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The map label for this gene is gudP [H]

Identifier: 116626074

GI number: 116626074

Start: 8843562

End: 8844770

Strand: Direct

Name: gudP [H]

Synonym: Acid_7032

Alternate gene names: 116626074

Gene position: 8843562-8844770 (Clockwise)

Preceding gene: 116626072

Following gene: 116626075

Centisome position: 88.74

GC content: 65.43

Gene sequence:

>1209_bases
TTGAAGACGCGATACAAGTGGACGGTGGTGGGGTTGCTATGGTTCGTCTGTCTGTTCAACTACGCGGACCGGCAGGCCAT
CTTTTCGGTGTTCCCGCTGTTGAAGGCGGAGATGCACCTGAGCGACGTGCAGCTGGGCTACGTCGCCTCGTCGTTCATGT
GGGTCTACGCAGCCGCCGCGCCCTTCGCAGGCCTGGCGGGCGACCGCTTCCGGCGTAAATCGGTAATCCTCGGCGGGCTG
ATCTTCTGGTCCCTGATTACGCTGGCGACGGCGCTGGCCACGCGCTACTGGCATCTGGTGCTTTTCCGCGCGCTGGAAGG
GCTAGGCGAGGCCTTCTATTTTCCCGCGTCGATGTCGCTGATCAGCTCGTGGCACGGCAAGGAGACCCGGTCGCGCGCCA
TGAGCTGGCATCAATCCAGTGTGTACGCCGGCACCATCGCCGGCGGAACCGCGGCGGGCTTCCTGGCGGAGCGGTTCGGA
TGGCGCAGCGGCTTCTACCTGTTCGGCTCTCTGGGCGTGGTTCTCGGTCTGGTGCTGCTGGTGCTGCTCAAGGAGCCGCC
AGAGGAAGCGCCTCGCGAAGAAGAGAAATTCCAATTCGGTAGCGCCTGGCGCGACGTGCTGCGCAACCCTATGGCCGGCG
CGCTGATGGCCGTCTTCATCTGCGCCAACTTCGTCGCCGTGGTCTTCCTCACCTGGCTGCCGTCTTACCTGAATCGCAAC
TTTCACATGAGCCTGACCATGGCCGGTTTCAGCGCGACGGCGTATCTTCAGGTGGCGAGCGTGCTCGGCGTTCTGACCGG
CGGCATGGTGGCCGACGCCTGGGTGCGCAAGAACCGCCGCGGGCGCATGTTCACGCAAGCCGTCGGACTGTTCGCGGGCG
TCCCCTTCCTGCTGCTGACCGGTTGGGCCTTCCAGGTGACGGTCTTCGTGTTCGCCACCATCGGCTTCGGATTCTTCAAG
GGCATGTACGACGCCAACATCTGGGCGTCGCTCCATGACGTGGTGCCGCCGGGCCGGCGTGCGACTGCGGTCGGCCTGAT
GAACTCGATCGGCTGGCTGGGCGGCGGTGTGGCGCCGGTGGCGATCGCGTCGGCCTCGGGAGTGTGGGGCATGGGCGCGT
GCTTGAGTGCGACGTCGGCCGTCTACGCACTGGCCGGTTCGCTGCTCGTGCTAGGCGGAGCGCGGTGGATGCGAAAGGCG
CAACCGTAA

Upstream 100 bases:

>100_bases
CGGCGCGGTCCAATTTTGATTTCGCTCCATGGAGATCGATTGCTCAGCATGATAGCAACTTGGTGGGAACGTCGCGGTAT
CGTAGTCCTCGGGACTTCAT

Downstream 100 bases:

