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The map label for this gene is phoP [H]

Identifier: 116624990

GI number: 116624990

Start: 7416579

End: 7418072

Strand: Direct

Name: phoP [H]

Synonym: Acid_5920

Alternate gene names: 116624990

Gene position: 7416579-7418072 (Clockwise)

Preceding gene: 116624989

Following gene: 116624991

Centisome position: 74.42

GC content: 64.39

Gene sequence:

>1494_bases
ATGGCGGGCGAAAGCATCCTGGTGGTGGACGATTCGGCGGTGAACCTGAAGCTAGCGGCGGCAGTCCTGCGCAGCGATGG
ATACCGGGTGACGGTTGCATCCAGCGCCGAGCAGGCGATCATGACGCTGCGCACCACCGTTCCCGACCTGGTGCTGGTGG
ACATCCAGCTCCCCGGCATGAGCGGGCTTGCCCTGACGCGCCATATTCGCGAGGACTCGCGCCTTCGCAAAGTGATGGTG
GTGGTGCTGACGGCCTCCACGGCGCCGGAATGCGAACAACAGGCCTATGAGGCGGGCTGCGATGGCTTCATCTGCAAGCC
GATCGACACACGCACGCTGGGACCGAGGCTGCGGAACTTTCTGGAAGGCGCTACCGCAATACCCGAAAGCAGCGCGAAGG
AGAGCGGAGGGGGCGGCGGGCTGGGGCTGTCCGGTCCGGAGATGGAGAGCTTGCGCCGGAGCTTCCTGGTGGACGGCCTG
CGCCAGGTGCGCCGCATGCTCGAATTTTCGGGCTCGGAGATGGACGCAAACACGGTGGCGCGCCAGTTTCATCAATGGAT
TGGCTCCGCGGGGGCGCTCGGCTACCTGGAGCTCGCGGAGCAGGCGCGCGCCGCTGAAGCGCTGCTCGGACACCCCGGCT
GGACCAGGGACGATCTGCGCCAGATGTTGGCGGCGCTCGCGTCCGCCTTCTCTTCCCCGCGTGAAGCCGCCGACACGCCG
ATTCCCGAACGCATGGCGCAGGAGTTAGAACGTAAGCGCATCGCCCTGGTCGGATTTGCGGACGAGGAGGCCGAGCGGGT
TTGCGTGGCCTTCGAAAAGGTGAAGGCGCTGCCGCGCCTGTTCAGCGGAGATGAGCCGCCCGATTCCGAGTTACTGCGCG
ATTGCAGCGTGGTCATGGTCCATGTCCGGGAGCAGACGCGAGACATTCCCTGGTTAAAAGTGGATTGCCCCTCGCGGAAG
CCAATGGTGCTGGTTGGCGGCCGCGACCAGCTGCTGGCGCTGCCGGCGGCGGTGCAGTCACGCGCTTGTGAATTCCTGAT
CGATGGGTGGCAGCCGGAGGAAGTAGTGTTGCGGCTCAGCTTCGCGCTGGCCCGGTCGGCCGAAACCGGCGTCGCGGCTC
AGGAGCCTCCGCAAGACTCGAGGCCGAACATCGTGATTGCCGATGACGATACTAACGTACTGGCGGTGGTTCGCAATACG
CTGGAGAGTCTGGGCATGCTGTGCAGATGCGCGATCAGCGGGGAAGAGGCACTGAGAATGATTCGAGAGCACTGCCCCCA
GGCCGCGGTGCTCGATGTCAACATGCCGGACATCGACGGATTTGACGTGCTTGCGGGCATCCGGCATGCAGGCTTGCGAG
TCAAAGTCATCATGCTGACTGCGCGCCAGCATGAACGGGACGTACTGCGCGGTTTTGAACTGGGCGCGGACGATTACGTC
GTAAAGCCGTTTAACCCACTGGAGCTGGCGGCACGATTAAAGCGGCTGGTGTAG

Upstream 100 bases:

>100_bases
CTGCGCAACGGCAAGGTCGAATTCGCCAGAGCGCGCTAACTTTTTCAGCACCTGTAGTAATCATTGCTACCGCGGGGGAT
GCGGAGTATTCTCTAGGTTC

Downstream 100 bases:

>100_bases
GACGCCCCCTGACGGTCGCGGCTCGTTGGGGACACATTCTTTGCGGTGCGAATCAAATACAGGAGTGGACAGGCCCGAAG
GCCTGTCCTACACTGCGCGC

Product: response regulator receiver protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MAGESILVVDDSAVNLKLAAAVLRSDGYRVTVASSAEQAIMTLRTTVPDLVLVDIQLPGMSGLALTRHIREDSRLRKVMV
VVLTASTAPECEQQAYEAGCDGFICKPIDTRTLGPRLRNFLEGATAIPESSAKESGGGGGLGLSGPEMESLRRSFLVDGL
RQVRRMLEFSGSEMDANTVARQFHQWIGSAGALGYLELAEQARAAEALLGHPGWTRDDLRQMLAALASAFSSPREAADTP
IPERMAQELERKRIALVGFADEEAERVCVAFEKVKALPRLFSGDEPPDSELLRDCSVVMVHVREQTRDIPWLKVDCPSRK
PMVLVGGRDQLLALPAAVQSRACEFLIDGWQPEEVVLRLSFALARSAETGVAAQEPPQDSRPNIVIADDDTNVLAVVRNT
LESLGMLCRCAISGEEALRMIREHCPQAAVLDVNMPDIDGFDVLAGIRHAGLRVKVIMLTARQHERDVLRGFELGADDYV
VKPFNPLELAARLKRLV

Sequences:

>Translated_497_residues
MAGESILVVDDSAVNLKLAAAVLRSDGYRVTVASSAEQAIMTLRTTVPDLVLVDIQLPGMSGLALTRHIREDSRLRKVMV
VVLTASTAPECEQQAYEAGCDGFICKPIDTRTLGPRLRNFLEGATAIPESSAKESGGGGGLGLSGPEMESLRRSFLVDGL
RQVRRMLEFSGSEMDANTVARQFHQWIGSAGALGYLELAEQARAAEALLGHPGWTRDDLRQMLAALASAFSSPREAADTP
IPERMAQELERKRIALVGFADEEAERVCVAFEKVKALPRLFSGDEPPDSELLRDCSVVMVHVREQTRDIPWLKVDCPSRK
PMVLVGGRDQLLALPAAVQSRACEFLIDGWQPEEVVLRLSFALARSAETGVAAQEPPQDSRPNIVIADDDTNVLAVVRNT
LESLGMLCRCAISGEEALRMIREHCPQAAVLDVNMPDIDGFDVLAGIRHAGLRVKVIMLTARQHERDVLRGFELGADDYV
VKPFNPLELAARLKRLV
>Mature_496_residues
AGESILVVDDSAVNLKLAAAVLRSDGYRVTVASSAEQAIMTLRTTVPDLVLVDIQLPGMSGLALTRHIREDSRLRKVMVV
VLTASTAPECEQQAYEAGCDGFICKPIDTRTLGPRLRNFLEGATAIPESSAKESGGGGGLGLSGPEMESLRRSFLVDGLR
QVRRMLEFSGSEMDANTVARQFHQWIGSAGALGYLELAEQARAAEALLGHPGWTRDDLRQMLAALASAFSSPREAADTPI
PERMAQELERKRIALVGFADEEAERVCVAFEKVKALPRLFSGDEPPDSELLRDCSVVMVHVREQTRDIPWLKVDCPSRKP
MVLVGGRDQLLALPAAVQSRACEFLIDGWQPEEVVLRLSFALARSAETGVAAQEPPQDSRPNIVIADDDTNVLAVVRNTL
ESLGMLCRCAISGEEALRMIREHCPQAAVLDVNMPDIDGFDVLAGIRHAGLRVKVIMLTARQHERDVLRGFELGADDYVV
KPFNPLELAARLKRLV

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=112, Percent_Identity=34.8214285714286, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1786599, Length=113, Percent_Identity=34.5132743362832, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790860, Length=118, Percent_Identity=33.8983050847458, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790863, Length=120, Percent_Identity=35, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788394, Length=161, Percent_Identity=31.055900621118, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI2367329, Length=111, Percent_Identity=41.4414414414414, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790552, Length=114, Percent_Identity=35.9649122807018, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789402, Length=114, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=146, Percent_Identity=30.1369863013699, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994928, Length=212, Percent_Identity=26.8867924528302, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786911, Length=112, Percent_Identity=34.8214285714286, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1787375, Length=114, Percent_Identity=28.9473684210526, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 54205; Mature: 54074

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGESILVVDDSAVNLKLAAAVLRSDGYRVTVASSAEQAIMTLRTTVPDLVLVDIQLPGM
CCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCEEEEEEECCCC
SGLALTRHIREDSRLRKVMVVVLTASTAPECEQQAYEAGCDGFICKPIDTRTLGPRLRNF
CCHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHCCCCCEEECCCCCCCCCHHHHHH
LEGATAIPESSAKESGGGGGLGLSGPEMESLRRSFLVDGLRQVRRMLEFSGSEMDANTVA
HCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RQFHQWIGSAGALGYLELAEQARAAEALLGHPGWTRDDLRQMLAALASAFSSPREAADTP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCC
IPERMAQELERKRIALVGFADEEAERVCVAFEKVKALPRLFSGDEPPDSELLRDCSVVMV
CHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
HVREQTRDIPWLKVDCPSRKPMVLVGGRDQLLALPAAVQSRACEFLIDGWQPEEVVLRLS
HHHHHHCCCCEEEEECCCCCCEEEECCCCCEEECHHHHHHHHHHHHHCCCCHHHHHHHHH
FALARSAETGVAAQEPPQDSRPNIVIADDDTNVLAVVRNTLESLGMLCRCAISGEEALRM
HHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IREHCPQAAVLDVNMPDIDGFDVLAGIRHAGLRVKVIMLTARQHERDVLRGFELGADDYV
HHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHCCCCCCEE
VKPFNPLELAARLKRLV
ECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AGESILVVDDSAVNLKLAAAVLRSDGYRVTVASSAEQAIMTLRTTVPDLVLVDIQLPGM
CCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCEEEEEEECCCC
SGLALTRHIREDSRLRKVMVVVLTASTAPECEQQAYEAGCDGFICKPIDTRTLGPRLRNF
CCHHHHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHCCCCCEEECCCCCCCCCHHHHHH
LEGATAIPESSAKESGGGGGLGLSGPEMESLRRSFLVDGLRQVRRMLEFSGSEMDANTVA
HCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RQFHQWIGSAGALGYLELAEQARAAEALLGHPGWTRDDLRQMLAALASAFSSPREAADTP
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCC
IPERMAQELERKRIALVGFADEEAERVCVAFEKVKALPRLFSGDEPPDSELLRDCSVVMV
CHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
HVREQTRDIPWLKVDCPSRKPMVLVGGRDQLLALPAAVQSRACEFLIDGWQPEEVVLRLS
HHHHHHCCCCEEEEECCCCCCEEEECCCCCEEECHHHHHHHHHHHHHCCCCHHHHHHHHH
FALARSAETGVAAQEPPQDSRPNIVIADDDTNVLAVVRNTLESLGMLCRCAISGEEALRM
HHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IREHCPQAAVLDVNMPDIDGFDVLAGIRHAGLRVKVIMLTARQHERDVLRGFELGADDYV
HHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHCCCCCCEE
VKPFNPLELAARLKRLV
ECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]