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The map label for this gene is ptrB [C]

Identifier: 116625306

GI number: 116625306

Start: 7832420

End: 7834534

Strand: Reverse

Name: ptrB [C]

Synonym: Acid_6251

Alternate gene names: 116625306

Gene position: 7834534-7832420 (Counterclockwise)

Preceding gene: 116625307

Following gene: 116625305

Centisome position: 78.62

GC content: 62.22

Gene sequence:

>2115_bases
ATGAAGCTGAACCCGCTGATCCTCATCACCGGCTGCGTGTTTACCATGCCGGGACAAAATATGCCGCGACTCAATTATCC
CGCCGCCCCGCAGAGCGGCCAGACGGATGCCTATCACGAAGTTCAAATCGCGGACCCTTACCGCGGGCTGGAGAACGCCG
ACGCGCCGGAGACGCGGAAATGGGTGGAAGACGAGAACGCGCTGACGCAATCGTGGCTTGGGAAGCAGCCAGACCGCGCG
CCGATTCGCAAGCAGCTCACCAAACTCTGGAATTACGAAAAATACGGAACGCTTTTCAAGGCTGGTCCTCACTACTTCTA
CTCGTACAACACGGGCCTTCAGAACCAGTCCGTGGTTTTTGTAGCGGACTCGCCGAATGCGAAAGGCAAGGAGCTGCTGG
ACCCAAACACCCATCGTAAAGACGGGACTGCGGCGTTATCGGGATGGTCGGTGAGCCGGAACGGGAAGCTGTACGGCTAC
GCCATCGCGGAGGCGGGTTCGGACTGGTCGGATTGCCGGATCCGGAGCGTTGCCGACGGCAAGGACCTGCCGGATGTGAT
CCGCTGGACCAAGTTCAGTAACATGGCCTGGGCCACAGACGACGGCGGGTTCTACTACTCGCGCTATCCGGAGCCACCGG
CGGGCGAACTGCTGACCGCGGCGGCGCTCAATCAGAAGGTTTACTTCCACAGACTCGGAGATCCGCAGACCGCCGACCGG
CTGGTGTATGAACGTCCCGATCGTCCGGCGTGGAGCATAGACCCGGTGCTGACTGACGACGGACGATACCTGCTGCTGAT
CATGTCCAGCGGAATTCCGGGGAAGAACATGCTCAGCTTCCAGGATATGCAGTCGCCGGACCGGCGAATCGTGGACCTGA
TCCCAATGGAGACCGCGAGCTATCAGCCGATCGAGGCGGTGGGCTCGACGCTGTACGTGCAGACCACCGATGGGGCGCCG
CGCGGCCGGGTGATCGCGATCGACTTACAGAAGCCGGTACCGTCGAAGTGGCGAGAGATCGTGCCCGAGGCCGCGGAGAC
GCTCGAGAGCGTGCAGATGGCTGACGGAAAATTGCTGCTCGCCTACATGAAGGACGCCCATGCGGCCGCGCGCTTGGTGA
CCACGGAAGGTAAACCAGTCGCCGAAGTGGCGATGCCGGGGCTCGGCACGGCGATCTGGTCGCCGGCGCGAGTGAAGGAC
AAGGAGATGTTCTACGGTTTCATGACCTACCTGGCGCCGACGACGATGTACCGACTCGATGTGGAGACGGGGCGCAGCGA
GGTGGCGCGTCCCGTGAAACTGCCGTTTGACCCCTCGGGGTTCGAAACTACCCAGGTGTTCTACCCGAGTAAGGATGGCA
GCCGCATTCCGATGTTCCTCACCAGGCGGAAAGGACTCAAGCTGGATGGGCGGAATCCGGCGCTGCTCTATGGCTATGGC
GGTTTCGACGTGCCCAATACTCCGGCGTTCAGCCCGACCGTCGCGGAATGGATCCGGATGGGCGGAGTGTTTGCCTCGGC
GTGCCTTCGCGGCGGGTCCGAGTACGGCGAAGAGTGGCACCAGGCCGGGATGAGGGCGAAGAAACAGAATGTGTTCAACG
ATTTCATCGCCGCGGCGGAGTGGTTGGTCGCCAACCGCTACACTTCCACGCCGAAGCTGGCCATTATGGGCGGTTCCAAT
GGCGGGCTCCTGGTGGGCGCGGTGTTAAACCAGCGCCCCGATCTATTCGGCGCCGCCGTAGCGCAGGTCGGCGTGATGGA
TATGCTGCGCTTCCAGAAATTCGGTTTCGGAACACAGTGGGTGGGCGAGTACGGATCGCCGGAGAATCCCGAAGATTTCA
AGGTGCTCCGGGCGTATTCTCCCCTGCACAATATCCGCGCGGGAACGGAGTATCCCGCGGTGCTGGTGACCACCTCCGAT
CACGACGACCGTGTGATGCCGGGCCACAGCCTGAAGTACACGGCGACGCTGCAGCAGGCGCAGAAGGGCCCAGCACCGAT
CCTGTTGCGTGTGGAGACGCGGGCCGGACACGGCGCGGGGAAGCCAACGGCCAAACAGATCGACGAAGCGGCGGATATCC
TCACGTTTCTCAAGGCGGCGCTGAAGGTGAACTGA

Upstream 100 bases:

>100_bases
TAGGGTAGGGGATTTGCTCTGCGATGCCACGGTGCGGGGTTCCGGCGCCACCGGGTGTGCCGGCGGCGGGCTGTATACTG
AACCGAAACGGAGCACCGTC

Downstream 100 bases:

>100_bases
ACGGCGGCCCCCCGCTAAAATAAGGGGAGGCCGTGAAGAAGCAAGGTCGCAATCCCGTCAACCGCAAGCTAACTGAGTCC
GACGGAGCGCCCGCCAAGCC

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: PE; Post-proline cleaving enzyme [H]

Number of amino acids: Translated: 704; Mature: 704

Protein sequence:

>704_residues
MKLNPLILITGCVFTMPGQNMPRLNYPAAPQSGQTDAYHEVQIADPYRGLENADAPETRKWVEDENALTQSWLGKQPDRA
PIRKQLTKLWNYEKYGTLFKAGPHYFYSYNTGLQNQSVVFVADSPNAKGKELLDPNTHRKDGTAALSGWSVSRNGKLYGY
AIAEAGSDWSDCRIRSVADGKDLPDVIRWTKFSNMAWATDDGGFYYSRYPEPPAGELLTAAALNQKVYFHRLGDPQTADR
LVYERPDRPAWSIDPVLTDDGRYLLLIMSSGIPGKNMLSFQDMQSPDRRIVDLIPMETASYQPIEAVGSTLYVQTTDGAP
RGRVIAIDLQKPVPSKWREIVPEAAETLESVQMADGKLLLAYMKDAHAAARLVTTEGKPVAEVAMPGLGTAIWSPARVKD
KEMFYGFMTYLAPTTMYRLDVETGRSEVARPVKLPFDPSGFETTQVFYPSKDGSRIPMFLTRRKGLKLDGRNPALLYGYG
GFDVPNTPAFSPTVAEWIRMGGVFASACLRGGSEYGEEWHQAGMRAKKQNVFNDFIAAAEWLVANRYTSTPKLAIMGGSN
GGLLVGAVLNQRPDLFGAAVAQVGVMDMLRFQKFGFGTQWVGEYGSPENPEDFKVLRAYSPLHNIRAGTEYPAVLVTTSD
HDDRVMPGHSLKYTATLQQAQKGPAPILLRVETRAGHGAGKPTAKQIDEAADILTFLKAALKVN

Sequences:

>Translated_704_residues
MKLNPLILITGCVFTMPGQNMPRLNYPAAPQSGQTDAYHEVQIADPYRGLENADAPETRKWVEDENALTQSWLGKQPDRA
PIRKQLTKLWNYEKYGTLFKAGPHYFYSYNTGLQNQSVVFVADSPNAKGKELLDPNTHRKDGTAALSGWSVSRNGKLYGY
AIAEAGSDWSDCRIRSVADGKDLPDVIRWTKFSNMAWATDDGGFYYSRYPEPPAGELLTAAALNQKVYFHRLGDPQTADR
LVYERPDRPAWSIDPVLTDDGRYLLLIMSSGIPGKNMLSFQDMQSPDRRIVDLIPMETASYQPIEAVGSTLYVQTTDGAP
RGRVIAIDLQKPVPSKWREIVPEAAETLESVQMADGKLLLAYMKDAHAAARLVTTEGKPVAEVAMPGLGTAIWSPARVKD
KEMFYGFMTYLAPTTMYRLDVETGRSEVARPVKLPFDPSGFETTQVFYPSKDGSRIPMFLTRRKGLKLDGRNPALLYGYG
GFDVPNTPAFSPTVAEWIRMGGVFASACLRGGSEYGEEWHQAGMRAKKQNVFNDFIAAAEWLVANRYTSTPKLAIMGGSN
GGLLVGAVLNQRPDLFGAAVAQVGVMDMLRFQKFGFGTQWVGEYGSPENPEDFKVLRAYSPLHNIRAGTEYPAVLVTTSD
HDDRVMPGHSLKYTATLQQAQKGPAPILLRVETRAGHGAGKPTAKQIDEAADILTFLKAALKVN
>Mature_704_residues
MKLNPLILITGCVFTMPGQNMPRLNYPAAPQSGQTDAYHEVQIADPYRGLENADAPETRKWVEDENALTQSWLGKQPDRA
PIRKQLTKLWNYEKYGTLFKAGPHYFYSYNTGLQNQSVVFVADSPNAKGKELLDPNTHRKDGTAALSGWSVSRNGKLYGY
AIAEAGSDWSDCRIRSVADGKDLPDVIRWTKFSNMAWATDDGGFYYSRYPEPPAGELLTAAALNQKVYFHRLGDPQTADR
LVYERPDRPAWSIDPVLTDDGRYLLLIMSSGIPGKNMLSFQDMQSPDRRIVDLIPMETASYQPIEAVGSTLYVQTTDGAP
RGRVIAIDLQKPVPSKWREIVPEAAETLESVQMADGKLLLAYMKDAHAAARLVTTEGKPVAEVAMPGLGTAIWSPARVKD
KEMFYGFMTYLAPTTMYRLDVETGRSEVARPVKLPFDPSGFETTQVFYPSKDGSRIPMFLTRRKGLKLDGRNPALLYGYG
GFDVPNTPAFSPTVAEWIRMGGVFASACLRGGSEYGEEWHQAGMRAKKQNVFNDFIAAAEWLVANRYTSTPKLAIMGGSN
GGLLVGAVLNQRPDLFGAAVAQVGVMDMLRFQKFGFGTQWVGEYGSPENPEDFKVLRAYSPLHNIRAGTEYPAVLVTTSD
HDDRVMPGHSLKYTATLQQAQKGPAPILLRVETRAGHGAGKPTAKQIDEAADILTFLKAALKVN

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=707, Percent_Identity=41.8670438472419, Blast_Score=563, Evalue=1e-160,
Organism=Homo sapiens, GI108860686, Length=215, Percent_Identity=27.4418604651163, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI284172420, Length=215, Percent_Identity=27.4418604651163, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI284172413, Length=215, Percent_Identity=27.4418604651163, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI70778815, Length=215, Percent_Identity=27.4418604651163, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI284172438, Length=215, Percent_Identity=27.4418604651163, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI284172431, Length=215, Percent_Identity=27.4418604651163, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI108860692, Length=214, Percent_Identity=27.1028037383178, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1788150, Length=535, Percent_Identity=25.607476635514, Blast_Score=189, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24583414, Length=715, Percent_Identity=41.8181818181818, Blast_Score=557, Evalue=1e-158,
Organism=Drosophila melanogaster, GI221510989, Length=710, Percent_Identity=41.2676056338028, Blast_Score=522, Evalue=1e-148,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 77737; Mature: 77737

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNPLILITGCVFTMPGQNMPRLNYPAAPQSGQTDAYHEVQIADPYRGLENADAPETRK
CCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHH
WVEDENALTQSWLGKQPDRAPIRKQLTKLWNYEKYGTLFKAGPHYFYSYNTGLQNQSVVF
HHCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHCCEEECCCCEEEEECCCCCCCEEEE
VADSPNAKGKELLDPNTHRKDGTAALSGWSVSRNGKLYGYAIAEAGSDWSDCRIRSVADG
EECCCCCCCCCCCCCCCCCCCCCEEEECCEECCCCEEEEEEEECCCCCHHHCEEEECCCC
KDLPDVIRWTKFSNMAWATDDGGFYYSRYPEPPAGELLTAAALNQKVYFHRLGDPQTADR
CCCHHHHHHHHCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCHHH
LVYERPDRPAWSIDPVLTDDGRYLLLIMSSGIPGKNMLSFQDMQSPDRRIVDLIPMETAS
HHEECCCCCCCCCCCEEECCCCEEEEEEECCCCCCCCCCHHCCCCCCCEEEEEECCCCCC
YQPIEAVGSTLYVQTTDGAPRGRVIAIDLQKPVPSKWREIVPEAAETLESVQMADGKLLL
CCCHHHCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
AYMKDAHAAARLVTTEGKPVAEVAMPGLGTAIWSPARVKDKEMFYGFMTYLAPTTMYRLD
EEHHHHHHHEEEEECCCCCHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEE
VETGRSEVARPVKLPFDPSGFETTQVFYPSKDGSRIPMFLTRRKGLKLDGRNPALLYGYG
CCCCHHHHCCCEECCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCEECCCCCEEEEECC
GFDVPNTPAFSPTVAEWIRMGGVFASACLRGGSEYGEEWHQAGMRAKKQNVFNDFIAAAE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLVANRYTSTPKLAIMGGSNGGLLVGAVLNQRPDLFGAAVAQVGVMDMLRFQKFGFGTQW
HHHHCCCCCCCEEEEEECCCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHH
VGEYGSPENPEDFKVLRAYSPLHNIRAGTEYPAVLVTTSDHDDRVMPGHSLKYTATLQQA
HCCCCCCCCCHHHHHHHHHCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCEEEEHHHHHH
QKGPAPILLRVETRAGHGAGKPTAKQIDEAADILTFLKAALKVN
HCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLNPLILITGCVFTMPGQNMPRLNYPAAPQSGQTDAYHEVQIADPYRGLENADAPETRK
CCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHH
WVEDENALTQSWLGKQPDRAPIRKQLTKLWNYEKYGTLFKAGPHYFYSYNTGLQNQSVVF
HHCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHCCEEECCCCEEEEECCCCCCCEEEE
VADSPNAKGKELLDPNTHRKDGTAALSGWSVSRNGKLYGYAIAEAGSDWSDCRIRSVADG
EECCCCCCCCCCCCCCCCCCCCCEEEECCEECCCCEEEEEEEECCCCCHHHCEEEECCCC
KDLPDVIRWTKFSNMAWATDDGGFYYSRYPEPPAGELLTAAALNQKVYFHRLGDPQTADR
CCCHHHHHHHHCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCHHH
LVYERPDRPAWSIDPVLTDDGRYLLLIMSSGIPGKNMLSFQDMQSPDRRIVDLIPMETAS
HHEECCCCCCCCCCCEEECCCCEEEEEEECCCCCCCCCCHHCCCCCCCEEEEEECCCCCC
YQPIEAVGSTLYVQTTDGAPRGRVIAIDLQKPVPSKWREIVPEAAETLESVQMADGKLLL
CCCHHHCCCEEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEE
AYMKDAHAAARLVTTEGKPVAEVAMPGLGTAIWSPARVKDKEMFYGFMTYLAPTTMYRLD
EEHHHHHHHEEEEECCCCCHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEE
VETGRSEVARPVKLPFDPSGFETTQVFYPSKDGSRIPMFLTRRKGLKLDGRNPALLYGYG
CCCCHHHHCCCEECCCCCCCCCEEEEEECCCCCCCCCEEEECCCCCEECCCCCEEEEECC
GFDVPNTPAFSPTVAEWIRMGGVFASACLRGGSEYGEEWHQAGMRAKKQNVFNDFIAAAE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLVANRYTSTPKLAIMGGSNGGLLVGAVLNQRPDLFGAAVAQVGVMDMLRFQKFGFGTQW
HHHHCCCCCCCEEEEEECCCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHH
VGEYGSPENPEDFKVLRAYSPLHNIRAGTEYPAVLVTTSDHDDRVMPGHSLKYTATLQQA
HCCCCCCCCCHHHHHHHHHCHHHHHCCCCCCCEEEEEECCCCCCCCCCCCEEEEHHHHHH
QKGPAPILLRVETRAGHGAGKPTAKQIDEAADILTFLKAALKVN
HCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370677 [H]