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The map label for this gene is sdhA [H]

Identifier: 116626440

GI number: 116626440

Start: 9287178

End: 9289091

Strand: Direct

Name: sdhA [H]

Synonym: Acid_7402

Alternate gene names: 116626440

Gene position: 9287178-9289091 (Clockwise)

Preceding gene: 116626439

Following gene: 116626441

Centisome position: 93.19

GC content: 63.48

Gene sequence:

>1914_bases
ATGGAACTCAATTCAAAAGCCCCGACAGGCCCGATCGAGACGCGATGGGAACGTCATCGCTTCAATCTCAAGCTGGTGAA
TCCGGCCAATAAGCGAAAGTACACGGTGATTGTGGTGGGCACGGGCCTGGCGGGCGGCGCCTCGGCGGCGAGCCTGGCGG
AGCTGGGCTATAACGTCAATTGTTTCTGCTTCCAGGATTCGCCGCGGCGCGCGCACAGCATCGCGGCCCAGGGCGGCATC
AACGCGGCGAAGAACTACCACAACGATGGTGACAGCATTTATCGCCTGTTCTACGACACGGTGAAGGGCGGCGATTTCCG
GGCGCGGGAATCGAACGTGTACCGGCTGGCGCAGGTGAGCGTCAACATTATCGACCAGTGCGTGGCGCAGGGCGTGCCGT
TCGCGCGGGAATACTCGGGGTACCTGGATAACCGGTCGTTCGGCGGGGCGCAGGTCTCACGAACGTTCTACGCGCGCGGG
CAGACGGGTCAGCAGCTGCTGCTGGGTGCGTACCAGGCGCTGGAGCGGCAGATCGGGCTGGGCACGGTGAAGATGCATCC
GCGCACCGAGATGCTGGACCTGATCGTGGTGGACGGGCGCGCGCGCGGGATCGTGACGCGCGACCTGATCACGGGCAAGG
TGGAAAGCCACTTCGGGGACGCGGTGGTGCTGGGCACGGGCGGCTACGGCAACGTTTATTACCTCTCGACGAACGCGAAG
GGATCCAACACGACGGCGATCTGGCGCGCGCACAAACGCGGCGCGCTGTTCGCCAATCCCTGCTTCACGCAGATTCACCC
GACCTGCATTCCGGTGTCGGGCGAGTATCAAAGCAAGCTGACGCTGATGAGCGAATCCCTGCGCAATGACGGGCGGGTGT
GGGTGCCGGTAAAGAAGGGCGATAAGCGGCAGCCGAGCCAGATTCCCGAAGCCGAGCGCGATTATTACCTGGAGCGCAAA
TATCCGAGCTTCGGCAACCTGGTGCCGCGCGACGTGGCGTCGCGCAATGCGAAGTCGGTGTGCGACGAAGGGCGCGGGGT
GGGGGAGAGCGGGCTGGCGGTCTACCTGGATTTCCGCGATGCCATTCAGCGGCTGGGCGCGGCGGTGATCAAGGAGCGCT
ACGGCAACCTGTTCGACATGTACAACCGGATCACGGGCGAGGATCCTTACAAGGAACCGATGCGGATCTACCCGGCGATT
CATTACACGATGGGCGGGCTTTGGGTAGATTACAACCTGATGTCCACGATTCCGGGACTGTACGTCATCGGCGAGGCGAA
TTTCAGCGATCACGGCGCTAACCGGTTGGGGGCGAGCGCGCTGATGCAGGGGCTGGCGGACGGCTATTTCGTGCTGCCGA
ACACGATCGGCGATTACCTGGCATCGAACAAGTTCGAGAAAGTGGATGGTTCGCACGCGGCGGCACGTGAGGCGGAGGCC
AACGTGGCCGCGATCACGAGGCGGCTGCTGGAGGCGAAGGGCACGCGATCGGTGGACTCGTATCATCGCGAACTGGGCAA
GATCATGTGGGAATACTGCGGCATGGCGCGCAATGCGAGCGGGTTGAAGCAGGCGCTCTCGCAGATTCCGGCGCTGCGCG
AGCAGTTCTGGAAGGACGTAAGGGTGCTGGGCGCGGGCGAAGAGCTCAACCAATCGCTGGAGAAGGCCGGGAGGGTGGCG
GACTTCTTCGAACTGGCCGAGCTGATGTGCCGGGACGCCCTGGAACGTAATGAAAGCTGCGGGGGACACTTCCGCGAGGA
GTATCAAACGCCGGACGGCGAAGCGGCTCGCGACGACGAGAACTACGCCTACGCGGCGGCCTGGGAATACAAGGGCCCGG
GCGCGGAGCCGGCGCTGAACAAGGAGCCGCTGACTTTCGAATACGTGCACCCCTCGCAACGGAGCTACAAGTAA

Upstream 100 bases:

>100_bases
GAAGAAGGGCGCGGCGATTTTCGCCATCCTGATTGCGATTGGCAACTGCTCGATACCGATCGCTGTTTTAGCCGGACTGG
TCAGTTAAGAGAGACCCAGC

Downstream 100 bases:

>100_bases
TGCGAATCATTCTCCATATCTGGCGGCAGCGCAACGCGAGCGATAAGGGCAAGATGGTGCGGTACGAGGTACCGGACGTC
AACCACGAAATGTCCTTTCT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MELNSKAPTGPIETRWERHRFNLKLVNPANKRKYTVIVVGTGLAGGASAASLAELGYNVNCFCFQDSPRRAHSIAAQGGI
NAAKNYHNDGDSIYRLFYDTVKGGDFRARESNVYRLAQVSVNIIDQCVAQGVPFAREYSGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYQALERQIGLGTVKMHPRTEMLDLIVVDGRARGIVTRDLITGKVESHFGDAVVLGTGGYGNVYYLSTNAK
GSNTTAIWRAHKRGALFANPCFTQIHPTCIPVSGEYQSKLTLMSESLRNDGRVWVPVKKGDKRQPSQIPEAERDYYLERK
YPSFGNLVPRDVASRNAKSVCDEGRGVGESGLAVYLDFRDAIQRLGAAVIKERYGNLFDMYNRITGEDPYKEPMRIYPAI
HYTMGGLWVDYNLMSTIPGLYVIGEANFSDHGANRLGASALMQGLADGYFVLPNTIGDYLASNKFEKVDGSHAAAREAEA
NVAAITRRLLEAKGTRSVDSYHRELGKIMWEYCGMARNASGLKQALSQIPALREQFWKDVRVLGAGEELNQSLEKAGRVA
DFFELAELMCRDALERNESCGGHFREEYQTPDGEAARDDENYAYAAAWEYKGPGAEPALNKEPLTFEYVHPSQRSYK

Sequences:

>Translated_637_residues
MELNSKAPTGPIETRWERHRFNLKLVNPANKRKYTVIVVGTGLAGGASAASLAELGYNVNCFCFQDSPRRAHSIAAQGGI
NAAKNYHNDGDSIYRLFYDTVKGGDFRARESNVYRLAQVSVNIIDQCVAQGVPFAREYSGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYQALERQIGLGTVKMHPRTEMLDLIVVDGRARGIVTRDLITGKVESHFGDAVVLGTGGYGNVYYLSTNAK
GSNTTAIWRAHKRGALFANPCFTQIHPTCIPVSGEYQSKLTLMSESLRNDGRVWVPVKKGDKRQPSQIPEAERDYYLERK
YPSFGNLVPRDVASRNAKSVCDEGRGVGESGLAVYLDFRDAIQRLGAAVIKERYGNLFDMYNRITGEDPYKEPMRIYPAI
HYTMGGLWVDYNLMSTIPGLYVIGEANFSDHGANRLGASALMQGLADGYFVLPNTIGDYLASNKFEKVDGSHAAAREAEA
NVAAITRRLLEAKGTRSVDSYHRELGKIMWEYCGMARNASGLKQALSQIPALREQFWKDVRVLGAGEELNQSLEKAGRVA
DFFELAELMCRDALERNESCGGHFREEYQTPDGEAARDDENYAYAAAWEYKGPGAEPALNKEPLTFEYVHPSQRSYK
>Mature_637_residues
MELNSKAPTGPIETRWERHRFNLKLVNPANKRKYTVIVVGTGLAGGASAASLAELGYNVNCFCFQDSPRRAHSIAAQGGI
NAAKNYHNDGDSIYRLFYDTVKGGDFRARESNVYRLAQVSVNIIDQCVAQGVPFAREYSGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYQALERQIGLGTVKMHPRTEMLDLIVVDGRARGIVTRDLITGKVESHFGDAVVLGTGGYGNVYYLSTNAK
GSNTTAIWRAHKRGALFANPCFTQIHPTCIPVSGEYQSKLTLMSESLRNDGRVWVPVKKGDKRQPSQIPEAERDYYLERK
YPSFGNLVPRDVASRNAKSVCDEGRGVGESGLAVYLDFRDAIQRLGAAVIKERYGNLFDMYNRITGEDPYKEPMRIYPAI
HYTMGGLWVDYNLMSTIPGLYVIGEANFSDHGANRLGASALMQGLADGYFVLPNTIGDYLASNKFEKVDGSHAAAREAEA
NVAAITRRLLEAKGTRSVDSYHRELGKIMWEYCGMARNASGLKQALSQIPALREQFWKDVRVLGAGEELNQSLEKAGRVA
DFFELAELMCRDALERNESCGGHFREEYQTPDGEAARDDENYAYAAAWEYKGPGAEPALNKEPLTFEYVHPSQRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=564, Percent_Identity=27.4822695035461, Blast_Score=160, Evalue=4e-39,
Organism=Escherichia coli, GI1790597, Length=543, Percent_Identity=29.6500920810313, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1786942, Length=594, Percent_Identity=27.4410774410774, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788928, Length=582, Percent_Identity=26.4604810996564, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17505833, Length=541, Percent_Identity=27.5415896487985, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17550100, Length=547, Percent_Identity=27.7879341864717, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322701, Length=602, Percent_Identity=30.0664451827243, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322416, Length=602, Percent_Identity=28.7375415282392, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17137288, Length=587, Percent_Identity=27.0868824531516, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24655642, Length=587, Percent_Identity=27.0868824531516, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24655647, Length=587, Percent_Identity=27.0868824531516, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24663005, Length=621, Percent_Identity=27.3752012882448, Blast_Score=158, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70658; Mature: 70658

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNSKAPTGPIETRWERHRFNLKLVNPANKRKYTVIVVGTGLAGGASAASLAELGYNVN
CCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHCCCCEE
CFCFQDSPRRAHSIAAQGGINAAKNYHNDGDSIYRLFYDTVKGGDFRARESNVYRLAQVS
EEEECCCCCHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEHHH
VNIIDQCVAQGVPFAREYSGYLDNRSFGGAQVSRTFYARGQTGQQLLLGAYQALERQIGL
HHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHCCC
GTVKMHPRTEMLDLIVVDGRARGIVTRDLITGKVESHFGDAVVLGTGGYGNVYYLSTNAK
CEEEECCCCCEEEEEEECCCCCCEEEHHHHHCHHHHCCCCEEEEECCCCCCEEEEEECCC
GSNTTAIWRAHKRGALFANPCFTQIHPTCIPVSGEYQSKLTLMSESLRNDGRVWVPVKKG
CCCCEEEEEECCCCCEEECCCHHCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCC
DKRQPSQIPEAERDYYLERKYPSFGNLVPRDVASRNAKSVCDEGRGVGESGLAVYLDFRD
CCCCCCCCCCHHHCCEECCCCCCCCCCCCHHHHHCCHHHHHHCCCCCCCCCCEEEEEHHH
AIQRLGAAVIKERYGNLFDMYNRITGEDPYKEPMRIYPAIHYTMGGLWVDYNLMSTIPGL
HHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHCCCEEECCCEEEEEEHHHHCCCE
YVIGEANFSDHGANRLGASALMQGLADGYFVLPNTIGDYLASNKFEKVDGSHAAAREAEA
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEECCHHHHHHHHCCCCHHCCCCHHHHHHHHH
NVAAITRRLLEAKGTRSVDSYHRELGKIMWEYCGMARNASGLKQALSQIPALREQFWKDV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
RVLGAGEELNQSLEKAGRVADFFELAELMCRDALERNESCGGHFREEYQTPDGEAARDDE
EEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCC
NYAYAAAWEYKGPGAEPALNKEPLTFEYVHPSQRSYK
CEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MELNSKAPTGPIETRWERHRFNLKLVNPANKRKYTVIVVGTGLAGGASAASLAELGYNVN
CCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHCCCCEE
CFCFQDSPRRAHSIAAQGGINAAKNYHNDGDSIYRLFYDTVKGGDFRARESNVYRLAQVS
EEEECCCCCHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEHHH
VNIIDQCVAQGVPFAREYSGYLDNRSFGGAQVSRTFYARGQTGQQLLLGAYQALERQIGL
HHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHCCC
GTVKMHPRTEMLDLIVVDGRARGIVTRDLITGKVESHFGDAVVLGTGGYGNVYYLSTNAK
CEEEECCCCCEEEEEEECCCCCCEEEHHHHHCHHHHCCCCEEEEECCCCCCEEEEEECCC
GSNTTAIWRAHKRGALFANPCFTQIHPTCIPVSGEYQSKLTLMSESLRNDGRVWVPVKKG
CCCCEEEEEECCCCCEEECCCHHCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCC
DKRQPSQIPEAERDYYLERKYPSFGNLVPRDVASRNAKSVCDEGRGVGESGLAVYLDFRD
CCCCCCCCCCHHHCCEECCCCCCCCCCCCHHHHHCCHHHHHHCCCCCCCCCCEEEEEHHH
AIQRLGAAVIKERYGNLFDMYNRITGEDPYKEPMRIYPAIHYTMGGLWVDYNLMSTIPGL
HHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHCCCEEECCCEEEEEEHHHHCCCE
YVIGEANFSDHGANRLGASALMQGLADGYFVLPNTIGDYLASNKFEKVDGSHAAAREAEA
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEECCHHHHHHHHCCCCHHCCCCHHHHHHHHH
NVAAITRRLLEAKGTRSVDSYHRELGKIMWEYCGMARNASGLKQALSQIPALREQFWKDV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
RVLGAGEELNQSLEKAGRVADFFELAELMCRDALERNESCGGHFREEYQTPDGEAARDDE
EEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCC
NYAYAAAWEYKGPGAEPALNKEPLTFEYVHPSQRSYK
CEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]