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The map label for this gene is mutA [H]

Identifier: 116625998

GI number: 116625998

Start: 8746104

End: 8747549

Strand: Reverse

Name: mutA [H]

Synonym: Acid_6956

Alternate gene names: 116625998

Gene position: 8747549-8746104 (Counterclockwise)

Preceding gene: 116625999

Following gene: 116625997

Centisome position: 87.78

GC content: 63.28

Gene sequence:

>1446_bases
ATGCCTGAAACCGCTGTCGCGGAAGAGATCCTGAACCTCACGCGCGATTTTCCGCCCGTTCCCACCGAGGCCTGGGAAGC
CGCCATCGCCAAAGACCTGAAGGGCGCCGACTACGAAAAGAAACTGGTCTGGCGAACCGAAGAAGGCCTCGGCATTCGTC
CCTACTACCGTAAGGAAGCGCTCGCCGGACTCGACGCTCAGGTCCAAACGATGCCCGGCCACTATCCCTTCGCGCGCGGC
GCGGGCCGGGGGTGGGAAATCGCGCAAGACTCCAAACCCGGTCCTCAAGCCGTGCGGGCGGACGTATTGCACGAGGCCGG
GGCGCATGCCATTCAGGAGCTGGGCTACGCGATTGCCGCCGGTGTAGAACGCCTGGCCGCGCTGACTGCAACCCTGCCGG
TAGACACCATCGCTCCCCAGATCGAGTTCGTCTTCGCCGTTGGACCCAGCTACTTCATCGAGATCGCCAAGCTGCGCGCC
GCGCGCATTCTTTGGGCGCTGGCAGTCGATGCTTTCGGATCGGGCGACGATGGGGCGTGCCGCATGCGCCTGCACGTGCG
AACGCCGCAGCGCAATAAGAGCGCGTACGACCGGTACACGAATTTACTGCGCGTGACCACCGAAGCCGCCTCGGCCGTGA
TCGGCGGCTGCGACCAGCTCAATGTGGAGCCCTTCGCGTTCGACGCGCACCTCGCGCTCAACGTCCAGCGCATTCTCCAG
GAAGAAGCGCATCTCGACGCGGTCGCCGATCCGGCGGGCGGGTCTTACTACATCGAGGCATTGACCGATTCACTGGCGCG
CGAAGCGTGGAAGCTCTTCCAGCAAATCGAGGCCGAAGGCGGATATGCGAAAGCACTCGCCTCCGGTGCGATCGCGAAGG
TTCTTGCGCAAACCCGCGCGGCGCGCGAGAAAGCTTATTCCGGGCGGCGACGCACCCTGGTGGGAGTCAATAACTATCCC
AGCGTGACAGAGAAGGCTCCGGATGCGGAGTTCCCAGCGCCGGGCCCAGCGACTCCGCTGCCGCAAGTTCGGATCGCCGA
ACCCTTCGAGCAAATCCGTCGGCGCACCAGCGAACACGCGATTGCAACGGGGCGATATCCCAAGGTATTGCTGCTCAAAC
GGGGCGACGTCAGGATGAAAGGCGCGCGCTCCAACTTCTGCTTCAATTTCTTCGGCTGCGCGGGCTTCGACATGGTGGAA
GCCGAGGAGTACGCCGGCACCGACGCCGACCTCGCCATCCTTTGCAGCTCCGACCCCGAGTACCTTGCCTTCGCGCAGGA
AGTCTGCGCCAACGTGAAGATACCGGTGCTCGTCGCAGGAAATCCCAAGGATCAAATCGAAGCCTTGCAGGCCGCGGGCG
TACTAGGCTTCATCCATGTCTTCAGCGACCTGATCCAAACCCTGACCGAGTGGCAGGACAAACTCGGCATGAGGAGCAGC
CAATGA

Upstream 100 bases:

>100_bases
CGCAAGGGTTCGCGCGGAACCACAGTCTTCTTCTTGCACCCCAAGACCACAGAGGCCGCCGCGTTCGGCTATCTGCTCGA
AGTAGTGCAGGAGGGCGCAC

Downstream 100 bases:

>100_bases
GACCGGACTTCTCGAAAATCGATTACCACATCAAACCGCAGAACTCCGAGATCTCCGGACCTGCCCAGGGCTCGTCCGTC
TGGAAGACCGCCGAGCAGAT

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MPETAVAEEILNLTRDFPPVPTEAWEAAIAKDLKGADYEKKLVWRTEEGLGIRPYYRKEALAGLDAQVQTMPGHYPFARG
AGRGWEIAQDSKPGPQAVRADVLHEAGAHAIQELGYAIAAGVERLAALTATLPVDTIAPQIEFVFAVGPSYFIEIAKLRA
ARILWALAVDAFGSGDDGACRMRLHVRTPQRNKSAYDRYTNLLRVTTEAASAVIGGCDQLNVEPFAFDAHLALNVQRILQ
EEAHLDAVADPAGGSYYIEALTDSLAREAWKLFQQIEAEGGYAKALASGAIAKVLAQTRAAREKAYSGRRRTLVGVNNYP
SVTEKAPDAEFPAPGPATPLPQVRIAEPFEQIRRRTSEHAIATGRYPKVLLLKRGDVRMKGARSNFCFNFFGCAGFDMVE
AEEYAGTDADLAILCSSDPEYLAFAQEVCANVKIPVLVAGNPKDQIEALQAAGVLGFIHVFSDLIQTLTEWQDKLGMRSS
Q

