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The map label for this gene is mmgC [H]

Identifier: 116626102

GI number: 116626102

Start: 8877476

End: 8878621

Strand: Reverse

Name: mmgC [H]

Synonym: Acid_7060

Alternate gene names: 116626102

Gene position: 8878621-8877476 (Counterclockwise)

Preceding gene: 116626103

Following gene: 116626101

Centisome position: 89.09

GC content: 63.35

Gene sequence:

>1146_bases
GTGGATTTCGAGTACACGCCGGAACAGATTCAACTGCGCAAGGCGGTTCGGGAGTTCGCCGAAGCGGAGATCGCCCCCCA
CGTTATGGAGTGGGACGAAGCGCAGACATTTCCGCTCGACGTCATCCGTAAGCTCGGCCGTCTCGGCTATATGGGCTCGA
TCTTTCCGGAGGAACTAGGCGGCGCCGGATTGGGGTACATCGAGTACTCCATCATCATCGAGGAACTCTCGCGTGTGGAT
GGCTCCGTGGGAATCATCCTGGCCGCCCACACCTCGCTCTGCTCCAATCACATTTTCAAAATGGGCAGCGACGAGCAGCG
CCGGCGCTACCTTCCGAAGCTCGCCTCGGGAGAGTGGATCGGGTGCTGGTCGTTGACCGAACCCGAAGCCGGCAGCGATG
CCGCGGGCACGCGCACCCACGCCGAGACGGATGAAAGCGGTGGGTGGGTACTTAACGGCTCCAAGACCTTCACCACCAAC
GCGCACTACGCCGACGTCTGCGTCGCGATGGCGGTCACGGATCGCGCGGCGGCGCAGCATGGGATCTCGGCATTCCTCAT
CGAGAAAGACACGCCGGGCTACCGCTGCGGCAAGAAGGAAAACAAATTGGGCCTGCGCGCCAGCGCCACCGGCGAAGTCA
TCTTCGAGAACTGCCGGCTCGGGCCCACCCAACTGCTGGGCAAACTGAACGACGGCTTTGTCGCCAGCCTGAAGGTGCTG
GACGGCGGACGCATCTCGATTGCGGCGCTCTCCATCGGGATGGCGCAGGGAGCGTACGACGCGGCGCTGCGCTATTCCAA
GCTCCGCAAGCAGTTCGGCCGCCCGATTTCCGAGTTCCAGGCGATCCAACACAAGCTGGTGGACATGGCAGTGGACCTCG
ATGCCGCGCGCCTGCTGAACTATCGCGCCGCGTGGATGCTGGATCGCGGGATGCGGGTGACGCGCGAATCCTCGATGGCC
AAGCTGTTCGCCTCCGAGGCCGCGGTGCGCATCGCCGGCGAGGCGGTGCAGATCCACGGCGGCTACGGCTTCATCAAAGA
CTACCCGGTGGAGAAGTTCTATCGCGACGTCAAGCTGTGCACCATCGGAGAGGGCACCAGCGAGATCCAGCGCCTGGTGA
TCGCACGGCAATTACTCAAGAGCTGA

Upstream 100 bases:

>100_bases
CCATCGCCTGCCGCATGGCGGTGGAAAGCTATCGCCAGCAGCGCACCGTACGTTGGGACCCAGCCAAAGAAGAGATCGTC
TAAGCACTATCGAGGCACAA

Downstream 100 bases:

>100_bases
TGAACGAACAGGCGCGAAAAATCCGCGAAGGGGACGCGCGCGCGCTGGCGCGCCTGGCCACCGGCATCGAGAACCGCGAT
GCGCAGGCACTCGAAACCCT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDFEYTPEQIQLRKAVREFAEAEIAPHVMEWDEAQTFPLDVIRKLGRLGYMGSIFPEELGGAGLGYIEYSIIIEELSRVD
GSVGIILAAHTSLCSNHIFKMGSDEQRRRYLPKLASGEWIGCWSLTEPEAGSDAAGTRTHAETDESGGWVLNGSKTFTTN
AHYADVCVAMAVTDRAAAQHGISAFLIEKDTPGYRCGKKENKLGLRASATGEVIFENCRLGPTQLLGKLNDGFVASLKVL
DGGRISIAALSIGMAQGAYDAALRYSKLRKQFGRPISEFQAIQHKLVDMAVDLDAARLLNYRAAWMLDRGMRVTRESSMA
KLFASEAAVRIAGEAVQIHGGYGFIKDYPVEKFYRDVKLCTIGEGTSEIQRLVIARQLLKS

Sequences:

>Translated_381_residues
MDFEYTPEQIQLRKAVREFAEAEIAPHVMEWDEAQTFPLDVIRKLGRLGYMGSIFPEELGGAGLGYIEYSIIIEELSRVD
GSVGIILAAHTSLCSNHIFKMGSDEQRRRYLPKLASGEWIGCWSLTEPEAGSDAAGTRTHAETDESGGWVLNGSKTFTTN
AHYADVCVAMAVTDRAAAQHGISAFLIEKDTPGYRCGKKENKLGLRASATGEVIFENCRLGPTQLLGKLNDGFVASLKVL
DGGRISIAALSIGMAQGAYDAALRYSKLRKQFGRPISEFQAIQHKLVDMAVDLDAARLLNYRAAWMLDRGMRVTRESSMA
KLFASEAAVRIAGEAVQIHGGYGFIKDYPVEKFYRDVKLCTIGEGTSEIQRLVIARQLLKS
>Mature_381_residues
MDFEYTPEQIQLRKAVREFAEAEIAPHVMEWDEAQTFPLDVIRKLGRLGYMGSIFPEELGGAGLGYIEYSIIIEELSRVD
GSVGIILAAHTSLCSNHIFKMGSDEQRRRYLPKLASGEWIGCWSLTEPEAGSDAAGTRTHAETDESGGWVLNGSKTFTTN
AHYADVCVAMAVTDRAAAQHGISAFLIEKDTPGYRCGKKENKLGLRASATGEVIFENCRLGPTQLLGKLNDGFVASLKVL
DGGRISIAALSIGMAQGAYDAALRYSKLRKQFGRPISEFQAIQHKLVDMAVDLDAARLLNYRAAWMLDRGMRVTRESSMA
KLFASEAAVRIAGEAVQIHGGYGFIKDYPVEKFYRDVKLCTIGEGTSEIQRLVIARQLLKS

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=46.8085106382979, Blast_Score=334, Evalue=8e-92,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=40.6417112299465, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=39.4666666666667, Blast_Score=284, Evalue=8e-77,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=40.7738095238095, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI7656849, Length=374, Percent_Identity=38.5026737967914, Blast_Score=261, Evalue=5e-70,
Organism=Homo sapiens, GI187960098, Length=383, Percent_Identity=38.6422976501305, Blast_Score=254, Evalue=7e-68,
Organism=Homo sapiens, GI4557231, Length=383, Percent_Identity=38.6422976501305, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=35.5437665782493, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI21361497, Length=351, Percent_Identity=39.031339031339, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI76496475, Length=358, Percent_Identity=37.1508379888268, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4557235, Length=358, Percent_Identity=37.1508379888268, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4503943, Length=379, Percent_Identity=29.287598944591, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI7669494, Length=372, Percent_Identity=29.0322580645161, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI211971008, Length=339, Percent_Identity=27.7286135693215, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI48976061, Length=339, Percent_Identity=27.7286135693215, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI38505218, Length=353, Percent_Identity=23.5127478753541, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI156104864, Length=259, Percent_Identity=27.7992277992278, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI156104866, Length=259, Percent_Identity=27.7992277992278, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=29.1338582677165, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=30.2872062663185, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI87082384, Length=263, Percent_Identity=28.8973384030418, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081702, Length=320, Percent_Identity=27.1875, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17538396, Length=384, Percent_Identity=39.84375, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=39.6782841823056, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17506239, Length=383, Percent_Identity=37.3368146214099, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17570075, Length=385, Percent_Identity=38.1818181818182, Blast_Score=257, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=37.1428571428571, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17534899, Length=387, Percent_Identity=36.4341085271318, Blast_Score=248, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17533517, Length=369, Percent_Identity=38.4823848238482, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71985184, Length=354, Percent_Identity=34.4632768361582, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=38.2671480144404, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=30.0531914893617, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71985192, Length=290, Percent_Identity=34.1379310344828, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=37.0689655172414, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17505929, Length=385, Percent_Identity=28.3116883116883, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=26.9333333333333, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=269, Percent_Identity=30.8550185873606, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17531909, Length=228, Percent_Identity=32.0175438596491, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17562446, Length=343, Percent_Identity=26.8221574344023, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17531913, Length=191, Percent_Identity=31.413612565445, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI86563381, Length=324, Percent_Identity=26.5432098765432, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=324, Percent_Identity=26.5432098765432, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356377, Length=369, Percent_Identity=42.8184281842818, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24646207, Length=369, Percent_Identity=40.1084010840108, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=38.6666666666667, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=37.8947368421053, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=37.1428571428571, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI281363737, Length=338, Percent_Identity=33.4319526627219, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=30.9711286089239, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24652780, Length=346, Percent_Identity=24.8554913294798, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281365206, Length=306, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585193, Length=306, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585195, Length=306, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585191, Length=306, Percent_Identity=27.4509803921569, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550141, Length=341, Percent_Identity=26.3929618768328, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221473076, Length=341, Percent_Identity=26.3929618768328, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41883; Mature: 41883

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFEYTPEQIQLRKAVREFAEAEIAPHVMEWDEAQTFPLDVIRKLGRLGYMGSIFPEELG
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHC
GAGLGYIEYSIIIEELSRVDGSVGIILAAHTSLCSNHIFKMGSDEQRRRYLPKLASGEWI
CCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEE
GCWSLTEPEAGSDAAGTRTHAETDESGGWVLNGSKTFTTNAHYADVCVAMAVTDRAAAQH
EEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEECCCHHHHHHHHHHHHHHHHHHC
GISAFLIEKDTPGYRCGKKENKLGLRASATGEVIFENCRLGPTQLLGKLNDGFVASLKVL
CCEEEEEECCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCCHHHHHHCCCCCEEEEEEEE
DGGRISIAALSIGMAQGAYDAALRYSKLRKQFGRPISEFQAIQHKLVDMAVDLDAARLLN
CCCCEEEEEEEHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHH
YRAAWMLDRGMRVTRESSMAKLFASEAAVRIAGEAVQIHGGYGFIKDYPVEKFYRDVKLC
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCCCCCCHHHHHCCCEEE
TIGEGTSEIQRLVIARQLLKS
EECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFEYTPEQIQLRKAVREFAEAEIAPHVMEWDEAQTFPLDVIRKLGRLGYMGSIFPEELG
CCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHC
GAGLGYIEYSIIIEELSRVDGSVGIILAAHTSLCSNHIFKMGSDEQRRRYLPKLASGEWI
CCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCCCHHHHHHCCCCCCCCEE
GCWSLTEPEAGSDAAGTRTHAETDESGGWVLNGSKTFTTNAHYADVCVAMAVTDRAAAQH
EEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEEEECCCHHHHHHHHHHHHHHHHHHC
GISAFLIEKDTPGYRCGKKENKLGLRASATGEVIFENCRLGPTQLLGKLNDGFVASLKVL
CCEEEEEECCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCCHHHHHHCCCCCEEEEEEEE
DGGRISIAALSIGMAQGAYDAALRYSKLRKQFGRPISEFQAIQHKLVDMAVDLDAARLLN
CCCCEEEEEEEHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHH
YRAAWMLDRGMRVTRESSMAKLFASEAAVRIAGEAVQIHGGYGFIKDYPVEKFYRDVKLC
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCCCCCCHHHHHCCCEEE
TIGEGTSEIQRLVIARQLLKS
EECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]