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The map label for this gene is iolS [H]

Identifier: 116624993

GI number: 116624993

Start: 7423265

End: 7424266

Strand: Reverse

Name: iolS [H]

Synonym: Acid_5923

Alternate gene names: 116624993

Gene position: 7424266-7423265 (Counterclockwise)

Preceding gene: 116624994

Following gene: 116624992

Centisome position: 74.5

GC content: 64.17

Gene sequence:

>1002_bases
TTGATTCTCGGTCCTCACGCTAAGCTGGTAGATATGCAATATCGCAAGCTTGGCAGGACCGGGTTCGAGGTCAGCGACAT
CGGCTACGGCGCCTGGGGCATCGGCGGCAAGCAGTGGCTCGGCGGCGCCGACGATGAATCCCTCGCCGCCCTCCGCCACG
CCATCGAATTGGGTGTCAACCTGATCGATACCGCGCTCGCCTATGGCGACGGCCACAGCGAAGAGCTGGTGGGCGAGATC
GTCCGACAGGCGCCGCACAAAATCTACGTCGCCACCAAGGTTCCCCCCAAGAATCGCGTCTGGCCCGCCCATGCCGGTAC
GCCGATCGACGACGTTTTCCCCTACGACTACATCGTCGCCAGCGCCGAGGAGAGCCTGCGCAATCTCAAGCTCGATACCA
TCGACCTCCTTCAACTGCACGTCTGGAACGACGCCTGGGTGGAGCGTGGCGAATGGCGCCGCGCGCTGGAAGACCTGAAG
CGCTCCGGCAAAGTGCGCAGCATCGGCGTCTCCGCCACGGAACACGATCCCGATTCCGCGCTGGCCGTCATGCGCACCGG
CCTGATCGACGCCGTGCAGGTAATCTACAACATCTTCGACCAGACGCCCGAGGCGCACATGCTGCCGCTCGCGCAGGAAT
TGAACATCGGCATTCTGGCGCGCGTCCCGCTCGATGAAGGCGCGCTCTCCGGCACCATGACCGCTGATACGACCTTCCCG
CCCGGAGATTTCCGCGAGTTCTATTTCCAGGGCAACCGCAAGCAGCAGGTGGTGGAGCATGTCGATGCGCTGCGTAAAGA
TCTGGGCGCCGGCGTGGGCCTGCCCGAGACCGCGCTCCGCTTCTGCCTCTCGCACCCCGCCGTCTCCAGCGTGATCCCCG
GTATGCGCACGCGCCGCCACGTGGAATCGAACGCCTCGCAGTCGGATCTCGGGGCTCTGGATGCAGCCACGCTCGCCATC
CTCAAGCGCCATGCCTGGGATCGCAATTTCTACAGCTTATGA

Upstream 100 bases:

>100_bases
CGCCGTGAACTAGTAAGAATTACCAACCGCTTGCTGACGCGCGCCGCCCATCAGAGCCGCGACCGTGAGGGAGCGGTCGC
TAATTTAAGATCTTAGTCTT

Downstream 100 bases:

>100_bases
CCAAGACCTCCTTGGATAAATCCAAGATCAAAATCCTCCTGCTCGAAGGCATTCATCCCAGTGCCGTGGAAAAATTCCGG
CAGGATGGCTATGACAACAT

Product: aldo/keto reductase

Products: NA

Alternate protein names: AKR11A; Vegetative protein 147; VEG147 [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MILGPHAKLVDMQYRKLGRTGFEVSDIGYGAWGIGGKQWLGGADDESLAALRHAIELGVNLIDTALAYGDGHSEELVGEI
VRQAPHKIYVATKVPPKNRVWPAHAGTPIDDVFPYDYIVASAEESLRNLKLDTIDLLQLHVWNDAWVERGEWRRALEDLK
RSGKVRSIGVSATEHDPDSALAVMRTGLIDAVQVIYNIFDQTPEAHMLPLAQELNIGILARVPLDEGALSGTMTADTTFP
PGDFREFYFQGNRKQQVVEHVDALRKDLGAGVGLPETALRFCLSHPAVSSVIPGMRTRRHVESNASQSDLGALDAATLAI
LKRHAWDRNFYSL

Sequences:

