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The map label for this gene is Hgd [H]

Identifier: 116626443

GI number: 116626443

Start: 9290301

End: 9291104

Strand: Direct

Name: Hgd [H]

Synonym: Acid_7405

Alternate gene names: 116626443

Gene position: 9290301-9291104 (Clockwise)

Preceding gene: 116626441

Following gene: 116626444

Centisome position: 93.22

GC content: 67.79

Gene sequence:

>804_bases
GTGGGCCTCCTGGGGTCCGCGATTGCCGACCGGCTTTCCGCGGCGGGGTACACGGTGGTGGGCTACGATCTCATCCCGGA
GCGCAGACGGGGCGCGGACTCGGCGCAGGAGGTGATTGGCAAGTGCCAGACCACGTTTCTCTGCCTGCCCACGTCTGATG
TGGTCGCGCAGGTGATCGGAAGCGTGAAGCCGGCCGCCGGCATCACGATGGTGGACTGCACGACTGGCGAGCCGGAGAGC
ATGGCGGCGATGGGTGAGAAGCTGGCGAAGAGCGGCGTCGATTACCTGGATGCGACGGTGCTGGGGTCGAGCAAAGTGGT
TCGCAGCGGGGCGGCGGTGGTGATGGCGGGCGGCCGCCGCGAGAGCTTCGACGCCGCATCTCCCCTGTTCCGCACCTTTG
CATCCCGGGCCTTCTACCTGGGGCCGTTCGGAGCGGGGGCGCGCATGAAGCTGGTGGTCAACCTCGCGCTGGGACTGCAC
CGCGCGGTGCTGGCCGAGACGCTCGCGTTCGCGCATGCCTGCGAGGTTTCGCCGACGGTCGCGCTCGAGGTGCTCAAGGC
CGGCGCGGCGTATTCGCGCGTGATGGAGGATAAGGGCGAGAAAATGCTGCACCATGACTTCACGGTGGAGGCGCGGCTCT
CGCAGCATCTGAAAGACGTCCGGCTGATCCTGGACGCGGCGGCGGCGAAGCATGCCAAGACGCCGCTTTCGCAGGTGCAC
CGGCAGCTGCTGGAGGGCCTGGTGACCGCCGGGTATGGCGACGCCGATAACAGCGCGATCATGATGGCGTATGAGCAGGG
CTGA

Upstream 100 bases:

>100_bases
CACATCATGCGCGTCTCCGAACGCCTCTCGTCCATACAGTGCATATCGGCCGAGGCGCGGGGTTACAGTAGGGCGTATGG
ACAGCATAGGGATTATTGGG

Downstream 100 bases:

>100_bases
GGACGAGTGGTTGTGGGGGTGGGACCCGACGCCGGGAATCGTCTCGGTGTGGGTCGAGGCGGACGGGCGCGCCACTATCT
GGAGGCGGATTGCGGCCACT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MGLLGSAIADRLSAAGYTVVGYDLIPERRRGADSAQEVIGKCQTTFLCLPTSDVVAQVIGSVKPAAGITMVDCTTGEPES
MAAMGEKLAKSGVDYLDATVLGSSKVVRSGAAVVMAGGRRESFDAASPLFRTFASRAFYLGPFGAGARMKLVVNLALGLH
RAVLAETLAFAHACEVSPTVALEVLKAGAAYSRVMEDKGEKMLHHDFTVEARLSQHLKDVRLILDAAAAKHAKTPLSQVH
RQLLEGLVTAGYGDADNSAIMMAYEQG

Sequences:

>Translated_267_residues
MGLLGSAIADRLSAAGYTVVGYDLIPERRRGADSAQEVIGKCQTTFLCLPTSDVVAQVIGSVKPAAGITMVDCTTGEPES
MAAMGEKLAKSGVDYLDATVLGSSKVVRSGAAVVMAGGRRESFDAASPLFRTFASRAFYLGPFGAGARMKLVVNLALGLH
RAVLAETLAFAHACEVSPTVALEVLKAGAAYSRVMEDKGEKMLHHDFTVEARLSQHLKDVRLILDAAAAKHAKTPLSQVH
RQLLEGLVTAGYGDADNSAIMMAYEQG
>Mature_266_residues
GLLGSAIADRLSAAGYTVVGYDLIPERRRGADSAQEVIGKCQTTFLCLPTSDVVAQVIGSVKPAAGITMVDCTTGEPESM
AAMGEKLAKSGVDYLDATVLGSSKVVRSGAAVVMAGGRRESFDAASPLFRTFASRAFYLGPFGAGARMKLVVNLALGLHR
AVLAETLAFAHACEVSPTVALEVLKAGAAYSRVMEDKGEKMLHHDFTVEARLSQHLKDVRLILDAAAAKHAKTPLSQVHR
QLLEGLVTAGYGDADNSAIMMAYEQG

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=279, Percent_Identity=26.8817204301075, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI23308751, Length=281, Percent_Identity=22.4199288256228, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI145693186, Length=281, Percent_Identity=28.1138790035587, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786719, Length=277, Percent_Identity=26.3537906137184, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789092, Length=205, Percent_Identity=27.3170731707317, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790315, Length=277, Percent_Identity=25.2707581227437, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28574115, Length=276, Percent_Identity=25.7246376811594, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 28058; Mature: 27926

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLGSAIADRLSAAGYTVVGYDLIPERRRGADSAQEVIGKCQTTFLCLPTSDVVAQVIG
CCCCHHHHHHHHHHCCCEEEEECCCCHHHCCCCHHHHHHHHHHHEEEEECCHHHHHHHHH
SVKPAAGITMVDCTTGEPESMAAMGEKLAKSGVDYLDATVLGSSKVVRSGAAVVMAGGRR
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCEEEEECCCC
ESFDAASPLFRTFASRAFYLGPFGAGARMKLVVNLALGLHRAVLAETLAFAHACEVSPTV
CCCCHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALEVLKAGAAYSRVMEDKGEKMLHHDFTVEARLSQHLKDVRLILDAAAAKHAKTPLSQVH
HHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RQLLEGLVTAGYGDADNSAIMMAYEQG
HHHHHHHHHCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
GLLGSAIADRLSAAGYTVVGYDLIPERRRGADSAQEVIGKCQTTFLCLPTSDVVAQVIG
CCCHHHHHHHHHHCCCEEEEECCCCHHHCCCCHHHHHHHHHHHEEEEECCHHHHHHHHH
SVKPAAGITMVDCTTGEPESMAAMGEKLAKSGVDYLDATVLGSSKVVRSGAAVVMAGGRR
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCEEEEECCCC
ESFDAASPLFRTFASRAFYLGPFGAGARMKLVVNLALGLHRAVLAETLAFAHACEVSPTV
CCCCHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ALEVLKAGAAYSRVMEDKGEKMLHHDFTVEARLSQHLKDVRLILDAAAAKHAKTPLSQVH
HHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RQLLEGLVTAGYGDADNSAIMMAYEQG
HHHHHHHHHCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA