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The map label for this gene is guaA [H]

Identifier: 116625520

GI number: 116625520

Start: 8105841

End: 8107577

Strand: Direct

Name: guaA [H]

Synonym: Acid_6467

Alternate gene names: 116625520

Gene position: 8105841-8107577 (Clockwise)

Preceding gene: 116625519

Following gene: 116625526

Centisome position: 81.34

GC content: 64.36

Gene sequence:

>1737_bases
TTGAACCCTACAGCTCAGATCATCGTCCTCGATGCGGGGGGGCAGTATTGCCACCTCATTGCCCGGAAGGTGCGCGACCT
CGGCGTGTACGCGGAGGTGCGGGCGAGTGAGACGCCGGCGGCGGAGCTCGCGGCGGCGAAGGGAATCATTATCTCTGGCG
GGCCGAGCAGCGTATATGACCCGGAAAGCCCCACGGTAGACCCCGACATTTTCTCGCTGGGCATTCCGGTGCTTGGCATT
TGCTACGGGCAGCAGCTTATGGCCCACCTTTTGGGGGGCGAGGTACGTCCGGGGCAGAAGGGCGAGTACGGGCTGGCTAC
GCTCGATCTGGCGGAGACCGGCGATCCGCTGTTCGGGGGACTCGGCGGCACGCAGCAAGTGTGGATGAGTCACCGCGACG
TAGTGGGCCGCGCGCCTGAGGGGTTCGCGGTCACAGGTCGCACGGGCACTTGCGAGATCGCTGCGATCGCGGACCCCAAG
CGCAGGTTCTACGCGGTGCAATTCCACCTGGAAGTGGTCCACACGCCGCGGGGCAAGGAGTACCTCGCGAACTTCACGTT
CCGCGTCTGCGGATGCGTTCCGGATTGGGACCCGCGGAATCGCGTGCCGATGCTGGAGCAGGAGATCCGCGAGTGCGTGG
GCGAGCGCAGCGTCTTCTTCTTCGTCAGCGGCGGGGTGGATTCGAGTGTGGCGTTCGCGTTGTGCACCCGCGCGCTCAGC
GCCGACCGGGTGCGGGGTGTCTATGTAGACACCGGCCTGATGCGCGAGGGCGAGACTGATTTCGTGCGACGGATCGGCAA
TCTGACGGTCGAGCACGCGGAGGATCAGTTTCTGACCGCGCTGAGCGGCGTCACCGACCCCGAAACCAAGCGCCACATCA
TCGGCGAAGAGTTCGTTCGCGTTCAGGAGCGCATCATCGAGTCGCGCCACCTGATGAACGAGAACTGGATTCTGGGACAA
GGGACGATTTATCCGGACACGATCGAGAGCGGCGGCACGGCCAAGGCCGCGCTCATCAAGACGCATCACAATCGCGTGGC
CGGTATCCAGAAGCTGATCGCATGCGGGCGCATTGTGGAGCCGCTCAAATCTTTCTACAAGGATGAAGTCCGCGAGGTCG
GACGGGAGTTGGGCCTGTCCAGCGAGTTGCTGGACCGGCATCCGTTCCCGGGTCCGGGACTGGCGATTCGCTGCCTGTGC
TCGGAGTTCGATGCGCCGGTGCGGGCCACCGCCGAAGGGCTGATCGTGCCCGTGCACTCGGTCGGAGTGCAGGGCGATTC
GCGGACCTACGCGCCAGTGCTGGCGATCGATGCACTGGACCACTCGCGCGCCACGGAGTTGATCAATGCAATCGCGGGAG
TGAATCGCGTGATCGCGCCGGTGGAGACGGCGGCGCCCGCTTCGGAGATGCAGGTGCGCGCCTGCTCGTTGACGGAGGAG
CGATTGAAGCGCCTCAGAAGGGCGGATTCCATTGTCCGGCGACTGAGCCACGCCAGCGGCTACGATCACCAAGTCTGGCA
GTTTCCGGTGATCCTGATTCCGCTGGGTACGCAGGGGGCGCCGGATTCGGTGGTGCTGCGTCCTGTGGATTCGGTGGACG
GAATGACCGCGCAATCGGTCTTGATGGACGCGGAATTGTCACATGCCATCTGCGCGGAAGTGCTCCAGATCGGTGGCATC
GCCGGAGTCTTTTATGACCTCACCCACAAGCCGCCGGGCACAATTGAGTGGGAGTAG

Upstream 100 bases:

>100_bases
GTGTGGACCATCGACAATGAGCGCTGGAAGCAAGCGTTGTACGCGGCGCTCGGTTAGTGCGGCTCGCTGGCGAGTTCGTC
GTCCTTGCTAAACTCGGAAG

Downstream 100 bases:

>100_bases
AAGCCGGTTTACTTCGCCGGGGACGGCAGCTTGAAATCGGTTCCCATTTCCTTGTTCAGGCGTTCGGTAAGATCGCGGTC
GATTAAAGAAACCGACACCT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MNPTAQIIVLDAGGQYCHLIARKVRDLGVYAEVRASETPAAELAAAKGIIISGGPSSVYDPESPTVDPDIFSLGIPVLGI
CYGQQLMAHLLGGEVRPGQKGEYGLATLDLAETGDPLFGGLGGTQQVWMSHRDVVGRAPEGFAVTGRTGTCEIAAIADPK
RRFYAVQFHLEVVHTPRGKEYLANFTFRVCGCVPDWDPRNRVPMLEQEIRECVGERSVFFFVSGGVDSSVAFALCTRALS
ADRVRGVYVDTGLMREGETDFVRRIGNLTVEHAEDQFLTALSGVTDPETKRHIIGEEFVRVQERIIESRHLMNENWILGQ
GTIYPDTIESGGTAKAALIKTHHNRVAGIQKLIACGRIVEPLKSFYKDEVREVGRELGLSSELLDRHPFPGPGLAIRCLC
SEFDAPVRATAEGLIVPVHSVGVQGDSRTYAPVLAIDALDHSRATELINAIAGVNRVIAPVETAAPASEMQVRACSLTEE
RLKRLRRADSIVRRLSHASGYDHQVWQFPVILIPLGTQGAPDSVVLRPVDSVDGMTAQSVLMDAELSHAICAEVLQIGGI
AGVFYDLTHKPPGTIEWE

Sequences:

>Translated_578_residues
MNPTAQIIVLDAGGQYCHLIARKVRDLGVYAEVRASETPAAELAAAKGIIISGGPSSVYDPESPTVDPDIFSLGIPVLGI
CYGQQLMAHLLGGEVRPGQKGEYGLATLDLAETGDPLFGGLGGTQQVWMSHRDVVGRAPEGFAVTGRTGTCEIAAIADPK
RRFYAVQFHLEVVHTPRGKEYLANFTFRVCGCVPDWDPRNRVPMLEQEIRECVGERSVFFFVSGGVDSSVAFALCTRALS
ADRVRGVYVDTGLMREGETDFVRRIGNLTVEHAEDQFLTALSGVTDPETKRHIIGEEFVRVQERIIESRHLMNENWILGQ
GTIYPDTIESGGTAKAALIKTHHNRVAGIQKLIACGRIVEPLKSFYKDEVREVGRELGLSSELLDRHPFPGPGLAIRCLC
SEFDAPVRATAEGLIVPVHSVGVQGDSRTYAPVLAIDALDHSRATELINAIAGVNRVIAPVETAAPASEMQVRACSLTEE
RLKRLRRADSIVRRLSHASGYDHQVWQFPVILIPLGTQGAPDSVVLRPVDSVDGMTAQSVLMDAELSHAICAEVLQIGGI
AGVFYDLTHKPPGTIEWE
>Mature_578_residues
MNPTAQIIVLDAGGQYCHLIARKVRDLGVYAEVRASETPAAELAAAKGIIISGGPSSVYDPESPTVDPDIFSLGIPVLGI
CYGQQLMAHLLGGEVRPGQKGEYGLATLDLAETGDPLFGGLGGTQQVWMSHRDVVGRAPEGFAVTGRTGTCEIAAIADPK
RRFYAVQFHLEVVHTPRGKEYLANFTFRVCGCVPDWDPRNRVPMLEQEIRECVGERSVFFFVSGGVDSSVAFALCTRALS
ADRVRGVYVDTGLMREGETDFVRRIGNLTVEHAEDQFLTALSGVTDPETKRHIIGEEFVRVQERIIESRHLMNENWILGQ
GTIYPDTIESGGTAKAALIKTHHNRVAGIQKLIACGRIVEPLKSFYKDEVREVGRELGLSSELLDRHPFPGPGLAIRCLC
SEFDAPVRATAEGLIVPVHSVGVQGDSRTYAPVLAIDALDHSRATELINAIAGVNRVIAPVETAAPASEMQVRACSLTEE
RLKRLRRADSIVRRLSHASGYDHQVWQFPVILIPLGTQGAPDSVVLRPVDSVDGMTAQSVLMDAELSHAICAEVLQIGGI
AGVFYDLTHKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=668, Percent_Identity=36.377245508982, Blast_Score=369, Evalue=1e-102,
Organism=Escherichia coli, GI1788854, Length=519, Percent_Identity=38.9210019267823, Blast_Score=311, Evalue=6e-86,
Organism=Escherichia coli, GI1789760, Length=192, Percent_Identity=29.6875, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992717, Length=425, Percent_Identity=42.5882352941177, Blast_Score=317, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71992710, Length=425, Percent_Identity=42.5882352941177, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI133901714, Length=425, Percent_Identity=42.5882352941177, Blast_Score=316, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6323873, Length=517, Percent_Identity=38.2978723404255, Blast_Score=310, Evalue=6e-85,
Organism=Drosophila melanogaster, GI281365319, Length=667, Percent_Identity=36.5817091454273, Blast_Score=368, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 62738; Mature: 62738

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTAQIIVLDAGGQYCHLIARKVRDLGVYAEVRASETPAAELAAAKGIIISGGPSSVYD
CCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCEEEECCCCCCCC
PESPTVDPDIFSLGIPVLGICYGQQLMAHLLGGEVRPGQKGEYGLATLDLAETGDPLFGG
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHCCCCCCCC
LGGTQQVWMSHRDVVGRAPEGFAVTGRTGTCEIAAIADPKRRFYAVQFHLEVVHTPRGKE
CCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEECCCCCEEEEEEEEEEEEECCCCHH
YLANFTFRVCGCVPDWDPRNRVPMLEQEIRECVGERSVFFFVSGGVDSSVAFALCTRALS
HHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
ADRVRGVYVDTGLMREGETDFVRRIGNLTVEHAEDQFLTALSGVTDPETKRHIIGEEFVR
HHHCCEEEEECCCCCCCCHHHHHHHHCCEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHH
VQERIIESRHLMNENWILGQGTIYPDTIESGGTAKAALIKTHHNRVAGIQKLIACGRIVE
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
PLKSFYKDEVREVGRELGLSSELLDRHPFPGPGLAIRCLCSEFDAPVRATAEGLIVPVHS
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEHH
VGVQGDSRTYAPVLAIDALDHSRATELINAIAGVNRVIAPVETAAPASEMQVRACSLTEE
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHH
RLKRLRRADSIVRRLSHASGYDHQVWQFPVILIPLGTQGAPDSVVLRPVDSVDGMTAQSV
HHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEECCCCCCCCCEEEEECCCCCCCCHHHH
LMDAELSHAICAEVLQIGGIAGVFYDLTHKPPGTIEWE
HHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNPTAQIIVLDAGGQYCHLIARKVRDLGVYAEVRASETPAAELAAAKGIIISGGPSSVYD
CCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCEEEECCCCCCCC
PESPTVDPDIFSLGIPVLGICYGQQLMAHLLGGEVRPGQKGEYGLATLDLAETGDPLFGG
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHCCCCCCCC
LGGTQQVWMSHRDVVGRAPEGFAVTGRTGTCEIAAIADPKRRFYAVQFHLEVVHTPRGKE
CCCHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEECCCCCEEEEEEEEEEEEECCCCHH
YLANFTFRVCGCVPDWDPRNRVPMLEQEIRECVGERSVFFFVSGGVDSSVAFALCTRALS
HHHHCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
ADRVRGVYVDTGLMREGETDFVRRIGNLTVEHAEDQFLTALSGVTDPETKRHIIGEEFVR
HHHCCEEEEECCCCCCCCHHHHHHHHCCEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHH
VQERIIESRHLMNENWILGQGTIYPDTIESGGTAKAALIKTHHNRVAGIQKLIACGRIVE
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
PLKSFYKDEVREVGRELGLSSELLDRHPFPGPGLAIRCLCSEFDAPVRATAEGLIVPVHS
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEHH
VGVQGDSRTYAPVLAIDALDHSRATELINAIAGVNRVIAPVETAAPASEMQVRACSLTEE
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHH
RLKRLRRADSIVRRLSHASGYDHQVWQFPVILIPLGTQGAPDSVVLRPVDSVDGMTAQSV
HHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEECCCCCCCCCEEEEECCCCCCCCHHHH
LMDAELSHAICAEVLQIGGIAGVFYDLTHKPPGTIEWE
HHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA