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The map label for this gene is algC [H]

Identifier: 116625526

GI number: 116625526

Start: 8114411

End: 8115775

Strand: Direct

Name: algC [H]

Synonym: Acid_6473

Alternate gene names: 116625526

Gene position: 8114411-8115775 (Clockwise)

Preceding gene: 116625520

Following gene: 116625542

Centisome position: 81.42

GC content: 62.12

Gene sequence:

>1365_bases
ATGTTCAAATCGACGATCTTTCGGGAATACGACATTCGCGGCATTGCCGACGTGGAATTGCTGGATGCCGATGTGGAACA
ACTGGGCCGCGCGTTCGGCACGTATATGCGGCGTCATGCGGGCAGCAAGGTCAACCTGGGCCGTGATACGCGCCTTAGTT
CGCCGCGCCTGCGCGATGCCCTGATTCGCGGTCTGATGGCCAGCGGATGCCAGGTCACCGACATCGGCGTGGTTCCCACT
CCGGTGCTCTACTATTCGGTATTTCACCTCAAGGCCGATGGCGCCGTGATGATTACGGGCAGCCACAACCCGAGCGAGTT
TAACGGCTTCAAAACCGTGTGCGGCGCCTCTACGATCCATGGCGAAGCGATTCAGGAGATCCGAATGCTGATCGAGCGGC
AGGACTTCGAGAGCGGGGAGGGCACGGAGGCCTCGGCCGACATGGTGACGCCCTACGTGGAGGAAGTCGCGTCGCAGTTT
CACTTCAAGCGTCGCGTGGGCTGCGTCTTCGACGCCGGCAATGGCACCGGCGGCCCGGTGATGCACCGCATTCTGGAACG
CATCAACGTCGCCGCGACCGAGATGTATTTCGAGATGGACGGGCGCTTCCCCAACCATCATCCCGACCCGACGGTTCCGG
AAAATCTGCGGGCCCTGATCGACAAGGTCCGCGAGACCAAGGCCGATCTCGGCATCGCGTTCGATGGCGACACGGACCGC
ATCGGCGCGGTGGACGACCAGGGGACGGTCGTCTGGGGCGATCAGCTGATGATCATCTACGGGCGCGAGATTCTGACGCG
CAAACCCGGCGCCACGTTCATTGGCGAGGTCAAATGCTCGCAGTTGATGTATGACGATTTGAAGGCGCGCGGCGGCAATC
CGATCATGTGGAAGACGGGCCACTCGCTGATCAAGGCCAAGATGCAGGAGACTGGCGCCGAACTGGCAGGGGAGATGAGC
GGCCACATGTTCTTCGCCGACCGCTACTACGGCTTCGACGATGCGCTCTATTCAGCGTGCCGCCTGCTGGAAATCGTCTC
CAACTCCGGCCAGCCGCTCTCCGCGCAGCTGGCGGATATGCCGAAGACTGTGACCACTCCTGAGATCCGCTTCGATTGTC
CCGACGAGTTGAAATTTGCCGTGGTCAGCCGGGCCATGGCGGAGCTGCGCGCGAAGCACAAGACGCTCGATGTGGATGGC
GTGCGTGTGATTTTCCCGAACGGCTGGGGCTTGGTGCGCGCATCCAACACGCAGCCGGTGCTGGTAATGCGATTTGAGGC
GACGACGCCTGAATTGCTGCAGGAGTACCGGCGCGAGGTGGAATCCGTCGTGGAGCGCGCGAAGGGTGCGGCGCAATCCG
CGTAG

Upstream 100 bases:

>100_bases
CATGAGTCCCCAACTATCCGTTATTCTAACCCCTGCGCGGCGGCGGACACCACGGTGATGTGGTTAACTCGCGCGCTATA
TTGAGAACGAAACCATCAAA

Downstream 100 bases:

>100_bases
CGGCTGAGAACTTCTATCCGAGCCGCGACTGTCAAGGAGCGGTTGCTAATCTGGGTGTTCACCGTCGAGGACGGACATTG
CATCGCCCTGTTCGGCGATG

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MFKSTIFREYDIRGIADVELLDADVEQLGRAFGTYMRRHAGSKVNLGRDTRLSSPRLRDALIRGLMASGCQVTDIGVVPT
PVLYYSVFHLKADGAVMITGSHNPSEFNGFKTVCGASTIHGEAIQEIRMLIERQDFESGEGTEASADMVTPYVEEVASQF
HFKRRVGCVFDAGNGTGGPVMHRILERINVAATEMYFEMDGRFPNHHPDPTVPENLRALIDKVRETKADLGIAFDGDTDR
IGAVDDQGTVVWGDQLMIIYGREILTRKPGATFIGEVKCSQLMYDDLKARGGNPIMWKTGHSLIKAKMQETGAELAGEMS
GHMFFADRYYGFDDALYSACRLLEIVSNSGQPLSAQLADMPKTVTTPEIRFDCPDELKFAVVSRAMAELRAKHKTLDVDG
VRVIFPNGWGLVRASNTQPVLVMRFEATTPELLQEYRREVESVVERAKGAAQSA

Sequences:

>Translated_454_residues
MFKSTIFREYDIRGIADVELLDADVEQLGRAFGTYMRRHAGSKVNLGRDTRLSSPRLRDALIRGLMASGCQVTDIGVVPT
PVLYYSVFHLKADGAVMITGSHNPSEFNGFKTVCGASTIHGEAIQEIRMLIERQDFESGEGTEASADMVTPYVEEVASQF
HFKRRVGCVFDAGNGTGGPVMHRILERINVAATEMYFEMDGRFPNHHPDPTVPENLRALIDKVRETKADLGIAFDGDTDR
IGAVDDQGTVVWGDQLMIIYGREILTRKPGATFIGEVKCSQLMYDDLKARGGNPIMWKTGHSLIKAKMQETGAELAGEMS
GHMFFADRYYGFDDALYSACRLLEIVSNSGQPLSAQLADMPKTVTTPEIRFDCPDELKFAVVSRAMAELRAKHKTLDVDG
VRVIFPNGWGLVRASNTQPVLVMRFEATTPELLQEYRREVESVVERAKGAAQSA
>Mature_454_residues
MFKSTIFREYDIRGIADVELLDADVEQLGRAFGTYMRRHAGSKVNLGRDTRLSSPRLRDALIRGLMASGCQVTDIGVVPT
PVLYYSVFHLKADGAVMITGSHNPSEFNGFKTVCGASTIHGEAIQEIRMLIERQDFESGEGTEASADMVTPYVEEVASQF
HFKRRVGCVFDAGNGTGGPVMHRILERINVAATEMYFEMDGRFPNHHPDPTVPENLRALIDKVRETKADLGIAFDGDTDR
IGAVDDQGTVVWGDQLMIIYGREILTRKPGATFIGEVKCSQLMYDDLKARGGNPIMWKTGHSLIKAKMQETGAELAGEMS
GHMFFADRYYGFDDALYSACRLLEIVSNSGQPLSAQLADMPKTVTTPEIRFDCPDELKFAVVSRAMAELRAKHKTLDVDG
VRVIFPNGWGLVRASNTQPVLVMRFEATTPELLQEYRREVESVVERAKGAAQSA

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=452, Percent_Identity=32.0796460176991, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789566, Length=448, Percent_Identity=28.5714285714286, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 50260; Mature: 50260

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSTIFREYDIRGIADVELLDADVEQLGRAFGTYMRRHAGSKVNLGRDTRLSSPRLRDA
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
LIRGLMASGCQVTDIGVVPTPVLYYSVFHLKADGAVMITGSHNPSEFNGFKTVCGASTIH
HHHHHHHCCCEEEECCCCCCHHHHHEEEEEECCCEEEEECCCCCCHHCCHHHHHCCCHHH
GEAIQEIRMLIERQDFESGEGTEASADMVTPYVEEVASQFHFKRRVGCVFDAGNGTGGPV
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHH
MHRILERINVAATEMYFEMDGRFPNHHPDPTVPENLRALIDKVRETKADLGIAFDGDTDR
HHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCC
IGAVDDQGTVVWGDQLMIIYGREILTRKPGATFIGEVKCSQLMYDDLKARGGNPIMWKTG
CCCCCCCCCEEECCCEEEEECCHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEECCC
HSLIKAKMQETGAELAGEMSGHMFFADRYYGFDDALYSACRLLEIVSNSGQPLSAQLADM
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCC
PKTVTTPEIRFDCPDELKFAVVSRAMAELRAKHKTLDVDGVRVIFPNGWGLVRASNTQPV
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCEECCCCEEEEECCCCEEEEECCCCCE
LVMRFEATTPELLQEYRREVESVVERAKGAAQSA
EEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFKSTIFREYDIRGIADVELLDADVEQLGRAFGTYMRRHAGSKVNLGRDTRLSSPRLRDA
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHH
LIRGLMASGCQVTDIGVVPTPVLYYSVFHLKADGAVMITGSHNPSEFNGFKTVCGASTIH
HHHHHHHCCCEEEECCCCCCHHHHHEEEEEECCCEEEEECCCCCCHHCCHHHHHCCCHHH
GEAIQEIRMLIERQDFESGEGTEASADMVTPYVEEVASQFHFKRRVGCVFDAGNGTGGPV
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHH
MHRILERINVAATEMYFEMDGRFPNHHPDPTVPENLRALIDKVRETKADLGIAFDGDTDR
HHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCC
IGAVDDQGTVVWGDQLMIIYGREILTRKPGATFIGEVKCSQLMYDDLKARGGNPIMWKTG
CCCCCCCCCEEECCCEEEEECCHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEECCC
HSLIKAKMQETGAELAGEMSGHMFFADRYYGFDDALYSACRLLEIVSNSGQPLSAQLADM
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCC
PKTVTTPEIRFDCPDELKFAVVSRAMAELRAKHKTLDVDGVRVIFPNGWGLVRASNTQPV
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCEECCCCEEEEECCCCEEEEECCCCCE
LVMRFEATTPELLQEYRREVESVVERAKGAAQSA
EEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]