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The map label for this gene is era [H]

Identifier: 116626742

GI number: 116626742

Start: 9689012

End: 9689926

Strand: Direct

Name: era [H]

Synonym: Acid_7714

Alternate gene names: 116626742

Gene position: 9689012-9689926 (Clockwise)

Preceding gene: 116626741

Following gene: 116626743

Centisome position: 97.22

GC content: 60.87

Gene sequence:

>915_bases
ATGAATATAGAATTCAGGTCCGGTTTCGTCTCCCTGATTGGCCGGCCTAACGCCGGCAAATCCACGCTCCTCAACGCCCT
GGTCGGCCAGAAAGTGGCGATCGTCGCCGATAAGCCCCAGACTACGCGCACCTCGATTCAGGGAGTGCTCACGCTCCCCG
AGGCGCAGATTGTTTTCGCCGATACTCCCGGCATCCACAAGGCCGACACGCCGCTGAACAAGCGCCTGATGGATACCGTG
CGCGGGGCCCTTGAAGAGCGCGACCTGTTGCTCTTCGTCGCCGACGCCACGCGCAAGTTCAATGAAGACGATCGCCGCGC
CATCGATATCGCGCGCCGCCACAAGACGCCTGTCGTGCTCGTCCTCAACAAAATCGATCTGCTCAAGGACAAGGCGCACC
TGCTGCCGTTGATCGAAGAATACAAGGCCGTCTTCGAGTTCACCGAGTACGTGCCGGTGTCCTCCGTCAAGAAAATCGGC
CTTGACCAGCTGCGCGCTGTGATCCTCAAGTACCTGCCCGTCGGCCCAGCCTATTTCCCCGAGGACTATGTCACCGACCA
GCCCGAGCGTTTTCTCGCCGCCGAGTTGATCCGCGAGAAGGTGCTGCTCGCCACTCGCCAGGAAGTGCCGCACGCCGTCG
CGGTCACGGTGGACCGCTGGGAAGAGACCCCGAAGATCACTCGCATCTACGCCACCATTCACCTGGAGCGCGACGGTCAG
AAAGCCATCGTCATCGGCTCAGGCGGCTCCATGCTCAAGCTGATCGGAACCCAGGCGCGGCATGAAATGGAGCGTCTCTT
CGAAGCCAAGATCTACCTCGACCTGCACGTTCACGTGCAGCCCGGATGGCGCCAGAACCGCGCCTTCCTGAACGCACTCG
ACTGGCGTACAATGACCGGAGAAGATGATGCATAA

Upstream 100 bases:

>100_bases
GCGAGTTCGTCGAACGCGACGGCGTCCGCCTCGAAGTGCTGGCCAGCGACGAATTGCGCGTCGGCCAGGTCCGAATCAGT
AAATCACAAACGGTTGCTCA

Downstream 100 bases:

>100_bases
AATAGCGCTTGCCATTCTCGCCGTGCTCCTCATGCAGACCGTTGCGTTAGCCAAGGATCCGCCGAAGCAAACCGACGACA
CCATCACCGATCAGGTACGC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNIEFRSGFVSLIGRPNAGKSTLLNALVGQKVAIVADKPQTTRTSIQGVLTLPEAQIVFADTPGIHKADTPLNKRLMDTV
RGALEERDLLLFVADATRKFNEDDRRAIDIARRHKTPVVLVLNKIDLLKDKAHLLPLIEEYKAVFEFTEYVPVSSVKKIG
LDQLRAVILKYLPVGPAYFPEDYVTDQPERFLAAELIREKVLLATRQEVPHAVAVTVDRWEETPKITRIYATIHLERDGQ
KAIVIGSGGSMLKLIGTQARHEMERLFEAKIYLDLHVHVQPGWRQNRAFLNALDWRTMTGEDDA

Sequences:

>Translated_304_residues
MNIEFRSGFVSLIGRPNAGKSTLLNALVGQKVAIVADKPQTTRTSIQGVLTLPEAQIVFADTPGIHKADTPLNKRLMDTV
RGALEERDLLLFVADATRKFNEDDRRAIDIARRHKTPVVLVLNKIDLLKDKAHLLPLIEEYKAVFEFTEYVPVSSVKKIG
LDQLRAVILKYLPVGPAYFPEDYVTDQPERFLAAELIREKVLLATRQEVPHAVAVTVDRWEETPKITRIYATIHLERDGQ
KAIVIGSGGSMLKLIGTQARHEMERLFEAKIYLDLHVHVQPGWRQNRAFLNALDWRTMTGEDDA
>Mature_304_residues
MNIEFRSGFVSLIGRPNAGKSTLLNALVGQKVAIVADKPQTTRTSIQGVLTLPEAQIVFADTPGIHKADTPLNKRLMDTV
RGALEERDLLLFVADATRKFNEDDRRAIDIARRHKTPVVLVLNKIDLLKDKAHLLPLIEEYKAVFEFTEYVPVSSVKKIG
LDQLRAVILKYLPVGPAYFPEDYVTDQPERFLAAELIREKVLLATRQEVPHAVAVTVDRWEETPKITRIYATIHLERDGQ
KAIVIGSGGSMLKLIGTQARHEMERLFEAKIYLDLHVHVQPGWRQNRAFLNALDWRTMTGEDDA

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=318, Percent_Identity=27.0440251572327, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1788919, Length=291, Percent_Identity=38.4879725085911, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI87082120, Length=119, Percent_Identity=36.1344537815126, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17532761, Length=141, Percent_Identity=31.2056737588652, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=123, Percent_Identity=31.7073170731707, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646434, Length=307, Percent_Identity=24.1042345276873, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34334; Mature: 34334

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIEFRSGFVSLIGRPNAGKSTLLNALVGQKVAIVADKPQTTRTSIQGVLTLPEAQIVFA
CCCCCCCCHHHEECCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHCEEEECCCCEEEEE
DTPGIHKADTPLNKRLMDTVRGALEERDLLLFVADATRKFNEDDRRAIDIARRHKTPVVL
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCHHHHHHHHHHCCCCEEE
VLNKIDLLKDKAHLLPLIEEYKAVFEFTEYVPVSSVKKIGLDQLRAVILKYLPVGPAYFP
EEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCC
EDYVTDQPERFLAAELIREKVLLATRQEVPHAVAVTVDRWEETPKITRIYATIHLERDGQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEEECCCC
KAIVIGSGGSMLKLIGTQARHEMERLFEAKIYLDLHVHVQPGWRQNRAFLNALDWRTMTG
EEEEEECCCCEEEHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCHHHHHHHCCEECCC
EDDA
CCCC
>Mature Secondary Structure
MNIEFRSGFVSLIGRPNAGKSTLLNALVGQKVAIVADKPQTTRTSIQGVLTLPEAQIVFA
CCCCCCCCHHHEECCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHCEEEECCCCEEEEE
DTPGIHKADTPLNKRLMDTVRGALEERDLLLFVADATRKFNEDDRRAIDIARRHKTPVVL
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCHHHHHHHHHHCCCCEEE
VLNKIDLLKDKAHLLPLIEEYKAVFEFTEYVPVSSVKKIGLDQLRAVILKYLPVGPAYFP
EEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCC
EDYVTDQPERFLAAELIREKVLLATRQEVPHAVAVTVDRWEETPKITRIYATIHLERDGQ
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEEECCCC
KAIVIGSGGSMLKLIGTQARHEMERLFEAKIYLDLHVHVQPGWRQNRAFLNALDWRTMTG
EEEEEECCCCEEEHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCHHHHHHHCCEECCC
EDDA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]