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The map label for this gene is tmk [H]

Identifier: 116626370

GI number: 116626370

Start: 9203914

End: 9204588

Strand: Direct

Name: tmk [H]

Synonym: Acid_7330

Alternate gene names: 116626370

Gene position: 9203914-9204588 (Clockwise)

Preceding gene: 116626368

Following gene: 116626371

Centisome position: 92.36

GC content: 66.07

Gene sequence:

>675_bases
ATGACGCAGCACCTCGACGCTACAATAGGATTTCACGTGAAACTCCCCGGCATCTTTATCACTTTCGAAGGCATGGACGG
CTCCGGCAAAACCACCCAAATGCACCGCCTGGCGGAACGCCTGCGCGGCATGGGGCGCACCGTCCTGGAGACCGCCGAAC
CCGGCGGCCCGCCCATCGCCCAGAAGATCCGCCGCATCGTGCTCGACGCCGCCAACCAGGAACTGAGCCCGACCGCCGAG
ATCCTTCTTTACTTCGCCTCGCGCGCCCAGAATGTCGATCAGTGGATCCAGCCCGCGCTCGCCCGCGGCGAAATCGTGCT
CGCCGACCGGTTCACCGATTCATCGCTGGTCTACCAGGGCATCGGCCGCGGACTCGGCGCCGATACCGTGGTCGCGCTCG
ACCGCATCGCCTGCCGCGGCCTCAAGCCCGACCTCACCATCCTGGTCGATGTCGATGCCGAGGCCAGCCTGACCCGCGCC
CGCGCCCGCAACCTGGCGCAGCCGCACTGCGAAACCCGCATGGACGACCAGGCGCTGGAGTTTCACCTCAAGGTCCACGC
CGCCTATCACGCGCTCGCCGCCGCTGAACCAGAGCGCGTGAAGGTGGCCAACGGCCGCGCCGGAATGGACGAGATCGAAC
GCGAAATCTGGAGTATCGTAAGCGCGCATGTTTGA

Upstream 100 bases:

>100_bases
GGCCACACGGTTGAAAATACGTGGCGATATTCGACAATTTAGGTGCTGATTGTCCGCTTGTGGGGCATTTCACTCAGCTG
CCAGCTCCAGCCGCCGGGAG

Downstream 100 bases:

>100_bases
AAACTTCTGGGGTAATACCGCCGTCACCGAAGCGCTGGAACAGATGATCGCGCAGCAGCGCGTTTCGCAGACCCTGCTCT
TCTCCGGCCCCGAAGGCGTC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MTQHLDATIGFHVKLPGIFITFEGMDGSGKTTQMHRLAERLRGMGRTVLETAEPGGPPIAQKIRRIVLDAANQELSPTAE
ILLYFASRAQNVDQWIQPALARGEIVLADRFTDSSLVYQGIGRGLGADTVVALDRIACRGLKPDLTILVDVDAEASLTRA
RARNLAQPHCETRMDDQALEFHLKVHAAYHALAAAEPERVKVANGRAGMDEIEREIWSIVSAHV

Sequences:

>Translated_224_residues
MTQHLDATIGFHVKLPGIFITFEGMDGSGKTTQMHRLAERLRGMGRTVLETAEPGGPPIAQKIRRIVLDAANQELSPTAE
ILLYFASRAQNVDQWIQPALARGEIVLADRFTDSSLVYQGIGRGLGADTVVALDRIACRGLKPDLTILVDVDAEASLTRA
RARNLAQPHCETRMDDQALEFHLKVHAAYHALAAAEPERVKVANGRAGMDEIEREIWSIVSAHV
>Mature_223_residues
TQHLDATIGFHVKLPGIFITFEGMDGSGKTTQMHRLAERLRGMGRTVLETAEPGGPPIAQKIRRIVLDAANQELSPTAEI
LLYFASRAQNVDQWIQPALARGEIVLADRFTDSSLVYQGIGRGLGADTVVALDRIACRGLKPDLTILVDVDAEASLTRAR
ARNLAQPHCETRMDDQALEFHLKVHAAYHALAAAEPERVKVANGRAGMDEIEREIWSIVSAHV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=182, Percent_Identity=36.8131868131868, Blast_Score=113, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 24537; Mature: 24406

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHLDATIGFHVKLPGIFITFEGMDGSGKTTQMHRLAERLRGMGRTVLETAEPGGPPIA
CCCCCCCEEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCHHH
QKIRRIVLDAANQELSPTAEILLYFASRAQNVDQWIQPALARGEIVLADRFTDSSLVYQG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCCHHHHHHH
IGRGLGADTVVALDRIACRGLKPDLTILVDVDAEASLTRARARNLAQPHCETRMDDQALE
HCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHCCCCCHHHH
FHLKVHAAYHALAAAEPERVKVANGRAGMDEIEREIWSIVSAHV
HHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQHLDATIGFHVKLPGIFITFEGMDGSGKTTQMHRLAERLRGMGRTVLETAEPGGPPIA
CCCCCCEEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCHHH
QKIRRIVLDAANQELSPTAEILLYFASRAQNVDQWIQPALARGEIVLADRFTDSSLVYQG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCCCHHHHHHH
IGRGLGADTVVALDRIACRGLKPDLTILVDVDAEASLTRARARNLAQPHCETRMDDQALE
HCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHCCCCCHHHH
FHLKVHAAYHALAAAEPERVKVANGRAGMDEIEREIWSIVSAHV
HHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA