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The map label for this gene is mprA [H]

Identifier: 116625937

GI number: 116625937

Start: 8668573

End: 8669301

Strand: Direct

Name: mprA [H]

Synonym: Acid_6895

Alternate gene names: 116625937

Gene position: 8668573-8669301 (Clockwise)

Preceding gene: 116625933

Following gene: 116625938

Centisome position: 86.98

GC content: 58.44

Gene sequence:

>729_bases
GTGCTCAGGCATTCCTCAGAAACGGCGGCCATACTGGTATCGATAGAGATGCGAATCCTTATTGTCGAGGATGATCGAAA
GCTCGCGCGTCAACTCAAGAAGGGAGTGGATGAATCTGGTCACGCCAGTATTCTTGCATTCGATGGGCGCGAAGGACTGG
AGGCTGCGCAAGGCAACGAGTTCGATGTCATCGTGCTCGACGTGATGCTGCCGAAGTTGGATGGGATCTCTGTACTCAGG
CAATTGCGGCAGACGCGAATCGGCACGCCCATCCTGCTGCTCACCGCGCTCGACACGCCGGACGACATCAGTACGGGACT
TGATGCCGGTGCCGACGACTACCTGACGAAACCATTCTCCTTTAAGGTCCTGCTGGCACGCCTCCGGGCCCTGTCGCGAC
GGCGTCAGGCCGATCGTCAGACGCTGTTGCGCATTGCCGATTTGGCACTCGATCCCGCAACCCATGATGTGAAGCGTGCC
GGCGCGATGGTCAGCCTTTCGAAAACAGAGTTCGTAATCCTCGAAATCCTGATGCGGAGTTCGGGCCGCGTGATCACTCG
AACCCGTTTGATCGACGCCGTCTGGGGTCATGAGAGGGATGTCCAGAGCAACACGCTGGACGTCTTCATCCGTCAACTTC
GGACGAAGATCGAACCGGCCGGAACAACCAAGTTGCTCCATACCGTCCGCGGCATCGGATACACGCTGCGAGAGGAGGAG
CCCGGGTGA

Upstream 100 bases:

>100_bases
GCATGAACAGCCAGACCGGCACCCACTTCCTCATCGCATTCCTCTAGAATCCAGTGTTCCCCATAAACATGAGGATTTCC
TGAGGGTTCAGGGAACAAGT

Downstream 100 bases:

>100_bases
AAACGCGATCCATCGGCTTTCGACTGTCCGCGTGGTATTTCCTCGTGTTCGCCTGCGGCGTCGCGGCCTTCAGTGTGGCC
GCCTGGTTCGCGATGCGCGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MLRHSSETAAILVSIEMRILIVEDDRKLARQLKKGVDESGHASILAFDGREGLEAAQGNEFDVIVLDVMLPKLDGISVLR
QLRQTRIGTPILLLTALDTPDDISTGLDAGADDYLTKPFSFKVLLARLRALSRRRQADRQTLLRIADLALDPATHDVKRA
GAMVSLSKTEFVILEILMRSSGRVITRTRLIDAVWGHERDVQSNTLDVFIRQLRTKIEPAGTTKLLHTVRGIGYTLREEE
PG

Sequences:

>Translated_242_residues
MLRHSSETAAILVSIEMRILIVEDDRKLARQLKKGVDESGHASILAFDGREGLEAAQGNEFDVIVLDVMLPKLDGISVLR
QLRQTRIGTPILLLTALDTPDDISTGLDAGADDYLTKPFSFKVLLARLRALSRRRQADRQTLLRIADLALDPATHDVKRA
GAMVSLSKTEFVILEILMRSSGRVITRTRLIDAVWGHERDVQSNTLDVFIRQLRTKIEPAGTTKLLHTVRGIGYTLREEE
PG
>Mature_242_residues
MLRHSSETAAILVSIEMRILIVEDDRKLARQLKKGVDESGHASILAFDGREGLEAAQGNEFDVIVLDVMLPKLDGISVLR
QLRQTRIGTPILLLTALDTPDDISTGLDAGADDYLTKPFSFKVLLARLRALSRRRQADRQTLLRIADLALDPATHDVKRA
GAMVSLSKTEFVILEILMRSSGRVITRTRLIDAVWGHERDVQSNTLDVFIRQLRTKIEPAGTTKLLHTVRGIGYTLREEE
PG

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=42.5339366515837, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=40.9090909090909, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=37.6681614349776, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35.4545454545455, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=36.1607142857143, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=32.5688073394495, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=33.7837837837838, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.3636363636364, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=32.7272727272727, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.5263157894737, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=31.6239316239316, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.0175438596491, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=28.3185840707965, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.004329004329, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=124, Percent_Identity=33.0645161290323, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=166, Percent_Identity=27.710843373494, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=32.6732673267327, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=161, Percent_Identity=27.3291925465839, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26942; Mature: 26942

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRHSSETAAILVSIEMRILIVEDDRKLARQLKKGVDESGHASILAFDGREGLEAAQGNE
CCCCCCCCEEEEEEEEEEEEEEECCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHCCCCC
FDVIVLDVMLPKLDGISVLRQLRQTRIGTPILLLTALDTPDDISTGLDAGADDYLTKPFS
CEEEEEEEHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCHHHHCCCHH
FKVLLARLRALSRRRQADRQTLLRIADLALDPATHDVKRAGAMVSLSKTEFVILEILMRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEECCHHHHHHHHHHHC
SGRVITRTRLIDAVWGHERDVQSNTLDVFIRQLRTKIEPAGTTKLLHTVRGIGYTLREEE
CCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEECCCC
PG
CC
>Mature Secondary Structure
MLRHSSETAAILVSIEMRILIVEDDRKLARQLKKGVDESGHASILAFDGREGLEAAQGNE
CCCCCCCCEEEEEEEEEEEEEEECCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHCCCCC
FDVIVLDVMLPKLDGISVLRQLRQTRIGTPILLLTALDTPDDISTGLDAGADDYLTKPFS
CEEEEEEEHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHCCCCCCHHHHCCCHH
FKVLLARLRALSRRRQADRQTLLRIADLALDPATHDVKRAGAMVSLSKTEFVILEILMRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCEEEECCHHHHHHHHHHHC
SGRVITRTRLIDAVWGHERDVQSNTLDVFIRQLRTKIEPAGTTKLLHTVRGIGYTLREEE
CCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEECCCC
PG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA