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The map label for this gene is hmgA [H]

Identifier: 116624804

GI number: 116624804

Start: 7174401

End: 7175936

Strand: Direct

Name: hmgA [H]

Synonym: Acid_5728

Alternate gene names: 116624804

Gene position: 7174401-7175936 (Clockwise)

Preceding gene: 116624802

Following gene: 116624807

Centisome position: 71.99

GC content: 63.35

Gene sequence:

>1536_bases
ATGATCCCGACTGCATTGCTCAACTCTCTGTACACCGTCGGCAGCCTCAAGAACGGCGCCGGCGGCGTGGAGTTCGCGAT
CAAGAACCGCCTGGCGGATGCTGAGCTTGTGGGCATCTCGGCGATTGCGATCGATGGGCACGCCGTTGCCATGGAGCAGG
TCTGGTTGGACCTGGAGGACGGCCGCGAGGTTTTGCCGCTGGAAGTAAGCGCGGCACAGCCGATTGCCTTTCCCCTGCGC
TGCACGGTCAAGGTCCACGCGGGCGGAGATCCGCTGCGCGCGGCGAAACACAGGCTTGAGATCGCGTTCGATACGCGCCC
CTTTGGAAAACTCGATCTGAAGGTAGAGGATGCGGTGGCCGAGAACGGCCAGCCGGCAGTTTCCATTCCGCGCGGCGAGG
ACGATTACAGCCCGGTGAACGTGGCCCGGCGGCGGGCCTTCCTGGAAAGCCAGACCGGAATGTCGCCGCGGCACATCTTC
CACCACTCGCTCGATCCGCGCGACGCCAAGGGCAATTGCGAGAACTTCGTGGGCGTAGCGCAGGTGCCGATCGGGATCGC
CGGACCACTTCATGTTCGCGGAGAGCACGCGCAGGGCAATTTCCTGATCCCGCTGGCGACTTCCGAAGGGACGCTGGTGG
CCTCCTACAACCGCGGCATGAAGGTACTCAACCTGTGCGGCGGCGTGAAAGTAACTGTGGTGGGCGACGCGATGCAGCGC
GCTCCCGCGTTCATCTTCGAGGACGCTCGCGCAGGCCGCGATTTTTCCATCTGGGTGCAGGACAATCTGGCGACGATCCG
CGCCCAGGCCGAGGCGACTTCGAGCGTGGCCAAGCTGCAGTACATCGACACCTACCTGGCGAGCAAGTTCGTTTACCTGC
GGTTCAATTTTTCAACCGGCGATGCCGCCGGCCAGAACATGGTGGGCCGCGCGACCCTCGCCGCCTGCGAGTGGATTCTG
GAGCACTATCACGGGATCGTCAGCTTCTATCTCGAATCGAACTTCGCCACGGATAAGAAGGCTTCGGACATCAACCGCCT
GCGAACCCGCGGCAAGCGTGTGACCGCGGAGGCCGTAATCCAGCGCGATGTGCTGATCGGCCACATGCGAGTGGAACCGG
AACAACTCACTCATCACTACGGCGTTGCCAATGTCGGGGCTCTGCTTTCGGGCGCGAACAACAACGGCGGCCACTCGGCC
AACGGGATCGCGGCCATGTTCATCGCCACCGGCCAGGACGCGGCCAACGTCGCCGAATCCTCGGCGGCCGTCCTGTATAC
GGAGTTGACGCCGCAGCGCGACCTGTATATCTCGTTGACGATTCCTTCGCTGATCGTCGCCACGCACGGGGGCGGCACTG
GATTGGCGACGCAGCGCGAATGTCTCGAAATCCTCCGATGTTACGGGCGCGATCGAGTCAATCGTCTGGCGGAGATCATC
GGCGGCGTAGCGCTGGCCGGGGAGATCTCCCTCGGCGCTGCGATTTCGGCGTCGGACTGGGTATCCAGCCACGAGAAGCA
CGGACGCAATCGATAA

Upstream 100 bases:

>100_bases
TGTCAAAAATAGACTACACCCGATATCAGAGAATAACATCATAAATTATTATTGCGGCCCGAATTGCTGTCTTCTACAAT
GCAACTGAGGGCAAGTCGCA

Downstream 100 bases:

>100_bases
GGCAGCGGGCGAAGCCGGCTGAAAACCGGCAGCACCGGTCGAAAGCCCCCACGAATCTCGGGGCTGCCGGGCGCTCCGGA
TCGCTCCTTAACAGTCGCAG

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MIPTALLNSLYTVGSLKNGAGGVEFAIKNRLADAELVGISAIAIDGHAVAMEQVWLDLEDGREVLPLEVSAAQPIAFPLR
CTVKVHAGGDPLRAAKHRLEIAFDTRPFGKLDLKVEDAVAENGQPAVSIPRGEDDYSPVNVARRRAFLESQTGMSPRHIF
HHSLDPRDAKGNCENFVGVAQVPIGIAGPLHVRGEHAQGNFLIPLATSEGTLVASYNRGMKVLNLCGGVKVTVVGDAMQR
APAFIFEDARAGRDFSIWVQDNLATIRAQAEATSSVAKLQYIDTYLASKFVYLRFNFSTGDAAGQNMVGRATLAACEWIL
EHYHGIVSFYLESNFATDKKASDINRLRTRGKRVTAEAVIQRDVLIGHMRVEPEQLTHHYGVANVGALLSGANNNGGHSA
NGIAAMFIATGQDAANVAESSAAVLYTELTPQRDLYISLTIPSLIVATHGGGTGLATQRECLEILRCYGRDRVNRLAEII
GGVALAGEISLGAAISASDWVSSHEKHGRNR

Sequences:

>Translated_511_residues
MIPTALLNSLYTVGSLKNGAGGVEFAIKNRLADAELVGISAIAIDGHAVAMEQVWLDLEDGREVLPLEVSAAQPIAFPLR
CTVKVHAGGDPLRAAKHRLEIAFDTRPFGKLDLKVEDAVAENGQPAVSIPRGEDDYSPVNVARRRAFLESQTGMSPRHIF
HHSLDPRDAKGNCENFVGVAQVPIGIAGPLHVRGEHAQGNFLIPLATSEGTLVASYNRGMKVLNLCGGVKVTVVGDAMQR
APAFIFEDARAGRDFSIWVQDNLATIRAQAEATSSVAKLQYIDTYLASKFVYLRFNFSTGDAAGQNMVGRATLAACEWIL
EHYHGIVSFYLESNFATDKKASDINRLRTRGKRVTAEAVIQRDVLIGHMRVEPEQLTHHYGVANVGALLSGANNNGGHSA
NGIAAMFIATGQDAANVAESSAAVLYTELTPQRDLYISLTIPSLIVATHGGGTGLATQRECLEILRCYGRDRVNRLAEII
GGVALAGEISLGAAISASDWVSSHEKHGRNR
>Mature_511_residues
MIPTALLNSLYTVGSLKNGAGGVEFAIKNRLADAELVGISAIAIDGHAVAMEQVWLDLEDGREVLPLEVSAAQPIAFPLR
CTVKVHAGGDPLRAAKHRLEIAFDTRPFGKLDLKVEDAVAENGQPAVSIPRGEDDYSPVNVARRRAFLESQTGMSPRHIF
HHSLDPRDAKGNCENFVGVAQVPIGIAGPLHVRGEHAQGNFLIPLATSEGTLVASYNRGMKVLNLCGGVKVTVVGDAMQR
APAFIFEDARAGRDFSIWVQDNLATIRAQAEATSSVAKLQYIDTYLASKFVYLRFNFSTGDAAGQNMVGRATLAACEWIL
EHYHGIVSFYLESNFATDKKASDINRLRTRGKRVTAEAVIQRDVLIGHMRVEPEQLTHHYGVANVGALLSGANNNGGHSA
NGIAAMFIATGQDAANVAESSAAVLYTELTPQRDLYISLTIPSLIVATHGGGTGLATQRECLEILRCYGRDRVNRLAEII
GGVALAGEISLGAAISASDWVSSHEKHGRNR

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=351, Percent_Identity=36.4672364672365, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI196049380, Length=297, Percent_Identity=35.016835016835, Blast_Score=158, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25144592, Length=382, Percent_Identity=38.2198952879581, Blast_Score=253, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6323483, Length=448, Percent_Identity=32.1428571428571, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6323565, Length=353, Percent_Identity=35.9773371104816, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI281362379, Length=350, Percent_Identity=36, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI45553469, Length=350, Percent_Identity=36, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24649399, Length=350, Percent_Identity=36, Blast_Score=185, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 54818; Mature: 54818

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPTALLNSLYTVGSLKNGAGGVEFAIKNRLADAELVGISAIAIDGHAVAMEQVWLDLED
CCCHHHHHHHHHHCCCCCCCCCEEEEEHHCCCCCEEEEEEEEEECCCEEEEEHHEEECCC
GREVLPLEVSAAQPIAFPLRCTVKVHAGGDPLRAAKHRLEIAFDTRPFGKLDLKVEDAVA
CCEEEEEEECCCCCEEEEEEEEEEEECCCCHHHHHHHEEEEEECCCCCCEEEEEEEHHHH
ENGQPAVSIPRGEDDYSPVNVARRRAFLESQTGMSPRHIFHHSLDPRDAKGNCENFVGVA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHCCEEE
QVPIGIAGPLHVRGEHAQGNFLIPLATSEGTLVASYNRGMKVLNLCGGVKVTVVGDAMQR
ECCCCCCCCEEEECCCCCCCEEEEEECCCCCEEEECCCCCHHHHHCCCCEEEEECCHHHH
APAFIFEDARAGRDFSIWVQDNLATIRAQAEATSSVAKLQYIDTYLASKFVYLRFNFSTG
CCCEEEECCCCCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCC
DAAGQNMVGRATLAACEWILEHYHGIVSFYLESNFATDKKASDINRLRTRGKRVTAEAVI
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCEEHHHHHH
QRDVLIGHMRVEPEQLTHHYGVANVGALLSGANNNGGHSANGIAAMFIATGQDAANVAES
HHHHEEEEEECCHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHCC
SAAVLYTELTPQRDLYISLTIPSLIVATHGGGTGLATQRECLEILRCYGRDRVNRLAEII
CCEEEEEECCCCCCEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHH
GGVALAGEISLGAAISASDWVSSHEKHGRNR
CCEEEEECEECCCEECHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIPTALLNSLYTVGSLKNGAGGVEFAIKNRLADAELVGISAIAIDGHAVAMEQVWLDLED
CCCHHHHHHHHHHCCCCCCCCCEEEEEHHCCCCCEEEEEEEEEECCCEEEEEHHEEECCC
GREVLPLEVSAAQPIAFPLRCTVKVHAGGDPLRAAKHRLEIAFDTRPFGKLDLKVEDAVA
CCEEEEEEECCCCCEEEEEEEEEEEECCCCHHHHHHHEEEEEECCCCCCEEEEEEEHHHH
ENGQPAVSIPRGEDDYSPVNVARRRAFLESQTGMSPRHIFHHSLDPRDAKGNCENFVGVA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHCCEEE
QVPIGIAGPLHVRGEHAQGNFLIPLATSEGTLVASYNRGMKVLNLCGGVKVTVVGDAMQR
ECCCCCCCCEEEECCCCCCCEEEEEECCCCCEEEECCCCCHHHHHCCCCEEEEECCHHHH
APAFIFEDARAGRDFSIWVQDNLATIRAQAEATSSVAKLQYIDTYLASKFVYLRFNFSTG
CCCEEEECCCCCCCEEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCC
DAAGQNMVGRATLAACEWILEHYHGIVSFYLESNFATDKKASDINRLRTRGKRVTAEAVI
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCEEHHHHHH
QRDVLIGHMRVEPEQLTHHYGVANVGALLSGANNNGGHSANGIAAMFIATGQDAANVAES
HHHHEEEEEECCHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHCC
SAAVLYTELTPQRDLYISLTIPSLIVATHGGGTGLATQRECLEILRCYGRDRVNRLAEII
CCEEEEEECCCCCCEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHH
GGVALAGEISLGAAISASDWVSSHEKHGRNR
CCEEEEECEECCCEECHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]