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The map label for this gene is ddc [H]

Identifier: 116625039

GI number: 116625039

Start: 7486395

End: 7487747

Strand: Direct

Name: ddc [H]

Synonym: Acid_5969

Alternate gene names: 116625039

Gene position: 7486395-7487747 (Clockwise)

Preceding gene: 116625037

Following gene: 116625040

Centisome position: 75.12

GC content: 68.22

Gene sequence:

>1353_bases
ATGACCGAAATATTGCAGCAGGTTGCCGGGCGCGCGGAGCGCTATCTGAAGGAGATCCGCGAGCGCGGCGTAGCTCCCTC
GGCGGAAGCGGTGGCGGGGCTCGATGGATTCCTGGAAGCGCTGCCGGAAGGTCCCACGGCTCCGGCGGATGTGATCGCGA
TGCTGGACGACCTGGGATCGCCGGCAACCATGGGAATCGCAGGGCCCCGATTCTTCGGCTTCGTCATCGGCGGCTCGCTG
CCCGCGGCGCTGGGCGCCAATTGGCTGGCGACGGCATGGGATCAGAACGCGGGCCTGTTCGCCGCGACGCCGATCTCCGC
GGTCATGGAAGAAGTGTCGCTGAGCTGGCTGGTGGACGTGTTAAAGCTCCCGGCGGGCTGCGGCGGAGCCTTCGTGACGG
GGGCGACGGTGGCCAACTTCACGGCGCTCGCGGCGGCGCGCCACGCGGTGCTGGAACGCGCCGGCTGGGACGTGGAAGCC
AAAGGACTCTTCGGCGCCCCGGAAATCCAGGTGGTGATCGGCGATGAAGGGCACCCTTCAATGATCAAATCGCTGGGCAT
GCTCGGGCTGGGGCGGGAGCGGGTGGTGCGCGTGCCGGTGGATGGCCAGGGGCGCATGCGCGCGGACCGGTTGCCGCCAT
TGAACGAGCGCAGCATCGTGTGCGTGCAGGCCGGTAATGTCAACACCGGATCGTTCGACCCCTTGGAAGAGATCATCGCG
AAGGCGCACGCGATGGGCGCGTGGGTCCACGTGGATGGCGCGTTCGGATTGTGGGCGGCGGCGAGCCCGAGTTACGCGCA
CCTCGCGGCGGGAGCGGGCGAAGCCGACTCCTGGGCGACCGATGCGCACAAATGGCTTAACGTGCCCTACGACAGCGGGC
TGGCCTTCGTGCGCAACCCGGACGATCTGCGCGGCGCGATGGGGCTGCAGGCCGCGTATCTGCCGCAGGGCGAGCATCGC
GAGCCATCGCAATTTGTCCCCGAGCTTTCGCGGCGGGCGCGCGCAGTGGACGTCTGGGCGGCGCTGAAATCGCTGGGCCG
CAGCGGCCTGGCCGAACTGATCGAACGCAATTGCCGCTGCGCCAAGCGGTTCGCCGAGGGACTCGCCGCGGCTGGCTTCG
AGGTGCTGAACGATGTGGTGCTGAACCAGGTGCTGGTGGCGTTCGGTTCTCCCGAGGAGACGCAGCGCGCGATCCGCGAG
ATCCAGGAAGACGGCACCTGCTGGTGCGGCGGCACTGCGTGGCAGGGGCGGACGGCGATGCGGATCAGCGTGTCCTCTTG
GGCGACTACCGAGGCTGATGTGGATCGCAGCCTGGAGGCGATGGTGCGAATCGCAACGGCGGCAGTGAAGTAA

Upstream 100 bases:

>100_bases
CTTGGTCTGGGCTGCGAGGACGAGCGGAAGCAGGAAGACAAGTGCGCGCATGAGGGCAAGTATAGCCGATAGGGTGCGGC
TGTCAGGTACTCTGGGTGGG

Downstream 100 bases:

>100_bases
CGCATCTGCCGCAGCCCGGGCGGCAAGCTGTCGCGCGCGCTCGCGGCCGGATGGTCCCATTGTTGATATTGCGGGACTTG
GTTCGCGGCGGGCGGATTGC

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTEILQQVAGRAERYLKEIRERGVAPSAEAVAGLDGFLEALPEGPTAPADVIAMLDDLGSPATMGIAGPRFFGFVIGGSL
PAALGANWLATAWDQNAGLFAATPISAVMEEVSLSWLVDVLKLPAGCGGAFVTGATVANFTALAAARHAVLERAGWDVEA
KGLFGAPEIQVVIGDEGHPSMIKSLGMLGLGRERVVRVPVDGQGRMRADRLPPLNERSIVCVQAGNVNTGSFDPLEEIIA
KAHAMGAWVHVDGAFGLWAAASPSYAHLAAGAGEADSWATDAHKWLNVPYDSGLAFVRNPDDLRGAMGLQAAYLPQGEHR
EPSQFVPELSRRARAVDVWAALKSLGRSGLAELIERNCRCAKRFAEGLAAAGFEVLNDVVLNQVLVAFGSPEETQRAIRE
IQEDGTCWCGGTAWQGRTAMRISVSSWATTEADVDRSLEAMVRIATAAVK

Sequences:

>Translated_450_residues
MTEILQQVAGRAERYLKEIRERGVAPSAEAVAGLDGFLEALPEGPTAPADVIAMLDDLGSPATMGIAGPRFFGFVIGGSL
PAALGANWLATAWDQNAGLFAATPISAVMEEVSLSWLVDVLKLPAGCGGAFVTGATVANFTALAAARHAVLERAGWDVEA
KGLFGAPEIQVVIGDEGHPSMIKSLGMLGLGRERVVRVPVDGQGRMRADRLPPLNERSIVCVQAGNVNTGSFDPLEEIIA
KAHAMGAWVHVDGAFGLWAAASPSYAHLAAGAGEADSWATDAHKWLNVPYDSGLAFVRNPDDLRGAMGLQAAYLPQGEHR
EPSQFVPELSRRARAVDVWAALKSLGRSGLAELIERNCRCAKRFAEGLAAAGFEVLNDVVLNQVLVAFGSPEETQRAIRE
IQEDGTCWCGGTAWQGRTAMRISVSSWATTEADVDRSLEAMVRIATAAVK
>Mature_449_residues
TEILQQVAGRAERYLKEIRERGVAPSAEAVAGLDGFLEALPEGPTAPADVIAMLDDLGSPATMGIAGPRFFGFVIGGSLP
AALGANWLATAWDQNAGLFAATPISAVMEEVSLSWLVDVLKLPAGCGGAFVTGATVANFTALAAARHAVLERAGWDVEAK
GLFGAPEIQVVIGDEGHPSMIKSLGMLGLGRERVVRVPVDGQGRMRADRLPPLNERSIVCVQAGNVNTGSFDPLEEIIAK
AHAMGAWVHVDGAFGLWAAASPSYAHLAAGAGEADSWATDAHKWLNVPYDSGLAFVRNPDDLRGAMGLQAAYLPQGEHRE
PSQFVPELSRRARAVDVWAALKSLGRSGLAELIERNCRCAKRFAEGLAAAGFEVLNDVVLNQVLVAFGSPEETQRAIREI
QEDGTCWCGGTAWQGRTAMRISVSSWATTEADVDRSLEAMVRIATAAVK

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI4503281, Length=479, Percent_Identity=25.8872651356994, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI132814448, Length=479, Percent_Identity=25.8872651356994, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI197383062, Length=357, Percent_Identity=27.4509803921569, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI92110055, Length=448, Percent_Identity=24.3303571428571, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI194294551, Length=412, Percent_Identity=26.6990291262136, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI58331246, Length=459, Percent_Identity=23.0936819172113, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI197276620, Length=354, Percent_Identity=24.2937853107345, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4503875, Length=354, Percent_Identity=24.2937853107345, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17534819, Length=461, Percent_Identity=27.114967462039, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17534817, Length=461, Percent_Identity=27.114967462039, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17555682, Length=443, Percent_Identity=23.2505643340858, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71993062, Length=412, Percent_Identity=23.7864077669903, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71993058, Length=358, Percent_Identity=23.463687150838, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI133931025, Length=428, Percent_Identity=24.5327102803738, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573972, Length=475, Percent_Identity=27.7894736842105, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24586044, Length=466, Percent_Identity=28.3261802575107, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI221476190, Length=458, Percent_Identity=26.6375545851528, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24585143, Length=458, Percent_Identity=26.6375545851528, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24585139, Length=458, Percent_Identity=26.6375545851528, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24652373, Length=471, Percent_Identity=26.5392781316348, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17136594, Length=327, Percent_Identity=27.217125382263, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17136190, Length=452, Percent_Identity=25.4424778761062, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24585135, Length=451, Percent_Identity=25.2771618625277, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21356415, Length=312, Percent_Identity=23.7179487179487, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24657193, Length=417, Percent_Identity=22.0623501199041, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24657185, Length=417, Percent_Identity=22.0623501199041, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24657188, Length=417, Percent_Identity=22.0623501199041, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 47560; Mature: 47428

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEILQQVAGRAERYLKEIRERGVAPSAEAVAGLDGFLEALPEGPTAPADVIAMLDDLGS
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
PATMGIAGPRFFGFVIGGSLPAALGANWLATAWDQNAGLFAATPISAVMEEVSLSWLVDV
CCEECCCCHHHHHHHCCCCCCHHHCCCHHEECCCCCCCEEEECCHHHHHHHHHHHHHHHH
LKLPAGCGGAFVTGATVANFTALAAARHAVLERAGWDVEAKGLFGAPEIQVVIGDEGHPS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEECCCCCHH
MIKSLGMLGLGRERVVRVPVDGQGRMRADRLPPLNERSIVCVQAGNVNTGSFDPLEEIIA
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHH
KAHAMGAWVHVDGAFGLWAAASPSYAHLAAGAGEADSWATDAHKWLNVPYDSGLAFVRNP
HHHHCCEEEEECCCCCHHHCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCC
DDLRGAMGLQAAYLPQGEHREPSQFVPELSRRARAVDVWAALKSLGRSGLAELIERNCRC
HHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AKRFAEGLAAAGFEVLNDVVLNQVLVAFGSPEETQRAIREIQEDGTCWCGGTAWQGRTAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCCEEE
RISVSSWATTEADVDRSLEAMVRIATAAVK
EEEECCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEILQQVAGRAERYLKEIRERGVAPSAEAVAGLDGFLEALPEGPTAPADVIAMLDDLGS
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
PATMGIAGPRFFGFVIGGSLPAALGANWLATAWDQNAGLFAATPISAVMEEVSLSWLVDV
CCEECCCCHHHHHHHCCCCCCHHHCCCHHEECCCCCCCEEEECCHHHHHHHHHHHHHHHH
LKLPAGCGGAFVTGATVANFTALAAARHAVLERAGWDVEAKGLFGAPEIQVVIGDEGHPS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEECCCCCHH
MIKSLGMLGLGRERVVRVPVDGQGRMRADRLPPLNERSIVCVQAGNVNTGSFDPLEEIIA
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHH
KAHAMGAWVHVDGAFGLWAAASPSYAHLAAGAGEADSWATDAHKWLNVPYDSGLAFVRNP
HHHHCCEEEEECCCCCHHHCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCEEEECCC
DDLRGAMGLQAAYLPQGEHREPSQFVPELSRRARAVDVWAALKSLGRSGLAELIERNCRC
HHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
AKRFAEGLAAAGFEVLNDVVLNQVLVAFGSPEETQRAIREIQEDGTCWCGGTAWQGRTAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCCEEE
RISVSSWATTEADVDRSLEAMVRIATAAVK
EEEECCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]