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The map label for this gene is nuoD2

Identifier: 116624760

GI number: 116624760

Start: 7121138

End: 7122250

Strand: Direct

Name: nuoD2

Synonym: Acid_5684

Alternate gene names: 116624760

Gene position: 7121138-7122250 (Clockwise)

Preceding gene: 116624759

Following gene: 116624761

Centisome position: 71.46

GC content: 61.37

Gene sequence:

>1113_bases
ATGCCGGACTCTACCTTTCTAGACTCCACCGAATTAGTTCTCAACATGGGCCCGCAGCACCCCTCCACGCACGGGGTGCT
CCGCGTCATCCTCAAACTGGATGGCGAGAAGGTCCTGGGGACGGATTGCATCATCGGCTATCTGCACCGTGGGGTGGAGA
AGATCGCCGAGAATCGCACCTACGCGCAATTCAATCCGTACGTGGACCGGATGGATTACGTGGCCGCGGTCTCTAACGGC
CTGGGCTATTGCCTGGCCATCGAGAAGCTGCTGAACGTGGAAGCGCCGCCGCGCGCGCAGTGCATTCGCGTCATCCTCAC
GGAGCTCAACCGCATCGCCAGCCACCTCTTGTGGCTGGGAACTCACGCGCTCGATATCGGCGCTATCACGCCGGTCTTCT
ACTGCCTGCGCGAACGCGAGGAAGCCCTCAAGATCTTCGAGAAGTACTGCGGCGCGCGGCTCACTACCCACGCCTTCCGC
ATCGGCGGACTGCTCTACGAGACCTACGACGGCTTCGAGCAGGAGATCCGCGACTTTTGCAAGATGTTCATCCCCAAAGT
GGATGAATACGAAGAACTCCTGACCAACAACCGCATCTGGGTCGGGCGCCTGAAGGATGTCGGCATCCTGAGCGCCGACG
AGTGCAAGGAATTCGGCGTGACCGGTCCGGTGCTGCGCGCCGCCGGCGTCAAGTGGGACCTGCGCAAGGCGCAGCCCTAC
TCGGGCTACGAGAAGTACGATTTCGAAATCCCCACGCGCGTGAACGGCGATACCTACGACCGGTACATCGTACGCATGGA
AGAGATGCGCCAATCCGTGCGCATCATGCAGCAGGCGGTGGATGGAATTCCCGAGGGGCCGATCATGGGCAAGGTCGGTA
AGGTGATCAAGCCGCCGATCGGAGAGGCGTACGTTTCGATCGAAGCGCCCAAGGGTGAGCTGGGATATTACGCGGTGAGC
GATGGCTCTACGCAACCTTACCGGATACGGGTGCGGCCGCCTTCGTTCGTGAACTTGCAGGCGTTGGACCGGATGATCCG
CGGCGGGCTGATCGCGGATGTGGTGGCGGTGATCGGGACGCTCGACATCGTCTTGGGCGAGATTGACCGGTGA

Upstream 100 bases:

>100_bases
TGGCAGGGCTATCCCCTGCGCAAGGATTACGGAATACTCCAGCAGGATGCGCGCTGGGTGCAGGAAAACCTGGAAATTGA
AAGCGGCCAGTGACGACCGT

Downstream 100 bases:

>100_bases
ACTTATGATTGAGTTGCTGAAAAAGATCTTCCTGGTGGATCTGTTCCAGGGTCTCTTCGTGACCTTCCGGAACCAGAACC
CGAAGTACATTTACACGGAG

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 2; NDH-1 subunit D 2

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MPDSTFLDSTELVLNMGPQHPSTHGVLRVILKLDGEKVLGTDCIIGYLHRGVEKIAENRTYAQFNPYVDRMDYVAAVSNG
LGYCLAIEKLLNVEAPPRAQCIRVILTELNRIASHLLWLGTHALDIGAITPVFYCLREREEALKIFEKYCGARLTTHAFR
IGGLLYETYDGFEQEIRDFCKMFIPKVDEYEELLTNNRIWVGRLKDVGILSADECKEFGVTGPVLRAAGVKWDLRKAQPY
SGYEKYDFEIPTRVNGDTYDRYIVRMEEMRQSVRIMQQAVDGIPEGPIMGKVGKVIKPPIGEAYVSIEAPKGELGYYAVS
DGSTQPYRIRVRPPSFVNLQALDRMIRGGLIADVVAVIGTLDIVLGEIDR

Sequences:

