Click here to switch to the map view.

The map label for this gene is hom [H]

Identifier: 116626072

GI number: 116626072

Start: 8841652

End: 8842623

Strand: Direct

Name: hom [H]

Synonym: Acid_7030

Alternate gene names: 116626072

Gene position: 8841652-8842623 (Clockwise)

Preceding gene: 116626066

Following gene: 116626074

Centisome position: 88.72

GC content: 65.12

Gene sequence:

>972_bases
TTGAAACTGGCGATCATCGGCTACGGTAATGTCGGGCGCGCGCTGACCCGCATGCTGCGCGAGAAGCGCAAAGAGTTTCC
GTTCAGCGTCACGGGCATCCATACCCTGAGTCATGGAACCGCGGCCGACCCGGCGGGACTGCCCGCGAAGGTGACGGACG
CCGCGGAGTTCGGACCGCGCGCGGCGTCGGTGGAGCACTTCCTGGACGCGGCGGCAGCGGACGCCATGGTGGAACTGACC
ACGCTCAACCCCTCCACCGGCGAGCCCGCGATCGGACACATTCGCGCGGCGCTGGCCCGTCGGATGCACGTGGTGACTGC
CAACAAGGGGCCGATCGCTCATGCGTATACGGCCCTGAGCGAAGAGGCCGCACGGGCGGGCGTAAGATTCCGCTTCGAAT
CGAGCGTGATGGATGGGGCGCCGGTATTCAACCTGTGGCGCCACACCATGCCGGGGGTCAAGGTCCTGGGTTTCACCGGC
GTGTTGAACTCGACCTCGAAGGTGGTGATCGAGACCATGGAGCACGGCGGAAGCTTTGAGGACGGCTTGGCGGAAGCGCG
CCGCATGGGAATCACGGAAGCCGATGGCGCCTACGACGTCGAGGGTTGGGATTCGGCGGCGAAGACCGCGGCGCTCGCCA
ACGTGCTGTTCGATGCCCGCACTACCCCGCAACAGGTATCCACAAAAGGCATCACGCGGTTGACTCCGGAGCGCATGGCA
GAGATGGGCCGCCAGGGGAAGACCGTGCGCCTGGTGAGCCGCGGACGCCGCACGGCAGCCGGAGTCTCGCTGCGCGTACG
GGCCGAAGTTCTGGATCGCGGCGATCTGCTGGCGTCGATGCCGGGCACCAGCAACTTGATCCTGTTCGACACGGATTTGA
TGGGCACTTTCGGCACAATTTCGATTGAACCGGGCGTGGAGCAGACCGCCTACGGAGTCTTCAGCGACCTTGTAAGCTTA
CGGGAGCGTTAA

Upstream 100 bases:

>100_bases
TGTAACGCGCCGTGGGGCGAATCAGCTCCAGGTGTTCGCGATGTTCGGGATTCAGCAGTGACAAATTCTAGAGTAGCGTG
ACTAAGGATACAATCGAACC

Downstream 100 bases:

>100_bases
CGAGCCGCGACCGTCAGGGAGCGTCCGCTGGCTCGCGTTTTGCGTAGCTCGCTAAGAGATCGCTCCCTTGCGCTCGCGGC
TCTGATCGTTGCGCTCGTTA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKLAIIGYGNVGRALTRMLREKRKEFPFSVTGIHTLSHGTAADPAGLPAKVTDAAEFGPRAASVEHFLDAAAADAMVELT
TLNPSTGEPAIGHIRAALARRMHVVTANKGPIAHAYTALSEEAARAGVRFRFESSVMDGAPVFNLWRHTMPGVKVLGFTG
VLNSTSKVVIETMEHGGSFEDGLAEARRMGITEADGAYDVEGWDSAAKTAALANVLFDARTTPQQVSTKGITRLTPERMA
EMGRQGKTVRLVSRGRRTAAGVSLRVRAEVLDRGDLLASMPGTSNLILFDTDLMGTFGTISIEPGVEQTAYGVFSDLVSL
RER

Sequences:

>Translated_323_residues
MKLAIIGYGNVGRALTRMLREKRKEFPFSVTGIHTLSHGTAADPAGLPAKVTDAAEFGPRAASVEHFLDAAAADAMVELT
TLNPSTGEPAIGHIRAALARRMHVVTANKGPIAHAYTALSEEAARAGVRFRFESSVMDGAPVFNLWRHTMPGVKVLGFTG
VLNSTSKVVIETMEHGGSFEDGLAEARRMGITEADGAYDVEGWDSAAKTAALANVLFDARTTPQQVSTKGITRLTPERMA
EMGRQGKTVRLVSRGRRTAAGVSLRVRAEVLDRGDLLASMPGTSNLILFDTDLMGTFGTISIEPGVEQTAYGVFSDLVSL
RER
>Mature_323_residues
MKLAIIGYGNVGRALTRMLREKRKEFPFSVTGIHTLSHGTAADPAGLPAKVTDAAEFGPRAASVEHFLDAAAADAMVELT
TLNPSTGEPAIGHIRAALARRMHVVTANKGPIAHAYTALSEEAARAGVRFRFESSVMDGAPVFNLWRHTMPGVKVLGFTG
VLNSTSKVVIETMEHGGSFEDGLAEARRMGITEADGAYDVEGWDSAAKTAALANVLFDARTTPQQVSTKGITRLTPERMA
EMGRQGKTVRLVSRGRRTAAGVSLRVRAEVLDRGDLLASMPGTSNLILFDTDLMGTFGTISIEPGVEQTAYGVFSDLVSL
RER

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 34497; Mature: 34497

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLAIIGYGNVGRALTRMLREKRKEFPFSVTGIHTLSHGTAADPAGLPAKVTDAAEFGPR
CEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHCCCC
AASVEHFLDAAAADAMVELTTLNPSTGEPAIGHIRAALARRMHVVTANKGPIAHAYTALS
HHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHEEEEECCCCCCHHHHHHHH
EEAARAGVRFRFESSVMDGAPVFNLWRHTMPGVKVLGFTGVLNSTSKVVIETMEHGGSFE
HHHHHCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEHHHHCCCHHHHHHHHHCCCCCH
DGLAEARRMGITEADGAYDVEGWDSAAKTAALANVLFDARTTPQQVSTKGITRLTPERMA
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHH
EMGRQGKTVRLVSRGRRTAAGVSLRVRAEVLDRGDLLASMPGTSNLILFDTDLMGTFGTI
HHCCCCCEEEEECCCCCHHCCEEEEEEHHHHCCCCEEEECCCCCCEEEEECCCCCCCEEE
SIEPGVEQTAYGVFSDLVSLRER
EECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLAIIGYGNVGRALTRMLREKRKEFPFSVTGIHTLSHGTAADPAGLPAKVTDAAEFGPR
CEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHCCCC
AASVEHFLDAAAADAMVELTTLNPSTGEPAIGHIRAALARRMHVVTANKGPIAHAYTALS
HHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHEEEEECCCCCCHHHHHHHH
EEAARAGVRFRFESSVMDGAPVFNLWRHTMPGVKVLGFTGVLNSTSKVVIETMEHGGSFE
HHHHHCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEEEHHHHCCCHHHHHHHHHCCCCCH
DGLAEARRMGITEADGAYDVEGWDSAAKTAALANVLFDARTTPQQVSTKGITRLTPERMA
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHH
EMGRQGKTVRLVSRGRRTAAGVSLRVRAEVLDRGDLLASMPGTSNLILFDTDLMGTFGTI
HHCCCCCEEEEECCCCCHHCCEEEEEEHHHHCCCCEEEECCCCCCEEEEECCCCCCCEEE
SIEPGVEQTAYGVFSDLVSLRER
EECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]