRMPHVQGAFRNALVCDAVQCVKVADHVPLSLAALAEPFAV
GLHAVSRAGPLIGKRVLVSGCGPIGVLAVAAARVHGAAEIVATDVVEAPLEVASALGADRTINAAADAGWVERYGADKGT
FDVMIECSGNARALRDGLDVMRPRGVVVQLGLGGDVSLPQNVVVAKELSICGSFRFHAEFALAVQLINAGRVDLRPAVTR
VFPMRDANLAFELAGDRQRAMKVLIDFANEAA

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=332, Percent_Identity=34.6385542168675, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI71565152, Length=361, Percent_Identity=23.2686980609418, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4501933, Length=348, Percent_Identity=26.7241379310345, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=25.1396648044693, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI156523966, Length=358, Percent_Identity=25.1396648044693, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4501929, Length=360, Percent_Identity=26.1111111111111, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI34577061, Length=212, Percent_Identity=31.6037735849057, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI262073058, Length=359, Percent_Identity=23.6768802228412, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI71743840, Length=359, Percent_Identity=23.6768802228412, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI71565154, Length=271, Percent_Identity=25.4612546125461, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1790718, Length=348, Percent_Identity=41.9540229885057, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1788073, Length=314, Percent_Identity=34.3949044585987, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1790045, Length=314, Percent_Identity=33.7579617834395, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1787863, Length=349, Percent_Identity=30.0859598853868, Blast_Score=141, Evalue=6e-35,
Organism=Escherichia coli, GI1788407, Length=316, Percent_Identity=29.1139240506329, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788075, Length=347, Percent_Identity=27.6657060518732, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI226510992, Length=334, Percent_Identity=29.3413173652695, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI87082125, Length=334, Percent_Identity=26.6467065868263, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786552, Length=351, Percent_Identity=28.4900284900285, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081918, Length=327, Percent_Identity=28.1345565749235, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786518, Length=256, Percent_Identity=28.515625, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=347, Percent_Identity=36.0230547550432, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17562878, Length=332, Percent_Identity=37.0481927710843, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25146526, Length=274, Percent_Identity=27.7372262773723, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=242, Percent_Identity=28.5123966942149, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=242, Percent_Identity=28.5123966942149, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=343, Percent_Identity=33.2361516034985, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322619, Length=336, Percent_Identity=34.2261904761905, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6323099, Length=312, Percent_Identity=33.6538461538462, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319257, Length=360, Percent_Identity=28.8888888888889, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=379, Percent_Identity=29.023746701847, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=25.4742547425474, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=297, Percent_Identity=29.6296296296296, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=278, Percent_Identity=28.0575539568345, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=277, Percent_Identity=28.158844765343, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=264, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=275, Percent_Identity=27.6363636363636, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=38.0239520958084, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI17137530, Length=334, Percent_Identity=36.5269461077844, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45550770, Length=301, Percent_Identity=25.2491694352159, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45551930, Length=301, Percent_Identity=25.2491694352159, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI221457811, Length=301, Percent_Identity=25.2491694352159, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17737895, Length=351, Percent_Identity=25.6410256410256, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 37093; Mature: 37093

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRCMCVVIHGPNDLRVEEQDAGEIGPGQVRVDVAMGGICGSDLHYFRHGGFGAIRLQQ
CCEEEEEEEEECCCCCEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHCCCEEEEEECC
PMVLGHEVAGTVAEVAPDVTSVKVGDRVAVNPSRPCGACRYCLEGLPNQCLDMRFYGSAM
CCEECHHHHHHHHHHCCCCEEEECCCEEEECCCCCHHHHHHHHHCCCHHHHHHEECCCHH
RMPHVQGAFRNALVCDAVQCVKVADHVPLSLAALAEPFAVGLHAVSRAGPLIGKRVLVSG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCHHEEEC
CGPIGVLAVAAARVHGAAEIVATDVVEAPLEVASALGADRTINAAADAGWVERYGADKGT
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEECCHHCCCHHHHHCCCCCC
FDVMIECSGNARALRDGLDVMRPRGVVVQLGLGGDVSLPQNVVVAKELSICGSFRFHAEF
EEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHCCEEHHHHH
ALAVQLINAGRVDLRPAVTRVFPMRDANLAFELAGDRQRAMKVLIDFANEAA
EEEEEHHCCCCCCCCHHHHHEECCCCCCEEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLRCMCVVIHGPNDLRVEEQDAGEIGPGQVRVDVAMGGICGSDLHYFRHGGFGAIRLQQ
CCEEEEEEEEECCCCCEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHCCCEEEEEECC
PMVLGHEVAGTVAEVAPDVTSVKVGDRVAVNPSRPCGACRYCLEGLPNQCLDMRFYGSAM
CCEECHHHHHHHHHHCCCCEEEECCCEEEECCCCCHHHHHHHHHCCCHHHHHHEECCCHH
RMPHVQGAFRNALVCDAVQCVKVADHVPLSLAALAEPFAVGLHAVSRAGPLIGKRVLVSG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCHHEEEC
CGPIGVLAVAAARVHGAAEIVATDVVEAPLEVASALGADRTINAAADAGWVERYGADKGT
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEECCHHCCCHHHHHCCCCCC
FDVMIECSGNARALRDGLDVMRPRGVVVQLGLGGDVSLPQNVVVAKELSICGSFRFHAEF
EEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHCCEEHHHHH
ALAVQLINAGRVDLRPAVTRVFPMRDANLAFELAGDRQRAMKVLIDFANEAA
EEEEEHHCCCCCCCCHHHHHEECCCCCCEEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]