Sequences:

>Translated_481_residues
MPETAVAEEILNLTRDFPPVPTEAWEAAIAKDLKGADYEKKLVWRTEEGLGIRPYYRKEALAGLDAQVQTMPGHYPFARG
AGRGWEIAQDSKPGPQAVRADVLHEAGAHAIQELGYAIAAGVERLAALTATLPVDTIAPQIEFVFAVGPSYFIEIAKLRA
ARILWALAVDAFGSGDDGACRMRLHVRTPQRNKSAYDRYTNLLRVTTEAASAVIGGCDQLNVEPFAFDAHLALNVQRILQ
EEAHLDAVADPAGGSYYIEALTDSLAREAWKLFQQIEAEGGYAKALASGAIAKVLAQTRAAREKAYSGRRRTLVGVNNYP
SVTEKAPDAEFPAPGPATPLPQVRIAEPFEQIRRRTSEHAIATGRYPKVLLLKRGDVRMKGARSNFCFNFFGCAGFDMVE
AEEYAGTDADLAILCSSDPEYLAFAQEVCANVKIPVLVAGNPKDQIEALQAAGVLGFIHVFSDLIQTLTEWQDKLGMRSS
Q
>Mature_480_residues
PETAVAEEILNLTRDFPPVPTEAWEAAIAKDLKGADYEKKLVWRTEEGLGIRPYYRKEALAGLDAQVQTMPGHYPFARGA
GRGWEIAQDSKPGPQAVRADVLHEAGAHAIQELGYAIAAGVERLAALTATLPVDTIAPQIEFVFAVGPSYFIEIAKLRAA
RILWALAVDAFGSGDDGACRMRLHVRTPQRNKSAYDRYTNLLRVTTEAASAVIGGCDQLNVEPFAFDAHLALNVQRILQE
EAHLDAVADPAGGSYYIEALTDSLAREAWKLFQQIEAEGGYAKALASGAIAKVLAQTRAAREKAYSGRRRTLVGVNNYPS
VTEKAPDAEFPAPGPATPLPQVRIAEPFEQIRRRTSEHAIATGRYPKVLLLKRGDVRMKGARSNFCFNFFGCAGFDMVEA
EEYAGTDADLAILCSSDPEYLAFAQEVCANVKIPVLVAGNPKDQIEALQAAGVLGFIHVFSDLIQTLTEWQDKLGMRSSQ

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=235, Percent_Identity=38.2978723404255, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1789284, Length=235, Percent_Identity=37.0212765957447, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI25144500, Length=227, Percent_Identity=36.1233480176211, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 52346; Mature: 52215

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETAVAEEILNLTRDFPPVPTEAWEAAIAKDLKGADYEKKLVWRTEEGLGIRPYYRKEA
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHEEEECCCCCCCCCHHHHHH
LAGLDAQVQTMPGHYPFARGAGRGWEIAQDSKPGPQAVRADVLHEAGAHAIQELGYAIAA
HHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVERLAALTATLPVDTIAPQIEFVFAVGPSYFIEIAKLRAARILWALAVDAFGSGDDGAC
HHHHHHHHHHHCCHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
RMRLHVRTPQRNKSAYDRYTNLLRVTTEAASAVIGGCDQLNVEPFAFDAHLALNVQRILQ
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHH
EEAHLDAVADPAGGSYYIEALTDSLAREAWKLFQQIEAEGGYAKALASGAIAKVLAQTRA
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AREKAYSGRRRTLVGVNNYPSVTEKAPDAEFPAPGPATPLPQVRIAEPFEQIRRRTSEHA
HHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
IATGRYPKVLLLKRGDVRMKGARSNFCFNFFGCAGFDMVEAEEYAGTDADLAILCSSDPE
EECCCCCEEEEEECCCEEECCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEECCCCH
YLAFAQEVCANVKIPVLVAGNPKDQIEALQAAGVLGFIHVFSDLIQTLTEWQDKLGMRSS
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
Q
C
>Mature Secondary Structure 
PETAVAEEILNLTRDFPPVPTEAWEAAIAKDLKGADYEKKLVWRTEEGLGIRPYYRKEA
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHEEEECCCCCCCCCHHHHHH
LAGLDAQVQTMPGHYPFARGAGRGWEIAQDSKPGPQAVRADVLHEAGAHAIQELGYAIAA
HHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GVERLAALTATLPVDTIAPQIEFVFAVGPSYFIEIAKLRAARILWALAVDAFGSGDDGAC
HHHHHHHHHHHCCHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
RMRLHVRTPQRNKSAYDRYTNLLRVTTEAASAVIGGCDQLNVEPFAFDAHLALNVQRILQ
EEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHH
EEAHLDAVADPAGGSYYIEALTDSLAREAWKLFQQIEAEGGYAKALASGAIAKVLAQTRA
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AREKAYSGRRRTLVGVNNYPSVTEKAPDAEFPAPGPATPLPQVRIAEPFEQIRRRTSEHA
HHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
IATGRYPKVLLLKRGDVRMKGARSNFCFNFFGCAGFDMVEAEEYAGTDADLAILCSSDPE
EECCCCCEEEEEECCCEEECCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEECCCCH
YLAFAQEVCANVKIPVLVAGNPKDQIEALQAAGVLGFIHVFSDLIQTLTEWQDKLGMRSS
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]