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The map label for this gene is serA [H]

Identifier: 116624992

GI number: 116624992

Start: 7422030

End: 7423268

Strand: Reverse

Name: serA [H]

Synonym: Acid_5922

Alternate gene names: 116624992

Gene position: 7423268-7422030 (Counterclockwise)

Preceding gene: 116624993

Following gene: 116624987

Centisome position: 74.49

GC content: 63.52

Gene sequence:

>1239_bases
ATGACCAAGACCTCCTTGGATAAATCCAAGATCAAAATCCTCCTGCTCGAAGGCATTCATCCCAGTGCCGTGGAAAAATT
CCGGCAGGATGGCTATGACAACATCGAATGCCACCAGAAGTCCCTCACCGGCTCCGCGCTGGAAGAGGCCGCCGCCGACG
CTTACTTTGTCGGCATTCGCTCCGCCACGCAGCTGGAGCGCGCCTTCTTCGAGAATGCTTCCCGGCTGACAGGCGTTGGC
TGCTTCTGCATCGGCACCAATCAGGTGAATCTTTCAGCCGCCGAAGAGCGCGGCGTCCCGGTCTTCAACGCGCCCTTTTC
CAACACGCGCAGCGTCGCCGAACTGGTGCTGGCGGAGATCATCATTCTCATGCGCGGCATCCCGCAGCGCAACGCCGCGG
CCCATCGCGGCGGCTGGCTGAAGACCGCCACCGGTAGCCACGAAGTGCGCGGCAAGACGCTCGGCATCGTCGGCTACGGC
CACATTGGGACCCAGGTCGGCGTACTGGCCGAATCGCTCGGCATGCAGGTGGTGACCTACGACGTGGAGAGCAAGCTCGC
GCTCGGCAATGCCCGCGCACTCGGCTCGCTCGACGCGCTGCTTGAAATCAGCGACGTGGTCACGCTCCATGTTCCCGAGA
CCCCGGCTACCTTTCAGATGATCGGCGCCGAGCAGCTGGCCCGCATGAAGCCGGGCGCGCGCCTGATCAACGCCTCCCGC
GGCACCGTGGTGGAGATTCAGGCGCTGGCCGCCGCCCTCGCTTCCCAACACCTGGCCGGGGCCGCGATCGACGTCTTCCC
GGCCGAGCCCAAGAGCACCGCCGACCTGTTCTACTCGCCTTTACGCGGCATGGATAACGTCCTGCTGACCCCGCACGTCG
GCGGCAGCACGGAGGAGGCGCAGGAGAATATCGGTGTCGAAGTGGCGCAGAAGCTGATCAAGTACAGCGATAACGGCTCC
ACGCTCGGCGCTGTCAATTTCCCGGAGGTCTCGCTCCCCGAACATCCCGGCAAGCATCGCGTGCTCCACATCCACCACAA
TCAGCCGGGCGTGCTTTCCGCGATCAACGCGGTCTTCTCCGAAGACGCGATCAACATCGCCGCCGAGTATCTGCAAACCG
ATGCGAAGGTCGGCTACGTGGTAATCGACGTGGAAACCGACGAGCGCGACGAGACCGCCAACATCCGCCGCAAACTCGAA
CTGGTCCCCGGCACCATCCGCACCCGCATCCTCTATTAA

Upstream 100 bases:

>100_bases
ACGTGGAATCGAACGCCTCGCAGTCGGATCTCGGGGCTCTGGATGCAGCCACGCTCGCCATCCTCAAGCGCCATGCCTGG
GATCGCAATTTCTACAGCTT

Downstream 100 bases:

>100_bases
CTCAACGAGCCGCGACCGTGAGGGAGCGATCCTTTGCGTCACGCCGCGTTGTACTACTCTGCATTGGTCTGCGCCATCAG
AGCCGCGACCGTCAGGGAGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTKTSLDKSKIKILLLEGIHPSAVEKFRQDGYDNIECHQKSLTGSALEEAAADAYFVGIRSATQLERAFFENASRLTGVG
CFCIGTNQVNLSAAEERGVPVFNAPFSNTRSVAELVLAEIIILMRGIPQRNAAAHRGGWLKTATGSHEVRGKTLGIVGYG
HIGTQVGVLAESLGMQVVTYDVESKLALGNARALGSLDALLEISDVVTLHVPETPATFQMIGAEQLARMKPGARLINASR
GTVVEIQALAAALASQHLAGAAIDVFPAEPKSTADLFYSPLRGMDNVLLTPHVGGSTEEAQENIGVEVAQKLIKYSDNGS
TLGAVNFPEVSLPEHPGKHRVLHIHHNQPGVLSAINAVFSEDAINIAAEYLQTDAKVGYVVIDVETDERDETANIRRKLE
LVPGTIRTRILY

Sequences:

>Translated_412_residues
MTKTSLDKSKIKILLLEGIHPSAVEKFRQDGYDNIECHQKSLTGSALEEAAADAYFVGIRSATQLERAFFENASRLTGVG
CFCIGTNQVNLSAAEERGVPVFNAPFSNTRSVAELVLAEIIILMRGIPQRNAAAHRGGWLKTATGSHEVRGKTLGIVGYG
HIGTQVGVLAESLGMQVVTYDVESKLALGNARALGSLDALLEISDVVTLHVPETPATFQMIGAEQLARMKPGARLINASR
GTVVEIQALAAALASQHLAGAAIDVFPAEPKSTADLFYSPLRGMDNVLLTPHVGGSTEEAQENIGVEVAQKLIKYSDNGS
TLGAVNFPEVSLPEHPGKHRVLHIHHNQPGVLSAINAVFSEDAINIAAEYLQTDAKVGYVVIDVETDERDETANIRRKLE
LVPGTIRTRILY
>Mature_411_residues
TKTSLDKSKIKILLLEGIHPSAVEKFRQDGYDNIECHQKSLTGSALEEAAADAYFVGIRSATQLERAFFENASRLTGVGC
FCIGTNQVNLSAAEERGVPVFNAPFSNTRSVAELVLAEIIILMRGIPQRNAAAHRGGWLKTATGSHEVRGKTLGIVGYGH
IGTQVGVLAESLGMQVVTYDVESKLALGNARALGSLDALLEISDVVTLHVPETPATFQMIGAEQLARMKPGARLINASRG
TVVEIQALAAALASQHLAGAAIDVFPAEPKSTADLFYSPLRGMDNVLLTPHVGGSTEEAQENIGVEVAQKLIKYSDNGST
LGAVNFPEVSLPEHPGKHRVLHIHHNQPGVLSAINAVFSEDAINIAAEYLQTDAKVGYVVIDVETDERDETANIRRKLEL
VPGTIRTRILY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=32.4921135646688, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI145580578, Length=228, Percent_Identity=33.7719298245614, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557499, Length=228, Percent_Identity=33.7719298245614, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI61743967, Length=240, Percent_Identity=32.0833333333333, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557497, Length=240, Percent_Identity=32.0833333333333, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580575, Length=238, Percent_Identity=32.7731092436975, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI6912396, Length=274, Percent_Identity=25.5474452554745, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1789279, Length=412, Percent_Identity=62.621359223301, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI87082289, Length=256, Percent_Identity=32.03125, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1787645, Length=244, Percent_Identity=29.0983606557377, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788660, Length=309, Percent_Identity=26.537216828479, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081824, Length=162, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=33.2298136645963, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=305, Percent_Identity=29.1803278688525, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=46.1352657004831, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=46.1352657004831, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324055, Length=239, Percent_Identity=28.4518828451883, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=28.90625, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19921140, Length=307, Percent_Identity=32.5732899022801, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24646446, Length=245, Percent_Identity=30.6122448979592, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646448, Length=245, Percent_Identity=30.6122448979592, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646452, Length=245, Percent_Identity=30.6122448979592, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646450, Length=245, Percent_Identity=30.6122448979592, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI62472511, Length=310, Percent_Identity=28.7096774193548, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI28571528, Length=272, Percent_Identity=27.2058823529412, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574286, Length=238, Percent_Identity=27.3109243697479, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45552429, Length=249, Percent_Identity=24.8995983935743, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24585514, Length=249, Percent_Identity=24.4979919678715, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28574282, Length=249, Percent_Identity=24.4979919678715, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28574284, Length=249, Percent_Identity=24.4979919678715, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45551003, Length=249, Percent_Identity=24.4979919678715, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24585516, Length=246, Percent_Identity=23.9837398373984, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44187; Mature: 44056

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTSLDKSKIKILLLEGIHPSAVEKFRQDGYDNIECHQKSLTGSALEEAAADAYFVGIR
CCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHCCEEEEECC
SATQLERAFFENASRLTGVGCFCIGTNQVNLSAAEERGVPVFNAPFSNTRSVAELVLAEI
CHHHHHHHHHHCCCHHCCEEEEEEECCEEEEEEHHHCCCCEEECCCCCHHHHHHHHHHHH
IILMRGIPQRNAAAHRGGWLKTATGSHEVRGKTLGIVGYGHIGTQVGVLAESLGMQVVTY
HHHHCCCCCCCCHHHCCCEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEE
DVESKLALGNARALGSLDALLEISDVVTLHVPETPATFQMIGAEQLARMKPGARLINASR
ECCCCEECCCCHHHHHHHHHHEEEEEEEEEECCCCCHHHHHCHHHHHHCCCCCEEEECCC
GTVVEIQALAAALASQHLAGAAIDVFPAEPKSTADLFYSPLRGMDNVLLTPHVGGSTEEA
CCEEEHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHH
QENIGVEVAQKLIKYSDNGSTLGAVNFPEVSLPEHPGKHRVLHIHHNQPGVLSAINAVFS
HHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHH
EDAINIAAEYLQTDAKVGYVVIDVETDERDETANIRRKLELVPGTIRTRILY
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure 
TKTSLDKSKIKILLLEGIHPSAVEKFRQDGYDNIECHQKSLTGSALEEAAADAYFVGIR
CCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHCCEEEEECC
SATQLERAFFENASRLTGVGCFCIGTNQVNLSAAEERGVPVFNAPFSNTRSVAELVLAEI
CHHHHHHHHHHCCCHHCCEEEEEEECCEEEEEEHHHCCCCEEECCCCCHHHHHHHHHHHH
IILMRGIPQRNAAAHRGGWLKTATGSHEVRGKTLGIVGYGHIGTQVGVLAESLGMQVVTY
HHHHCCCCCCCCHHHCCCEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEE
DVESKLALGNARALGSLDALLEISDVVTLHVPETPATFQMIGAEQLARMKPGARLINASR
ECCCCEECCCCHHHHHHHHHHEEEEEEEEEECCCCCHHHHHCHHHHHHCCCCCEEEECCC
GTVVEIQALAAALASQHLAGAAIDVFPAEPKSTADLFYSPLRGMDNVLLTPHVGGSTEEA
CCEEEHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHH
QENIGVEVAQKLIKYSDNGSTLGAVNFPEVSLPEHPGKHRVLHIHHNQPGVLSAINAVFS
HHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHH
EDAINIAAEYLQTDAKVGYVVIDVETDERDETANIRRKLELVPGTIRTRILY
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]