>Translated_333_residues
MILGPHAKLVDMQYRKLGRTGFEVSDIGYGAWGIGGKQWLGGADDESLAALRHAIELGVNLIDTALAYGDGHSEELVGEI
VRQAPHKIYVATKVPPKNRVWPAHAGTPIDDVFPYDYIVASAEESLRNLKLDTIDLLQLHVWNDAWVERGEWRRALEDLK
RSGKVRSIGVSATEHDPDSALAVMRTGLIDAVQVIYNIFDQTPEAHMLPLAQELNIGILARVPLDEGALSGTMTADTTFP
PGDFREFYFQGNRKQQVVEHVDALRKDLGAGVGLPETALRFCLSHPAVSSVIPGMRTRRHVESNASQSDLGALDAATLAI
LKRHAWDRNFYSL
>Mature_333_residues
MILGPHAKLVDMQYRKLGRTGFEVSDIGYGAWGIGGKQWLGGADDESLAALRHAIELGVNLIDTALAYGDGHSEELVGEI
VRQAPHKIYVATKVPPKNRVWPAHAGTPIDDVFPYDYIVASAEESLRNLKLDTIDLLQLHVWNDAWVERGEWRRALEDLK
RSGKVRSIGVSATEHDPDSALAVMRTGLIDAVQVIYNIFDQTPEAHMLPLAQELNIGILARVPLDEGALSGTMTADTTFP
PGDFREFYFQGNRKQQVVEHVDALRKDLGAGVGLPETALRFCLSHPAVSSVIPGMRTRRHVESNASQSDLGALDAATLAI
LKRHAWDRNFYSL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=324, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI27436964, Length=325, Percent_Identity=26.1538461538462, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4504825, Length=322, Percent_Identity=25.776397515528, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI27436962, Length=320, Percent_Identity=25.9375, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI27436966, Length=320, Percent_Identity=25.625, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788070, Length=325, Percent_Identity=29.2307692307692, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081735, Length=296, Percent_Identity=29.0540540540541, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788081, Length=314, Percent_Identity=28.6624203821656, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789199, Length=335, Percent_Identity=26.2686567164179, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789375, Length=334, Percent_Identity=24.251497005988, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI212645785, Length=309, Percent_Identity=26.8608414239482, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325169, Length=289, Percent_Identity=24.9134948096886, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646155, Length=339, Percent_Identity=28.6135693215339, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24646159, Length=234, Percent_Identity=33.7606837606838, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 36674; Mature: 36674

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILGPHAKLVDMQYRKLGRTGFEVSDIGYGAWGIGGKQWLGGADDESLAALRHAIELGVN
CCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHH
LIDTALAYGDGHSEELVGEIVRQAPHKIYVATKVPPKNRVWPAHAGTPIDDVFPYDYIVA
HHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCHHHHHH
SAEESLRNLKLDTIDLLQLHVWNDAWVERGEWRRALEDLKRSGKVRSIGVSATEHDPDSA
HHHHHHHHCCCCCEEEHEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHH
LAVMRTGLIDAVQVIYNIFDQTPEAHMLPLAQELNIGILARVPLDEGALSGTMTADTTFP
HHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHCCCCEEEECCCCCCCCCCCEECCCCCC
PGDFREFYFQGNRKQQVVEHVDALRKDLGAGVGLPETALRFCLSHPAVSSVIPGMRTRRH
CCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHCCCHHHHHH
VESNASQSDLGALDAATLAILKRHAWDRNFYSL
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MILGPHAKLVDMQYRKLGRTGFEVSDIGYGAWGIGGKQWLGGADDESLAALRHAIELGVN
CCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHH
LIDTALAYGDGHSEELVGEIVRQAPHKIYVATKVPPKNRVWPAHAGTPIDDVFPYDYIVA
HHHHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHCCCHHHHHH
SAEESLRNLKLDTIDLLQLHVWNDAWVERGEWRRALEDLKRSGKVRSIGVSATEHDPDSA
HHHHHHHHCCCCCEEEHEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHH
LAVMRTGLIDAVQVIYNIFDQTPEAHMLPLAQELNIGILARVPLDEGALSGTMTADTTFP
HHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHCCCCEEEECCCCCCCCCCCEECCCCCC
PGDFREFYFQGNRKQQVVEHVDALRKDLGAGVGLPETALRFCLSHPAVSSVIPGMRTRRH
CCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHCCCHHHHHH
VESNASQSDLGALDAATLAILKRHAWDRNFYSL
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377; 9298659 [H]