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The map label for this gene is acsA [H]

Identifier: 116626871

GI number: 116626871

Start: 9842029

End: 9843861

Strand: Direct

Name: acsA [H]

Synonym: Acid_7846

Alternate gene names: 116626871

Gene position: 9842029-9843861 (Clockwise)

Preceding gene: 116626869

Following gene: 116626872

Centisome position: 98.76

GC content: 63.39

Gene sequence:

>1833_bases
ATGGATGGAAAGATGATCTGGACTCCGACTCGGGAATTTGTGGAGACCACGAACGTATGGCGATTGATGAAGCGCCTGGG
GTTTGACGACCGCGAAGAGTTCCTGCGTTTCTCACGCGAGAATCCGGAGCGATTCTGGGGCGAGATGATGCGTGAAATGC
GTGTGGAGTGGTTCACGCCTTACTCGAAAGAGCTAGACCTCTCGGGCGGCCCGGAATGGGCGCGCTGGTTCATCGGCGGG
CGTTTGAACATCGCGCATAATTGCCTCGACCGCTGGGCGGACAGCGATTGCGCGGCTTGTATCTGGGAGGGCGAGAGCGG
CGCGGGCGGCACATTGACATTCCGCGAACTCCGCGAGCAGGCCAATCGCACGGCGAACGGGCTGCGGGCGCTCGGTCTGG
AAGCGGGCGACCGGGTAGCGCTGTGTCTGCCGATGACGCCGGAGATCCTGCCGATTCTCTATGGATGCTTCAAGGCCGGG
CTCACGGTGGTGCCGATTTTCGCGGGTTTCGGCACCGGCGCGATTGCGACGCGGTTGATTGACTCGGGCGCATGCGTGTT
GTTCACGGCGGAATTTTTGGAGCGGCGCGGCAAGCGGATTCCGCTGGCGGCCAAGATGCCGGAGTTCGCTGGAAGGACTA
TCGTGCTGGGCAGCGAGTGGCAGGAATTCCTGGCGAGTCAGCCGGCGGAGTTCGCGACGGAATCACTGGAGGCGGAGGCT
CGCGCCTTCATCCTGTATACTTCGGGGACCACGGGCAAGCCGAAGGGCACGGTGCACACGCACGCGGGATCGCTGGCTCA
GATGGGGAAGGAGATCTGGCTGGGCTTCGATCATCGAGAAGGGGAGCGGTTTTTCTGGCTGAGCGACATCGGCTGGATGA
TGGGACCGTGGACCATTCTGGGGAACCACCTGTTCGGCGGCACGATTTTTCTATACGACGGCGCGCCCGATTATCCGGGG
CCGATGCGGTTATGGGAGACGATCGACCGGCACCGGATCACGACGTTCGGAGTTTCGCCGACCGCGATCCGCGTCCTCCG
GAAATCGCCGGGCGAGCTGCCGGCGATGGAGTCGCTGCGGCTGCTGGGCTCGACTGGGGAGCCTTGGGACGATGCCTCGT
GGCTGTGGTTTTTCGAGCGAGTGGGCCGGAGGCGCTGCCCGATCATCAACATTTCAGGCGGCACCGAGATCGTGGGCAGC
TTCCTGTTTCCACTGCCGATTCAGGCGTTGAAACCAAGCAGCCTGGGCGGTCCGGCGCCAGGCATGTCCACGGAGGTGGT
GGACGAGAGCGGAGTTCCGGTGCGTGGGCGCAAGGGCTACCTGGTGTGCACGCGGCCGGCGCCTTCCATGACGCGGGGGA
TCTGGGGCGACCCGGAGAGGTACATCGAGACGTATTGGAGCAAGTTCCCGGGCATGTGGTATCACGGCGATTGGGCTAGC
GTGGATGAAGACGGCCACTGGTTTCTTCACGGGCGCGCCGACGAATCGATGAACGTAGCGGGACGGAAGGTGGGTCCAGC
GGAGGTCGAAGAGGCGATGATGCAGCATCCGGACGTGGCGGAGGCAGCGGTGATCGGCGTCCCGGACGAGTTGAAGGGCG
AGACCATCGTGGGCTTCGCGGTGGCGAAGGCGGGGACTGTTTTGGATGCAGCGGCGGTGGTCAGGACTGTGGTAGAAGTG
CTCGGCCCTACGTTCCGGCCGCGCGAGATCGTGGTGGTGACGGAGTTGCCGAAGACGCAGAGCGGGAAGATCGTGCGGCG
TTTAATTCGCCAGAAGTATCTGGGAGAAGAGCTGGGAGATCTCTCGACCGTGGCGAATCCGTGGGCTTTGTGA

Upstream 100 bases:

>100_bases
AGCCGAGGTTTCATGACAACCTGAAACAGATTAAACGTTATATCTATTAAACCAGGAGTTGCACAAAATTTCTTGAGAGT
CTGAGACTTTGAGGATACCG

Downstream 100 bases:

>100_bases
GCAGAACTCGATATCCGATTCATAACTCCCTGGCGGCTTTTGGGTTAACCATATGGGTACTGGAACCGGCAGGTAAGGTC
GTGTATATTCCGATCGGATG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MDGKMIWTPTREFVETTNVWRLMKRLGFDDREEFLRFSRENPERFWGEMMREMRVEWFTPYSKELDLSGGPEWARWFIGG
RLNIAHNCLDRWADSDCAACIWEGESGAGGTLTFRELREQANRTANGLRALGLEAGDRVALCLPMTPEILPILYGCFKAG
LTVVPIFAGFGTGAIATRLIDSGACVLFTAEFLERRGKRIPLAAKMPEFAGRTIVLGSEWQEFLASQPAEFATESLEAEA
RAFILYTSGTTGKPKGTVHTHAGSLAQMGKEIWLGFDHREGERFFWLSDIGWMMGPWTILGNHLFGGTIFLYDGAPDYPG
PMRLWETIDRHRITTFGVSPTAIRVLRKSPGELPAMESLRLLGSTGEPWDDASWLWFFERVGRRRCPIINISGGTEIVGS
FLFPLPIQALKPSSLGGPAPGMSTEVVDESGVPVRGRKGYLVCTRPAPSMTRGIWGDPERYIETYWSKFPGMWYHGDWAS
VDEDGHWFLHGRADESMNVAGRKVGPAEVEEAMMQHPDVAEAAVIGVPDELKGETIVGFAVAKAGTVLDAAAVVRTVVEV
LGPTFRPREIVVVTELPKTQSGKIVRRLIRQKYLGEELGDLSTVANPWAL

Sequences:

>Translated_610_residues
MDGKMIWTPTREFVETTNVWRLMKRLGFDDREEFLRFSRENPERFWGEMMREMRVEWFTPYSKELDLSGGPEWARWFIGG
RLNIAHNCLDRWADSDCAACIWEGESGAGGTLTFRELREQANRTANGLRALGLEAGDRVALCLPMTPEILPILYGCFKAG
LTVVPIFAGFGTGAIATRLIDSGACVLFTAEFLERRGKRIPLAAKMPEFAGRTIVLGSEWQEFLASQPAEFATESLEAEA
RAFILYTSGTTGKPKGTVHTHAGSLAQMGKEIWLGFDHREGERFFWLSDIGWMMGPWTILGNHLFGGTIFLYDGAPDYPG
PMRLWETIDRHRITTFGVSPTAIRVLRKSPGELPAMESLRLLGSTGEPWDDASWLWFFERVGRRRCPIINISGGTEIVGS
FLFPLPIQALKPSSLGGPAPGMSTEVVDESGVPVRGRKGYLVCTRPAPSMTRGIWGDPERYIETYWSKFPGMWYHGDWAS
VDEDGHWFLHGRADESMNVAGRKVGPAEVEEAMMQHPDVAEAAVIGVPDELKGETIVGFAVAKAGTVLDAAAVVRTVVEV
LGPTFRPREIVVVTELPKTQSGKIVRRLIRQKYLGEELGDLSTVANPWAL
>Mature_610_residues
MDGKMIWTPTREFVETTNVWRLMKRLGFDDREEFLRFSRENPERFWGEMMREMRVEWFTPYSKELDLSGGPEWARWFIGG
RLNIAHNCLDRWADSDCAACIWEGESGAGGTLTFRELREQANRTANGLRALGLEAGDRVALCLPMTPEILPILYGCFKAG
LTVVPIFAGFGTGAIATRLIDSGACVLFTAEFLERRGKRIPLAAKMPEFAGRTIVLGSEWQEFLASQPAEFATESLEAEA
RAFILYTSGTTGKPKGTVHTHAGSLAQMGKEIWLGFDHREGERFFWLSDIGWMMGPWTILGNHLFGGTIFLYDGAPDYPG
PMRLWETIDRHRITTFGVSPTAIRVLRKSPGELPAMESLRLLGSTGEPWDDASWLWFFERVGRRRCPIINISGGTEIVGS
FLFPLPIQALKPSSLGGPAPGMSTEVVDESGVPVRGRKGYLVCTRPAPSMTRGIWGDPERYIETYWSKFPGMWYHGDWAS
VDEDGHWFLHGRADESMNVAGRKVGPAEVEEAMMQHPDVAEAAVIGVPDELKGETIVGFAVAKAGTVLDAAAVVRTVVEV
LGPTFRPREIVVVTELPKTQSGKIVRRLIRQKYLGEELGDLSTVANPWAL

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=666, Percent_Identity=33.1831831831832, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI28416953, Length=602, Percent_Identity=35.3820598006645, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI253970489, Length=398, Percent_Identity=38.6934673366834, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI13375727, Length=614, Percent_Identity=28.3387622149837, Blast_Score=229, Evalue=7e-60,
Organism=Homo sapiens, GI31982927, Length=626, Percent_Identity=26.1980830670927, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI38505220, Length=559, Percent_Identity=28.0858676207513, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI42544132, Length=545, Percent_Identity=27.3394495412844, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI115511026, Length=561, Percent_Identity=27.4509803921569, Blast_Score=171, Evalue=3e-42,
Organism=Homo sapiens, GI58082049, Length=566, Percent_Identity=29.1519434628975, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI157311624, Length=563, Percent_Identity=29.3072824156306, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI157311622, Length=563, Percent_Identity=29.3072824156306, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI122937307, Length=552, Percent_Identity=26.9927536231884, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI187761345, Length=550, Percent_Identity=26.1818181818182, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI187761343, Length=550, Percent_Identity=26.1818181818182, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI42544134, Length=390, Percent_Identity=25.3846153846154, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI156151445, Length=521, Percent_Identity=23.4165067178503, Blast_Score=93, Evalue=9e-19,
Organism=Escherichia coli, GI1790505, Length=613, Percent_Identity=35.0734094616639, Blast_Score=355, Evalue=5e-99,
Organism=Escherichia coli, GI1786529, Length=630, Percent_Identity=33.6507936507937, Blast_Score=291, Evalue=7e-80,
Organism=Escherichia coli, GI1788107, Length=591, Percent_Identity=25.7191201353638, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI221142682, Length=506, Percent_Identity=24.1106719367589, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI145693145, Length=518, Percent_Identity=24.5173745173745, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786810, Length=529, Percent_Identity=25.5198487712665, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71982997, Length=633, Percent_Identity=31.4375987361769, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71983001, Length=633, Percent_Identity=31.4375987361769, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17569507, Length=625, Percent_Identity=25.92, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17557194, Length=568, Percent_Identity=25.1760563380282, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17559526, Length=517, Percent_Identity=23.7911025145068, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17538037, Length=567, Percent_Identity=24.3386243386243, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71996755, Length=501, Percent_Identity=23.3532934131737, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17560308, Length=541, Percent_Identity=27.1719038817006, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=376, Percent_Identity=25.531914893617, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=501, Percent_Identity=22.5548902195609, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=398, Percent_Identity=23.6180904522613, Blast_Score=86, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=624, Percent_Identity=33.3333333333333, Blast_Score=339, Evalue=7e-94,
Organism=Saccharomyces cerevisiae, GI6319264, Length=631, Percent_Identity=33.4389857369255, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6319699, Length=390, Percent_Identity=24.3589743589744, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24667955, Length=636, Percent_Identity=33.1761006289308, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI62472339, Length=540, Percent_Identity=34.4444444444444, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24667959, Length=509, Percent_Identity=33.7917485265226, Blast_Score=279, Evalue=5e-75,
Organism=Drosophila melanogaster, GI21355225, Length=602, Percent_Identity=27.2425249169435, Blast_Score=208, Evalue=8e-54,
Organism=Drosophila melanogaster, GI18859661, Length=553, Percent_Identity=23.869801084991, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21355181, Length=543, Percent_Identity=23.3885819521179, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24648260, Length=515, Percent_Identity=23.495145631068, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356947, Length=506, Percent_Identity=24.901185770751, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648257, Length=360, Percent_Identity=25.2777777777778, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656500, Length=517, Percent_Identity=23.5976789168279, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922652, Length=572, Percent_Identity=22.5524475524476, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281365686, Length=494, Percent_Identity=21.6599190283401, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24653035, Length=532, Percent_Identity=21.8045112781955, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 67868; Mature: 67868

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGKMIWTPTREFVETTNVWRLMKRLGFDDREEFLRFSRENPERFWGEMMREMRVEWFTP
CCCCEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
YSKELDLSGGPEWARWFIGGRLNIAHNCLDRWADSDCAACIWEGESGAGGTLTFRELREQ
CCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEHHHHHHH
ANRTANGLRALGLEAGDRVALCLPMTPEILPILYGCFKAGLTVVPIFAGFGTGAIATRLI
HHHHHHHHHEECCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEHHHCCCCHHHHHHHH
DSGACVLFTAEFLERRGKRIPLAAKMPEFAGRTIVLGSEWQEFLASQPAEFATESLEAEA
CCCCEEEEEHHHHHHCCCCCCCCCCCHHHCCCEEEECCHHHHHHHCCCHHHHHHHHCCCC
RAFILYTSGTTGKPKGTVHTHAGSLAQMGKEIWLGFDHREGERFFWLSDIGWMMGPWTIL
EEEEEEECCCCCCCCCCEEECCCHHHHCCHHHEEECCCCCCCEEEEECCCCHHHCCHHHH
GNHLFGGTIFLYDGAPDYPGPMRLWETIDRHRITTFGVSPTAIRVLRKSPGELPAMESLR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCHHHHHH
LLGSTGEPWDDASWLWFFERVGRRRCPIINISGGTEIVGSFLFPLPIQALKPSSLGGPAP
HHCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCHHHCCCCCCCCCCC
GMSTEVVDESGVPVRGRKGYLVCTRPAPSMTRGIWGDPERYIETYWSKFPGMWYHGDWAS
CCCCHHCCCCCCCCCCCCCEEEECCCCCHHHCCCCCCHHHHHHHHHHHCCCCEECCCCCC
VDEDGHWFLHGRADESMNVAGRKVGPAEVEEAMMQHPDVAEAAVIGVPDELKGETIVGFA
CCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCHHHEEEECCCHHHCCCEEEEEE
VAKAGTVLDAAAVVRTVVEVLGPTFRPREIVVVTELPKTQSGKIVRRLIRQKYLGEELGD
HHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
LSTVANPWAL
HHHCCCCCCC
>Mature Secondary Structure
MDGKMIWTPTREFVETTNVWRLMKRLGFDDREEFLRFSRENPERFWGEMMREMRVEWFTP
CCCCEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
YSKELDLSGGPEWARWFIGGRLNIAHNCLDRWADSDCAACIWEGESGAGGTLTFRELREQ
CCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEHHHHHHH
ANRTANGLRALGLEAGDRVALCLPMTPEILPILYGCFKAGLTVVPIFAGFGTGAIATRLI
HHHHHHHHHEECCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEHHHCCCCHHHHHHHH
DSGACVLFTAEFLERRGKRIPLAAKMPEFAGRTIVLGSEWQEFLASQPAEFATESLEAEA
CCCCEEEEEHHHHHHCCCCCCCCCCCHHHCCCEEEECCHHHHHHHCCCHHHHHHHHCCCC
RAFILYTSGTTGKPKGTVHTHAGSLAQMGKEIWLGFDHREGERFFWLSDIGWMMGPWTIL
EEEEEEECCCCCCCCCCEEECCCHHHHCCHHHEEECCCCCCCEEEEECCCCHHHCCHHHH
GNHLFGGTIFLYDGAPDYPGPMRLWETIDRHRITTFGVSPTAIRVLRKSPGELPAMESLR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHCCCCCCCHHHHHH
LLGSTGEPWDDASWLWFFERVGRRRCPIINISGGTEIVGSFLFPLPIQALKPSSLGGPAP
HHCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCHHHCCCCCCCCCCC
GMSTEVVDESGVPVRGRKGYLVCTRPAPSMTRGIWGDPERYIETYWSKFPGMWYHGDWAS
CCCCHHCCCCCCCCCCCCCEEEECCCCCHHHCCCCCCHHHHHHHHHHHCCCCEECCCCCC
VDEDGHWFLHGRADESMNVAGRKVGPAEVEEAMMQHPDVAEAAVIGVPDELKGETIVGFA
CCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCHHHEEEECCCHHHCCCEEEEEE
VAKAGTVLDAAAVVRTVVEVLGPTFRPREIVVVTELPKTQSGKIVRRLIRQKYLGEELGD
HHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
LSTVANPWAL
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA