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The map label for this gene is pepQ [H]

Identifier: 116626470

GI number: 116626470

Start: 9324383

End: 9325465

Strand: Direct

Name: pepQ [H]

Synonym: Acid_7433

Alternate gene names: 116626470

Gene position: 9324383-9325465 (Clockwise)

Preceding gene: 116626469

Following gene: 116626472

Centisome position: 93.57

GC content: 63.43

Gene sequence:

>1083_bases
ATGGCAAATAAAGATTACGAACAGCGCCGCCGCTCGGTTGCCGCGGGGCTGCGTGAACGCAAACTGGATGTGCTGCTGGT
TTCCCACAGCCCCAATCTTCGCTATCTCTCCGGGTTTACGGGCAGTAACGGCGCGCTGCTGGTGCTGCCTGGAAAGAGCA
TTCTCTTCACGGATCCGCGCTATCAGATTCAGGCCGCGCAGGAGTCCTCCTGCCAGATTCGAATCGTCAAGGGTCCACTG
GTCACGGGGCTGCTGGCGGCAATCCAGAAGCTCGGGGTCAAGCGCATCGGCTACGAACCGGCGCGCATGACGTGCGATTT
CTACGATGCGCTGAAGGCAGGGCTTACGCTCCGCGCCTCGCTCGAGCCCGTGCGGGAGTGGATCGAGGAAATGCGGATGG
TGAAGTCCGAGGCGGAACTGGCGCTCATCCGGCGCAGCGTGGAGACCAACTCGCGCGCCTTCGAACAGACCATCGCGCGG
ATCAAGCCCGGCATCAAGGAGCAGGACCTGGCGGCCGAGTTCGAATATCGAATGCGCCGCCTGGGGGCCGAAAAACCGAG
CTTCGAGAGCATTGTCGCCACCGGCGTTCGTTCTGCCCTCCCGCACGCACAGCCCACCGCGATGCGGCTCGCGGATGGAG
ACCTTGTGGTGGTGGACATGGGCGCCTTTCAGGATGGCTACGCCAGCGACATGACGCGCATGCTCTCGGTCGGTCCGCCC
AACAGCAAGGCCAAGCGCATGTATCGGGCCGTTCTGGAGGCGCAACTGGCGGCGATCGATGCGGTGCGCGCGGGTGCGGC
CACGGCGCGCGTGGATGGCGCGGCGCGCAAGGTGCTGAAGTCCTACGGACTCGATCGCGCCTTTATTCACTCCACCGGAC
ACGGCCTGGGATTGGAGATCCACGAGCCGCCACGGCTGGGCAAGCGCGACAAAATGCGTCTGCAGACCGGGATGGCAATC
ACGATCGAGCCGGGAGCGTACCTCGAAGGTTTCGGCGGCGTGCGCATCGAGGACACCGTAGTGGTGACCGACACAGGCTG
CGAAATTCTGACGCCCACGTCAAAGGACCTTTATATCGTCTAA

Upstream 100 bases:

>100_bases
AACTTCATGGCGCTCTCCGACGAGGCCGAGAAACGCAACGACATTCGCCAAGCGGACGCTTTCGCGGAACGCGCCCAGAT
TTTGGCGCGGGATTTACAGA

Downstream 100 bases:

>100_bases
AAATTTCCGGGCTTTTGCGGCCGTGGCGGCGCGCGGGTTGCCCCGTTGGCGGCGCGCGAATGCGCGAATGGCGCGGTTAT
TCGGCAGCACGCGGCAAAGC

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MANKDYEQRRRSVAAGLRERKLDVLLVSHSPNLRYLSGFTGSNGALLVLPGKSILFTDPRYQIQAAQESSCQIRIVKGPL
VTGLLAAIQKLGVKRIGYEPARMTCDFYDALKAGLTLRASLEPVREWIEEMRMVKSEAELALIRRSVETNSRAFEQTIAR
IKPGIKEQDLAAEFEYRMRRLGAEKPSFESIVATGVRSALPHAQPTAMRLADGDLVVVDMGAFQDGYASDMTRMLSVGPP
NSKAKRMYRAVLEAQLAAIDAVRAGAATARVDGAARKVLKSYGLDRAFIHSTGHGLGLEIHEPPRLGKRDKMRLQTGMAI
TIEPGAYLEGFGGVRIEDTVVVTDTGCEILTPTSKDLYIV

Sequences:

>Translated_360_residues
MANKDYEQRRRSVAAGLRERKLDVLLVSHSPNLRYLSGFTGSNGALLVLPGKSILFTDPRYQIQAAQESSCQIRIVKGPL
VTGLLAAIQKLGVKRIGYEPARMTCDFYDALKAGLTLRASLEPVREWIEEMRMVKSEAELALIRRSVETNSRAFEQTIAR
IKPGIKEQDLAAEFEYRMRRLGAEKPSFESIVATGVRSALPHAQPTAMRLADGDLVVVDMGAFQDGYASDMTRMLSVGPP
NSKAKRMYRAVLEAQLAAIDAVRAGAATARVDGAARKVLKSYGLDRAFIHSTGHGLGLEIHEPPRLGKRDKMRLQTGMAI
TIEPGAYLEGFGGVRIEDTVVVTDTGCEILTPTSKDLYIV
>Mature_359_residues
ANKDYEQRRRSVAAGLRERKLDVLLVSHSPNLRYLSGFTGSNGALLVLPGKSILFTDPRYQIQAAQESSCQIRIVKGPLV
TGLLAAIQKLGVKRIGYEPARMTCDFYDALKAGLTLRASLEPVREWIEEMRMVKSEAELALIRRSVETNSRAFEQTIARI
KPGIKEQDLAAEFEYRMRRLGAEKPSFESIVATGVRSALPHAQPTAMRLADGDLVVVDMGAFQDGYASDMTRMLSVGPPN
SKAKRMYRAVLEAQLAAIDAVRAGAATARVDGAARKVLKSYGLDRAFIHSTGHGLGLEIHEPPRLGKRDKMRLQTGMAIT
IEPGAYLEGFGGVRIEDTVVVTDTGCEILTPTSKDLYIV

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=376, Percent_Identity=29.2553191489362, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI260593665, Length=291, Percent_Identity=29.2096219931272, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI149589008, Length=291, Percent_Identity=29.2096219931272, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI93141226, Length=226, Percent_Identity=30.0884955752212, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI264681563, Length=227, Percent_Identity=31.7180616740088, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI260593663, Length=265, Percent_Identity=28.6792452830189, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI164420681, Length=222, Percent_Identity=27.9279279279279, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI264681565, Length=223, Percent_Identity=30.0448430493274, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI40385867, Length=184, Percent_Identity=27.1739130434783, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788728, Length=352, Percent_Identity=35.5113636363636, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1789275, Length=271, Percent_Identity=31.3653136531365, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786364, Length=189, Percent_Identity=29.6296296296296, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508215, Length=381, Percent_Identity=27.8215223097113, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71989583, Length=287, Percent_Identity=25.0871080139373, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320922, Length=256, Percent_Identity=28.515625, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321118, Length=288, Percent_Identity=25, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322999, Length=167, Percent_Identity=32.3353293413174, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19920384, Length=264, Percent_Identity=28.030303030303, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21357079, Length=288, Percent_Identity=28.4722222222222, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17137632, Length=354, Percent_Identity=27.4011299435028, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 39491; Mature: 39360

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKDYEQRRRSVAAGLRERKLDVLLVSHSPNLRYLSGFTGSNGALLVLPGKSILFTDPR
CCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCCCCEEEEECCCEEEEECCC
YQIQAAQESSCQIRIVKGPLVTGLLAAIQKLGVKRIGYEPARMTCDFYDALKAGLTLRAS
EEEEECCCCCCEEEEECCHHHHHHHHHHHHHCHHHCCCCHHHEEEHHHHHHHHCCEEEEC
LEPVREWIEEMRMVKSEAELALIRRSVETNSRAFEQTIARIKPGIKEQDLAAEFEYRMRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LGAEKPSFESIVATGVRSALPHAQPTAMRLADGDLVVVDMGAFQDGYASDMTRMLSVGPP
HCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCCC
NSKAKRMYRAVLEAQLAAIDAVRAGAATARVDGAARKVLKSYGLDRAFIHSTGHGLGLEI
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEE
HEPPRLGKRDKMRLQTGMAITIEPGAYLEGFGGVRIEDTVVVTDTGCEILTPTSKDLYIV
CCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEEEEECCCEEECCCCCCEEEC
>Mature Secondary Structure 
ANKDYEQRRRSVAAGLRERKLDVLLVSHSPNLRYLSGFTGSNGALLVLPGKSILFTDPR
CCCCHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCCCCEEEEECCCEEEEECCC
YQIQAAQESSCQIRIVKGPLVTGLLAAIQKLGVKRIGYEPARMTCDFYDALKAGLTLRAS
EEEEECCCCCCEEEEECCHHHHHHHHHHHHHCHHHCCCCHHHEEEHHHHHHHHCCEEEEC
LEPVREWIEEMRMVKSEAELALIRRSVETNSRAFEQTIARIKPGIKEQDLAAEFEYRMRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LGAEKPSFESIVATGVRSALPHAQPTAMRLADGDLVVVDMGAFQDGYASDMTRMLSVGPP
HCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCCC
NSKAKRMYRAVLEAQLAAIDAVRAGAATARVDGAARKVLKSYGLDRAFIHSTGHGLGLEI
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEE
HEPPRLGKRDKMRLQTGMAITIEPGAYLEGFGGVRIEDTVVVTDTGCEILTPTSKDLYIV
CCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEEEEECCCEEECCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]