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The map label for this gene is maeB [H]

Identifier: 116688342

GI number: 116688342

Start: 360075

End: 362345

Strand: Direct

Name: maeB [H]

Synonym: Bcen2424_0318

Alternate gene names: 116688342

Gene position: 360075-362345 (Clockwise)

Preceding gene: 116688334

Following gene: 116688344

Centisome position: 10.34

GC content: 65.83

Gene sequence:

>2271_bases
ATGGACGAACAACTGAAGCAGGCCGCTCTCGCTTATCACCTGAACCCGAAACCCGGCAAGATTTCGGTCACCCCGACCAA
GCCGCTGTCGAACCAGCTCGATCTGTCGCTCGCGTATTCGCCCGGCGTCGCCGCTGCGTGCGAGGCGATCCACGCCGATC
CGCTCGACGCGCAGAAGTACACGTCGCGCGGCAACCTCGTCGGCGTCATCACGAACGGCACCGCCGTGCTCGGCCTCGGC
AACATCGGCCCGCTGGCCGCGAAGCCGGTGATGGAAGGCAAGGGCTGCCTCTTCAAGAAATTCGCGGGCATCGACGTGTT
CGACATCGAACTGTCGGAGTCCGACCCCGACAAGCTCGTCGAGGCGATCGCGATGCTCGAGCCGACGCTCGGCGGCATCA
ACCTCGAGGACATCAAGGCGCCGGAGTGCTTCTACATCGAGCAGAAGCTGCGCGAGCGCATGAAGATTCCCGTTTTCCAC
GACGACCAGCACGGCACCGCGATCATCGCGTCGGCTGCGATCCTGAACGGCCTGAAGGTCGTCGGCAAGAAGCTGTCGGA
AGTGAAGCTCGTGTGTTCGGGCGCGGGCGCGGCGGCGATCGCGTGCCTGGACCTGCTGGTGAACCTCGGCCTCACGAAGT
CGAACATCCTCGTCGCCGATTCGAAGGGCGTGATCTACGAAGGGCGCAGCAACCTCGATCCGTCGAAGCAGCGCTATGCG
GCGAACACCGACGCGCGCACGCTTGCCGACGCGATCGTCGGCGCGGACGTATTCCTCGGCTGCTCGAGTGCGGGCGTGCT
GAAGCAGGACATGGTCAAGACGATGGGGGAGCGCCCGCTGATCCTGGCGCTCGCGAACCCGGAACCGGAAATCCGCCCGG
AAGACGCGAAGGCCGTGCGCCCGGACGCGATCGTCGCGACCGGCCGTTCGGACTACCCGAACCAGGTCAACAACGTGCTG
TGCTTCCCGTTCATCTTCCGCGGCGCGCTCGACGTCGGCGCGACGACGATCACGGAAGAAATGAAGCTCGCGTGCGTGCG
CGCGATCGCCGAGCTGGCCGAGGAAACCGACCAGAGCGAGGAAGTCGCGAAGGCGTATGAAGGCCATTCGCTCGAATTCG
GGCCGGACTACCTGATTCCGAAGCCGTTCGATCCGCGCCTGATCATCAAGATCGCGCCGGCGGTGGCTCAAGCCGCGATG
GATTCGGGCGTCGCCACGCGTCCGATCCAGGACATGGACGCGTACCGCGAGCAGCTCGGCGCGACCGTCTACCGCACCGG
CATGGTGATGCGCCCGGTGTTCGCGGCCGCGAAGCAGAAGGAGGCCCGTATCGTGTTCGCCGAAGGCGAGGACGAGCGCG
TGCTGCGCGCTGCACAGTTCGTGCTGCTGGAAAAGATCGCCAAGCCGATCATCGTCGGCCGTCCGTCGGTCGTCGACATG
CGCTTGCAGAAGATCGGCTCGAAGCTGAAGGCCGGCGTCGATTTCGAAATCGTCGATCCGGAAGACGATGCGCGCTACCA
CCGCTACTGGCAGGCGTATCAGGAGATCGGCGCGCGCGACGGCGTGACGCCGGAAGTCGCGAAGGCCGCGATGCGCAAGT
TCAACACGCTGATCGGCGCGATGCTCGTCCATCTGGGCGATGCGGACGGGATGATCTGCGGGATGATCGACACGTTCCAC
AGCCACCTGAAGTTCATCGAGCAGGTGCTGGGCCGCGCGAAGGGCGCCGAGCACTTCGCCGCGATGAACCTGCTGATGCT
GCCGGGCCGCAACCTGTTCGTGTGCGACACGTACGTGAACGAGCTGCCGAGCGCCGACCAGCTCGCCGACATGACGATCC
AGGCCGCGGCCGAGATCGAGCGCTTCGGCATCGCGCCGAAGGCCGCGCTGCTGTCGAACTCGAACTTCGGCAGCGCGCCG
TCGGCGTCGTCGCGCCGGATGGCCGAGGCCCGCAAGCTGATCGTCGAACGTGCGCCGAACCTCGAAGTCGACGGCGAAAT
GCACGGCGACGCGGCGCTGTCGGAACTGATCCGCAAGCAGGCGTTCCCGGGCACGACGCTGTCGGGCGAAGCGAACCTGC
TGATCATGCCGAACGTCGAAGCGGCGAACATCGCGTACAACCTGCTGAAGATGGTCGGCGGCGAAGGCGTGACGGTCGGC
CCGTTCCTGCTCGGCGCCGCCAAGCCGGTCCACATCCTGACGCCGGCCGCGACCGTGCGCCGGATCATCAACATGACGGC
CGTTGCCGCCGCGAACGTGAACACGAAGTAA

Upstream 100 bases:

>100_bases
GGCCGTCTCGCAGTCGACCATCCCCTCGATTCAAGCAGACGCGGCCGAAGGTGCTGTGTACTGAGTCGTCAATATTTCGC
ATGTCTCTCGCAGGTCAATC

Downstream 100 bases:

>100_bases
GTCCACGCCCGCGTGTGCCGCGCGTTACTCGCGGCACAATGAAAAACGCCACGGAACCTGCGTTCCGTGGCGTTTTTTTT
CGCGTGAACCGTAAGGGCGA

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MDEQLKQAALAYHLNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVITNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKKLSEVKLVCSGAGAAAIACLDLLVNLGLTKSNILVADSKGVIYEGRSNLDPSKQRYA
ANTDARTLADAIVGADVFLGCSSAGVLKQDMVKTMGERPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAEETDQSEEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFAAAKQKEARIVFAEGEDERVLRAAQFVLLEKIAKPIIVGRPSVVDM
RLQKIGSKLKAGVDFEIVDPEDDARYHRYWQAYQEIGARDGVTPEVAKAAMRKFNTLIGAMLVHLGDADGMICGMIDTFH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVNELPSADQLADMTIQAAAEIERFGIAPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPNLEVDGEMHGDAALSELIRKQAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVNTK

Sequences:

>Translated_756_residues
MDEQLKQAALAYHLNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVITNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKKLSEVKLVCSGAGAAAIACLDLLVNLGLTKSNILVADSKGVIYEGRSNLDPSKQRYA
ANTDARTLADAIVGADVFLGCSSAGVLKQDMVKTMGERPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAEETDQSEEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFAAAKQKEARIVFAEGEDERVLRAAQFVLLEKIAKPIIVGRPSVVDM
RLQKIGSKLKAGVDFEIVDPEDDARYHRYWQAYQEIGARDGVTPEVAKAAMRKFNTLIGAMLVHLGDADGMICGMIDTFH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVNELPSADQLADMTIQAAAEIERFGIAPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPNLEVDGEMHGDAALSELIRKQAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVNTK
>Mature_756_residues
MDEQLKQAALAYHLNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVITNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKKLSEVKLVCSGAGAAAIACLDLLVNLGLTKSNILVADSKGVIYEGRSNLDPSKQRYA
ANTDARTLADAIVGADVFLGCSSAGVLKQDMVKTMGERPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAEETDQSEEVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFAAAKQKEARIVFAEGEDERVLRAAQFVLLEKIAKPIIVGRPSVVDM
RLQKIGSKLKAGVDFEIVDPEDDARYHRYWQAYQEIGARDGVTPEVAKAAMRKFNTLIGAMLVHLGDADGMICGMIDTFH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVNELPSADQLADMTIQAAAEIERFGIAPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPNLEVDGEMHGDAALSELIRKQAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVNTK

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=356, Percent_Identity=28.0898876404494, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI62420882, Length=355, Percent_Identity=27.887323943662, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI62420880, Length=355, Percent_Identity=27.887323943662, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI239049447, Length=355, Percent_Identity=27.887323943662, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4505145, Length=350, Percent_Identity=26.8571428571429, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI270265879, Length=317, Percent_Identity=28.0757097791798, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1788806, Length=758, Percent_Identity=63.3245382585752, Blast_Score=978, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=341, Percent_Identity=28.7390029325513, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI1788800, Length=323, Percent_Identity=31.8885448916409, Blast_Score=136, Evalue=5e-33,
Organism=Escherichia coli, GI87081919, Length=411, Percent_Identity=23.8442822384428, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17537199, Length=349, Percent_Identity=27.5071633237822, Blast_Score=66, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=30.5970149253731, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281362672, Length=402, Percent_Identity=26.865671641791, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281362674, Length=402, Percent_Identity=26.865671641791, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356279, Length=402, Percent_Identity=26.865671641791, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646388, Length=350, Percent_Identity=29.7142857142857, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646386, Length=350, Percent_Identity=29.4285714285714, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI78707242, Length=410, Percent_Identity=25.1219512195122, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI78707238, Length=410, Percent_Identity=25.1219512195122, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI78707240, Length=355, Percent_Identity=24.7887323943662, Blast_Score=74, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81041; Mature: 81041

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQLKQAALAYHLNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKY
CCHHHHHHHHHEECCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCHHHH
TSRGNLVGVITNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VGKKLSEVKLVCSGAGAAAIACLDLLVNLGLTKSNILVADSKGVIYEGRSNLDPSKQRYA
HHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCCCCCHHHHHC
ANTDARTLADAIVGADVFLGCSSAGVLKQDMVKTMGERPLILALANPEPEIRPEDAKAVR
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAEETDQSE
CCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIQDMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHC
ATVYRTGMVMRPVFAAAKQKEARIVFAEGEDERVLRAAQFVLLEKIAKPIIVGRPSVVDM
CHHHHCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCCHHHH
RLQKIGSKLKAGVDFEIVDPEDDARYHRYWQAYQEIGARDGVTPEVAKAAMRKFNTLIGA
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
MLVHLGDADGMICGMIDTFHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVN
HHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEEHHHH
ELPSADQLADMTIQAAAEIERFGIAPKAALLSNSNFGSAPSASSRRMAEARKLIVERAPN
HCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSELIRKQAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVNTK
HHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDEQLKQAALAYHLNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKY
CCHHHHHHHHHEECCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCHHHH
TSRGNLVGVITNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VGKKLSEVKLVCSGAGAAAIACLDLLVNLGLTKSNILVADSKGVIYEGRSNLDPSKQRYA
HHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCCCCCHHHHHC
ANTDARTLADAIVGADVFLGCSSAGVLKQDMVKTMGERPLILALANPEPEIRPEDAKAVR
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAEETDQSE
CCEEEECCCCCCCHHHHCEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
EVAKAYEGHSLEFGPDYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIQDMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHC
ATVYRTGMVMRPVFAAAKQKEARIVFAEGEDERVLRAAQFVLLEKIAKPIIVGRPSVVDM
CHHHHCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCCHHHH
RLQKIGSKLKAGVDFEIVDPEDDARYHRYWQAYQEIGARDGVTPEVAKAAMRKFNTLIGA
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
MLVHLGDADGMICGMIDTFHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVN
HHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEEHHHH
ELPSADQLADMTIQAAAEIERFGIAPKAALLSNSNFGSAPSASSRRMAEARKLIVERAPN
HCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSELIRKQAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVNTK
HHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]