Click here to switch to the map view.

The map label for this gene is ykoH [H]

Identifier: 116625938

GI number: 116625938

Start: 8669298

End: 8670695

Strand: Direct

Name: ykoH [H]

Synonym: Acid_6896

Alternate gene names: 116625938

Gene position: 8669298-8670695 (Clockwise)

Preceding gene: 116625937

Following gene: 116625939

Centisome position: 86.99

GC content: 60.3

Gene sequence:

>1398_bases
GTGAAAACGCGATCCATCGGCTTTCGACTGTCCGCGTGGTATTTCCTCGTGTTCGCCTGCGGCGTCGCGGCCTTCAGTGT
GGCCGCCTGGTTCGCGATGCGCGCGAGCCTATATCATGCGATCGACGAGGCATTGGAAGACCGGGTTCGGGGTGTCCAGA
CCTTCATGGAGAAGCAGATCTCGTCGCTCTCCGTCCCGGAAATCAGGGACGAGTTTCGCGAGCATTCCGTACTCGGTCCT
GGAGGCGACCTGTTTCAAGTCTGTGATGAAGCCGGTCAGTTCCTCTACAGGTCGGTTCCCCTGGAAGCGAACAACGTCCC
CGTGGCATTGCCGGGCACTCTCAGCGATTCGCGATTTGAGACGCAAGCCGTACAAGGACACATGCTGCGTTTCTATTCGC
AGCGCATCTCGGTGAATGGCAAGGTGTACACGGTTCAGGTGGCCGCACCGGTTGACGAAGCTCTGGAGGCTTTAGAGCGA
TTCCGGGTCATCCTCGCGTTCGCGGCGCCGCTGCTGTTGATCGCGGCGAGCGCCGGCGGATATTGGATCAGCAGGCGGGC
ACTGGCTCCCGTCGATGAGATCTCGCGTGCCGCCCAGCGCATCAGCATCGAGAACCTCACCGACCGTTTGCAAGTCCCGC
AAACCGGGGATCAGCTTCAGCGCCTGTCGGAAACCCTGAACGAAATGCTCTCGCGCCTGGAAGCGTCTGTCCGCCGGATG
ACCCAGTTCACAGCGGATGCTTCTCACGAGTTGCGAGCGCCGGTATCATTAATCCGCACCACAGCAGAGGTGGCGGCGCT
GAAACGCGATCGGCCTGCCAGCGAGTACTTGGAAGCGCTAGACGGTATTCAGGAGGAAGCCGAGCGGACATCTCAGGTCG
TGGACAGCCTGATGCTTCTGGCTCGCACGGATTCGGGAAAGGAAATGTTGGATTGCGTGCCAGTCGATGCCTGCGCCGTA
GTTCGGGAAGCCGCTGAGCAGGGCGAACGGCTCGCGCAAAACCGCGGCGTCGAATTCAGCATCGACGTGCCGAATAGTTC
CATTCGCATCCAGGCCGACGCCGAAGCGCTCCGCCGTGCGCTCTTGATCCTGATGGACAACGCGGCGAAATACACTCCGA
GCGGCGGCTCGATTAAGGTAGCTGTTGCGTCGCGCGATGGGTTTGCACAGGCTTCCGTCTCGGACACTGGAATCGGTATT
GCTTCTCAGGACATGCCTCATCTCTTCGATCGCTTCTGGCGTGCGGACAAAGCCCGCTCGCGCGAACAGGGTGGGGCAGG
CTTGGGTCTGTCAATCGCGAAATGGATCGTGGACATGCATGGCGGCTCCATTTCTGTTCAGAGTGAACCGGGGAAAGGAT
CTGTGTTCACGATCCAGGTGCCCTTAACCGTCGGCTAG

Upstream 100 bases:

>100_bases
TCATCCGTCAACTTCGGACGAAGATCGAACCGGCCGGAACAACCAAGTTGCTCCATACCGTCCGCGGCATCGGATACACG
CTGCGAGAGGAGGAGCCCGG

Downstream 100 bases:

>100_bases
AGCCAAAACCTGGACGGTCGGCGTGCTCGGTGTCGTTTCCGACTACACCGCGTATTCACCGAAATAAGGGTTCCCACCGC
TCACGGAATCCTCAGAAAAG

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKTRSIGFRLSAWYFLVFACGVAAFSVAAWFAMRASLYHAIDEALEDRVRGVQTFMEKQISSLSVPEIRDEFREHSVLGP
GGDLFQVCDEAGQFLYRSVPLEANNVPVALPGTLSDSRFETQAVQGHMLRFYSQRISVNGKVYTVQVAAPVDEALEALER
FRVILAFAAPLLLIAASAGGYWISRRALAPVDEISRAAQRISIENLTDRLQVPQTGDQLQRLSETLNEMLSRLEASVRRM
TQFTADASHELRAPVSLIRTTAEVAALKRDRPASEYLEALDGIQEEAERTSQVVDSLMLLARTDSGKEMLDCVPVDACAV
VREAAEQGERLAQNRGVEFSIDVPNSSIRIQADAEALRRALLILMDNAAKYTPSGGSIKVAVASRDGFAQASVSDTGIGI
ASQDMPHLFDRFWRADKARSREQGGAGLGLSIAKWIVDMHGGSISVQSEPGKGSVFTIQVPLTVG

Sequences:

>Translated_465_residues
MKTRSIGFRLSAWYFLVFACGVAAFSVAAWFAMRASLYHAIDEALEDRVRGVQTFMEKQISSLSVPEIRDEFREHSVLGP
GGDLFQVCDEAGQFLYRSVPLEANNVPVALPGTLSDSRFETQAVQGHMLRFYSQRISVNGKVYTVQVAAPVDEALEALER
FRVILAFAAPLLLIAASAGGYWISRRALAPVDEISRAAQRISIENLTDRLQVPQTGDQLQRLSETLNEMLSRLEASVRRM
TQFTADASHELRAPVSLIRTTAEVAALKRDRPASEYLEALDGIQEEAERTSQVVDSLMLLARTDSGKEMLDCVPVDACAV
VREAAEQGERLAQNRGVEFSIDVPNSSIRIQADAEALRRALLILMDNAAKYTPSGGSIKVAVASRDGFAQASVSDTGIGI
ASQDMPHLFDRFWRADKARSREQGGAGLGLSIAKWIVDMHGGSISVQSEPGKGSVFTIQVPLTVG
>Mature_465_residues
MKTRSIGFRLSAWYFLVFACGVAAFSVAAWFAMRASLYHAIDEALEDRVRGVQTFMEKQISSLSVPEIRDEFREHSVLGP
GGDLFQVCDEAGQFLYRSVPLEANNVPVALPGTLSDSRFETQAVQGHMLRFYSQRISVNGKVYTVQVAAPVDEALEALER
FRVILAFAAPLLLIAASAGGYWISRRALAPVDEISRAAQRISIENLTDRLQVPQTGDQLQRLSETLNEMLSRLEASVRRM
TQFTADASHELRAPVSLIRTTAEVAALKRDRPASEYLEALDGIQEEAERTSQVVDSLMLLARTDSGKEMLDCVPVDACAV
VREAAEQGERLAQNRGVEFSIDVPNSSIRIQADAEALRRALLILMDNAAKYTPSGGSIKVAVASRDGFAQASVSDTGIGI
ASQDMPHLFDRFWRADKARSREQGGAGLGLSIAKWIVDMHGGSISVQSEPGKGSVFTIQVPLTVG

Specific function: Probable member of the two-component regulatory system ykoH/ykoG. Potentially phosphorylates ykoG [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=326, Percent_Identity=32.5153374233129, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=30.2158273381295, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=31.3492063492063, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788279, Length=319, Percent_Identity=26.3322884012539, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789149, Length=267, Percent_Identity=28.0898876404494, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790346, Length=273, Percent_Identity=27.4725274725275, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789403, Length=277, Percent_Identity=27.4368231046931, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=27.5590551181102, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790861, Length=293, Percent_Identity=26.962457337884, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790436, Length=244, Percent_Identity=28.2786885245902, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=27.0916334661355, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=28.2051282051282, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790551, Length=269, Percent_Identity=27.5092936802974, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=24.6913580246914, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1787894, Length=279, Percent_Identity=25.4480286738351, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789808, Length=302, Percent_Identity=27.8145695364238, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=265, Percent_Identity=25.6603773584906, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50779; Mature: 50779

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRSIGFRLSAWYFLVFACGVAAFSVAAWFAMRASLYHAIDEALEDRVRGVQTFMEKQI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLSVPEIRDEFREHSVLGPGGDLFQVCDEAGQFLYRSVPLEANNVPVALPGTLSDSRFE
HCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHH
TQAVQGHMLRFYSQRISVNGKVYTVQVAAPVDEALEALERFRVILAFAAPLLLIAASAGG
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YWISRRALAPVDEISRAAQRISIENLTDRLQVPQTGDQLQRLSETLNEMLSRLEASVRRM
CEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TQFTADASHELRAPVSLIRTTAEVAALKRDRPASEYLEALDGIQEEAERTSQVVDSLMLL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARTDSGKEMLDCVPVDACAVVREAAEQGERLAQNRGVEFSIDVPNSSIRIQADAEALRRA
HCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECHHHHHHH
LLILMDNAAKYTPSGGSIKVAVASRDGFAQASVSDTGIGIASQDMPHLFDRFWRADKARS
HHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
REQGGAGLGLSIAKWIVDMHGGSISVQSEPGKGSVFTIQVPLTVG
HHCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MKTRSIGFRLSAWYFLVFACGVAAFSVAAWFAMRASLYHAIDEALEDRVRGVQTFMEKQI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSLSVPEIRDEFREHSVLGPGGDLFQVCDEAGQFLYRSVPLEANNVPVALPGTLSDSRFE
HCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCHHH
TQAVQGHMLRFYSQRISVNGKVYTVQVAAPVDEALEALERFRVILAFAAPLLLIAASAGG
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YWISRRALAPVDEISRAAQRISIENLTDRLQVPQTGDQLQRLSETLNEMLSRLEASVRRM
CEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TQFTADASHELRAPVSLIRTTAEVAALKRDRPASEYLEALDGIQEEAERTSQVVDSLMLL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARTDSGKEMLDCVPVDACAVVREAAEQGERLAQNRGVEFSIDVPNSSIRIQADAEALRRA
HCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECHHHHHHH
LLILMDNAAKYTPSGGSIKVAVASRDGFAQASVSDTGIGIASQDMPHLFDRFWRADKARS
HHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
REQGGAGLGLSIAKWIVDMHGGSISVQSEPGKGSVFTIQVPLTVG
HHCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]