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The map label for this gene is proA [H]

Identifier: 116625687

GI number: 116625687

Start: 8324613

End: 8325287

Strand: Reverse

Name: proA [H]

Synonym: Acid_6636

Alternate gene names: 116625687

Gene position: 8325287-8324613 (Counterclockwise)

Preceding gene: 116625688

Following gene: 116625686

Centisome position: 83.54

GC content: 67.11

Gene sequence:

>675_bases
ATGAAGCCCACAATCAGGCGCCGCATCGAACGTCCCGACGCCGCCGTGGTGCGCCTGCTCGGCGAATTGGGAGTGGCCAC
CGTCCACGAGTCGCAAGGCCGCGGTGGTCTCCTGCGTCCCTACATGCGGCCGATCTATCCCGCGGCGCGCGTGGCGGGGC
CGGCCGTTACTGTCTCCTGCCAGCCCGGCGATAACCTGATGATTCACGCCTCCATCGACGTCGTGCAGTCCGGGGATGTG
CTGGTGGTCACCACGACCGCCGAATCCACCGACGGGATGTTCGGCGAACTGCTGGCCGAGTCTTGCCGCGCCCACGGAGT
GGTGGGCCTGGTGATCGATGCCGGCGTCCGCGATGTCTCCGAGCTGACCGCGATGGCATTCCCCGTCTGGTCCAAGGCGA
TCTCCGCGCAGGGCACCGTCAAGGCCACCGCCGGATCGGTGAACGTTCCTGTAGTGTGCGCCGGCGCCCTGGTTCGACCG
GGCGACGTGATCGTCGGCGATCAGGATGGCGTAGTCGTTGTTCCTCGGGAGACCGCGGCGGAAATTGCGATTCTCGGCGA
ACAGCGCCGCGCCAAAGAAGAACGTACCCGCGAGCGTCTGCGCGCCGGCGAGAAGGCTCTCGACCTGTACGGCCTGCGCG
CCCGGCTCAAGGAACTCGGCGTGGAATACGAATAG

Upstream 100 bases:

>100_bases
AACGGCGCGGCGTACAGGCGGTGCGCAACTCGGGGCGCCGCGGCATTCGCTACGCCGAGGCCTACCAGCGCGTCTACCCG
CAGGTAACGGACACGCTCGC

Downstream 100 bases:

>100_bases
TTCCTTTTACAACTTGTTTACATCGTCCCCACGATTGCGTCCCAGCCCGCCGCTAAGATCGAATCAGGTGCAGCCTTGGG
ATCTCTCCCCGTCATTCGTC

Product: hypothetical protein

Products: NA

Alternate protein names: 4-hydroxy-2-oxoglutarate aldolase [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKPTIRRRIERPDAAVVRLLGELGVATVHESQGRGGLLRPYMRPIYPAARVAGPAVTVSCQPGDNLMIHASIDVVQSGDV
LVVTTTAESTDGMFGELLAESCRAHGVVGLVIDAGVRDVSELTAMAFPVWSKAISAQGTVKATAGSVNVPVVCAGALVRP
GDVIVGDQDGVVVVPRETAAEIAILGEQRRAKEERTRERLRAGEKALDLYGLRARLKELGVEYE

Sequences:

>Translated_224_residues
MKPTIRRRIERPDAAVVRLLGELGVATVHESQGRGGLLRPYMRPIYPAARVAGPAVTVSCQPGDNLMIHASIDVVQSGDV
LVVTTTAESTDGMFGELLAESCRAHGVVGLVIDAGVRDVSELTAMAFPVWSKAISAQGTVKATAGSVNVPVVCAGALVRP
GDVIVGDQDGVVVVPRETAAEIAILGEQRRAKEERTRERLRAGEKALDLYGLRARLKELGVEYE
>Mature_224_residues
MKPTIRRRIERPDAAVVRLLGELGVATVHESQGRGGLLRPYMRPIYPAARVAGPAVTVSCQPGDNLMIHASIDVVQSGDV
LVVTTTAESTDGMFGELLAESCRAHGVVGLVIDAGVRDVSELTAMAFPVWSKAISAQGTVKATAGSVNVPVVCAGALVRP
GDVIVGDQDGVVVVPRETAAEIAILGEQRRAKEERTRERLRAGEKALDLYGLRARLKELGVEYE

Specific function: Plays a role in protocatechuate degradation. Has a broad substrate specificity and catalyzes the aldol cleavage of 4- hydroxy-4-methyl-2-oxoglutarate, 4-hydroxy-2-oxoglutarate and 4- carboxy-4-hydroxy-2-oxoadipate, and the decarboxylation of oxaloacetate.

COG id: COG0684

COG function: function code H; Demethylmenaquinone methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014165
- InterPro:   IPR005493 [H]

Pfam domain/function: PF03737 Methyltransf_6 [H]

EC number: =4.1.1.3; =4.1.3.16; =4.1.3.17 [H]

Molecular weight: Translated: 23774; Mature: 23774

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTIRRRIERPDAAVVRLLGELGVATVHESQGRGGLLRPYMRPIYPAARVAGPAVTVSC
CCCHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHCCHHHHHCCCEEEEEE
QPGDNLMIHASIDVVQSGDVLVVTTTAESTDGMFGELLAESCRAHGVVGLVIDAGVRDVS
CCCCCEEEEEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEECCCHHHH
ELTAMAFPVWSKAISAQGTVKATAGSVNVPVVCAGALVRPGDVIVGDQDGVVVVPRETAA
HHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEECCEECCCCEEEECCCCEEEEECCCCC
EIAILGEQRRAKEERTRERLRAGEKALDLYGLRARLKELGVEYE
CEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKPTIRRRIERPDAAVVRLLGELGVATVHESQGRGGLLRPYMRPIYPAARVAGPAVTVSC
CCCHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHCCHHHHHCCCEEEEEE
QPGDNLMIHASIDVVQSGDVLVVTTTAESTDGMFGELLAESCRAHGVVGLVIDAGVRDVS
CCCCCEEEEEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEEECCCHHHH
ELTAMAFPVWSKAISAQGTVKATAGSVNVPVVCAGALVRPGDVIVGDQDGVVVVPRETAA
HHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEECCEECCCCEEEECCCCEEEEECCCCC
EIAILGEQRRAKEERTRERLRAGEKALDLYGLRARLKELGVEYE
CEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11826967 [H]