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The map label for this gene is fabZ

Identifier: 116625257

GI number: 116625257

Start: 7780153

End: 7780641

Strand: Direct

Name: fabZ

Synonym: Acid_6202

Alternate gene names: 116625257

Gene position: 7780153-7780641 (Clockwise)

Preceding gene: 116625249

Following gene: 116625258

Centisome position: 78.07

GC content: 60.33

Gene sequence:

>489_bases
ATGGCAATTCTGGACATCAACGAGATCCGTGCAATTCTGCCTCATCGTTACCCCTTTCTCCTGGTAGACCGCATCCTGGA
GATGGAAACCGACCGCATTGTCGGGATCAAGAACGTCACATTCAACGAGCCGCAGTTCACCGGCCACTTCCCCGATTTTC
CGGTGATGCCGGGCGTGATGATCGTGGAAGCCATGGCGCAGACGGCGGGCGTGCTGGTGCTGCATAGCATGCCGGACCGC
GCCAATAAACTGGTGCTGCTGGTCGCGATTGAGAATGCGCGCTTCCGCAAGCCGGTGGTGCCCGGCGACACCCTGCGCAT
GGAGATGAAGATCATCAAGCGCAAGGCCAGCGTGGCCAAAATGGCGGGAATCGCGACGGTGGATGGCGTAGTGGTGGCCG
AGGCGGAAGTGATGTGCAAGCTCGCCGACAAGGAAGAGAAGCCGCCGGCCGCGCCGGAAATCAAAGTACCCGCTGAAGCC
GCCGTCTAA

Upstream 100 bases:

>100_bases
TTCGCACTCCACGAAGCGGCGCAGCGTCATCATCATTTCGGCCTGGTGAGCGCGCGCAAAAGAGAGAATAGAGTCCACGG
CTGTTATAATACAGGCTTCC

Downstream 100 bases:

>100_bases
GTCACGGTCTGACCGATGCCGATTCATCCCACCGCCATCGTCGACCCCAAAGCGGAAATCGCCGAGAGCGCCGACGTTGG
CCCGTACTGCGTGATCGGCC

Product: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase

Products: trans-Delta2-enoyl-acyl-ACP; H2O [C]

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MAILDINEIRAILPHRYPFLLVDRILEMETDRIVGIKNVTFNEPQFTGHFPDFPVMPGVMIVEAMAQTAGVLVLHSMPDR
ANKLVLLVAIENARFRKPVVPGDTLRMEMKIIKRKASVAKMAGIATVDGVVVAEAEVMCKLADKEEKPPAAPEIKVPAEA
AV

Sequences:

>Translated_162_residues
MAILDINEIRAILPHRYPFLLVDRILEMETDRIVGIKNVTFNEPQFTGHFPDFPVMPGVMIVEAMAQTAGVLVLHSMPDR
ANKLVLLVAIENARFRKPVVPGDTLRMEMKIIKRKASVAKMAGIATVDGVVVAEAEVMCKLADKEEKPPAAPEIKVPAEA
AV
>Mature_161_residues
AILDINEIRAILPHRYPFLLVDRILEMETDRIVGIKNVTFNEPQFTGHFPDFPVMPGVMIVEAMAQTAGVLVLHSMPDRA
NKLVLLVAIENARFRKPVVPGDTLRMEMKIIKRKASVAKMAGIATVDGVVVAEAEVMCKLADKEEKPPAAPEIKVPAEAA
V

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=138, Percent_Identity=48.5507246376812, Blast_Score=137, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_SOLUE (Q01T92)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_827413.1
- ProteinModelPortal:   Q01T92
- SMR:   Q01T92
- STRING:   Q01T92
- GeneID:   4425573
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_6202
- NMPDR:   fig|234267.9.peg.5890
- eggNOG:   COG0764
- HOGENOM:   HBG433282
- OMA:   KERRGVA
- PhylomeDB:   Q01T92
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.- [C]

Molecular weight: Translated: 17808; Mature: 17677

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: ACT_SITE 49-49

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILDINEIRAILPHRYPFLLVDRILEMETDRIVGIKNVTFNEPQFTGHFPDFPVMPGVM
CEEECHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHH
IVEAMAQTAGVLVLHSMPDRANKLVLLVAIENARFRKPVVPGDTLRMEMKIIKRKASVAK
HHHHHHHHCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
MAGIATVDGVVVAEAEVMCKLADKEEKPPAAPEIKVPAEAAV
HHCCHHCCCEEEEHHHHHHHHCCCCCCCCCCCCEECCHHCCC
>Mature Secondary Structure 
AILDINEIRAILPHRYPFLLVDRILEMETDRIVGIKNVTFNEPQFTGHFPDFPVMPGVM
EEECHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHH
IVEAMAQTAGVLVLHSMPDRANKLVLLVAIENARFRKPVVPGDTLRMEMKIIKRKASVAK
HHHHHHHHCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
MAGIATVDGVVVAEAEVMCKLADKEEKPPAAPEIKVPAEAAV
HHCCHHCCCEEEEHHHHHHHHCCCCCCCCCCCCEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-3-hydroxy-acyl-ACP [C]

Specific reaction: D-3-hydroxy-acyl-ACP = trans-Delta2-enoyl-acyl-ACP + H2O [C]

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA