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The map label for this gene is hemN [H]

Identifier: 116624996

GI number: 116624996

Start: 7428206

End: 7429285

Strand: Reverse

Name: hemN [H]

Synonym: Acid_5926

Alternate gene names: 116624996

Gene position: 7429285-7428206 (Counterclockwise)

Preceding gene: 116624999

Following gene: 116624995

Centisome position: 74.55

GC content: 67.22

Gene sequence:

>1080_bases
GTGCCCGGAGTCTACGTCTCATACCCCTTCTGCGCGCAGAAGTGTACCTACTGCAACTTCGCCAGCGGAGTTTTTCCGCG
CGACCAGGAGGCGCCCTATCTCGACGCCCTCGCGCGCGAAATCCGCGCCCACCAGTGGCGCTGGAACCCAGACACCGTCT
ACCTCGGCGGCGGCACGCCCAGCAACCTCGCGCCCGTCGCCCTCCGCGGGCTGCTCGACCTCATCCCCGGCCGTCCCTGG
GCGGAGGCTACGCTCGAAGCCGCACCGGGGAACATCACTCCTGAACTCGCCCGCAGCTGGTCCGACGCCGGGATCAACCG
CGTCTCGCTCGGCGTGCAGTCCTTCTCCGAACCCGAAATCCGCCGCAGCGGCCGCAAGCACACCGCCCAGATCGTCGCCG
CCGAAATCGCCGCCCTGCGCGACGCCGGCATCCGCGACATCAATATCGACCTGATCGCCGGCCTCGCCGCCCAGACCGCC
GACTCCTGGCGCGAATCGCTCGACTGGATCGAGCGCCTCGCCCCCGAGCACGTCTCCGTCTACATGCTCGAAATCGACGA
AGACAGCCGCCTCGGCAAGGAACTCATGCTCGGCGGCGTCCGGTACGGCGCGCTCGACACCCCATCCGAAGACGCCACCG
CCGATTTCTACGAATACGCCGTGGAGCGCCTGGCCGGCATCGGCATCGCGCGCTACGAAATCTCCAACTTCGCGCGCCCC
GGCCACGAATCGCGCCACAATCTGAAATACTGGTGCCTCGAGCCCTACGTCGGTTTCGGCGCCGACGCCCACTCCTTCGA
CGGCAGCACCCGCCATCAGAATCCCGAATCGCTCGCCGACTATCTCGCCGGCACCGCCCAGGTCCCCGACCAGCCGCACC
TCTCCGACGAACGCCTCTTCATCGGACTCCGCCTCTCGGCCGGCGTCCGTCCCGACCCCGACGAGTGGCAGCGCTACGAG
GCGCCCATCCACCGCTTCCTCGATGCCGGATTGCTCGAAACCAGCGACGGCATTCTGCGTCTCACCAACCGCGGCGTCCT
GCTCTCCAACGAAGTCTTCCAGGAGTTCCTAAACATATGA

Upstream 100 bases:

>100_bases
TCGGAGAAGGGGTGCGCCCGAATCCCTGTGCCGTGCGCATCCCGTCACTTGCCGAGAAACGCCCGTTGCTGCCAACCGCG
CGCGTTATCATAGAAGAAAC

Downstream 100 bases:

>100_bases
TCGATCTGCGCAGCGATACCGTCACCAGGCCCACGCCCGCCATGCGCCAGGCCATGTTCGAAGCCGAGGTCGGCGACGAC
GTTTATCGCGAAGACCCCAC

Product: coproporphyrinogen III oxidase, anaerobic

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MPGVYVSYPFCAQKCTYCNFASGVFPRDQEAPYLDALAREIRAHQWRWNPDTVYLGGGTPSNLAPVALRGLLDLIPGRPW
AEATLEAAPGNITPELARSWSDAGINRVSLGVQSFSEPEIRRSGRKHTAQIVAAEIAALRDAGIRDINIDLIAGLAAQTA
DSWRESLDWIERLAPEHVSVYMLEIDEDSRLGKELMLGGVRYGALDTPSEDATADFYEYAVERLAGIGIARYEISNFARP
GHESRHNLKYWCLEPYVGFGADAHSFDGSTRHQNPESLADYLAGTAQVPDQPHLSDERLFIGLRLSAGVRPDPDEWQRYE
APIHRFLDAGLLETSDGILRLTNRGVLLSNEVFQEFLNI

Sequences:

>Translated_359_residues
MPGVYVSYPFCAQKCTYCNFASGVFPRDQEAPYLDALAREIRAHQWRWNPDTVYLGGGTPSNLAPVALRGLLDLIPGRPW
AEATLEAAPGNITPELARSWSDAGINRVSLGVQSFSEPEIRRSGRKHTAQIVAAEIAALRDAGIRDINIDLIAGLAAQTA
DSWRESLDWIERLAPEHVSVYMLEIDEDSRLGKELMLGGVRYGALDTPSEDATADFYEYAVERLAGIGIARYEISNFARP
GHESRHNLKYWCLEPYVGFGADAHSFDGSTRHQNPESLADYLAGTAQVPDQPHLSDERLFIGLRLSAGVRPDPDEWQRYE
APIHRFLDAGLLETSDGILRLTNRGVLLSNEVFQEFLNI
>Mature_358_residues
PGVYVSYPFCAQKCTYCNFASGVFPRDQEAPYLDALAREIRAHQWRWNPDTVYLGGGTPSNLAPVALRGLLDLIPGRPWA
EATLEAAPGNITPELARSWSDAGINRVSLGVQSFSEPEIRRSGRKHTAQIVAAEIAALRDAGIRDINIDLIAGLAAQTAD
SWRESLDWIERLAPEHVSVYMLEIDEDSRLGKELMLGGVRYGALDTPSEDATADFYEYAVERLAGIGIARYEISNFARPG
HESRHNLKYWCLEPYVGFGADAHSFDGSTRHQNPESLADYLAGTAQVPDQPHLSDERLFIGLRLSAGVRPDPDEWQRYEA
PIHRFLDAGLLETSDGILRLTNRGVLLSNEVFQEFLNI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=268, Percent_Identity=31.7164179104478, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1789325, Length=270, Percent_Identity=36.2962962962963, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI87082341, Length=306, Percent_Identity=26.4705882352941, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 39868; Mature: 39737

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGVYVSYPFCAQKCTYCNFASGVFPRDQEAPYLDALAREIRAHQWRWNPDTVYLGGGTP
CCCCEECCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCC
SNLAPVALRGLLDLIPGRPWAEATLEAAPGNITPELARSWSDAGINRVSLGVQSFSEPEI
CCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCHHCCCCCHH
RRSGRKHTAQIVAAEIAALRDAGIRDINIDLIAGLAAQTADSWRESLDWIERLAPEHVSV
HHCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
YMLEIDEDSRLGKELMLGGVRYGALDTPSEDATADFYEYAVERLAGIGIARYEISNFARP
EEEEECCCHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCHHEEEHHHCCCC
GHESRHNLKYWCLEPYVGFGADAHSFDGSTRHQNPESLADYLAGTAQVPDQPHLSDERLF
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEE
IGLRLSAGVRPDPDEWQRYEAPIHRFLDAGLLETSDGILRLTNRGVLLSNEVFQEFLNI
EEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEECHHHHHHHHCC
>Mature Secondary Structure 
PGVYVSYPFCAQKCTYCNFASGVFPRDQEAPYLDALAREIRAHQWRWNPDTVYLGGGTP
CCCEECCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCC
SNLAPVALRGLLDLIPGRPWAEATLEAAPGNITPELARSWSDAGINRVSLGVQSFSEPEI
CCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCHHCCCCCHH
RRSGRKHTAQIVAAEIAALRDAGIRDINIDLIAGLAAQTADSWRESLDWIERLAPEHVSV
HHCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
YMLEIDEDSRLGKELMLGGVRYGALDTPSEDATADFYEYAVERLAGIGIARYEISNFARP
EEEEECCCHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCHHEEEHHHCCCC
GHESRHNLKYWCLEPYVGFGADAHSFDGSTRHQNPESLADYLAGTAQVPDQPHLSDERLF
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEE
IGLRLSAGVRPDPDEWQRYEAPIHRFLDAGLLETSDGILRLTNRGVLLSNEVFQEFLNI
EEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]