Click here to switch to the map view.

The map label for this gene is yfcY [C]

Identifier: 116625632

GI number: 116625632

Start: 8253250

End: 8254455

Strand: Direct

Name: yfcY [C]

Synonym: Acid_6581

Alternate gene names: 116625632

Gene position: 8253250-8254455 (Clockwise)

Preceding gene: 116625631

Following gene: 116625633

Centisome position: 82.82

GC content: 62.94

Gene sequence:

>1206_bases
GTGAAACCTATTTACATTGCGACCTTTCACCAGTCGAAGTTCGGAAAACTGCTGGGCATGAGCGTGCCCGGAATTCTGGA
CAACGCCATTCAGGGAGCCTGCCGCGAGATCTCCGCCGACCCCGCCGATCTCGATGTTGGCAGCGTCGGCGCGGCCTGCA
ACTTTTCGCTTAACGAGCAGGGCCTGCTGGCCGGACTGATGGCCAATACTCCCGGCCTGGAGGGCAAGCCCATCGAGGCC
GTGGAGAATGCCTGCGCGTCCGGCGGACAGGCCGTGCTCAGCGTGATCCAGAAGCTGCAGCTCGGCATGGGCGAAACCGG
AATCGCCGTCGGCTACGAAAAAATGCGCGATGCCGAAGGCAAGATGGATGGCAAGCTGATCGGCAAAGTGCTCGGCTACT
TCTCCGACCCCCGCGAGCGCGAAGGCAAGGTCTTCGTCTTCCCGCACATCTTCGCCGAGGTGATGAAGGAGTACATGGAG
ACCTACGGCGTGACCGAGCGCGACCTCGCCGCGATCGCCGTCCAGGAGTACGCCAACGCGAAGTTCAATCCGTGCGCGCA
GATGAACAAGGTGCAGATCACGATCGACCAGGCGCTCGCGATCGAAGGCTTTAATCGCTACGTGGTCGATGGACTGCCGC
TCAAGACCTACGATTGCTCGCAAATCACCGACGGCTACGCGTCGTTGATCCTGGCCACGGAAGAGGGACTCGCCAAACTC
GGCGTGCCGAAATCCGAATGCGTGGAGATCGCCGGCTGGGGCCAGGCCACCGACCCGATTCGCAAGCAGGGCCGCGACGT
GCTGCATCCCAGGGGCGCCAATCGCGCCATGCGCACCGCCTACCAGATGGCCGGCGTAAAACCGGCCGATGTCAACGTCG
CCGAGGTCCACGATTGTTTCACCGTGATGGGCGCGCTCGGCACCGAGGTGATCGGCAAGGCCGAGCCCGGCAAGGGCGCG
CAGTACTGGGTAGAGGGCAAGGCAGCCCCGGATGGCGAATGCGCCATCAACACCTCGGGCGGACTGATCGCCAAGGGTCA
TCCGATCGGTGCCACCGGGATCGCGATGATCGGCTGGAGCGCGCTCCAATTGCACGGCAAGGCGCCAGTGGAGTTGCAGG
TCAAAAATCCGCGTGCTGCGGCGACATTCAATATCGGCGGACCCATCTGTGCCAGCGTGTGCACGGTGCTGCGCGCAGTA
GAATAA

Upstream 100 bases:

>100_bases
TATTCCTGGCATCGAACCAGGCGTCATTCATCACCGGCGCGGTGCTCAGCGTGGACGGTGGCGCAGTCACCGGGACCTAG
AATAGAAACAGGACATTACC

Downstream 100 bases:

>100_bases
GTGATCACCGCGCAAAAGCAGAACGTCACCGCATTTCGCATTCTGGGGGCCATCAGCTTCTGTCATCTGTTGAACGACAT
GATGCAGTCGCTGATTCCCG

Product: acetyl-CoA acyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKPIYIATFHQSKFGKLLGMSVPGILDNAIQGACREISADPADLDVGSVGAACNFSLNEQGLLAGLMANTPGLEGKPIEA
VENACASGGQAVLSVIQKLQLGMGETGIAVGYEKMRDAEGKMDGKLIGKVLGYFSDPREREGKVFVFPHIFAEVMKEYME
TYGVTERDLAAIAVQEYANAKFNPCAQMNKVQITIDQALAIEGFNRYVVDGLPLKTYDCSQITDGYASLILATEEGLAKL
GVPKSECVEIAGWGQATDPIRKQGRDVLHPRGANRAMRTAYQMAGVKPADVNVAEVHDCFTVMGALGTEVIGKAEPGKGA
QYWVEGKAAPDGECAINTSGGLIAKGHPIGATGIAMIGWSALQLHGKAPVELQVKNPRAAATFNIGGPICASVCTVLRAV
E

Sequences:

>Translated_401_residues
MKPIYIATFHQSKFGKLLGMSVPGILDNAIQGACREISADPADLDVGSVGAACNFSLNEQGLLAGLMANTPGLEGKPIEA
VENACASGGQAVLSVIQKLQLGMGETGIAVGYEKMRDAEGKMDGKLIGKVLGYFSDPREREGKVFVFPHIFAEVMKEYME
TYGVTERDLAAIAVQEYANAKFNPCAQMNKVQITIDQALAIEGFNRYVVDGLPLKTYDCSQITDGYASLILATEEGLAKL
GVPKSECVEIAGWGQATDPIRKQGRDVLHPRGANRAMRTAYQMAGVKPADVNVAEVHDCFTVMGALGTEVIGKAEPGKGA
QYWVEGKAAPDGECAINTSGGLIAKGHPIGATGIAMIGWSALQLHGKAPVELQVKNPRAAATFNIGGPICASVCTVLRAV
E
>Mature_401_residues
MKPIYIATFHQSKFGKLLGMSVPGILDNAIQGACREISADPADLDVGSVGAACNFSLNEQGLLAGLMANTPGLEGKPIEA
VENACASGGQAVLSVIQKLQLGMGETGIAVGYEKMRDAEGKMDGKLIGKVLGYFSDPREREGKVFVFPHIFAEVMKEYME
TYGVTERDLAAIAVQEYANAKFNPCAQMNKVQITIDQALAIEGFNRYVVDGLPLKTYDCSQITDGYASLILATEEGLAKL
GVPKSECVEIAGWGQATDPIRKQGRDVLHPRGANRAMRTAYQMAGVKPADVNVAEVHDCFTVMGALGTEVIGKAEPGKGA
QYWVEGKAAPDGECAINTSGGLIAKGHPIGATGIAMIGWSALQLHGKAPVELQVKNPRAAATFNIGGPICASVCTVLRAV
E

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI302344760, Length=329, Percent_Identity=31.6109422492401, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI19923233, Length=329, Percent_Identity=31.6109422492401, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI302344767, Length=328, Percent_Identity=31.4024390243902, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI302344762, Length=324, Percent_Identity=29.9382716049383, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI55956775, Length=291, Percent_Identity=29.8969072164948, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17537653, Length=403, Percent_Identity=28.7841191066998, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19921506, Length=329, Percent_Identity=30.6990881458967, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24585051, Length=329, Percent_Identity=30.3951367781155, Blast_Score=128, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42319; Mature: 42319

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00737 THIOLASE_2 ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIYIATFHQSKFGKLLGMSVPGILDNAIQGACREISADPADLDVGSVGAACNFSLNEQ
CCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCC
GLLAGLMANTPGLEGKPIEAVENACASGGQAVLSVIQKLQLGMGETGIAVGYEKMRDAEG
CHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEECHHHHHCCCC
KMDGKLIGKVLGYFSDPREREGKVFVFPHIFAEVMKEYMETYGVTERDLAAIAVQEYANA
CCCHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
KFNPCAQMNKVQITIDQALAIEGFNRYVVDGLPLKTYDCSQITDGYASLILATEEGLAKL
CCCCCCCCCEEEEEEEHHHHHCCCCEEEECCCCCCCCCHHHHHCCHHEEEEECCCCHHHC
GVPKSECVEIAGWGQATDPIRKQGRDVLHPRGANRAMRTAYQMAGVKPADVNVAEVHDCF
CCCHHHHEEEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
TVMGALGTEVIGKAEPGKGAQYWVEGKAAPDGECAINTSGGLIAKGHPIGATGIAMIGWS
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCEEECCCCCCCCHHHHHCHH
ALQLHGKAPVELQVKNPRAAATFNIGGPICASVCTVLRAVE
HEEECCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPIYIATFHQSKFGKLLGMSVPGILDNAIQGACREISADPADLDVGSVGAACNFSLNEQ
CCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCC
GLLAGLMANTPGLEGKPIEAVENACASGGQAVLSVIQKLQLGMGETGIAVGYEKMRDAEG
CHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEECHHHHHCCCC
KMDGKLIGKVLGYFSDPREREGKVFVFPHIFAEVMKEYMETYGVTERDLAAIAVQEYANA
CCCHHHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
KFNPCAQMNKVQITIDQALAIEGFNRYVVDGLPLKTYDCSQITDGYASLILATEEGLAKL
CCCCCCCCCEEEEEEEHHHHHCCCCEEEECCCCCCCCCHHHHHCCHHEEEEECCCCHHHC
GVPKSECVEIAGWGQATDPIRKQGRDVLHPRGANRAMRTAYQMAGVKPADVNVAEVHDCF
CCCHHHHEEEECCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
TVMGALGTEVIGKAEPGKGAQYWVEGKAAPDGECAINTSGGLIAKGHPIGATGIAMIGWS
HHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCEEECCCCCCCCHHHHHCHH
ALQLHGKAPVELQVKNPRAAATFNIGGPICASVCTVLRAVE
HEEECCCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]