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The map label for this gene is hmgA [H]

Identifier: 116625187

GI number: 116625187

Start: 7665630

End: 7666880

Strand: Reverse

Name: hmgA [H]

Synonym: Acid_6132

Alternate gene names: 116625187

Gene position: 7666880-7665630 (Counterclockwise)

Preceding gene: 116625188

Following gene: 116625186

Centisome position: 76.93

GC content: 52.36

Gene sequence:

>1251_bases
ATGGATGCTGACAAAATGAACTCGGCCCGCAGATCCCAAACTCCCACCGCGGAAATACCAGATGGCGAGACTCAAAAGGT
GCAGGTAAGAAAGTTCCTGCGCAACAAAGCGACTGCCTATACGGCCGAAATGATACGCAGCCGCCGGGAATGGCTGGCGG
AGCTTACACAGACCCGGCTGAAGCATCTGGCGCATTTTTCGGAAGACCCCGCGGATTTTAAGGGGAAAATTGAATGCCCC
ATCGGTGTGGCTCATGTGCCCCTCGGGATTGCCGGGCCCCTTCAAATCAATGGTGAACACGCCCGAGGCGTTTTTTTCAT
CCCTATGGCAACCACCGAGGGAGCACTCATTACCTCTTATACCTTCGGTTCGAACATCATCACGCGATCTGGGGGAGTCA
ATGTCCGGATTCTGAAGGATGCTTTAAAATCAGATCCAACATTTGTCTTTAAATCCTCGACCGAAGCACTGTCCTTTGTC
ACCTGGATTGAAAACAACTTTGGCGCGATCAAAGAGATCGCTGAAAAAACAAGTGGTCATCTCCGATTGATTAAGGCCGT
TCCCGTGATTAATGGCCGTCGCGTGATCCTCTGTTTCCACTTCCAGACTGGAGATGCCCTCGGAATGAACATGGTTTACA
AGGCGACTGATGTCGTATGTAAGATGATTCGCGATTCCGTAGAGCCCGAGGAGTTCTGGCTGCATTCGAATTTCACAACG
ATCAAGAAAACTACGGCTGAGAACTTTGTGAACGGATATGGGAAGTCGGCGATGGCGGATGTCACGGTTCCCCGAAAGTT
GGTTGCGCGGTTCAACACGACACCGGAACAAATGGAGCGATTTTTTCTCCGGACGCTGTTAGGGTCGGCGCAAGGGGGCT
TATTCGGAATCAGCGCGCATATGGCGAACGCAATGACCGCCATAGCCATTGCTTGCGGGCAGGATGCGGCGCTCGTTGCC
AATACCCATTACGCCAACGCCACGTGCGAAACGACCAAAAATGGCGACTTATATTTCAGCGCACATTTTCCCAGTTTGTT
CGCCGCGACCGTCGGAGGAGGAACTTCCTTTGGGACGGCGCGTGAATGCCTCGAAACGCTGGGGTGTTATGGAAACGGCA
AATCCAAACGATTCGCCGAGATCATCGCGGGCACAGCATTGGCTGGAGAAATCAGCCTCATGATTTCTATCGTCAACGGC
AGCTATATCTATGCCCATGAGACATTTGGGAGAAACCGGCCGCGTCAGTAA

Upstream 100 bases:

>100_bases
GTGAAAGCAATCGATTGAAATAGTTCAAATTTGGCTGCTAACGATGTGCGAACCTCTGCTCTTCAAGTCGTCGCACGCTT
AACCGCCGGTAAATCTTCCG

Downstream 100 bases:

>100_bases
GAGGCCAACGTAGAGAACGGGAATCTGATATGGAAAACGCGACGATTGACGGACTATCCCAGCGCCTGGCGCACACCTAC
AACGGCTCTAAGCTGCCCGT

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MDADKMNSARRSQTPTAEIPDGETQKVQVRKFLRNKATAYTAEMIRSRREWLAELTQTRLKHLAHFSEDPADFKGKIECP
IGVAHVPLGIAGPLQINGEHARGVFFIPMATTEGALITSYTFGSNIITRSGGVNVRILKDALKSDPTFVFKSSTEALSFV
TWIENNFGAIKEIAEKTSGHLRLIKAVPVINGRRVILCFHFQTGDALGMNMVYKATDVVCKMIRDSVEPEEFWLHSNFTT
IKKTTAENFVNGYGKSAMADVTVPRKLVARFNTTPEQMERFFLRTLLGSAQGGLFGISAHMANAMTAIAIACGQDAALVA
NTHYANATCETTKNGDLYFSAHFPSLFAATVGGGTSFGTARECLETLGCYGNGKSKRFAEIIAGTALAGEISLMISIVNG
SYIYAHETFGRNRPRQ

Sequences:

>Translated_416_residues
MDADKMNSARRSQTPTAEIPDGETQKVQVRKFLRNKATAYTAEMIRSRREWLAELTQTRLKHLAHFSEDPADFKGKIECP
IGVAHVPLGIAGPLQINGEHARGVFFIPMATTEGALITSYTFGSNIITRSGGVNVRILKDALKSDPTFVFKSSTEALSFV
TWIENNFGAIKEIAEKTSGHLRLIKAVPVINGRRVILCFHFQTGDALGMNMVYKATDVVCKMIRDSVEPEEFWLHSNFTT
IKKTTAENFVNGYGKSAMADVTVPRKLVARFNTTPEQMERFFLRTLLGSAQGGLFGISAHMANAMTAIAIACGQDAALVA
NTHYANATCETTKNGDLYFSAHFPSLFAATVGGGTSFGTARECLETLGCYGNGKSKRFAEIIAGTALAGEISLMISIVNG
SYIYAHETFGRNRPRQ
>Mature_416_residues
MDADKMNSARRSQTPTAEIPDGETQKVQVRKFLRNKATAYTAEMIRSRREWLAELTQTRLKHLAHFSEDPADFKGKIECP
IGVAHVPLGIAGPLQINGEHARGVFFIPMATTEGALITSYTFGSNIITRSGGVNVRILKDALKSDPTFVFKSSTEALSFV
TWIENNFGAIKEIAEKTSGHLRLIKAVPVINGRRVILCFHFQTGDALGMNMVYKATDVVCKMIRDSVEPEEFWLHSNFTT
IKKTTAENFVNGYGKSAMADVTVPRKLVARFNTTPEQMERFFLRTLLGSAQGGLFGISAHMANAMTAIAIACGQDAALVA
NTHYANATCETTKNGDLYFSAHFPSLFAATVGGGTSFGTARECLETLGCYGNGKSKRFAEIIAGTALAGEISLMISIVNG
SYIYAHETFGRNRPRQ

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=347, Percent_Identity=35.7348703170029, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI196049380, Length=297, Percent_Identity=35.016835016835, Blast_Score=155, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI25144592, Length=346, Percent_Identity=36.7052023121387, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323565, Length=354, Percent_Identity=32.4858757062147, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323483, Length=354, Percent_Identity=32.4858757062147, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI281362379, Length=390, Percent_Identity=31.2820512820513, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45553469, Length=390, Percent_Identity=31.2820512820513, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24649399, Length=390, Percent_Identity=31.2820512820513, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 45460; Mature: 45460

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDADKMNSARRSQTPTAEIPDGETQKVQVRKFLRNKATAYTAEMIRSRREWLAELTQTRL
CCCHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHLAHFSEDPADFKGKIECPIGVAHVPLGIAGPLQINGEHARGVFFIPMATTEGALITSY
HHHHHCCCCCCCCCCEEECCEEEEECCCCCCCCEEECCCCCCEEEEEEECCCCCCEEEEE
TFGSNIITRSGGVNVRILKDALKSDPTFVFKSSTEALSFVTWIENNFGAIKEIAEKTSGH
ECCCCEEEECCCCEEEEEHHHHHCCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCC
LRLIKAVPVINGRRVILCFHFQTGDALGMNMVYKATDVVCKMIRDSVEPEEFWLHSNFTT
EEEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEEECCCCH
IKKTTAENFVNGYGKSAMADVTVPRKLVARFNTTPEQMERFFLRTLLGSAQGGLFGISAH
HHHHHHHHHHHHCCCCCEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEHHH
MANAMTAIAIACGQDAALVANTHYANATCETTKNGDLYFSAHFPSLFAATVGGGTSFGTA
HHHHHHHEEEECCCCCEEEEECCCCCCEECCCCCCCEEEEECCCHHHHHHCCCCCCCHHH
RECLETLGCYGNGKSKRFAEIIAGTALAGEISLMISIVNGSYIYAHETFGRNRPRQ
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEEEEEECCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MDADKMNSARRSQTPTAEIPDGETQKVQVRKFLRNKATAYTAEMIRSRREWLAELTQTRL
CCCHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KHLAHFSEDPADFKGKIECPIGVAHVPLGIAGPLQINGEHARGVFFIPMATTEGALITSY
HHHHHCCCCCCCCCCEEECCEEEEECCCCCCCCEEECCCCCCEEEEEEECCCCCCEEEEE
TFGSNIITRSGGVNVRILKDALKSDPTFVFKSSTEALSFVTWIENNFGAIKEIAEKTSGH
ECCCCEEEECCCCEEEEEHHHHHCCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHCCCC
LRLIKAVPVINGRRVILCFHFQTGDALGMNMVYKATDVVCKMIRDSVEPEEFWLHSNFTT
EEEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHEEEECCCCH
IKKTTAENFVNGYGKSAMADVTVPRKLVARFNTTPEQMERFFLRTLLGSAQGGLFGISAH
HHHHHHHHHHHHCCCCCEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEHHH
MANAMTAIAIACGQDAALVANTHYANATCETTKNGDLYFSAHFPSLFAATVGGGTSFGTA
HHHHHHHEEEECCCCCEEEEECCCCCCEECCCCCCCEEEEECCCHHHHHHCCCCCCCHHH
RECLETLGCYGNGKSKRFAEIIAGTALAGEISLMISIVNGSYIYAHETFGRNRPRQ
HHHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEEEEEECCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]