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The map label for this gene is lpxA [H]

Identifier: 116625258

GI number: 116625258

Start: 7780657

End: 7781433

Strand: Direct

Name: lpxA [H]

Synonym: Acid_6203

Alternate gene names: 116625258

Gene position: 7780657-7781433 (Clockwise)

Preceding gene: 116625257

Following gene: 116625259

Centisome position: 78.07

GC content: 64.86

Gene sequence:

>777_bases
ATGCCGATTCATCCCACCGCCATCGTCGACCCCAAAGCGGAAATCGCCGAGAGCGCCGACGTTGGCCCGTACTGCGTGAT
CGGCCCCGAGGTCCACGTCGGCGAGGGCACGCGGCTGATGGCCAACAACTACCTGGAAGGCCCTACGTGGATCGGCGAAG
ACAACATCTTCTTCCCGTACAGCACGGTGGGCGTGGCTTCGCAAGATCTGAAGTACAAGGGCGAGCGCGCCGAGACCCGC
ATCGGCGACCGCAACCGCGTGCGCGAATTCGTCACCATTCATCGCGGCACGCAGGGCGGCGGCCTGGTGACCGCAATCGG
CAGCGACAATTTGCTGATGGCCTACGCGCACATCGCGCACGACGTAGTGATCGGCGATCACGTGATCATGGCCAACGGAG
TGACGCTCGCCGGGCATGTGACCATCGGCGATTGGGCCGACATCAGCGCCTTCGCGGGCGTGCATCAGTTCTGCCGGATC
GGGCGTCACGCGTTCGTGGGCCCATACAGCGTGGTGATTCAGGACGTGCTGCCCTACTCGACCACGGTGGGCAAGCGCGA
GATCGGGGTCTACGGCGCGAACCGCATCGGGCTCGAACGGCGCGGCTTTGAGACGCCCGTGATCGAATCGCTGCAGACCG
CATTCCGGCTGCTGACGCGCTCCAAGCTGAATACCAGCCAGGCGGTCGAGCGGATCCGCGCCGAGGTGCCGCCCTGCGCC
GAGTTGGAAGAGCTGCTCGAGTTCATCCGCACCAGCGAACGCGGAATCGTGAAATGA

Upstream 100 bases:

>100_bases
GGAAGTGATGTGCAAGCTCGCCGACAAGGAAGAGAAGCCGCCGGCCGCGCCGGAAATCAAAGTACCCGCTGAAGCCGCCG
TCTAAGTCACGGTCTGACCG

Downstream 100 bases:

>100_bases
TTCGCTACGGCATGATCGCCGGGAACGGGCGCTTTCCGCTGCTCGCGCTGGAGAGCGCGCGGCAGCTCGGCTACGAGATC
GTGGTGATCGCGCTCCAGGA

Product: acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MPIHPTAIVDPKAEIAESADVGPYCVIGPEVHVGEGTRLMANNYLEGPTWIGEDNIFFPYSTVGVASQDLKYKGERAETR
IGDRNRVREFVTIHRGTQGGGLVTAIGSDNLLMAYAHIAHDVVIGDHVIMANGVTLAGHVTIGDWADISAFAGVHQFCRI
GRHAFVGPYSVVIQDVLPYSTTVGKREIGVYGANRIGLERRGFETPVIESLQTAFRLLTRSKLNTSQAVERIRAEVPPCA
ELEELLEFIRTSERGIVK

Sequences:

>Translated_258_residues
MPIHPTAIVDPKAEIAESADVGPYCVIGPEVHVGEGTRLMANNYLEGPTWIGEDNIFFPYSTVGVASQDLKYKGERAETR
IGDRNRVREFVTIHRGTQGGGLVTAIGSDNLLMAYAHIAHDVVIGDHVIMANGVTLAGHVTIGDWADISAFAGVHQFCRI
GRHAFVGPYSVVIQDVLPYSTTVGKREIGVYGANRIGLERRGFETPVIESLQTAFRLLTRSKLNTSQAVERIRAEVPPCA
ELEELLEFIRTSERGIVK
>Mature_257_residues
PIHPTAIVDPKAEIAESADVGPYCVIGPEVHVGEGTRLMANNYLEGPTWIGEDNIFFPYSTVGVASQDLKYKGERAETRI
GDRNRVREFVTIHRGTQGGGLVTAIGSDNLLMAYAHIAHDVVIGDHVIMANGVTLAGHVTIGDWADISAFAGVHQFCRIG
RHAFVGPYSVVIQDVLPYSTTVGKREIGVYGANRIGLERRGFETPVIESLQTAFRLLTRSKLNTSQAVERIRAEVPPCAE
LEELLEFIRTSERGIVK

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=260, Percent_Identity=44.6153846153846, Blast_Score=224, Evalue=3e-60,
Organism=Escherichia coli, GI1786376, Length=168, Percent_Identity=29.7619047619048, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28179; Mature: 28048

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIHPTAIVDPKAEIAESADVGPYCVIGPEVHVGEGTRLMANNYLEGPTWIGEDNIFFPY
CCCCCCEEECCHHHHHHCCCCCCEEEECCEEEECCCCEEEECCCCCCCCEECCCCEECCC
STVGVASQDLKYKGERAETRIGDRNRVREFVTIHRGTQGGGLVTAIGSDNLLMAYAHIAH
HHCCCCCCCHHCCCCHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEHHHHHHH
DVVIGDHVIMANGVTLAGHVTIGDWADISAFAGVHQFCRIGRHAFVGPYSVVIQDVLPYS
HHEECCEEEEECCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
TTVGKREIGVYGANRIGLERRGFETPVIESLQTAFRLLTRSKLNTSQAVERIRAEVPPCA
CCCCCCEECEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
ELEELLEFIRTSERGIVK
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PIHPTAIVDPKAEIAESADVGPYCVIGPEVHVGEGTRLMANNYLEGPTWIGEDNIFFPY
CCCCCEEECCHHHHHHCCCCCCEEEECCEEEECCCCEEEECCCCCCCCEECCCCEECCC
STVGVASQDLKYKGERAETRIGDRNRVREFVTIHRGTQGGGLVTAIGSDNLLMAYAHIAH
HHCCCCCCCHHCCCCHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEHHHHHHH
DVVIGDHVIMANGVTLAGHVTIGDWADISAFAGVHQFCRIGRHAFVGPYSVVIQDVLPYS
HHEECCEEEEECCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
TTVGKREIGVYGANRIGLERRGFETPVIESLQTAFRLLTRSKLNTSQAVERIRAEVPPCA
CCCCCCEECEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
ELEELLEFIRTSERGIVK
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA