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The map label for this gene is pepQ [H]

Identifier: 116625701

GI number: 116625701

Start: 8343577

End: 8344731

Strand: Reverse

Name: pepQ [H]

Synonym: Acid_6650

Alternate gene names: 116625701

Gene position: 8344731-8343577 (Counterclockwise)

Preceding gene: 116625702

Following gene: 116625700

Centisome position: 83.74

GC content: 65.28

Gene sequence:

>1155_bases
ATGAACCGTCGGGTATTTCTAGCCACAGCCGCGGCGGGCGTCGCCGCGGCGCAGCAGAGCGATACTCCAGAGCCGATCCG
CAAGCTCCGCCCCATGCTGGCTGGCGTGGTGCCGATCAGTGAAGAGGAGCGTGCGGCGCGGCGCGAGAAGGCGCGGCGCC
TGATGGCCGAGAACAAGCTGGACGCGATTTATCTGGAGAGCGGCTCCAGCATGTACTACTTCACCGGCCAGCGCACGCCG
GGACAGGCCGTCATCCTCGCGGCGAAGAGCAAGTCCCAACCGGTCTGGATTGCGGCGGACGCCGCAAAGTCAGCACAGGC
TCTGCGCGATTTGGGTGTCGCGACCGGCAAGGTCGGGATGGAGGAGCAGGTCCGCTTCGCCACCTTCGACGGATTGCGCA
GGGAACTGCCGGCGGTGGAATGCGTCAGTGGAACGCCGGTGGTGGCGGGCTGCCGGGTGATCAAATCGCCGGCGGAAATC
GCGCTGCTGCAGCGCGCCAACGATATTACGATCGAGGCTTACAAGGCGGCGCTCGCGACCATGCGCGAGGGAATGACGCA
GCGCGAACTCAGCGCGAATATCTCTGCCGCCTTCCGCGCACTCGGCACTGGGGGCGCGGCGATGGCGATCTTCGGCAAGT
ACACCGCCTTCCCGCATGGCAGCATCCAGCCGCAGCAGTTGCGTGAGGGAGATATGGTGCTGATCGATGACGGCTGCAGC
GTGGAGGGCTATCAAAGCGATATCACGCGCACCACGGTCTTCGGCAAGCCGGCCAAGCGCCAGCGTGAGATCTGGGACCT
GGAGCGCAAGGCGCAGGACGCGGCGCTGGCGGCCGCCAAACCGGGCGCGCCCTGCGAAAGCGTGGACGCGGCGGCGCGCA
AAGTGATCACCGACGCGGGCTTTGGTCCCGGTTATAAGACGCCCGGCCTGCCGCATCGCACCGGTCACGGAATCGGGCTC
GACGGACACGAGTGGACCTACTTGGTGAAGGGCAATAAGACCAGGATCGAACCGGGGATGTGCTTCAGTAACGAGCCGAC
CATCGCCATCTACGGCGAATTCGGCGTGCGTCTCGAGGATTGCATGTACATCACGCCTGGCGGGGCGCGGATGTTCACCA
AACAAAGTCCCGCGATCGATCAGCCGTTCGGATAG

Upstream 100 bases:

>100_bases
TGGGAAAGATTTACGATGAGGGCGCGCCGCTGCGCGTGGCGCTGGCCTACGAGCAGGCCACCGAGTGGCACAAGCAGAAT
CCGGTGCTGGAGGTATGACG

Downstream 100 bases:

>100_bases
GAGAGCGAAATGCAGGCACCACAAACCACGGAAACATCGCCGGAAACCTATCGGGCGCGCGTCGCCAAACTGCAGGAGGC
GATGAAGGAATTCGGACTGC

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNRRVFLATAAAGVAAAQQSDTPEPIRKLRPMLAGVVPISEEERAARREKARRLMAENKLDAIYLESGSSMYYFTGQRTP
GQAVILAAKSKSQPVWIAADAAKSAQALRDLGVATGKVGMEEQVRFATFDGLRRELPAVECVSGTPVVAGCRVIKSPAEI
ALLQRANDITIEAYKAALATMREGMTQRELSANISAAFRALGTGGAAMAIFGKYTAFPHGSIQPQQLREGDMVLIDDGCS
VEGYQSDITRTTVFGKPAKRQREIWDLERKAQDAALAAAKPGAPCESVDAAARKVITDAGFGPGYKTPGLPHRTGHGIGL
DGHEWTYLVKGNKTRIEPGMCFSNEPTIAIYGEFGVRLEDCMYITPGGARMFTKQSPAIDQPFG

Sequences:

>Translated_384_residues
MNRRVFLATAAAGVAAAQQSDTPEPIRKLRPMLAGVVPISEEERAARREKARRLMAENKLDAIYLESGSSMYYFTGQRTP
GQAVILAAKSKSQPVWIAADAAKSAQALRDLGVATGKVGMEEQVRFATFDGLRRELPAVECVSGTPVVAGCRVIKSPAEI
ALLQRANDITIEAYKAALATMREGMTQRELSANISAAFRALGTGGAAMAIFGKYTAFPHGSIQPQQLREGDMVLIDDGCS
VEGYQSDITRTTVFGKPAKRQREIWDLERKAQDAALAAAKPGAPCESVDAAARKVITDAGFGPGYKTPGLPHRTGHGIGL
DGHEWTYLVKGNKTRIEPGMCFSNEPTIAIYGEFGVRLEDCMYITPGGARMFTKQSPAIDQPFG
>Mature_384_residues
MNRRVFLATAAAGVAAAQQSDTPEPIRKLRPMLAGVVPISEEERAARREKARRLMAENKLDAIYLESGSSMYYFTGQRTP
GQAVILAAKSKSQPVWIAADAAKSAQALRDLGVATGKVGMEEQVRFATFDGLRRELPAVECVSGTPVVAGCRVIKSPAEI
ALLQRANDITIEAYKAALATMREGMTQRELSANISAAFRALGTGGAAMAIFGKYTAFPHGSIQPQQLREGDMVLIDDGCS
VEGYQSDITRTTVFGKPAKRQREIWDLERKAQDAALAAAKPGAPCESVDAAARKVITDAGFGPGYKTPGLPHRTGHGIGL
DGHEWTYLVKGNKTRIEPGMCFSNEPTIAIYGEFGVRLEDCMYITPGGARMFTKQSPAIDQPFG

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=257, Percent_Identity=27.6264591439689, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI93141226, Length=257, Percent_Identity=30.3501945525292, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788728, Length=264, Percent_Identity=34.0909090909091, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1789275, Length=270, Percent_Identity=30.3703703703704, Blast_Score=111, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17508215, Length=201, Percent_Identity=30.8457711442786, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19920384, Length=254, Percent_Identity=29.1338582677165, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357079, Length=303, Percent_Identity=26.4026402640264, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 41284; Mature: 41284

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRVFLATAAAGVAAAQQSDTPEPIRKLRPMLAGVVPISEEERAARREKARRLMAENKL
CCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
DAIYLESGSSMYYFTGQRTPGQAVILAAKSKSQPVWIAADAAKSAQALRDLGVATGKVGM
CEEEEECCCEEEEEECCCCCCCEEEEEECCCCCCEEEEECCHHHHHHHHHHCCCCCCCCH
EEQVRFATFDGLRRELPAVECVSGTPVVAGCRVIKSPAEIALLQRANDITIEAYKAALAT
HHHEEEHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCHHHHEECCCCCCCHHHHHHHHHH
MREGMTQRELSANISAAFRALGTGGAAMAIFGKYTAFPHGSIQPQQLREGDMVLIDDGCS
HHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCHHHHCCCCEEEEECCCC
VEGYQSDITRTTVFGKPAKRQREIWDLERKAQDAALAAAKPGAPCESVDAAARKVITDAG
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
FGPGYKTPGLPHRTGHGIGLDGHEWTYLVKGNKTRIEPGMCFSNEPTIAIYGEFGVRLED
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEECCCCCEECCCCCEEEEECCCCEEEE
CMYITPGGARMFTKQSPAIDQPFG
EEEECCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MNRRVFLATAAAGVAAAQQSDTPEPIRKLRPMLAGVVPISEEERAARREKARRLMAENKL
CCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
DAIYLESGSSMYYFTGQRTPGQAVILAAKSKSQPVWIAADAAKSAQALRDLGVATGKVGM
CEEEEECCCEEEEEECCCCCCCEEEEEECCCCCCEEEEECCHHHHHHHHHHCCCCCCCCH
EEQVRFATFDGLRRELPAVECVSGTPVVAGCRVIKSPAEIALLQRANDITIEAYKAALAT
HHHEEEHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCHHHHEECCCCCCCHHHHHHHHHH
MREGMTQRELSANISAAFRALGTGGAAMAIFGKYTAFPHGSIQPQQLREGDMVLIDDGCS
HHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCHHHHCCCCEEEEECCCC
VEGYQSDITRTTVFGKPAKRQREIWDLERKAQDAALAAAKPGAPCESVDAAARKVITDAG
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
FGPGYKTPGLPHRTGHGIGLDGHEWTYLVKGNKTRIEPGMCFSNEPTIAIYGEFGVRLED
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEECCCCCEECCCCCEEEEECCCCEEEE
CMYITPGGARMFTKQSPAIDQPFG
EEEECCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]