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The map label for this gene is mntH [H]

Identifier: 116624700

GI number: 116624700

Start: 7050172

End: 7052085

Strand: Direct

Name: mntH [H]

Synonym: Acid_5624

Alternate gene names: 116624700

Gene position: 7050172-7052085 (Clockwise)

Preceding gene: 116624699

Following gene: 116624701

Centisome position: 70.74

GC content: 64.79

Gene sequence:

>1914_bases
ATGTTGCCGACGAGTCGTACGGCGGAGGAATCGCGGTCCCTGGCGGACGTGCACTCAAGCGTCGGGACATCCCAAGTCTC
GTTCTGGAAGCGGATGTTTGCGTTTGCAGGACCGGCGTACCTGGTGAGCGTGGGGTACATGGACCCCGGGAACTGGGCCA
CGGACCTGGAGGGCGGAGCGCGTTTCGGCTACAAGCTGCTCTGGGTGCTGGTGATGTCCAACCTGATGGCGGTGCTGCTG
CAGACGCTGAGCGCCCGGCTTGGGATTGTGCGCGGGCGCGACCTGGCGCAGGCCTGCCGGGAGACGTACCCGCGGGCAGT
CAACCTGGCTTTGTGGGCGCTCTGCGAAATCGCGGTGGCGGCCTGCGACTTGGCGGAAGTGATCGGCGCCGCGATCGGGC
TCAACCTGCTGTTCCACATTCCGCTGCTCATGGGCGTGCTGATCACGTCGGCGGACACGCTGCTGCTGTTGTGGTTCCAG
AGCTTCGGCATCCGCACGATCGAGGCGGTGGTGCTGGCGTTGATCACGGTGATCGCGGCCTGCTTCTGCATCGAGATTTT
CTGGGCCAGGCCCGCGGTGAGCGAGTTATTTACCGGGCTGGTGCCAAGGCTCAACGGCAGCAGCCTTTACGTAGCGATCG
GTATCTTGGGCGCGACGGTGATGCCGCACAATCTCTACCTGCATTCGGCGCTGGTACAGACGCGCAACATCGGGCAGAGC
GAGGCGGCCAAACGGACGGCCTGCAAGTACAACTTCATCGATAGCGTGGTGGCGCTGAATGGCGCGCTGCTGGTGAATGC
CGGAATCCTGGTGATGGCGGCGGCGGTCTTCTTCCGGCGCGGAATCGTGGTGACCGAGATCCAGCAGGCGCACCTGCTGC
TGGCGCCGTTGCTGGGCACAGGCCTGGCCGGTGTTCTGTTCGCGATCGCGCTGCTGGCTTCGGGCCAATCTTCCACGCTG
ACCGGGACGCTGGCAGGGCAGATCGTGATGGAAGGCTTCCTGAACTTCCGCATGCGGGCATGGCTGCGGCGCTTGATCAC
CCGCACCATCGCGGTGGCGCCGGCGGCATTCACCATCTGGTACGCGGGGGAGAAATCCACCTACCAGCTGCTCATTTTGA
GCCAGGTGATCCTCAGCATGCAACTGCCGTTCGCGGTCATCCCGCTGATACACTTCACGAGCGACCGGCAGCGCATGGGC
AACTTCGCCAACGCGCTCTGGGTGCGGATTCTGGCGTGGCTGACGGCGGCGGTGATTATCGCGCTCAATATTCGCCTGGC
CGCGGCGGCGATTGCGGACTGGCTGGATGCCGCCGGCCGCTGGAAGCCGCTGGTGATCGCCGGCCTGGTTCCGGTGTTGG
GCGGTTTCCTGCTGCTGCTGCTCTGGGTCTCCTTCGAGCCGCTGCTGAGCGGAAGGACAGGCAAATACGGGCGTTCCCCG
GTTTCCCTCCCCGAACCGGCCGGCGCGGAAGTGCCGGCGCCGATCTATCAGCGCATCCTGGTGCCGCTCGATCATACCGA
CCTGGACCGCCTGGCGATCAGCCATGCGGTGGCCATGGGAAAGCTGTACGGAGCCCGGGTCTACCTGCTGCACGTGGAGG
AGGGCGTGACCAGCCAGATTTACGGCGGGGACGCCTCTTCGGCGGAGGAGGAGGCGGGCCAGCGATACCTGGAGCGCGTC
GCGCAGTCGCTGCGGGATCAAGGAGTTACGGTGGAGACGGCAATCCGGCATTCGTCCTCGCCGACGAAGGAGATCCTGAG
CTACGCCCGGGAGGTCGGGCCGGATCTGGTGATCATGGGCGCGCACGGGCACGGCGGTTTGAAGGACCTGATCTTTGGCA
CCACCATCAGCCCGGTCCGTCATCACCTGCAGGTACCTATGCTGATTGTTCGTCCTGGAAAGCCCAAAAATTGA

Upstream 100 bases:

>100_bases
AAACCGACCAACCGCCCGGAATACCGGTTCGGGGACGGCTCGGTGACCGATCAGTAGGAGCGCTTGCCAAACAGGCCGCG
ACTTAACTATAGTTAAGTAC

Downstream 100 bases:

>100_bases
GGCAGGATCTGCCCCACCGTGTGTCACAGGGAAACAGGTCAAAATTTGGTTACAAAGCTAACCTTTGTGCTATCAATATG
ATTAGCTGGCATGTTACATG

Product: Mn2+/Fe2+ transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MLPTSRTAEESRSLADVHSSVGTSQVSFWKRMFAFAGPAYLVSVGYMDPGNWATDLEGGARFGYKLLWVLVMSNLMAVLL
QTLSARLGIVRGRDLAQACRETYPRAVNLALWALCEIAVAACDLAEVIGAAIGLNLLFHIPLLMGVLITSADTLLLLWFQ
SFGIRTIEAVVLALITVIAACFCIEIFWARPAVSELFTGLVPRLNGSSLYVAIGILGATVMPHNLYLHSALVQTRNIGQS
EAAKRTACKYNFIDSVVALNGALLVNAGILVMAAAVFFRRGIVVTEIQQAHLLLAPLLGTGLAGVLFAIALLASGQSSTL
TGTLAGQIVMEGFLNFRMRAWLRRLITRTIAVAPAAFTIWYAGEKSTYQLLILSQVILSMQLPFAVIPLIHFTSDRQRMG
NFANALWVRILAWLTAAVIIALNIRLAAAAIADWLDAAGRWKPLVIAGLVPVLGGFLLLLLWVSFEPLLSGRTGKYGRSP
VSLPEPAGAEVPAPIYQRILVPLDHTDLDRLAISHAVAMGKLYGARVYLLHVEEGVTSQIYGGDASSAEEEAGQRYLERV
AQSLRDQGVTVETAIRHSSSPTKEILSYAREVGPDLVIMGAHGHGGLKDLIFGTTISPVRHHLQVPMLIVRPGKPKN

Sequences:

>Translated_637_residues
MLPTSRTAEESRSLADVHSSVGTSQVSFWKRMFAFAGPAYLVSVGYMDPGNWATDLEGGARFGYKLLWVLVMSNLMAVLL
QTLSARLGIVRGRDLAQACRETYPRAVNLALWALCEIAVAACDLAEVIGAAIGLNLLFHIPLLMGVLITSADTLLLLWFQ
SFGIRTIEAVVLALITVIAACFCIEIFWARPAVSELFTGLVPRLNGSSLYVAIGILGATVMPHNLYLHSALVQTRNIGQS
EAAKRTACKYNFIDSVVALNGALLVNAGILVMAAAVFFRRGIVVTEIQQAHLLLAPLLGTGLAGVLFAIALLASGQSSTL
TGTLAGQIVMEGFLNFRMRAWLRRLITRTIAVAPAAFTIWYAGEKSTYQLLILSQVILSMQLPFAVIPLIHFTSDRQRMG
NFANALWVRILAWLTAAVIIALNIRLAAAAIADWLDAAGRWKPLVIAGLVPVLGGFLLLLLWVSFEPLLSGRTGKYGRSP
VSLPEPAGAEVPAPIYQRILVPLDHTDLDRLAISHAVAMGKLYGARVYLLHVEEGVTSQIYGGDASSAEEEAGQRYLERV
AQSLRDQGVTVETAIRHSSSPTKEILSYAREVGPDLVIMGAHGHGGLKDLIFGTTISPVRHHLQVPMLIVRPGKPKN
>Mature_637_residues
MLPTSRTAEESRSLADVHSSVGTSQVSFWKRMFAFAGPAYLVSVGYMDPGNWATDLEGGARFGYKLLWVLVMSNLMAVLL
QTLSARLGIVRGRDLAQACRETYPRAVNLALWALCEIAVAACDLAEVIGAAIGLNLLFHIPLLMGVLITSADTLLLLWFQ
SFGIRTIEAVVLALITVIAACFCIEIFWARPAVSELFTGLVPRLNGSSLYVAIGILGATVMPHNLYLHSALVQTRNIGQS
EAAKRTACKYNFIDSVVALNGALLVNAGILVMAAAVFFRRGIVVTEIQQAHLLLAPLLGTGLAGVLFAIALLASGQSSTL
TGTLAGQIVMEGFLNFRMRAWLRRLITRTIAVAPAAFTIWYAGEKSTYQLLILSQVILSMQLPFAVIPLIHFTSDRQRMG
NFANALWVRILAWLTAAVIIALNIRLAAAAIADWLDAAGRWKPLVIAGLVPVLGGFLLLLLWVSFEPLLSGRTGKYGRSP
VSLPEPAGAEVPAPIYQRILVPLDHTDLDRLAISHAVAMGKLYGARVYLLHVEEGVTSQIYGGDASSAEEEAGQRYLERV
AQSLRDQGVTVETAIRHSSSPTKEILSYAREVGPDLVIMGAHGHGGLKDLIFGTTISPVRHHLQVPMLIVRPGKPKN

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=427, Percent_Identity=37.7049180327869, Blast_Score=262, Evalue=9e-70,
Organism=Homo sapiens, GI295293167, Length=435, Percent_Identity=38.3908045977011, Blast_Score=260, Evalue=4e-69,
Organism=Homo sapiens, GI295293175, Length=435, Percent_Identity=38.3908045977011, Blast_Score=259, Evalue=6e-69,
Organism=Homo sapiens, GI295293173, Length=435, Percent_Identity=38.3908045977011, Blast_Score=259, Evalue=6e-69,
Organism=Homo sapiens, GI10835169, Length=435, Percent_Identity=38.3908045977011, Blast_Score=259, Evalue=6e-69,
Organism=Homo sapiens, GI295293171, Length=435, Percent_Identity=38.3908045977011, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI295293169, Length=435, Percent_Identity=38.3908045977011, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI295293178, Length=435, Percent_Identity=38.3908045977011, Blast_Score=259, Evalue=8e-69,
Organism=Escherichia coli, GI1788736, Length=400, Percent_Identity=41.5, Blast_Score=281, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI193210616, Length=496, Percent_Identity=33.4677419354839, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI17569473, Length=369, Percent_Identity=40.1084010840108, Blast_Score=249, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI71999499, Length=462, Percent_Identity=35.0649350649351, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71993856, Length=238, Percent_Identity=40.7563025210084, Blast_Score=180, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321841, Length=431, Percent_Identity=38.5150812064965, Blast_Score=259, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6323062, Length=404, Percent_Identity=41.0891089108911, Blast_Score=253, Evalue=7e-68,
Organism=Saccharomyces cerevisiae, GI6324450, Length=447, Percent_Identity=36.241610738255, Blast_Score=247, Evalue=5e-66,
Organism=Drosophila melanogaster, GI24648607, Length=454, Percent_Identity=35.0220264317181, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI281362176, Length=454, Percent_Identity=35.0220264317181, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24648609, Length=454, Percent_Identity=35.0220264317181, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI45553443, Length=427, Percent_Identity=36.0655737704918, Blast_Score=255, Evalue=7e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 68809; Mature: 68809

