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The map label for this gene is glyA

Identifier: 116626059

GI number: 116626059

Start: 8820655

End: 8821935

Strand: Reverse

Name: glyA

Synonym: Acid_7017

Alternate gene names: 116626059

Gene position: 8821935-8820655 (Counterclockwise)

Preceding gene: 116626060

Following gene: 116626058

Centisome position: 88.52

GC content: 63.86

Gene sequence:

>1281_bases
ATGACCGAATCACAACGCATGTCCCGCACCCTCGCCGAAGTAGACCCTGAAATTTACCAGGCCATCCAGCACGAGACGGC
GCGCCAGGACGGTCAGCTCGAACTGATCGCCAGCGAGAACTTCACCTCCGAAGCCGTGCTCGAAGCCACCGGCAGCGTCT
TCACCAACAAGTACGCGGAAGGCTATCCCGGCAAACGCTACTACGGCGGCTGCGAGTATACCGACGTGGTCGAAAACCTG
GCCCGCGAGCGCGCCAGCAAGCTCTTCGGCGCCGAGTACGTCAACGTACAGCCCCACTCCGGCTCGCAGGCCAACCAGGC
CGCTTACGGGGCCGTGGTCTCCCCCGGCGATACCGTGATGGGCCTCAACCTCGCGCACGGCGGACACCTCACCCACGGCC
ATGCCCTCAACTTCTCCGGCAAGACTTACAAGATCGTCCCCTACAACGTCCGTAAGGAAGACGAGTTGATCGATTACGAC
GAAGTCGAAAAGCTAGCCCGCGAGCACCAGCCCAAGATGATCATCGCGGGCGCCAGCGCCTACCCGCGCATCATCGATTT
CGCCCGTTTCCGCAAAATCGCCGATGCCGTCGGCGCCGTCTTCCTCGTCGATATGGCGCACATCTCCGGCCTGGTCGCCG
CCGGCGTCCATCCGAACCCTTGCGAGTTCGCCGACATCGTCACCTCCACCACCCATAAGACCCTGCGCGGACCGCGCGCC
GGCATCATCCTCGCCCGCGAAAAATACGGCAAGGAGATCGATAAGAACGTCTTCCCCGGCACCCAGGGCGGCCCCCTCGT
CCACGTCATGGCGGCCAAGGCCGTCTGCTTCCTCGAAGCCCTGCAGCCCGAATTCGCCGTCTACCAGCGGCAGGTCGTCG
CCAATGCCAAAGCCCTCGCGCAGAGCCTGATCGATGCCGGCTTCCGCGTGGTCTCCGGCGGCACCGATACCCACGTTGTC
CTGCTCGACGTCTTCTCGAAAGGGCTCCGTGGCAAGGAGAGCGAACAGGCCCTCGACCGCGCGCGCATCACGGTCAACAA
GAACGCCATCCCGTTCGATACCAATCCGCCCATGAACCCGAGCGGTATCCGCCTCGGCTCGCCCGCCGTCACCACCCGCG
GCTTCAAAGAGGCCGAGATGCGCGAAGTCGGCACGCTGATCGCCGAGGTGCTCACTAATATCGCAAACGAGGATGTCATC
GCCGGCGTACGGCAGAAGGTGCAGGCGCTCACCACCCGCTTCCCGCTCTACAGTTGGAAACGCGATACCGTCCAGGCCTA
G

Upstream 100 bases:

>100_bases
CGGAATTCGCCGGCGGACGCCATGCCCGCCGCGTCGCCAAGATCGCCCAGTTGGAAAAATAAGAGGCGGCTTTTCGCCCA
GCCTCGGAGGAAAAATCGAT

Downstream 100 bases:

>100_bases
AATGGCGGCGCACATCGTCATCGACGCCCGCCGCGTCCGCGACTTCGGCATCGGGACCTACATCCGCAGCCTCGTCCAGG
CACTCGGCGCCATCGACCGG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTESQRMSRTLAEVDPEIYQAIQHETARQDGQLELIASENFTSEAVLEATGSVFTNKYAEGYPGKRYYGGCEYTDVVENL
ARERASKLFGAEYVNVQPHSGSQANQAAYGAVVSPGDTVMGLNLAHGGHLTHGHALNFSGKTYKIVPYNVRKEDELIDYD
EVEKLAREHQPKMIIAGASAYPRIIDFARFRKIADAVGAVFLVDMAHISGLVAAGVHPNPCEFADIVTSTTHKTLRGPRA
GIILAREKYGKEIDKNVFPGTQGGPLVHVMAAKAVCFLEALQPEFAVYQRQVVANAKALAQSLIDAGFRVVSGGTDTHVV
LLDVFSKGLRGKESEQALDRARITVNKNAIPFDTNPPMNPSGIRLGSPAVTTRGFKEAEMREVGTLIAEVLTNIANEDVI
AGVRQKVQALTTRFPLYSWKRDTVQA

Sequences:

>Translated_426_residues
MTESQRMSRTLAEVDPEIYQAIQHETARQDGQLELIASENFTSEAVLEATGSVFTNKYAEGYPGKRYYGGCEYTDVVENL
ARERASKLFGAEYVNVQPHSGSQANQAAYGAVVSPGDTVMGLNLAHGGHLTHGHALNFSGKTYKIVPYNVRKEDELIDYD
EVEKLAREHQPKMIIAGASAYPRIIDFARFRKIADAVGAVFLVDMAHISGLVAAGVHPNPCEFADIVTSTTHKTLRGPRA
GIILAREKYGKEIDKNVFPGTQGGPLVHVMAAKAVCFLEALQPEFAVYQRQVVANAKALAQSLIDAGFRVVSGGTDTHVV
LLDVFSKGLRGKESEQALDRARITVNKNAIPFDTNPPMNPSGIRLGSPAVTTRGFKEAEMREVGTLIAEVLTNIANEDVI
AGVRQKVQALTTRFPLYSWKRDTVQA
>Mature_425_residues
TESQRMSRTLAEVDPEIYQAIQHETARQDGQLELIASENFTSEAVLEATGSVFTNKYAEGYPGKRYYGGCEYTDVVENLA
RERASKLFGAEYVNVQPHSGSQANQAAYGAVVSPGDTVMGLNLAHGGHLTHGHALNFSGKTYKIVPYNVRKEDELIDYDE
VEKLAREHQPKMIIAGASAYPRIIDFARFRKIADAVGAVFLVDMAHISGLVAAGVHPNPCEFADIVTSTTHKTLRGPRAG
IILAREKYGKEIDKNVFPGTQGGPLVHVMAAKAVCFLEALQPEFAVYQRQVVANAKALAQSLIDAGFRVVSGGTDTHVVL
LDVFSKGLRGKESEQALDRARITVNKNAIPFDTNPPMNPSGIRLGSPAVTTRGFKEAEMREVGTLIAEVLTNIANEDVIA
GVRQKVQALTTRFPLYSWKRDTVQA

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=452, Percent_Identity=44.6902654867257, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI261862350, Length=452, Percent_Identity=44.6902654867257, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI261862348, Length=452, Percent_Identity=44.6902654867257, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI19923315, Length=452, Percent_Identity=44.6902654867257, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI261862346, Length=452, Percent_Identity=43.8053097345133, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI22547186, Length=437, Percent_Identity=45.3089244851259, Blast_Score=348, Evalue=6e-96,
Organism=Homo sapiens, GI22547189, Length=422, Percent_Identity=43.1279620853081, Blast_Score=318, Evalue=5e-87,
Organism=Escherichia coli, GI1788902, Length=412, Percent_Identity=57.0388349514563, Blast_Score=480, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=46.75, Blast_Score=354, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=46.75, Blast_Score=354, Evalue=6e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=405, Percent_Identity=46.4197530864198, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323087, Length=401, Percent_Identity=46.3840399002494, Blast_Score=347, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24640005, Length=414, Percent_Identity=48.3091787439614, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI221329721, Length=414, Percent_Identity=48.3091787439614, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_SOLUE (Q01QZ0)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_828215.1
- ProteinModelPortal:   Q01QZ0
- SMR:   Q01QZ0
- STRING:   Q01QZ0
- GeneID:   4424912
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_7017
- NMPDR:   fig|234267.9.peg.6654
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   TNIANED
- PhylomeDB:   Q01QZ0
- ProtClustDB:   PRK00011
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 46431; Mature: 46300

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESQRMSRTLAEVDPEIYQAIQHETARQDGQLELIASENFTSEAVLEATGSVFTNKYAE
CCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCC
GYPGKRYYGGCEYTDVVENLARERASKLFGAEYVNVQPHSGSQANQAAYGAVVSPGDTVM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHCCCEECCCCCEE
GLNLAHGGHLTHGHALNFSGKTYKIVPYNVRKEDELIDYDEVEKLAREHQPKMIIAGASA
EEEECCCCCCCCCCEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCC
YPRIIDFARFRKIADAVGAVFLVDMAHISGLVAAGVHPNPCEFADIVTSTTHKTLRGPRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GIILAREKYGKEIDKNVFPGTQGGPLVHVMAAKAVCFLEALQPEFAVYQRQVVANAKALA
CEEEEHHHHCCHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
QSLIDAGFRVVSGGTDTHVVLLDVFSKGLRGKESEQALDRARITVNKNAIPFDTNPPMNP
HHHHHCCCEEEECCCCCEEEEHHHHHHCCCCCHHHHHHHHHEEEECCCCCCCCCCCCCCC
SGIRLGSPAVTTRGFKEAEMREVGTLIAEVLTNIANEDVIAGVRQKVQALTTRFPLYSWK
CCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCC
RDTVQA
CHHCCC
>Mature Secondary Structure 
TESQRMSRTLAEVDPEIYQAIQHETARQDGQLELIASENFTSEAVLEATGSVFTNKYAE
CCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCC
GYPGKRYYGGCEYTDVVENLARERASKLFGAEYVNVQPHSGSQANQAAYGAVVSPGDTVM
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHCCCEECCCCCEE
GLNLAHGGHLTHGHALNFSGKTYKIVPYNVRKEDELIDYDEVEKLAREHQPKMIIAGASA
EEEECCCCCCCCCCEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCC
YPRIIDFARFRKIADAVGAVFLVDMAHISGLVAAGVHPNPCEFADIVTSTTHKTLRGPRA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC
GIILAREKYGKEIDKNVFPGTQGGPLVHVMAAKAVCFLEALQPEFAVYQRQVVANAKALA
CEEEEHHHHCCHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
QSLIDAGFRVVSGGTDTHVVLLDVFSKGLRGKESEQALDRARITVNKNAIPFDTNPPMNP
HHHHHCCCEEEECCCCCEEEEHHHHHHCCCCCHHHHHHHHHEEEECCCCCCCCCCCCCCC
SGIRLGSPAVTTRGFKEAEMREVGTLIAEVLTNIANEDVIAGVRQKVQALTTRFPLYSWK
CCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCC
RDTVQA
CHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA