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The map label for this gene is pip [H]

Identifier: 116626012

GI number: 116626012

Start: 8758481

End: 8759470

Strand: Reverse

Name: pip [H]

Synonym: Acid_6970

Alternate gene names: 116626012

Gene position: 8759470-8758481 (Counterclockwise)

Preceding gene: 116626013

Following gene: 116626011

Centisome position: 87.9

GC content: 62.63

Gene sequence:

>990_bases
ATGCCCAACCACCCACTGTCCCGATCGGTCGCGAAGGATCCCGTCACCTGGCTGTACCCTGCGATCGAGCCGTACAACAC
AGGACGACTCCAGGTCTCGCCGGTGCACGAGCTCTATTTTGAGGAGTCCGGCAATCCCTCCGGCAAGCCGGTGATCTTTC
TGCATGGCGGTCCCGGCGGCGGCTCGGATCCGAAACAGCGCCGCTTTTTTCACCCCGAGAAGTACCGCATCGTGAACTTC
GACCAGCGCGGCTGCGGCAAGAGCACACCCTACGCTTCGCTCGAAGCCAACACCACGTGGGACCTGGTCGCCGACATCGA
GAAGATCCGCGAGCACCTCGGGATCGAACGCTGGCAGGTATTCGGCGGATCCTGGGGTTCTACGTTAGCTCTCGCTTATT
CCGAGACTCATCCGGAACGCGCTACCGAAGTCGTCCTGCGCGGCATTTTCCTCCTTAGAAAACAGGAATTGGATTGGTTC
TACCAGCGCGGTGCCTCGGTGCTCTATCCCGACGCGTGGGAGCCGTATCTCGCCCACATCCCCGAGCACGAGCGCGATGA
TTTGCTGTCCGCGTACCACCGGCGCCTTACCAGCGATGACCCTGCGGTGCGGCTCGCCGCTGCCAAGATCTGGAGCGGAT
GGGAAGGCGCTACTTCAAAGCTCCTCCCCGACGCTGCCTTTGCCGGCCATTACGAAGAGGATGAATTCGCCCTGGCCTTC
GCGCGCATCGAGGCCCACTATTTCCTCAACAAGGGCTTCTTCGAAACGGAAGACCAGCTGCTGCGCAACGTCTCGCGGAT
ACGGCACCTCCCCGGAGTAATCGTGCAGGGCCGTTACGACGTTGTCTGCCCGATGGAGAGCGCGTGGGCGCTCTATCGTG
CGTGGCCCGAAGCCGAGCTCATCATCACTCCGGACAGCGGCCACAGCGCCTTTGATCCTCCGAATACCCGCGCCCTGGTG
GTGGCGACGGACCGGCTGGCCGGCAGCTGA

Upstream 100 bases:

>100_bases
CGGCTTCCGCCAAGCAGTTGTTATCCGTTCTCAACGCCAAATCCCCGCGAAACAGATCGCAGCGAGGCTGACGCCGGCGG
CACGGGATATACTGGCCGCG

Downstream 100 bases:

>100_bases
CCTTGTCAGGCTTGCCGGCGCGGTAAGCGATGCTGCGTCCGGTGCTTAGTCGTGATACTAATTGCGTGTTGAGTCAAACC
ATCGTCTCTTCACGCGCCAG

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MPNHPLSRSVAKDPVTWLYPAIEPYNTGRLQVSPVHELYFEESGNPSGKPVIFLHGGPGGGSDPKQRRFFHPEKYRIVNF
DQRGCGKSTPYASLEANTTWDLVADIEKIREHLGIERWQVFGGSWGSTLALAYSETHPERATEVVLRGIFLLRKQELDWF
YQRGASVLYPDAWEPYLAHIPEHERDDLLSAYHRRLTSDDPAVRLAAAKIWSGWEGATSKLLPDAAFAGHYEEDEFALAF
ARIEAHYFLNKGFFETEDQLLRNVSRIRHLPGVIVQGRYDVVCPMESAWALYRAWPEAELIITPDSGHSAFDPPNTRALV
VATDRLAGS

Sequences:

>Translated_329_residues
MPNHPLSRSVAKDPVTWLYPAIEPYNTGRLQVSPVHELYFEESGNPSGKPVIFLHGGPGGGSDPKQRRFFHPEKYRIVNF
DQRGCGKSTPYASLEANTTWDLVADIEKIREHLGIERWQVFGGSWGSTLALAYSETHPERATEVVLRGIFLLRKQELDWF
YQRGASVLYPDAWEPYLAHIPEHERDDLLSAYHRRLTSDDPAVRLAAAKIWSGWEGATSKLLPDAAFAGHYEEDEFALAF
ARIEAHYFLNKGFFETEDQLLRNVSRIRHLPGVIVQGRYDVVCPMESAWALYRAWPEAELIITPDSGHSAFDPPNTRALV
VATDRLAGS
>Mature_328_residues
PNHPLSRSVAKDPVTWLYPAIEPYNTGRLQVSPVHELYFEESGNPSGKPVIFLHGGPGGGSDPKQRRFFHPEKYRIVNFD
QRGCGKSTPYASLEANTTWDLVADIEKIREHLGIERWQVFGGSWGSTLALAYSETHPERATEVVLRGIFLLRKQELDWFY
QRGASVLYPDAWEPYLAHIPEHERDDLLSAYHRRLTSDDPAVRLAAAKIWSGWEGATSKLLPDAAFAGHYEEDEFALAFA
RIEAHYFLNKGFFETEDQLLRNVSRIRHLPGVIVQGRYDVVCPMESAWALYRAWPEAELIITPDSGHSAFDPPNTRALVV
ATDRLAGS

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 37215; Mature: 37084

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNHPLSRSVAKDPVTWLYPAIEPYNTGRLQVSPVHELYFEESGNPSGKPVIFLHGGPGG
CCCCCCCCHHHHCCCEEEECCCCCCCCCEEEECHHHHHHHHCCCCCCCCEEEEEECCCCC
GSDPKQRRFFHPEKYRIVNFDQRGCGKSTPYASLEANTTWDLVADIEKIREHLGIERWQV
CCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCEEEEE
FGGSWGSTLALAYSETHPERATEVVLRGIFLLRKQELDWFYQRGASVLYPDAWEPYLAHI
ECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHC
PEHERDDLLSAYHRRLTSDDPAVRLAAAKIWSGWEGATSKLLPDAAFAGHYEEDEFALAF
CCCCHHHHHHHHHHHCCCCCCHHEEEHHHHHCCCCCCHHHCCCCHHHCCCCCCCHHEEEH
ARIEAHYFLNKGFFETEDQLLRNVSRIRHLPGVIVQGRYDVVCPMESAWALYRAWPEAEL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCEEEECCCHHHHHHHHCCCCCEE
IITPDSGHSAFDPPNTRALVVATDRLAGS
EEECCCCCCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
PNHPLSRSVAKDPVTWLYPAIEPYNTGRLQVSPVHELYFEESGNPSGKPVIFLHGGPGG
CCCCCCCHHHHCCCEEEECCCCCCCCCEEEECHHHHHHHHCCCCCCCCEEEEEECCCCC
GSDPKQRRFFHPEKYRIVNFDQRGCGKSTPYASLEANTTWDLVADIEKIREHLGIERWQV
CCCHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCEEEEE
FGGSWGSTLALAYSETHPERATEVVLRGIFLLRKQELDWFYQRGASVLYPDAWEPYLAHI
ECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHC
PEHERDDLLSAYHRRLTSDDPAVRLAAAKIWSGWEGATSKLLPDAAFAGHYEEDEFALAF
CCCCHHHHHHHHHHHCCCCCCHHEEEHHHHHCCCCCCHHHCCCCHHHCCCCCCCHHEEEH
ARIEAHYFLNKGFFETEDQLLRNVSRIRHLPGVIVQGRYDVVCPMESAWALYRAWPEAEL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCEEEECCCHHHHHHHHCCCCCEE
IITPDSGHSAFDPPNTRALVVATDRLAGS
EEECCCCCCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]