Click here to switch to the map view.

The map label for this gene is vpr [H]

Identifier: 116625240

GI number: 116625240

Start: 7756988

End: 7759342

Strand: Reverse

Name: vpr [H]

Synonym: Acid_6185

Alternate gene names: 116625240

Gene position: 7759342-7756988 (Counterclockwise)

Preceding gene: 116625243

Following gene: 116625239

Centisome position: 77.86

GC content: 66.88

Gene sequence:

>2355_bases
ATGAAAACGATCTCGTTGCTTGTTCTGCTGTCCGTTGCGGTGTCGGGACAGGTGGTCCCCAACCGGTATGTCTTGGAACT
CTCGGGCGAACCGGCGGCCTCAGCAGGCGTCCGCGCGACTGCCCGGATCGCGGCTCGAGCGGCAGTGCGGCAATCGCAGG
TGGCGGCGCGCGCGGCGGTCGCGGCCAAAGGCGGCGCCGTAATCGAAAACCTGGACACTGTCTTCAACGGGTTGATCGTC
AACATCCCGGATGCGCGGTCGGCGGAACTGATGTCAATTCCAGGAGCGGTAAAGGTCCATCCCGTGCGGCGCGTGCGTCC
GCTGCTGACCCACGCGCTGCCGCTCCACAAGGTCCCCGATGCTTGGAATCTGCTGCCGCTGGGACAGGCCGGAGCGGGCG
CCGGAATCAAGATCGGCATGATCGATAGCGGAGTGGACGTCAACAATCCGGCGTTCGGCGACCTGCTGCCGCCTGTGGAC
GGGTTCCCCAAAGTGCGGTCGGCGGCCGACACCCGGTTCACCAATGCCAAGATCATCGTGGCCAGGAACTATACGCCGCT
CTTGCCCGATGGAGGCGATGCCGATGCCAACGATCACGATGGGCATGGCACCGGGACGGCCCTGGCCGCGGCCGGCGGGA
CTGCGAGCACCCCCTACGGAGTGGTCACGGGCGTGGCCCCGAAGGCGTACATCGGCAGCTACAAGGTCCTGGATGCGAAC
GGCGGCACCTCGGACGTGATCGCCAAGGCGATCGACGACGCGGTGGCGGACGGCATGGACGTGATCAACATCAGCCTGGG
GTCCTACGTGACTTCGTACTCCGATATAGACCCGGGAGAAGTCGGGATGGCGGCGATTGCGCGCGCGGCGAAGGCGGGTG
TGATCGTGGTGGTCGCGGCGGGCAACCAGGGTCCGGCCGCCGGCACGATCGCCGATTATGCGAGCGCCCCGGATGCCATT
ACGGTGGGCGCGATTCACAACGACCGCTCGCTGGGCTATGGGATCGAGGCGACGGGCATCGCGCCGTACCCGGCCTACGC
GGGGGACGGGCCCAACCCGGGGCAGGCGATCGGCGGCACCCTGTTCGACCTGACCGCGCTGGATCCCTCGGGGCTCGCGT
GCGCGGCGCTCCCGGAAGGTTCGGTGGCGGGAAAGATCGTGCTGGTGTTGCGTGGCACGTGCACGTTCGAGAGCAAGTTG
AACGATGCGGCCGCCGGCGGGGCGCTCGGGATCGTGGTCTACAACAATCCGGGGAACAACAGTTTTTCGACCGGTGGCGT
GACCGTCGGCTCGGCCACCCTGCCGGCGCTCTTCGTCAACCAGTCCGACGGCCTCGATTTGAAGGCCCGCGCGGCACAGG
ACGGCGGCCTGCAGGTGACGCTGGATTTTTCGGGCGCTATCGCGTTTCCGGCGCGCACCGACGTGAGCAGTTTTTCGAGC
CGCGGGCCCAGCCTCGGCAGCGCGCTCAAGCCCGACCTGGCGGCCGTCGGGGAAGAGATCGTCACCGGCGCGCAGAATTC
CTTCAGCGGCGGTGAGTCGTATAGTGCGTCCGGTTTCGTCGATACGGCGGGCACGAGTTTTTCGGCGCCGCTGGCCGCGG
GAGCAGCCGCGGTGCTGAAGGGCGCGCGGCCGGGGCTCACAGGGCAGCAGTACCGGTCGCTGCTGGTAAACGGTGCCGCT
GCGGCCACAGTGTCGGATGGTGTCGCGGCAACGGCGTCGCAGGCGGGAGCGGGGATTTTGAACCTCTTGGCCGCCGTCAG
CGGGACGGTCGCGGCGTATCCCACCTCGCTCAACTTCGGCACGGGCAATACTACGGTGGCGCTCTCCCTATTGAATGTGA
GCCCGGCGCTGGATACGTTCACGTTGCGGGCGGTGCCCGCTGGCAGCGCTCCGGCCCCAGTGCCGGCTGCCGCCACGGTG
GTGTTGGACGCGGGTGCGTCGCAGCAGGTCGCCTTGACGCTGGATGCCGCAGGACTGGCGCCGGGCGAGTACTCGGGATA
CGTCACGGTTTCGGGAACGGCGAGTTCGACCGTGGCGAAGATTCCGTATTGGTTTGCGGTCCCAGGCGGAGATCCGGTGG
GGATCTCGCTGCTCTATCAGGATTATTACGACGCAGTGCGGACGAGCTCGACACAGGCGGTGGTCCTCCGCATAGTGGAT
GCGGCCGGACTGCCGTACACCGGTGCATTGCGCCCCTCGCTCACCGTGGCGGGGTCGGGCAGCGTGCGGAGTTTCTACCG
CACAGGCACGATTCCGGGGACGTATGCAGTGGATATTCGGACGGGGACTGCGAACATGGAGCTTACGTTTACCATCGGCA
GTATCACCGAGACCGTCGTCATCCCCGTGTACTAG

Upstream 100 bases:

>100_bases
ATTGGCGGGAAGACGAAGCACTTAGCGGTACGGACGGCGGCAGTCTGTCGCAGGACGTATTTTCTTTTGGCGGCAAGCTG
CCGCGTGGTGAATTTCGGCT

Downstream 100 bases:

>100_bases
CAGGTAATTGCTCGCACGCCGCGAGAATTCGCCGCACTGTATTCCACTGCTCTTGTTTGCTCGCAGGCCGCAAACATCCG
CACCGGAATTCGCCGCCCCA

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MKTISLLVLLSVAVSGQVVPNRYVLELSGEPAASAGVRATARIAARAAVRQSQVAARAAVAAKGGAVIENLDTVFNGLIV
NIPDARSAELMSIPGAVKVHPVRRVRPLLTHALPLHKVPDAWNLLPLGQAGAGAGIKIGMIDSGVDVNNPAFGDLLPPVD
GFPKVRSAADTRFTNAKIIVARNYTPLLPDGGDADANDHDGHGTGTALAAAGGTASTPYGVVTGVAPKAYIGSYKVLDAN
GGTSDVIAKAIDDAVADGMDVINISLGSYVTSYSDIDPGEVGMAAIARAAKAGVIVVVAAGNQGPAAGTIADYASAPDAI
TVGAIHNDRSLGYGIEATGIAPYPAYAGDGPNPGQAIGGTLFDLTALDPSGLACAALPEGSVAGKIVLVLRGTCTFESKL
NDAAAGGALGIVVYNNPGNNSFSTGGVTVGSATLPALFVNQSDGLDLKARAAQDGGLQVTLDFSGAIAFPARTDVSSFSS
RGPSLGSALKPDLAAVGEEIVTGAQNSFSGGESYSASGFVDTAGTSFSAPLAAGAAAVLKGARPGLTGQQYRSLLVNGAA
AATVSDGVAATASQAGAGILNLLAAVSGTVAAYPTSLNFGTGNTTVALSLLNVSPALDTFTLRAVPAGSAPAPVPAAATV
VLDAGASQQVALTLDAAGLAPGEYSGYVTVSGTASSTVAKIPYWFAVPGGDPVGISLLYQDYYDAVRTSSTQAVVLRIVD
AAGLPYTGALRPSLTVAGSGSVRSFYRTGTIPGTYAVDIRTGTANMELTFTIGSITETVVIPVY

Sequences:

>Translated_784_residues
MKTISLLVLLSVAVSGQVVPNRYVLELSGEPAASAGVRATARIAARAAVRQSQVAARAAVAAKGGAVIENLDTVFNGLIV
NIPDARSAELMSIPGAVKVHPVRRVRPLLTHALPLHKVPDAWNLLPLGQAGAGAGIKIGMIDSGVDVNNPAFGDLLPPVD
GFPKVRSAADTRFTNAKIIVARNYTPLLPDGGDADANDHDGHGTGTALAAAGGTASTPYGVVTGVAPKAYIGSYKVLDAN
GGTSDVIAKAIDDAVADGMDVINISLGSYVTSYSDIDPGEVGMAAIARAAKAGVIVVVAAGNQGPAAGTIADYASAPDAI
TVGAIHNDRSLGYGIEATGIAPYPAYAGDGPNPGQAIGGTLFDLTALDPSGLACAALPEGSVAGKIVLVLRGTCTFESKL
NDAAAGGALGIVVYNNPGNNSFSTGGVTVGSATLPALFVNQSDGLDLKARAAQDGGLQVTLDFSGAIAFPARTDVSSFSS
RGPSLGSALKPDLAAVGEEIVTGAQNSFSGGESYSASGFVDTAGTSFSAPLAAGAAAVLKGARPGLTGQQYRSLLVNGAA
AATVSDGVAATASQAGAGILNLLAAVSGTVAAYPTSLNFGTGNTTVALSLLNVSPALDTFTLRAVPAGSAPAPVPAAATV
VLDAGASQQVALTLDAAGLAPGEYSGYVTVSGTASSTVAKIPYWFAVPGGDPVGISLLYQDYYDAVRTSSTQAVVLRIVD
AAGLPYTGALRPSLTVAGSGSVRSFYRTGTIPGTYAVDIRTGTANMELTFTIGSITETVVIPVY
>Mature_784_residues
MKTISLLVLLSVAVSGQVVPNRYVLELSGEPAASAGVRATARIAARAAVRQSQVAARAAVAAKGGAVIENLDTVFNGLIV
NIPDARSAELMSIPGAVKVHPVRRVRPLLTHALPLHKVPDAWNLLPLGQAGAGAGIKIGMIDSGVDVNNPAFGDLLPPVD
GFPKVRSAADTRFTNAKIIVARNYTPLLPDGGDADANDHDGHGTGTALAAAGGTASTPYGVVTGVAPKAYIGSYKVLDAN
GGTSDVIAKAIDDAVADGMDVINISLGSYVTSYSDIDPGEVGMAAIARAAKAGVIVVVAAGNQGPAAGTIADYASAPDAI
TVGAIHNDRSLGYGIEATGIAPYPAYAGDGPNPGQAIGGTLFDLTALDPSGLACAALPEGSVAGKIVLVLRGTCTFESKL
NDAAAGGALGIVVYNNPGNNSFSTGGVTVGSATLPALFVNQSDGLDLKARAAQDGGLQVTLDFSGAIAFPARTDVSSFSS
RGPSLGSALKPDLAAVGEEIVTGAQNSFSGGESYSASGFVDTAGTSFSAPLAAGAAAVLKGARPGLTGQQYRSLLVNGAA
AATVSDGVAATASQAGAGILNLLAAVSGTVAAYPTSLNFGTGNTTVALSLLNVSPALDTFTLRAVPAGSAPAPVPAAATV
VLDAGASQQVALTLDAAGLAPGEYSGYVTVSGTASSTVAKIPYWFAVPGGDPVGISLLYQDYYDAVRTSSTQAVVLRIVD
AAGLPYTGALRPSLTVAGSGSVRSFYRTGTIPGTYAVDIRTGTANMELTFTIGSITETVVIPVY

Specific function: Not required for growth or sporulation [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR010259
- InterPro:   IPR003137 [H]

Pfam domain/function: PF05922 Inhibitor_I9; PF02225 PA; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 78007; Mature: 78007

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00136 SUBTILASE_ASP ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTISLLVLLSVAVSGQVVPNRYVLELSGEPAASAGVRATARIAARAAVRQSQVAARAAV
CCHHHHHHHHHHHHCCEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AAKGGAVIENLDTVFNGLIVNIPDARSAELMSIPGAVKVHPVRRVRPLLTHALPLHKVPD
HCCCCHHHHHHHHHHCCEEEECCCCCCCEEEECCCCEEECHHHHHHHHHHHCCCCCCCCC
AWNLLPLGQAGAGAGIKIGMIDSGVDVNNPAFGDLLPPVDGFPKVRSAADTRFTNAKIIV
CCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCEECCEEEEE
ARNYTPLLPDGGDADANDHDGHGTGTALAAAGGTASTPYGVVTGVAPKAYIGSYKVLDAN
EECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCHHHHCCEEEEECC
GGTSDVIAKAIDDAVADGMDVINISLGSYVTSYSDIDPGEVGMAAIARAAKAGVIVVVAA
CCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEE
GNQGPAAGTIADYASAPDAITVGAIHNDRSLGYGIEATGIAPYPAYAGDGPNPGQAIGGT
CCCCCCCCCHHHHCCCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCHHHCCE
LFDLTALDPSGLACAALPEGSVAGKIVLVLRGTCTFESKLNDAAAGGALGIVVYNNPGNN
EEEEEECCCCCCEEEECCCCCCCCEEEEEEECCEEEHHHCCCCCCCCEEEEEEEECCCCC
SFSTGGVTVGSATLPALFVNQSDGLDLKARAAQDGGLQVTLDFSGAIAFPARTDVSSFSS
CCCCCCEEECCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCEEECCCCCCHHHHHC
RGPSLGSALKPDLAAVGEEIVTGAQNSFSGGESYSASGFVDTAGTSFSAPLAAGAAAVLK
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHC
GARPGLTGQQYRSLLVNGAAAATVSDGVAATASQAGAGILNLLAAVSGTVAAYPTSLNFG
CCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHCCHHHHHHHHHHCCCEEECCCEEECC
TGNTTVALSLLNVSPALDTFTLRAVPAGSAPAPVPAAATVVLDAGASQQVALTLDAAGLA
CCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCC
PGEYSGYVTVSGTASSTVAKIPYWFAVPGGDPVGISLLYQDYYDAVRTSSTQAVVLRIVD
CCCCCCEEEEECCCCCCEEECCEEEECCCCCCCEEEEEEHHHHHHHHCCCCEEEEEEEEE
AAGLPYTGALRPSLTVAGSGSVRSFYRTGTIPGTYAVDIRTGTANMELTFTIGSITETVV
CCCCCCCCCCCCCEEEECCCCCHHHEECCCCCCEEEEEEEECCCCEEEEEEECCCCEEEE
IPVY
EEEC
>Mature Secondary Structure
MKTISLLVLLSVAVSGQVVPNRYVLELSGEPAASAGVRATARIAARAAVRQSQVAARAAV
CCHHHHHHHHHHHHCCEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AAKGGAVIENLDTVFNGLIVNIPDARSAELMSIPGAVKVHPVRRVRPLLTHALPLHKVPD
HCCCCHHHHHHHHHHCCEEEECCCCCCCEEEECCCCEEECHHHHHHHHHHHCCCCCCCCC
AWNLLPLGQAGAGAGIKIGMIDSGVDVNNPAFGDLLPPVDGFPKVRSAADTRFTNAKIIV
CCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCEECCEEEEE
ARNYTPLLPDGGDADANDHDGHGTGTALAAAGGTASTPYGVVTGVAPKAYIGSYKVLDAN
EECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCHHHHCCEEEEECC
GGTSDVIAKAIDDAVADGMDVINISLGSYVTSYSDIDPGEVGMAAIARAAKAGVIVVVAA
CCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEE
GNQGPAAGTIADYASAPDAITVGAIHNDRSLGYGIEATGIAPYPAYAGDGPNPGQAIGGT
CCCCCCCCCHHHHCCCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCHHHCCE
LFDLTALDPSGLACAALPEGSVAGKIVLVLRGTCTFESKLNDAAAGGALGIVVYNNPGNN
EEEEEECCCCCCEEEECCCCCCCCEEEEEEECCEEEHHHCCCCCCCCEEEEEEEECCCCC
SFSTGGVTVGSATLPALFVNQSDGLDLKARAAQDGGLQVTLDFSGAIAFPARTDVSSFSS
CCCCCCEEECCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCEEECCCCCCHHHHHC
RGPSLGSALKPDLAAVGEEIVTGAQNSFSGGESYSASGFVDTAGTSFSAPLAAGAAAVLK
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHC
GARPGLTGQQYRSLLVNGAAAATVSDGVAATASQAGAGILNLLAAVSGTVAAYPTSLNFG
CCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHCCHHHHHHHHHHCCCEEECCCEEECC
TGNTTVALSLLNVSPALDTFTLRAVPAGSAPAPVPAAATVVLDAGASQQVALTLDAAGLA
CCCCEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCC
PGEYSGYVTVSGTASSTVAKIPYWFAVPGGDPVGISLLYQDYYDAVRTSSTQAVVLRIVD
CCCCCCEEEEECCCCCCEEECCEEEECCCCCCCEEEEEEHHHHHHHHCCCCEEEEEEEEE
AAGLPYTGALRPSLTVAGSGSVRSFYRTGTIPGTYAVDIRTGTANMELTFTIGSITETVV
CCCCCCCCCCCCCEEEECCCCCHHHEECCCCCCEEEEEEEECCCCEEEEEEECCCCEEEE
IPVY
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1938892; 7934828; 9384377; 10658653 [H]