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The map label for this gene is czcC [H]

Identifier: 116625506

GI number: 116625506

Start: 8087574

End: 8088830

Strand: Direct

Name: czcC [H]

Synonym: Acid_6453

Alternate gene names: 116625506

Gene position: 8087574-8088830 (Clockwise)

Preceding gene: 116625505

Following gene: 116625507

Centisome position: 81.15

GC content: 62.21

Gene sequence:

>1257_bases
GTGAAAAAGCTGCAAGTCATCGGTAGTATTGCGTTGCTTTCGGTACGAGGGCTGTGTGCCCAAACGGCCGATCATGTGAC
CATCGAACAGGCCGTGCAGGAGGCGGTGGATCACAACCTCGGCCTGCTGGCGGAGCGTTATAACCTCAGCATCGCCGACG
CAAGGATTATCACGGCAAAGCTGCGGCCCAACCCGGTGCTGACCGCCGCCGTGGATTACATCGATTTTCAGAATCACTTC
AACAACGACAATCAGGGCGGTCCCACGGAGTACAACATCCGCACCGACTTCGTGCTGGAGCGCGGCGCTAAGCGCGAGCG
GCGCATCGAAGTAGCGCAGACCGCGCGGGAGGTGGCGCAGCTGCAGCTACTGAACACCACCCGCATGCTGGCGCTGGACG
TGGAGAATGCGTTTATCGATGTGCTGCAGGCCAAGGACAACCTGGCGTTGGCGCGGGAAAACCTGCAGGCCTTCCGCAAC
ATCGTGGAAGTGAATGCGACGCGGGTTCGCGCCGGCGACCTGGCAAAGGTGGAGCTGGTGCGGACGCAGGTGGCGGCCCT
GCAATTTCAGAGCGCGGTGCGGCAGGCTGAATCCAAACTCAAGATCGCCGGCAACCGCCTGCAAACGCTGATGGGGCGGA
GGGTGCCCTCGCCGACATTCGAGGCAACGGGGACGATGCGCCGCGATTCGACGCCGGTGGTGATGGAAACCGTCGCCACG
CAGGCGCTCGACCTGCGTCCGGACCTTTTGGCGCTGCGCAAAGACCAGGCGCGGTCGCAGGCCGAGCTCCGGTCGCAACT
GGCGCAGGGCAAAGTGGATTTCACGGTGGGCACGGAATTCCACCGGCAGTTTTACAACGGCAACGCCAACGCACTCGGAG
TTTTCTTCAGTTCGCCGCTGCCGGTATTCAACAAGAACCAGGGAGAGATCGAGCGCGCGCGTCAGGAGCAGCAACAGATT
CTGGCGCGTATCCGGGCGGCCGAAGCGGACGTACAAAATGACGTTCGCAATGCCTGGCTGCAGTACGCCACGTCGCGGGA
ACTGCTCGAGAGCATCGAGCATGACTTGCTGGACCAGGCGCGCGAGGTGCGCACCACGATGGAGTATTCCTACCGGCGCG
GCGAGGCTTCGCTGGTGGAGTTTCTGGATGCGCAGCGCGCCTTCAACGACGCGCGGCAAAGTTACAACGACGCGCGCGCG
GACTTTGCACGCAGTCTCTACACGATCGATTCGATCTCTGGAAAGGCAGTCCGATGA

Upstream 100 bases:

>100_bases
CCCCTCTCTCATAGACAATCTCGCTGATTTTCATCGGTTCGGCTTCCGCGTTCGAAGCATGCGGTGGTAGCTCCGTACCT
CGTACGGAGGAGGATTGTAA

Downstream 100 bases:

>100_bases
AAAACGTACACGCGAGTTGCGCTCTTATCCTATCGATCCTGGCGATTCTGTTGACCGGATGTGCGAAGCAAGAGGCGAAG
CCGGTGGCGGCGGCTGCTCC

Product: outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MKKLQVIGSIALLSVRGLCAQTADHVTIEQAVQEAVDHNLGLLAERYNLSIADARIITAKLRPNPVLTAAVDYIDFQNHF
NNDNQGGPTEYNIRTDFVLERGAKRERRIEVAQTAREVAQLQLLNTTRMLALDVENAFIDVLQAKDNLALARENLQAFRN
IVEVNATRVRAGDLAKVELVRTQVAALQFQSAVRQAESKLKIAGNRLQTLMGRRVPSPTFEATGTMRRDSTPVVMETVAT
QALDLRPDLLALRKDQARSQAELRSQLAQGKVDFTVGTEFHRQFYNGNANALGVFFSSPLPVFNKNQGEIERARQEQQQI
LARIRAAEADVQNDVRNAWLQYATSRELLESIEHDLLDQAREVRTTMEYSYRRGEASLVEFLDAQRAFNDARQSYNDARA
DFARSLYTIDSISGKAVR

Sequences:

>Translated_418_residues
MKKLQVIGSIALLSVRGLCAQTADHVTIEQAVQEAVDHNLGLLAERYNLSIADARIITAKLRPNPVLTAAVDYIDFQNHF
NNDNQGGPTEYNIRTDFVLERGAKRERRIEVAQTAREVAQLQLLNTTRMLALDVENAFIDVLQAKDNLALARENLQAFRN
IVEVNATRVRAGDLAKVELVRTQVAALQFQSAVRQAESKLKIAGNRLQTLMGRRVPSPTFEATGTMRRDSTPVVMETVAT
QALDLRPDLLALRKDQARSQAELRSQLAQGKVDFTVGTEFHRQFYNGNANALGVFFSSPLPVFNKNQGEIERARQEQQQI
LARIRAAEADVQNDVRNAWLQYATSRELLESIEHDLLDQAREVRTTMEYSYRRGEASLVEFLDAQRAFNDARQSYNDARA
DFARSLYTIDSISGKAVR
>Mature_418_residues
MKKLQVIGSIALLSVRGLCAQTADHVTIEQAVQEAVDHNLGLLAERYNLSIADARIITAKLRPNPVLTAAVDYIDFQNHF
NNDNQGGPTEYNIRTDFVLERGAKRERRIEVAQTAREVAQLQLLNTTRMLALDVENAFIDVLQAKDNLALARENLQAFRN
IVEVNATRVRAGDLAKVELVRTQVAALQFQSAVRQAESKLKIAGNRLQTLMGRRVPSPTFEATGTMRRDSTPVVMETVAT
QALDLRPDLLALRKDQARSQAELRSQLAQGKVDFTVGTEFHRQFYNGNANALGVFFSSPLPVFNKNQGEIERARQEQQQI
LARIRAAEADVQNDVRNAWLQYATSRELLESIEHDLLDQAREVRTTMEYSYRRGEASLVEFLDAQRAFNDARQSYNDARA
DFARSLYTIDSISGKAVR

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 46985; Mature: 46985

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLQVIGSIALLSVRGLCAQTADHVTIEQAVQEAVDHNLGLLAERYNLSIADARIITAK
CCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHCCEEECCEEEEEE
LRPNPVLTAAVDYIDFQNHFNNDNQGGPTEYNIRTDFVLERGAKRERRIEVAQTAREVAQ
CCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHH
LQLLNTTRMLALDVENAFIDVLQAKDNLALARENLQAFRNIVEVNATRVRAGDLAKVELV
HHHHHHHEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHEEECCCCHHHHHH
RTQVAALQFQSAVRQAESKLKIAGNRLQTLMGRRVPSPTFEATGTMRRDSTPVVMETVAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
QALDLRPDLLALRKDQARSQAELRSQLAQGKVDFTVGTEFHRQFYNGNANALGVFFSSPL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCCEEEEEECCCC
PVFNKNQGEIERARQEQQQILARIRAAEADVQNDVRNAWLQYATSRELLESIEHDLLDQA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REVRTTMEYSYRRGEASLVEFLDAQRAFNDARQSYNDARADFARSLYTIDSISGKAVR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKKLQVIGSIALLSVRGLCAQTADHVTIEQAVQEAVDHNLGLLAERYNLSIADARIITAK
CCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHCCEEECCEEEEEE
LRPNPVLTAAVDYIDFQNHFNNDNQGGPTEYNIRTDFVLERGAKRERRIEVAQTAREVAQ
CCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHH
LQLLNTTRMLALDVENAFIDVLQAKDNLALARENLQAFRNIVEVNATRVRAGDLAKVELV
HHHHHHHEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHEEECCCCHHHHHH
RTQVAALQFQSAVRQAESKLKIAGNRLQTLMGRRVPSPTFEATGTMRRDSTPVVMETVAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHH
QALDLRPDLLALRKDQARSQAELRSQLAQGKVDFTVGTEFHRQFYNGNANALGVFFSSPL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCCEEEEEECCCC
PVFNKNQGEIERARQEQQQILARIRAAEADVQNDVRNAWLQYATSRELLESIEHDLLDQA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REVRTTMEYSYRRGEASLVEFLDAQRAFNDARQSYNDARADFARSLYTIDSISGKAVR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]