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The map label for this gene is 116625553

Identifier: 116625553

GI number: 116625553

Start: 8147804

End: 8149420

Strand: Direct

Name: 116625553

Synonym: Acid_6500

Alternate gene names: NA

Gene position: 8147804-8149420 (Clockwise)

Preceding gene: 116625551

Following gene: 116625554

Centisome position: 81.76

GC content: 63.51

Gene sequence:

>1617_bases
ATGCAAAAACTACGCTTTTTCGCACCACTGCTTCTCCTCTCATCCGGGCTGGCCCTCGCGCAGCAGACGGAGAAGGTAGA
CCTCAACACGATTCATCGCATTAAGGAGGAGACGCTCGGCCGCAACTCCAAAGTGATGGACCACATGTTCTACCTCACGG
ACGTGAACGGCCCACGGCTGAACAACTCGAAGGGCTACCGGGCGGCGGGCGAGTGGGCAGTAAAACGCCTCAAGGAGTAT
GGCCTGGCGAACGTCCACCTGGAAAAGTGGGGGCCCTTCGGCAAGGGCTGGAACCTGGAACTCTATTCGGGACACATGCT
GGAGCCGATGTATCAGCCGATCATCGCCATGCCCGTGGCGTGGACCGCGGGAACCAATGGCGTAGTCAGCGGGAACCCGA
TGCTGGTGACGCCGCAGACGCAGGCGGAGCTGGACGCGTTCAAAGGCAAGCTGGCCGGCAAGATCGTCCTGATTTCGCCG
AAGCGGGATCTGGAAATGGTCACCACGCCGCTCGGCGTACGCTATAACGACGCCGAGTTGCAGGAAATCCAGAGTGCCCA
GATCCAGATGCCCGGCCTGTTCGGACGCGGCGGACGGGGCGCTCCCGGAGCTGCGGGTGGGCGCGGCGGTGCGGCCGGCG
GACTGAGTCCCATGGCGATCCAGAATTTCCTGAAGGAGGAGAAGTCGGCGCTCGTGATCCAGATCTCGGCCCGCGGCGAT
GGCGGCACGCTGTTCGGCGGCGGCGCCCAGAATCGCGACGTGACCGACAATCTGCCAACCCTGGTCATGGCCGCGGAGCA
CTACAACCGCATCGTGCGCCTGATCGAGCACGAAATCCCCGTGAAGCTACAGTTCGAAATCAAGGTGAGCTTCGACGACG
TGGATGCCTTCAACGTGATCGCCGAACTCCCGGGCAACGCCAAAAAGGACGAGCTCGTGATGGTGGGCGGACACTTCGAT
AGCTGGCACTACGGCACCGGCGCCACCGATAACGCCGCCGGCTCCGCGATCGCGATGGAAGTCATGCGCAGCCTCAAGAG
CCTGAACCTCAACATGGACCGCACCGTGCGCATGGCGCTGTGGGGCGGCGAAGAGGAAGGTTTGATGGGCTCCCGCGCCT
ACGTGAAGGAGCACTTCGCGGATCCCACCACCATGAAGCCGACCGCGGAACACGAGAAGGTGGCCGGCTATTGGAACATC
GACAACGGCACCGGCAAGGTCCGCGGCATTTACCTCCAGGGCAACGACATGTGCCGGCCGATCTTCGAGAGATGGCTGGA
GCCCTTCCGCGACCTCGGCGTCACTACCATCACCAGCCGCAACACCGGCGGCACCGATCACCAGGCCTTCGACGGCGTCG
GCATCCCCGGCTTCCAATTCATTCAGGACACCATGGATTACAACACCCGCACCCACCACTCCAACATGGACACTTACGAT
CGCATCCAGGCGACCGACATGATGCAGATGTCGGCGGTGGAAGCGTCAATGGTTTACCTCACGGCCGTGCGTCCGGAGAA
ACTCCCGCGCAAGCCTTTGCCTCCTCCCCAGCCCGCCGGGCGCGGCGGCCGCGGCGGCGCCGCCGGCGCTCCCACAGCGG
GACGTGGCGGCAACTAA

Upstream 100 bases:

>100_bases
CTATTGTAGGCGAGAGATGCGCATCCTGACCCGATTGAGTAACCCCACCGGGGATCTTTGCGCCAATGTAATGTCTGATA
TCCTCGAAAACCTAAAGTCT

Downstream 100 bases:

>100_bases
CCGGGTCTAGATCTGTGACCAACGGCCCAGGGGCAACCCTGGGCCGTTTTTCTTTACATCTCAGCGATTGCGAACTACGT
CGTCTAGCGATATAGTTGAA

Product: peptidase M28

Products: NA

Alternate protein names: SGAP [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MQKLRFFAPLLLLSSGLALAQQTEKVDLNTIHRIKEETLGRNSKVMDHMFYLTDVNGPRLNNSKGYRAAGEWAVKRLKEY
GLANVHLEKWGPFGKGWNLELYSGHMLEPMYQPIIAMPVAWTAGTNGVVSGNPMLVTPQTQAELDAFKGKLAGKIVLISP
KRDLEMVTTPLGVRYNDAELQEIQSAQIQMPGLFGRGGRGAPGAAGGRGGAAGGLSPMAIQNFLKEEKSALVIQISARGD
GGTLFGGGAQNRDVTDNLPTLVMAAEHYNRIVRLIEHEIPVKLQFEIKVSFDDVDAFNVIAELPGNAKKDELVMVGGHFD
SWHYGTGATDNAAGSAIAMEVMRSLKSLNLNMDRTVRMALWGGEEEGLMGSRAYVKEHFADPTTMKPTAEHEKVAGYWNI
DNGTGKVRGIYLQGNDMCRPIFERWLEPFRDLGVTTITSRNTGGTDHQAFDGVGIPGFQFIQDTMDYNTRTHHSNMDTYD
RIQATDMMQMSAVEASMVYLTAVRPEKLPRKPLPPPQPAGRGGRGGAAGAPTAGRGGN

Sequences:

>Translated_538_residues
MQKLRFFAPLLLLSSGLALAQQTEKVDLNTIHRIKEETLGRNSKVMDHMFYLTDVNGPRLNNSKGYRAAGEWAVKRLKEY
GLANVHLEKWGPFGKGWNLELYSGHMLEPMYQPIIAMPVAWTAGTNGVVSGNPMLVTPQTQAELDAFKGKLAGKIVLISP
KRDLEMVTTPLGVRYNDAELQEIQSAQIQMPGLFGRGGRGAPGAAGGRGGAAGGLSPMAIQNFLKEEKSALVIQISARGD
GGTLFGGGAQNRDVTDNLPTLVMAAEHYNRIVRLIEHEIPVKLQFEIKVSFDDVDAFNVIAELPGNAKKDELVMVGGHFD
SWHYGTGATDNAAGSAIAMEVMRSLKSLNLNMDRTVRMALWGGEEEGLMGSRAYVKEHFADPTTMKPTAEHEKVAGYWNI
DNGTGKVRGIYLQGNDMCRPIFERWLEPFRDLGVTTITSRNTGGTDHQAFDGVGIPGFQFIQDTMDYNTRTHHSNMDTYD
RIQATDMMQMSAVEASMVYLTAVRPEKLPRKPLPPPQPAGRGGRGGAAGAPTAGRGGN
>Mature_538_residues
MQKLRFFAPLLLLSSGLALAQQTEKVDLNTIHRIKEETLGRNSKVMDHMFYLTDVNGPRLNNSKGYRAAGEWAVKRLKEY
GLANVHLEKWGPFGKGWNLELYSGHMLEPMYQPIIAMPVAWTAGTNGVVSGNPMLVTPQTQAELDAFKGKLAGKIVLISP
KRDLEMVTTPLGVRYNDAELQEIQSAQIQMPGLFGRGGRGAPGAAGGRGGAAGGLSPMAIQNFLKEEKSALVIQISARGD
GGTLFGGGAQNRDVTDNLPTLVMAAEHYNRIVRLIEHEIPVKLQFEIKVSFDDVDAFNVIAELPGNAKKDELVMVGGHFD
SWHYGTGATDNAAGSAIAMEVMRSLKSLNLNMDRTVRMALWGGEEEGLMGSRAYVKEHFADPTTMKPTAEHEKVAGYWNI
DNGTGKVRGIYLQGNDMCRPIFERWLEPFRDLGVTTITSRNTGGTDHQAFDGVGIPGFQFIQDTMDYNTRTHHSNMDTYD
RIQATDMMQMSAVEASMVYLTAVRPEKLPRKPLPPPQPAGRGGRGGAAGAPTAGRGGN

Specific function: Specific for larger hydrophobic acids, especially leucine. No cleavage occurs if the next residue is proline [H]

COG id: COG2234

COG function: function code R; Predicted aminopeptidases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M28 family. M28A subfamily [H]

Homologues:

Organism=Homo sapiens, GI7706387, Length=489, Percent_Identity=25.3578732106339, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007484 [H]

Pfam domain/function: PF04389 Peptidase_M28 [H]

EC number: =3.4.11.24 [H]

Molecular weight: Translated: 58658; Mature: 58658

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLRFFAPLLLLSSGLALAQQTEKVDLNTIHRIKEETLGRNSKVMDHMFYLTDVNGPRL
CCCHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHCCCCCHHHEEEEEEEECCCCCC
NNSKGYRAAGEWAVKRLKEYGLANVHLEKWGPFGKGWNLELYSGHMLEPMYQPIIAMPVA
CCCCCCCCHHHHHHHHHHHCCCCEEEHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCEE
WTAGTNGVVSGNPMLVTPQTQAELDAFKGKLAGKIVLISPKRDLEMVTTPLGVRYNDAEL
EECCCCCEECCCCEEECCCHHHHHHHHHHHHCCEEEEECCCCCCEEEECCCCCEECCHHH
QEIQSAQIQMPGLFGRGGRGAPGAAGGRGGAAGGLSPMAIQNFLKEEKSALVIQISARGD
HHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCC
GGTLFGGGAQNRDVTDNLPTLVMAAEHYNRIVRLIEHEIPVKLQFEIKVSFDDVDAFNVI
CCEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHH
AELPGNAKKDELVMVGGHFDSWHYGTGATDNAAGSAIAMEVMRSLKSLNLNMDRTVRMAL
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEE
WGGEEEGLMGSRAYVKEHFADPTTMKPTAEHEKVAGYWNIDNGTGKVRGIYLQGNDMCRP
ECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCHHH
IFERWLEPFRDLGVTTITSRNTGGTDHQAFDGVGIPGFQFIQDTMDYNTRTHHSNMDTYD
HHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHH
RIQATDMMQMSAVEASMVYLTAVRPEKLPRKPLPPPQPAGRGGRGGAAGAPTAGRGGN
HHHHHHHHHHHHHHHEEEEEEEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKLRFFAPLLLLSSGLALAQQTEKVDLNTIHRIKEETLGRNSKVMDHMFYLTDVNGPRL
CCCHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHCCCCCHHHEEEEEEEECCCCCC
NNSKGYRAAGEWAVKRLKEYGLANVHLEKWGPFGKGWNLELYSGHMLEPMYQPIIAMPVA
CCCCCCCCHHHHHHHHHHHCCCCEEEHHHCCCCCCCEEEEEECCCCCCHHHHHHHHCCEE
WTAGTNGVVSGNPMLVTPQTQAELDAFKGKLAGKIVLISPKRDLEMVTTPLGVRYNDAEL
EECCCCCEECCCCEEECCCHHHHHHHHHHHHCCEEEEECCCCCCEEEECCCCCEECCHHH
QEIQSAQIQMPGLFGRGGRGAPGAAGGRGGAAGGLSPMAIQNFLKEEKSALVIQISARGD
HHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCC
GGTLFGGGAQNRDVTDNLPTLVMAAEHYNRIVRLIEHEIPVKLQFEIKVSFDDVDAFNVI
CCEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHH
AELPGNAKKDELVMVGGHFDSWHYGTGATDNAAGSAIAMEVMRSLKSLNLNMDRTVRMAL
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEE
WGGEEEGLMGSRAYVKEHFADPTTMKPTAEHEKVAGYWNIDNGTGKVRGIYLQGNDMCRP
ECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCHHH
IFERWLEPFRDLGVTTITSRNTGGTDHQAFDGVGIPGFQFIQDTMDYNTRTHHSNMDTYD
HHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHH
RIQATDMMQMSAVEASMVYLTAVRPEKLPRKPLPPPQPAGRGGRGGAAGAPTAGRGGN
HHHHHHHHHHHHHHHEEEEEEEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8665903; 2503378; 8444149; 9048953 [H]