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The map label for this gene is mutB [H]

Identifier: 116625997

GI number: 116625997

Start: 8743960

End: 8746107

Strand: Reverse

Name: mutB [H]

Synonym: Acid_6955

Alternate gene names: 116625997

Gene position: 8746107-8743960 (Counterclockwise)

Preceding gene: 116625998

Following gene: 116625996

Centisome position: 87.76

GC content: 62.15

Gene sequence:

>2148_bases
ATGAGACCGGACTTCTCGAAAATCGATTACCACATCAAACCGCAGAACTCCGAGATCTCCGGACCTGCCCAGGGCTCGTC
CGTCTGGAAGACCGCCGAGCAGATCGCCGTCAAAGCCTGGTACACGGCCGACGATCTCTACGCAATGGAGCATCTGGATT
ACGCGGCGGGCGTTGCGCCATTCCTCCGCGGGCCTTACTCCACCATGTACGCCATGCAGCCGTGGACGATTCGCCAGTAC
GCCGGATTCTCTACCGCCGAGGAGTCCAATGCGTTCTACCGCGCCAATCTCGCGGCCGGCCAAAAGGGACTTTCGGTGGC
CTTCGACCTGGCCACCCACCGCGGTTACGACTCCGACAACGAACGCGTCTCGGGCGATGTCGGCAAGGCCGGCGTCGCCA
TCGATTCTGTCGAAGACATGAAGATTCTCTTCGACCAGATCCCGCTCGGCCAAATGTCCGTCTCCATGACCATGAACGGC
GCCGTACTGCCCATCATGGCGTTCTACATTGTTGCCGCCGAAGAACAGGGCGTCGCCCCCAAAGATCTCAGCGGCACCAT
TCAGAACGACATTCTGAAAGAATTCATGGTGCGCAACACCTATATCTATCCGCCGGGGCCTTCCATGCGGATGATCGGGC
ATATCTTCCAGTACTGCTCGGAGAAGATGCCTAAATTCAACTGCATCTCGATCAGCGGCTACCACATGCAGGAGGCCGGC
GCCGGCGCCGATCTCGAACTCGGCTACACGCTGGCCGACGGCCTGGAATATATCCGCACGGGAATTCAGGCAGGGCTCGA
TATCGACACATTCGCGCCGCGGCTCAGCTTCTTCTGGGGCATCGGCATGAATCACTTTATGGAGATCGCCAAGATGCGCG
CCGCGCGCGTGCTGTGGGCGAAGATCATCCAGGGCTTCCATCCGAAGAATCCGAAATCGATGGCGCTGCGTACGCACTCG
CAGACATCGGGTTGGAGCCTGGCCGCGCAGGACGTCTTCAACAATGTTCCGCGAACCTGCATGGAGGCGCTCGCTGCCGT
ACTCGGGCACACGCAATCGCTGCACACGAACGCGCTCGACGAGGCGATCGCGCTGCCCACCGATTTCTCGGCACGCATCG
CGCGCAATACGCAGATCTTCCTGCAGGAGGAAACCGGCGTCACGAAGGTGGTCGATCCGTGGGCCGGCAGCTACTACGTG
GAGTCGTTGACCCACGAACTGATGCACAATGCGTGGCATCACATTCAGGAGATCGAAAGCCTCGGCGGCATGGCGAAGGC
GATCGAGACCGGGATTCCCAAGATGCGCATCGAAGAGGCGGCCGCCCGGCGCCAGGCGCAGATCGATTCGGGACGCGAGA
CCATCGTCGGCGTCAACAAGTACAAGCCCGCCGAAGTCGAACAGCTCGACGTGCGAATCGTTGACAATAAAGCGGTGCGC
GAATCCCAATTGCGCCGGCTCGCGGAAATCCGCGCGACACGAGATGCGCTCGCGGTGGAGGAATCGCTGGCGGCGTTGAC
CAGCGCGGCGGAAACCGGCTCCGGCAACCTGCTGGAACTGGCGGTGCAGGCAGCTCGCCTTCGCGCCACCCTGGGTGAGA
TCTCCTCCGCCCTCGAGAAAGTCTTCGGGAGGTATCAGGCCGTGAATCGTACCATCTCCGGCGTATATTCGTCCGAGAGT
CAGGGCGACCCAGAGTTCCAGGAAGCGCAACGCCTGGCCGCGGAGTTTGCCGCTGCCGAAGGGCGGCGTCCACGCATCCT
GCTGGCCAAGATGGGGCAGGACGGACACGATCGCGGGGCCAAGGTGATTGCCACAGCGTTCGCCGACCTGGGCTTCGACG
TCGATGTCGGGCCGCTGTTCCAGACCCCGCGCGAGGCTGCCCGCATGGCGGCGGAGAATGACGTCCACGTACTCGGCGTA
TCCAGCCTCGCGGGCGGACATTCCACGTTGGTGCCGGAAGTCATCGCCGAGTTGAAAGCGCTCGGCCGCGAAGACATTCT
CGTAATCGTCGGGGGCGTAATTCCTCCGCAGGATTACGCGGCGCTGTTCCAGGCAGGAGTGACCGATGTATTCGGCCCCG
GCACGGTCATCCCGGTAGCCGCGCAGAAGATTCTCCACGCGCTGATCGGGAGTGCGCGTGCGCTGTAA

Upstream 100 bases:

>100_bases
CCTTGCAGGCCGCGGGCGTACTAGGCTTCATCCATGTCTTCAGCGACCTGATCCAAACCCTGACCGAGTGGCAGGACAAA
CTCGGCATGAGGAGCAGCCA

Downstream 100 bases:

>100_bases
AACTACCCCGCCGCACGTCTGCCGAATTGCCATGCCGTCGCCCGACCAACGCATGAAACGTCTCCATCCGAGCCGCGACC
GTCAGGGAGCGTCCGGTAAT

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 715; Mature: 715

Protein sequence:

>715_residues
MRPDFSKIDYHIKPQNSEISGPAQGSSVWKTAEQIAVKAWYTADDLYAMEHLDYAAGVAPFLRGPYSTMYAMQPWTIRQY
AGFSTAEESNAFYRANLAAGQKGLSVAFDLATHRGYDSDNERVSGDVGKAGVAIDSVEDMKILFDQIPLGQMSVSMTMNG
AVLPIMAFYIVAAEEQGVAPKDLSGTIQNDILKEFMVRNTYIYPPGPSMRMIGHIFQYCSEKMPKFNCISISGYHMQEAG
AGADLELGYTLADGLEYIRTGIQAGLDIDTFAPRLSFFWGIGMNHFMEIAKMRAARVLWAKIIQGFHPKNPKSMALRTHS
QTSGWSLAAQDVFNNVPRTCMEALAAVLGHTQSLHTNALDEAIALPTDFSARIARNTQIFLQEETGVTKVVDPWAGSYYV
ESLTHELMHNAWHHIQEIESLGGMAKAIETGIPKMRIEEAAARRQAQIDSGRETIVGVNKYKPAEVEQLDVRIVDNKAVR
ESQLRRLAEIRATRDALAVEESLAALTSAAETGSGNLLELAVQAARLRATLGEISSALEKVFGRYQAVNRTISGVYSSES
QGDPEFQEAQRLAAEFAAAEGRRPRILLAKMGQDGHDRGAKVIATAFADLGFDVDVGPLFQTPREAARMAAENDVHVLGV
SSLAGGHSTLVPEVIAELKALGREDILVIVGGVIPPQDYAALFQAGVTDVFGPGTVIPVAAQKILHALIGSARAL

Sequences:

>Translated_715_residues
MRPDFSKIDYHIKPQNSEISGPAQGSSVWKTAEQIAVKAWYTADDLYAMEHLDYAAGVAPFLRGPYSTMYAMQPWTIRQY
AGFSTAEESNAFYRANLAAGQKGLSVAFDLATHRGYDSDNERVSGDVGKAGVAIDSVEDMKILFDQIPLGQMSVSMTMNG
AVLPIMAFYIVAAEEQGVAPKDLSGTIQNDILKEFMVRNTYIYPPGPSMRMIGHIFQYCSEKMPKFNCISISGYHMQEAG
AGADLELGYTLADGLEYIRTGIQAGLDIDTFAPRLSFFWGIGMNHFMEIAKMRAARVLWAKIIQGFHPKNPKSMALRTHS
QTSGWSLAAQDVFNNVPRTCMEALAAVLGHTQSLHTNALDEAIALPTDFSARIARNTQIFLQEETGVTKVVDPWAGSYYV
ESLTHELMHNAWHHIQEIESLGGMAKAIETGIPKMRIEEAAARRQAQIDSGRETIVGVNKYKPAEVEQLDVRIVDNKAVR
ESQLRRLAEIRATRDALAVEESLAALTSAAETGSGNLLELAVQAARLRATLGEISSALEKVFGRYQAVNRTISGVYSSES
QGDPEFQEAQRLAAEFAAAEGRRPRILLAKMGQDGHDRGAKVIATAFADLGFDVDVGPLFQTPREAARMAAENDVHVLGV
SSLAGGHSTLVPEVIAELKALGREDILVIVGGVIPPQDYAALFQAGVTDVFGPGTVIPVAAQKILHALIGSARAL
>Mature_715_residues
MRPDFSKIDYHIKPQNSEISGPAQGSSVWKTAEQIAVKAWYTADDLYAMEHLDYAAGVAPFLRGPYSTMYAMQPWTIRQY
AGFSTAEESNAFYRANLAAGQKGLSVAFDLATHRGYDSDNERVSGDVGKAGVAIDSVEDMKILFDQIPLGQMSVSMTMNG
AVLPIMAFYIVAAEEQGVAPKDLSGTIQNDILKEFMVRNTYIYPPGPSMRMIGHIFQYCSEKMPKFNCISISGYHMQEAG
AGADLELGYTLADGLEYIRTGIQAGLDIDTFAPRLSFFWGIGMNHFMEIAKMRAARVLWAKIIQGFHPKNPKSMALRTHS
QTSGWSLAAQDVFNNVPRTCMEALAAVLGHTQSLHTNALDEAIALPTDFSARIARNTQIFLQEETGVTKVVDPWAGSYYV
ESLTHELMHNAWHHIQEIESLGGMAKAIETGIPKMRIEEAAARRQAQIDSGRETIVGVNKYKPAEVEQLDVRIVDNKAVR
ESQLRRLAEIRATRDALAVEESLAALTSAAETGSGNLLELAVQAARLRATLGEISSALEKVFGRYQAVNRTISGVYSSES
QGDPEFQEAQRLAAEFAAAEGRRPRILLAKMGQDGHDRGAKVIATAFADLGFDVDVGPLFQTPREAARMAAENDVHVLGV
SSLAGGHSTLVPEVIAELKALGREDILVIVGGVIPPQDYAALFQAGVTDVFGPGTVIPVAAQKILHALIGSARAL

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=691, Percent_Identity=63.5311143270622, Blast_Score=908, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=687, Percent_Identity=63.1732168850073, Blast_Score=857, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=684, Percent_Identity=64.1812865497076, Blast_Score=898, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 77755; Mature: 77755

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPDFSKIDYHIKPQNSEISGPAQGSSVWKTAEQIAVKAWYTADDLYAMEHLDYAAGVAP
CCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHH
FLRGPYSTMYAMQPWTIRQYAGFSTAEESNAFYRANLAAGQKGLSVAFDLATHRGYDSDN
HHCCCCHHHEECCCCCHHHHCCCCCCCCCCCEEEEEHHCCCCCCEEEEEHHHHCCCCCCC
ERVSGDVGKAGVAIDSVEDMKILFDQIPLGQMSVSMTMNGAVLPIMAFYIVAAEEQGVAP
CCCCCCCCCCCEEECCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCC
KDLSGTIQNDILKEFMVRNTYIYPPGPSMRMIGHIFQYCSEKMPKFNCISISGYHMQEAG
CCCCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEECCCC
AGADLELGYTLADGLEYIRTGIQAGLDIDTFAPRLSFFWGIGMNHFMEIAKMRAARVLWA
CCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
KIIQGFHPKNPKSMALRTHSQTSGWSLAAQDVFNNVPRTCMEALAAVLGHTQSLHTNALD
HHHHCCCCCCCHHHEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHH
EAIALPTDFSARIARNTQIFLQEETGVTKVVDPWAGSYYVESLTHELMHNAWHHIQEIES
HHHCCCCCCHHHHCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGGMAKAIETGIPKMRIEEAAARRQAQIDSGRETIVGVNKYKPAEVEQLDVRIVDNKAVR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHEEEEEEECCHHHH
ESQLRRLAEIRATRDALAVEESLAALTSAAETGSGNLLELAVQAARLRATLGEISSALEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VFGRYQAVNRTISGVYSSESQGDPEFQEAQRLAAEFAAAEGRRPRILLAKMGQDGHDRGA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
KVIATAFADLGFDVDVGPLFQTPREAARMAAENDVHVLGVSSLAGGHSTLVPEVIAELKA
HHHHHHHHHCCCCCCCCHHHCCHHHHHHHHCCCCEEEEEEHHCCCCCHHHHHHHHHHHHH
LGREDILVIVGGVIPPQDYAALFQAGVTDVFGPGTVIPVAAQKILHALIGSARAL
CCCCCEEEEECCCCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRPDFSKIDYHIKPQNSEISGPAQGSSVWKTAEQIAVKAWYTADDLYAMEHLDYAAGVAP
CCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHH
FLRGPYSTMYAMQPWTIRQYAGFSTAEESNAFYRANLAAGQKGLSVAFDLATHRGYDSDN
HHCCCCHHHEECCCCCHHHHCCCCCCCCCCCEEEEEHHCCCCCCEEEEEHHHHCCCCCCC
ERVSGDVGKAGVAIDSVEDMKILFDQIPLGQMSVSMTMNGAVLPIMAFYIVAAEEQGVAP
CCCCCCCCCCCEEECCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCC
KDLSGTIQNDILKEFMVRNTYIYPPGPSMRMIGHIFQYCSEKMPKFNCISISGYHMQEAG
CCCCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEECCCC
AGADLELGYTLADGLEYIRTGIQAGLDIDTFAPRLSFFWGIGMNHFMEIAKMRAARVLWA
CCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
KIIQGFHPKNPKSMALRTHSQTSGWSLAAQDVFNNVPRTCMEALAAVLGHTQSLHTNALD
HHHHCCCCCCCHHHEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHH
EAIALPTDFSARIARNTQIFLQEETGVTKVVDPWAGSYYVESLTHELMHNAWHHIQEIES
HHHCCCCCCHHHHCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LGGMAKAIETGIPKMRIEEAAARRQAQIDSGRETIVGVNKYKPAEVEQLDVRIVDNKAVR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHEEEEEEECCHHHH
ESQLRRLAEIRATRDALAVEESLAALTSAAETGSGNLLELAVQAARLRATLGEISSALEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VFGRYQAVNRTISGVYSSESQGDPEFQEAQRLAAEFAAAEGRRPRILLAKMGQDGHDRGA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
KVIATAFADLGFDVDVGPLFQTPREAARMAAENDVHVLGVSSLAGGHSTLVPEVIAELKA
HHHHHHHHHCCCCCCCCHHHCCHHHHHHHHCCCCEEEEEEHHCCCCCHHHHHHHHHHHHH
LGREDILVIVGGVIPPQDYAALFQAGVTDVFGPGTVIPVAAQKILHALIGSARAL
CCCCCEEEEECCCCCCHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]