>100_bases
GGTTCGGCACGGCCGACTTACAAGTTAACTTACCGGGCTTCCGATCCTGTTGTTTAATCGGGTCATGTTAGTTCGACCTG
CTCTTCTTACCCTGATCGCG

Product: major facilitator transporter

Products: NA

Alternate protein names: D-glucarate permease [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKTRYKWTVVGLLWFVCLFNYADRQAIFSVFPLLKAEMHLSDVQLGYVASSFMWVYAAAAPFAGLAGDRFRRKSVILGGL
IFWSLITLATALATRYWHLVLFRALEGLGEAFYFPASMSLISSWHGKETRSRAMSWHQSSVYAGTIAGGTAAGFLAERFG
WRSGFYLFGSLGVVLGLVLLVLLKEPPEEAPREEEKFQFGSAWRDVLRNPMAGALMAVFICANFVAVVFLTWLPSYLNRN
FHMSLTMAGFSATAYLQVASVLGVLTGGMVADAWVRKNRRGRMFTQAVGLFAGVPFLLLTGWAFQVTVFVFATIGFGFFK
GMYDANIWASLHDVVPPGRRATAVGLMNSIGWLGGGVAPVAIASASGVWGMGACLSATSAVYALAGSLLVLGGARWMRKA
QP

Sequences:

>Translated_402_residues
MKTRYKWTVVGLLWFVCLFNYADRQAIFSVFPLLKAEMHLSDVQLGYVASSFMWVYAAAAPFAGLAGDRFRRKSVILGGL
IFWSLITLATALATRYWHLVLFRALEGLGEAFYFPASMSLISSWHGKETRSRAMSWHQSSVYAGTIAGGTAAGFLAERFG
WRSGFYLFGSLGVVLGLVLLVLLKEPPEEAPREEEKFQFGSAWRDVLRNPMAGALMAVFICANFVAVVFLTWLPSYLNRN
FHMSLTMAGFSATAYLQVASVLGVLTGGMVADAWVRKNRRGRMFTQAVGLFAGVPFLLLTGWAFQVTVFVFATIGFGFFK
GMYDANIWASLHDVVPPGRRATAVGLMNSIGWLGGGVAPVAIASASGVWGMGACLSATSAVYALAGSLLVLGGARWMRKA
QP
>Mature_402_residues
MKTRYKWTVVGLLWFVCLFNYADRQAIFSVFPLLKAEMHLSDVQLGYVASSFMWVYAAAAPFAGLAGDRFRRKSVILGGL
IFWSLITLATALATRYWHLVLFRALEGLGEAFYFPASMSLISSWHGKETRSRAMSWHQSSVYAGTIAGGTAAGFLAERFG
WRSGFYLFGSLGVVLGLVLLVLLKEPPEEAPREEEKFQFGSAWRDVLRNPMAGALMAVFICANFVAVVFLTWLPSYLNRN
FHMSLTMAGFSATAYLQVASVLGVLTGGMVADAWVRKNRRGRMFTQAVGLFAGVPFLLLTGWAFQVTVFVFATIGFGFFK
GMYDANIWASLHDVVPPGRRATAVGLMNSIGWLGGGVAPVAIASASGVWGMGACLSATSAVYALAGSLLVLGGARWMRKA
QP

Specific function: Uptake of D-glucarate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI215490096, Length=368, Percent_Identity=28.804347826087, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI14042968, Length=368, Percent_Identity=28.804347826087, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI185136021, Length=363, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI215490100, Length=354, Percent_Identity=28.5310734463277, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI215490102, Length=348, Percent_Identity=27.5862068965517, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI9966811, Length=362, Percent_Identity=23.4806629834254, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI9945322, Length=362, Percent_Identity=24.0331491712707, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI6912666, Length=345, Percent_Identity=24.3478260869565, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI21322234, Length=362, Percent_Identity=23.2044198895028, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI148743791, Length=329, Percent_Identity=24.6200607902736, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI215490098, Length=348, Percent_Identity=26.4367816091954, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI154350196, Length=318, Percent_Identity=26.7295597484277, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789152, Length=401, Percent_Identity=26.4339152119701, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI2367379, Length=376, Percent_Identity=25.531914893617, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI87082320, Length=410, Percent_Identity=23.4146341463415, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789515, Length=437, Percent_Identity=24.4851258581236, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082404, Length=393, Percent_Identity=26.7175572519084, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87081723, Length=361, Percent_Identity=25.4847645429363, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193209775, Length=414, Percent_Identity=22.463768115942, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17557872, Length=374, Percent_Identity=25.4010695187166, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71992409, Length=421, Percent_Identity=23.9904988123515, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17554148, Length=354, Percent_Identity=22.5988700564972, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17561094, Length=345, Percent_Identity=22.6086956521739, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115533556, Length=294, Percent_Identity=25.1700680272109, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115533554, Length=294, Percent_Identity=25.1700680272109, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17535049, Length=430, Percent_Identity=22.5581395348837, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539092, Length=197, Percent_Identity=25.3807106598985, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554962, Length=267, Percent_Identity=21.7228464419476, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32565914, Length=283, Percent_Identity=23.6749116607774, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17552542, Length=347, Percent_Identity=25.3602305475504, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24654039, Length=359, Percent_Identity=27.8551532033426, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17864456, Length=359, Percent_Identity=27.8551532033426, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24654037, Length=363, Percent_Identity=26.9972451790634, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24654041, Length=363, Percent_Identity=26.9972451790634, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24648416, Length=341, Percent_Identity=28.1524926686217, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21356189, Length=341, Percent_Identity=28.1524926686217, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24654044, Length=240, Percent_Identity=28.3333333333333, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24583789, Length=345, Percent_Identity=27.536231884058, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19922400, Length=347, Percent_Identity=26.5129682997118, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24654215, Length=347, Percent_Identity=26.5129682997118, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24580790, Length=349, Percent_Identity=26.9340974212034, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19920686, Length=256, Percent_Identity=25.78125, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI62484226, Length=384, Percent_Identity=24.21875, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45550460, Length=183, Percent_Identity=27.8688524590164, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24655255, Length=183, Percent_Identity=27.8688524590164, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130135, Length=373, Percent_Identity=21.1796246648794, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24655271, Length=373, Percent_Identity=21.1796246648794, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24584153, Length=342, Percent_Identity=24.2690058479532, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43813; Mature: 43813

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRYKWTVVGLLWFVCLFNYADRQAIFSVFPLLKAEMHLSDVQLGYVASSFMWVYAAAA
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PFAGLAGDRFRRKSVILGGLIFWSLITLATALATRYWHLVLFRALEGLGEAFYFPASMSL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHH
ISSWHGKETRSRAMSWHQSSVYAGTIAGGTAAGFLAERFGWRSGFYLFGSLGVVLGLVLL
HHHHCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VLLKEPPEEAPREEEKFQFGSAWRDVLRNPMAGALMAVFICANFVAVVFLTWLPSYLNRN
HHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FHMSLTMAGFSATAYLQVASVLGVLTGGMVADAWVRKNRRGRMFTQAVGLFAGVPFLLLT
EEEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHH
GWAFQVTVFVFATIGFGFFKGMYDANIWASLHDVVPPGRRATAVGLMNSIGWLGGGVAPV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHH
AIASASGVWGMGACLSATSAVYALAGSLLVLGGARWMRKAQP
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure
MKTRYKWTVVGLLWFVCLFNYADRQAIFSVFPLLKAEMHLSDVQLGYVASSFMWVYAAAA
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PFAGLAGDRFRRKSVILGGLIFWSLITLATALATRYWHLVLFRALEGLGEAFYFPASMSL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHH
ISSWHGKETRSRAMSWHQSSVYAGTIAGGTAAGFLAERFGWRSGFYLFGSLGVVLGLVLL
HHHHCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VLLKEPPEEAPREEEKFQFGSAWRDVLRNPMAGALMAVFICANFVAVVFLTWLPSYLNRN
HHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FHMSLTMAGFSATAYLQVASVLGVLTGGMVADAWVRKNRRGRMFTQAVGLFAGVPFLLLT
EEEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHH
GWAFQVTVFVFATIGFGFFKGMYDANIWASLHDVVPPGRRATAVGLMNSIGWLGGGVAPV
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHH
AIASASGVWGMGACLSATSAVYALAGSLLVLGGARWMRKAQP
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]