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPTSRTAEESRSLADVHSSVGTSQVSFWKRMFAFAGPAYLVSVGYMDPGNWATDLEGGA
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCCCCCCCCCH
RFGYKLLWVLVMSNLMAVLLQTLSARLGIVRGRDLAQACRETYPRAVNLALWALCEIAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ACDLAEVIGAAIGLNLLFHIPLLMGVLITSADTLLLLWFQSFGIRTIEAVVLALITVIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
CFCIEIFWARPAVSELFTGLVPRLNGSSLYVAIGILGATVMPHNLYLHSALVQTRNIGQS
HHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHCCCHH
EAAKRTACKYNFIDSVVALNGALLVNAGILVMAAAVFFRRGIVVTEIQQAHLLLAPLLGT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHC
GLAGVLFAIALLASGQSSTLTGTLAGQIVMEGFLNFRMRAWLRRLITRTIAVAPAAFTIW
CHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
YAGEKSTYQLLILSQVILSMQLPFAVIPLIHFTSDRQRMGNFANALWVRILAWLTAAVII
ECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALNIRLAAAAIADWLDAAGRWKPLVIAGLVPVLGGFLLLLLWVSFEPLLSGRTGKYGRSP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VSLPEPAGAEVPAPIYQRILVPLDHTDLDRLAISHAVAMGKLYGARVYLLHVEEGVTSQI
CCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHC
YGGDASSAEEEAGQRYLERVAQSLRDQGVTVETAIRHSSSPTKEILSYAREVGPDLVIMG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCCHHHHHHHHHHCCCCEEEEE
AHGHGGLKDLIFGTTISPVRHHLQVPMLIVRPGKPKN
CCCCCCHHHHHHCCCHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure
MLPTSRTAEESRSLADVHSSVGTSQVSFWKRMFAFAGPAYLVSVGYMDPGNWATDLEGGA
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHEEEECCCCCCCCCCCCCCCH
RFGYKLLWVLVMSNLMAVLLQTLSARLGIVRGRDLAQACRETYPRAVNLALWALCEIAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ACDLAEVIGAAIGLNLLFHIPLLMGVLITSADTLLLLWFQSFGIRTIEAVVLALITVIAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
CFCIEIFWARPAVSELFTGLVPRLNGSSLYVAIGILGATVMPHNLYLHSALVQTRNIGQS
HHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHCCCHHHHHHHHHHHHCCCHH
EAAKRTACKYNFIDSVVALNGALLVNAGILVMAAAVFFRRGIVVTEIQQAHLLLAPLLGT
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHC
GLAGVLFAIALLASGQSSTLTGTLAGQIVMEGFLNFRMRAWLRRLITRTIAVAPAAFTIW
CHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
YAGEKSTYQLLILSQVILSMQLPFAVIPLIHFTSDRQRMGNFANALWVRILAWLTAAVII
ECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALNIRLAAAAIADWLDAAGRWKPLVIAGLVPVLGGFLLLLLWVSFEPLLSGRTGKYGRSP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VSLPEPAGAEVPAPIYQRILVPLDHTDLDRLAISHAVAMGKLYGARVYLLHVEEGVTSQI
CCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHC
YGGDASSAEEEAGQRYLERVAQSLRDQGVTVETAIRHSSSPTKEILSYAREVGPDLVIMG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCCHHHHHHHHHHCCCCEEEEE
AHGHGGLKDLIFGTTISPVRHHLQVPMLIVRPGKPKN
CCCCCCHHHHHHCCCHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]