>Translated_370_residues
MPDSTFLDSTELVLNMGPQHPSTHGVLRVILKLDGEKVLGTDCIIGYLHRGVEKIAENRTYAQFNPYVDRMDYVAAVSNG
LGYCLAIEKLLNVEAPPRAQCIRVILTELNRIASHLLWLGTHALDIGAITPVFYCLREREEALKIFEKYCGARLTTHAFR
IGGLLYETYDGFEQEIRDFCKMFIPKVDEYEELLTNNRIWVGRLKDVGILSADECKEFGVTGPVLRAAGVKWDLRKAQPY
SGYEKYDFEIPTRVNGDTYDRYIVRMEEMRQSVRIMQQAVDGIPEGPIMGKVGKVIKPPIGEAYVSIEAPKGELGYYAVS
DGSTQPYRIRVRPPSFVNLQALDRMIRGGLIADVVAVIGTLDIVLGEIDR
>Mature_369_residues
PDSTFLDSTELVLNMGPQHPSTHGVLRVILKLDGEKVLGTDCIIGYLHRGVEKIAENRTYAQFNPYVDRMDYVAAVSNGL
GYCLAIEKLLNVEAPPRAQCIRVILTELNRIASHLLWLGTHALDIGAITPVFYCLREREEALKIFEKYCGARLTTHAFRI
GGLLYETYDGFEQEIRDFCKMFIPKVDEYEELLTNNRIWVGRLKDVGILSADECKEFGVTGPVLRAAGVKWDLRKAQPYS
GYEKYDFEIPTRVNGDTYDRYIVRMEEMRQSVRIMQQAVDGIPEGPIMGKVGKVIKPPIGEAYVSIEAPKGELGYYAVSD
GSTQPYRIRVRPPSFVNLQALDRMIRGGLIADVVAVIGTLDIVLGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=385, Percent_Identity=46.2337662337662, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI260898743, Length=379, Percent_Identity=45.646437994723, Blast_Score=339, Evalue=3e-93,
Organism=Escherichia coli, GI145693162, Length=389, Percent_Identity=40.1028277634961, Blast_Score=304, Evalue=6e-84,
Organism=Escherichia coli, GI1789076, Length=364, Percent_Identity=28.8461538461538, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788832, Length=364, Percent_Identity=28.2967032967033, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17555284, Length=384, Percent_Identity=43.4895833333333, Blast_Score=344, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17568379, Length=384, Percent_Identity=42.96875, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=46.09375, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221459469, Length=393, Percent_Identity=46.3104325699746, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD2_SOLUE (Q01UN9)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_826916.1
- ProteinModelPortal:   Q01UN9
- SMR:   Q01UN9
- STRING:   Q01UN9
- GeneID:   4426094
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_5684
- NMPDR:   fig|234267.9.peg.5407
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   GVFIQGN
- PhylomeDB:   Q01UN9
- ProtClustDB:   CLSK774497
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 41614; Mature: 41482

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSTFLDSTELVLNMGPQHPSTHGVLRVILKLDGEKVLGTDCIIGYLHRGVEKIAENRT
CCCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCC
YAQFNPYVDRMDYVAAVSNGLGYCLAIEKLLNVEAPPRAQCIRVILTELNRIASHLLWLG
EEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
THALDIGAITPVFYCLREREEALKIFEKYCGARLTTHAFRIGGLLYETYDGFEQEIRDFC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KMFIPKVDEYEELLTNNRIWVGRLKDVGILSADECKEFGVTGPVLRAAGVKWDLRKAQPY
HHHCCCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCCCHHHHHCCCCEECCCCCCC
SGYEKYDFEIPTRVNGDTYDRYIVRMEEMRQSVRIMQQAVDGIPEGPIMGKVGKVIKPPI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCC
GEAYVSIEAPKGELGYYAVSDGSTQPYRIRVRPPSFVNLQALDRMIRGGLIADVVAVIGT
CCEEEEEECCCCCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHH
LDIVLGEIDR
HHHHHHCCCC
>Mature Secondary Structure 
PDSTFLDSTELVLNMGPQHPSTHGVLRVILKLDGEKVLGTDCIIGYLHRGVEKIAENRT
CCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHCCCC
YAQFNPYVDRMDYVAAVSNGLGYCLAIEKLLNVEAPPRAQCIRVILTELNRIASHLLWLG
EEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
THALDIGAITPVFYCLREREEALKIFEKYCGARLTTHAFRIGGLLYETYDGFEQEIRDFC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
KMFIPKVDEYEELLTNNRIWVGRLKDVGILSADECKEFGVTGPVLRAAGVKWDLRKAQPY
HHHCCCCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCCCHHHHHCCCCEECCCCCCC
SGYEKYDFEIPTRVNGDTYDRYIVRMEEMRQSVRIMQQAVDGIPEGPIMGKVGKVIKPPI
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCC
GEAYVSIEAPKGELGYYAVSDGSTQPYRIRVRPPSFVNLQALDRMIRGGLIADVVAVIGT
CCEEEEEECCCCCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHH
LDIVLGEIDR
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA