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The map label for this gene is gnd [H]

Identifier: 116626124

GI number: 116626124

Start: 8897542

End: 8898999

Strand: Direct

Name: gnd [H]

Synonym: Acid_7082

Alternate gene names: 116626124

Gene position: 8897542-8898999 (Clockwise)

Preceding gene: 116626120

Following gene: 116626125

Centisome position: 89.28

GC content: 61.11

Gene sequence:

>1458_bases
ATGGAACAAACGGCAGACATCGCATTGATCGGTCTGGCAGTCATGGGCCAGAACCTGATTATGAATATGAACGACCACGG
GTACACGGTGGTCGCTTATAACCGCACGACCTCCAAGGTCGATGAATTCCTGAACGACGCCGCCAAAGGCAGCAAGGTCA
TCGGCGCGCACTCGATCGAGGAGATGGTCAAACTTCTCAAGCGCCCCCGCAAGATCATGCTCATGGTCAAGGCCGGCAAG
CCGGTGGACGAATTCATCGAGACCCTGCTCCCCTACCTCGAGCCCGGCGACCTGATCATCGATGGCGGCAATTCGCATTT
CCCGGATACCATCCGCCGCACCCAATACCTCGAAAGCAAGGGCCTTCTGTTCGTCGGCACCGGCGTTTCCGGCGGCGAGG
AAGGCGCGCGTTTCGGCCCGTCCATGATGCCCGGAGGTACCCCCGCCGCGTGGCCCCTCGTGAAGGACATCTTCCAGGCC
ATCTGCGCCAAGACACCCGAGGGCGAGCCCTGCTGCGATTGGGTCGGCCGCGATGGCGCCGGCCACTTCGTCAAGATGAC
CCACAACGGCATCGAGTACGGCGATATGCAGCTCATCTGCGAGGCCTACCAACTCATGAAGGAAGGCCTCGGCATGAGCA
ACGAAGAAATGCACGAAGTCTTCGCCGAATGGAACAAGGGCGAGCTCGATAGCTACCTCATCGAAATCACCCGCGACATT
CTGGGCTACAAAGACCCCGCCACCGGCGAACAGACCCTCGACAAAATCCTCGATACCGCCGGCCAAAAGGGTACCGGCAA
GTGGACCAGCGTCAGCTCGCTCGATCTCGGCATGCCCGTTACCCTGATCGGCGAAGCCGTCTACGCGCGCTGCCTCAGCG
CTATGAAGGACGATCGCGTCAAGGCTTCCAAGATCCTCACCGGACCCAAGGCCAAGTTCCCCGGTGACAAGAAGGCCTTC
GTGGAAGACATCCGCCAGGCCCTTCTCGCCTCCAAGATCGTCAGCTACGCGCAGGGCTTCATGCTCCTCGCCGAAGCCGC
CAAGGAATATAAGTGGGACCTGAACTACGGTTCCATCGCCATGATGTGGCGCGAAGGCTGCATCATCCGCAGCGTCTTCC
TCGGCAAAATTAAGGCCGCGTTTGCCAACAACCCGACGCTGGCGAACCTGCTGCTCGATAGCTACTTCAGGGGCCTGCTG
GACCGTTGCCAGGGTTCCTGGCGCCACACCGTTTCCGAAGCCGTCCTCAATGGCGTGCCGGTGCCCGCCTTCACCACCGC
TCTCGCCTTCTACGATGGCTACCGCAGCGAACGCCTGCCTGCCAACCTGCTCCAGGCACAGCGCGATTACTTCGGCGCCC
ACACCTTCGAGCGCGTCGATCAGCCGCGCGGCAAGTTCTTCCACACCAATTGGACCGGCAAGGGCGGCAACGTCTCGGCC
GGAGTCTACACCGTATGA

Upstream 100 bases:

>100_bases
CCCTCCCGGAACTCACCCGTGAGTGCCTCCTACTCCGTCGTAGTGCGGCTTCCGGCAAGTGCCTTAAGGGTCGGTCGGTA
CACGGTTTTTGGAGCAGATC

Downstream 100 bases:

>100_bases
GCGCGGACGTCCCTCGTCTCGCCTCCAAAATCCGCTTGCTGCTGATGGACGTCGATGGCGTCCTCACCGATGGCAAGCTC
TATAACGTGCCGGGACCCGA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MEQTADIALIGLAVMGQNLIMNMNDHGYTVVAYNRTTSKVDEFLNDAAKGSKVIGAHSIEEMVKLLKRPRKIMLMVKAGK
PVDEFIETLLPYLEPGDLIIDGGNSHFPDTIRRTQYLESKGLLFVGTGVSGGEEGARFGPSMMPGGTPAAWPLVKDIFQA
ICAKTPEGEPCCDWVGRDGAGHFVKMTHNGIEYGDMQLICEAYQLMKEGLGMSNEEMHEVFAEWNKGELDSYLIEITRDI
LGYKDPATGEQTLDKILDTAGQKGTGKWTSVSSLDLGMPVTLIGEAVYARCLSAMKDDRVKASKILTGPKAKFPGDKKAF
VEDIRQALLASKIVSYAQGFMLLAEAAKEYKWDLNYGSIAMMWREGCIIRSVFLGKIKAAFANNPTLANLLLDSYFRGLL
DRCQGSWRHTVSEAVLNGVPVPAFTTALAFYDGYRSERLPANLLQAQRDYFGAHTFERVDQPRGKFFHTNWTGKGGNVSA
GVYTV

Sequences:

>Translated_485_residues
MEQTADIALIGLAVMGQNLIMNMNDHGYTVVAYNRTTSKVDEFLNDAAKGSKVIGAHSIEEMVKLLKRPRKIMLMVKAGK
PVDEFIETLLPYLEPGDLIIDGGNSHFPDTIRRTQYLESKGLLFVGTGVSGGEEGARFGPSMMPGGTPAAWPLVKDIFQA
ICAKTPEGEPCCDWVGRDGAGHFVKMTHNGIEYGDMQLICEAYQLMKEGLGMSNEEMHEVFAEWNKGELDSYLIEITRDI
LGYKDPATGEQTLDKILDTAGQKGTGKWTSVSSLDLGMPVTLIGEAVYARCLSAMKDDRVKASKILTGPKAKFPGDKKAF
VEDIRQALLASKIVSYAQGFMLLAEAAKEYKWDLNYGSIAMMWREGCIIRSVFLGKIKAAFANNPTLANLLLDSYFRGLL
DRCQGSWRHTVSEAVLNGVPVPAFTTALAFYDGYRSERLPANLLQAQRDYFGAHTFERVDQPRGKFFHTNWTGKGGNVSA
GVYTV
>Mature_485_residues
MEQTADIALIGLAVMGQNLIMNMNDHGYTVVAYNRTTSKVDEFLNDAAKGSKVIGAHSIEEMVKLLKRPRKIMLMVKAGK
PVDEFIETLLPYLEPGDLIIDGGNSHFPDTIRRTQYLESKGLLFVGTGVSGGEEGARFGPSMMPGGTPAAWPLVKDIFQA
ICAKTPEGEPCCDWVGRDGAGHFVKMTHNGIEYGDMQLICEAYQLMKEGLGMSNEEMHEVFAEWNKGELDSYLIEITRDI
LGYKDPATGEQTLDKILDTAGQKGTGKWTSVSSLDLGMPVTLIGEAVYARCLSAMKDDRVKASKILTGPKAKFPGDKKAF
VEDIRQALLASKIVSYAQGFMLLAEAAKEYKWDLNYGSIAMMWREGCIIRSVFLGKIKAAFANNPTLANLLLDSYFRGLL
DRCQGSWRHTVSEAVLNGVPVPAFTTALAFYDGYRSERLPANLLQAQRDYFGAHTFERVDQPRGKFFHTNWTGKGGNVSA
GVYTV

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=481, Percent_Identity=67.1517671517671, Blast_Score=662, Evalue=0.0,
Organism=Escherichia coli, GI1788341, Length=465, Percent_Identity=55.4838709677419, Blast_Score=539, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17542558, Length=483, Percent_Identity=63.3540372670807, Blast_Score=647, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321695, Length=486, Percent_Identity=62.5514403292181, Blast_Score=638, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321977, Length=488, Percent_Identity=62.5, Blast_Score=619, Evalue=1e-178,
Organism=Drosophila melanogaster, GI24639279, Length=484, Percent_Identity=64.6694214876033, Blast_Score=622, Evalue=1e-178,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53379; Mature: 53379

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTADIALIGLAVMGQNLIMNMNDHGYTVVAYNRTTSKVDEFLNDAAKGSKVIGAHSIE
CCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCEECHHHHH
EMVKLLKRPRKIMLMVKAGKPVDEFIETLLPYLEPGDLIIDGGNSHFPDTIRRTQYLESK
HHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCC
GLLFVGTGVSGGEEGARFGPSMMPGGTPAAWPLVKDIFQAICAKTPEGEPCCDWVGRDGA
CEEEEECCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
GHFVKMTHNGIEYGDMQLICEAYQLMKEGLGMSNEEMHEVFAEWNKGELDSYLIEITRDI
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGYKDPATGEQTLDKILDTAGQKGTGKWTSVSSLDLGMPVTLIGEAVYARCLSAMKDDRV
HCCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCH
KASKILTGPKAKFPGDKKAFVEDIRQALLASKIVSYAQGFMLLAEAAKEYKWDLNYGSIA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEE
MMWREGCIIRSVFLGKIKAAFANNPTLANLLLDSYFRGLLDRCQGSWRHTVSEAVLNGVP
HHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
VPAFTTALAFYDGYRSERLPANLLQAQRDYFGAHTFERVDQPRGKFFHTNWTGKGGNVSA
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCC
GVYTV
CCEEC
>Mature Secondary Structure
MEQTADIALIGLAVMGQNLIMNMNDHGYTVVAYNRTTSKVDEFLNDAAKGSKVIGAHSIE
CCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCEECHHHHH
EMVKLLKRPRKIMLMVKAGKPVDEFIETLLPYLEPGDLIIDGGNSHFPDTIRRTQYLESK
HHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHCC
GLLFVGTGVSGGEEGARFGPSMMPGGTPAAWPLVKDIFQAICAKTPEGEPCCDWVGRDGA
CEEEEECCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCC
GHFVKMTHNGIEYGDMQLICEAYQLMKEGLGMSNEEMHEVFAEWNKGELDSYLIEITRDI
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGYKDPATGEQTLDKILDTAGQKGTGKWTSVSSLDLGMPVTLIGEAVYARCLSAMKDDRV
HCCCCCCCCHHHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCH
KASKILTGPKAKFPGDKKAFVEDIRQALLASKIVSYAQGFMLLAEAAKEYKWDLNYGSIA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEE
MMWREGCIIRSVFLGKIKAAFANNPTLANLLLDSYFRGLLDRCQGSWRHTVSEAVLNGVP
HHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
VPAFTTALAFYDGYRSERLPANLLQAQRDYFGAHTFERVDQPRGKFFHTNWTGKGGNVSA
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCC
GVYTV
CCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]