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The map label for this gene is aqpZ [H]

Identifier: 116688272

GI number: 116688272

Start: 288421

End: 289164

Strand: Reverse

Name: aqpZ [H]

Synonym: Bcen2424_0248

Alternate gene names: 116688272

Gene position: 289164-288421 (Counterclockwise)

Preceding gene: 116688274

Following gene: 116688269

Centisome position: 8.3

GC content: 68.01

Gene sequence:

>744_bases
ATGAATCTTTCTCAGCGTCTCGCTGCAGAGGTATTCGGCACGTTCTGGCTGGTGCTCGGCGGGTGCGGAAGCGCCGTGCT
GGCCGCCGCCTTTCCGGGCCTCGGCATCGGCTTTGCCGGCGTCGCACTCGCCTTCGGCCTGACCGTGCTGACGATGGCAT
TCGCAATCGGCCACATCTCGGGTTGCCACCTGAATCCGGCGGTGAGCGTCGGCCTGACGGTCGCCGGCCGCTTCCCGGCA
CGCGATCTCGCGCCGTACATCGTCGCGCAGGTCGTCGGCGCCACGCTCGGCGCCTTCGTGCTGTACCTGATCGCAACCGG
CAAGCCGGGTTTCGACGTCGTCGGCAGCGGCTTTGCGACGAACGGCTTCGGCGATCGCTCGCCCGGCCACTACTCGCTCA
CCGCGTCGTTCATCTGCGAAGTCGTGATGACGGGCTTCTTCCTGTTCGTGATCCTCGGCGCGACCGACAAGCGCGGGGTG
CCGGCCGGCTTCGCGCCGATCGCGATCGGGCTGTGCCTGACGCTGATTCACCTGATCTCGATTCCGGTCACCAACACGTC
GGTGAACCCGGCGCGCTCGACCGGCCCCGCGCTGTTCGTGGGCGGCGACGCGATCGGCCAGCTGTGGCTGTTCTGGGTCG
CGCCGCTGATCGGCGCGGTACTCGCGGGGATCATCTACCCACTGGTCGCCGGGCGTGACGACGCCGTCGACCTGCTGCCG
GCATCCGCTCGCACAAGCGAATAA

Upstream 100 bases:

>100_bases
CGAACCCGATTCATTTCCTATAATCCAGACCAATTCCGGACGACGAAATAAATCCGTTGCGTCGGCCGGGGTCTTCAACC
CACTTGGACGAGGTCCTTAC

Downstream 100 bases:

>100_bases
AACACTACGGGGTCAAGCGAGCAGAGCAGCGAGCCTCACGCTGTCGAAGAACATCGAGGCAGGTAATTTCGACGGGCGCC
CCTGGCGCCCGTTTTTCATT

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLTVAGRFPA
RDLAPYIVAQVVGATLGAFVLYLIATGKPGFDVVGSGFATNGFGDRSPGHYSLTASFICEVVMTGFFLFVILGATDKRGV
PAGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGDAIGQLWLFWVAPLIGAVLAGIIYPLVAGRDDAVDLLP
ASARTSE

Sequences:

>Translated_247_residues
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLTVAGRFPA
RDLAPYIVAQVVGATLGAFVLYLIATGKPGFDVVGSGFATNGFGDRSPGHYSLTASFICEVVMTGFFLFVILGATDKRGV
PAGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGDAIGQLWLFWVAPLIGAVLAGIIYPLVAGRDDAVDLLP
ASARTSE
>Mature_247_residues
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLTVAGRFPA
RDLAPYIVAQVVGATLGAFVLYLIATGKPGFDVVGSGFATNGFGDRSPGHYSLTASFICEVVMTGFFLFVILGATDKRGV
PAGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGDAIGQLWLFWVAPLIGAVLAGIIYPLVAGRDDAVDLLP
ASARTSE

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4755125, Length=190, Percent_Identity=38.4210526315789, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4502181, Length=190, Percent_Identity=38.4210526315789, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI37694062, Length=190, Percent_Identity=36.8421052631579, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI4502183, Length=219, Percent_Identity=35.6164383561644, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI4502179, Length=227, Percent_Identity=34.3612334801762, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI6912506, Length=219, Percent_Identity=32.8767123287671, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI157266307, Length=245, Percent_Identity=31.4285714285714, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI22538420, Length=271, Percent_Identity=30.6273062730627, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4826645, Length=248, Percent_Identity=32.258064516129, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI86792455, Length=231, Percent_Identity=32.034632034632, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI4502187, Length=242, Percent_Identity=30.1652892561983, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI45446752, Length=209, Percent_Identity=29.1866028708134, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=69.7115384615385, Blast_Score=282, Evalue=1e-77,
Organism=Escherichia coli, GI1790362, Length=268, Percent_Identity=28.7313432835821, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71992966, Length=261, Percent_Identity=29.5019157088123, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71993722, Length=243, Percent_Identity=31.2757201646091, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17558372, Length=209, Percent_Identity=29.1866028708134, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71992961, Length=260, Percent_Identity=28.8461538461538, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994009, Length=238, Percent_Identity=28.1512605042017, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=252, Percent_Identity=30.5555555555556, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17531431, Length=252, Percent_Identity=30.5555555555556, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544068, Length=259, Percent_Identity=29.3436293436293, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=201, Percent_Identity=27.8606965174129, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24652747, Length=240, Percent_Identity=35.8333333333333, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45551084, Length=240, Percent_Identity=35.8333333333333, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24652751, Length=234, Percent_Identity=32.0512820512821, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922038, Length=234, Percent_Identity=32.0512820512821, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24762342, Length=211, Percent_Identity=29.3838862559242, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550503, Length=245, Percent_Identity=26.530612244898, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24762344, Length=227, Percent_Identity=30.3964757709251, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24762346, Length=227, Percent_Identity=30.3964757709251, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24762348, Length=227, Percent_Identity=30.3964757709251, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI20130305, Length=227, Percent_Identity=30.3964757709251, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17136672, Length=224, Percent_Identity=27.6785714285714, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 25122; Mature: 25122

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSVGLTVAGRFPARDLAPYIVAQVVGATLGAFVLYLIATGKPGFDVVGSGFAT
CCCCCCHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCC
NGFGDRSPGHYSLTASFICEVVMTGFFLFVILGATDKRGVPAGFAPIAIGLCLTLIHLIS
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IPVTNTSVNPARSTGPALFVGGDAIGQLWLFWVAPLIGAVLAGIIYPLVAGRDDAVDLLP
CCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
ASARTSE
CCCCCCC
>Mature Secondary Structure
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSVGLTVAGRFPARDLAPYIVAQVVGATLGAFVLYLIATGKPGFDVVGSGFAT
CCCCCCHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCC
NGFGDRSPGHYSLTASFICEVVMTGFFLFVILGATDKRGVPAGFAPIAIGLCLTLIHLIS
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IPVTNTSVNPARSTGPALFVGGDAIGQLWLFWVAPLIGAVLAGIIYPLVAGRDDAVDLLP
CCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
ASARTSE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]