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The map label for this gene is qor [C]

Identifier: 116624675

GI number: 116624675

Start: 7009266

End: 7010243

Strand: Reverse

Name: qor [C]

Synonym: Acid_5599

Alternate gene names: 116624675

Gene position: 7010243-7009266 (Counterclockwise)

Preceding gene: 116624676

Following gene: 116624673

Centisome position: 70.34

GC content: 64.62

Gene sequence:

>978_bases
ATGCAGGCGTATCTTGTCGAGCGGGTGGGTGGAGAGTTCCGGAAAGCCGAGCTTGCGCGTCCGGTGGCGGGGTGGAACCA
GGTGCTGGTCAGGATCGCCGCGAGCGGGGTGAATCCGCTGGATACCAAGATTCGCGGGGGCAAGGCGGCGCATGCGAAGC
AACCTCTTCCCGCGGTGCTAGGGCTGGACATGGCGGGGACGGTGGAAGAAGTTGGGCCCGGCGTGACGGGCTTCCTGACC
GGCGATGAAGTTTACGGCGCGGTGGGCGGGGTGGGCGGACTGCAGGGTACGCTCGCGGAACTGGTTGCGGCGGATGTGGA
CCTGGTCGCGCACAAACCGAAGAATCTTTCGATGCGGGAAGCGGCGGCGCTCCCGCTCGGCATCATCACAGCCTGGGAGG
GATTGGTGGACCGGGCCGGTGTGCACGCGGGCCAGAAGGTGTTGATCCATGGCGGAGCCGGGGGCGTGGGACACATCGCG
GTTCAGGTTGCGCGGGCTTTCGGGGCGGAGGTTTTCGCCACGGTATCGCCGGAAAAGAAGAGCGTGGTGGAGGGTTTCGG
CGCCGTTCCGATTGATTATCGTTCGGTCCAGGTGGAGGAGTATATGGCCGCCCACACGGAAGGGAACGGGTTCGACATCG
TCTATGACACCGTGGGCGGGGCGACGCTGGATGCCTCTTTCGCGGTGGTGAAGCGATACACCGGGCACGTATTGAGCTCG
CTCGGCTGGGGGACACACGCGCTGGCTCCGCTCTCTTTTCGCAGCGCCAGTTATTCGGGCGTATTCACGCTGTTTCCGAT
GATTTCAGGCGAAGGCCGGGCGCATCACGGCAAGATCCTGACCGAGGCCGCGGCGCTGGCGGAAGAAGGGAAACTGAGGC
CGCTGCTCCATAAGCAATGCTTCGCGATTGCGGAGATTGAAGCGGCGCATGCGCTGGTGGAGGCCGGCGCCTTGGGGAAA
GTGGTGGTGGAAGTGTGA

Upstream 100 bases:

>100_bases
GACAGCCCGCGGTAGCATCCTCCTACGATGGAGCCGCCTGAAAGCCGGCGGCCGGCCAGACTGCCGCTAGAATAGTGATT
CACTGGCGGGAGGACTCGTG

Downstream 100 bases:

>100_bases
GGCAAAGACTGGTTCTGCAGAGCCGCAGAGCCGCAAAGTAGAGCAGAGAAAACTTTAAGCCAAAGGACTACGAAAATCGG
CGGCGTGGTCGGTCGCCCAG

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MQAYLVERVGGEFRKAELARPVAGWNQVLVRIAASGVNPLDTKIRGGKAAHAKQPLPAVLGLDMAGTVEEVGPGVTGFLT
GDEVYGAVGGVGGLQGTLAELVAADVDLVAHKPKNLSMREAAALPLGIITAWEGLVDRAGVHAGQKVLIHGGAGGVGHIA
VQVARAFGAEVFATVSPEKKSVVEGFGAVPIDYRSVQVEEYMAAHTEGNGFDIVYDTVGGATLDASFAVVKRYTGHVLSS
LGWGTHALAPLSFRSASYSGVFTLFPMISGEGRAHHGKILTEAAALAEEGKLRPLLHKQCFAIAEIEAAHALVEAGALGK
VVVEV

Sequences:

>Translated_325_residues
MQAYLVERVGGEFRKAELARPVAGWNQVLVRIAASGVNPLDTKIRGGKAAHAKQPLPAVLGLDMAGTVEEVGPGVTGFLT
GDEVYGAVGGVGGLQGTLAELVAADVDLVAHKPKNLSMREAAALPLGIITAWEGLVDRAGVHAGQKVLIHGGAGGVGHIA
VQVARAFGAEVFATVSPEKKSVVEGFGAVPIDYRSVQVEEYMAAHTEGNGFDIVYDTVGGATLDASFAVVKRYTGHVLSS
LGWGTHALAPLSFRSASYSGVFTLFPMISGEGRAHHGKILTEAAALAEEGKLRPLLHKQCFAIAEIEAAHALVEAGALGK
VVVEV
>Mature_325_residues
MQAYLVERVGGEFRKAELARPVAGWNQVLVRIAASGVNPLDTKIRGGKAAHAKQPLPAVLGLDMAGTVEEVGPGVTGFLT
GDEVYGAVGGVGGLQGTLAELVAADVDLVAHKPKNLSMREAAALPLGIITAWEGLVDRAGVHAGQKVLIHGGAGGVGHIA
VQVARAFGAEVFATVSPEKKSVVEGFGAVPIDYRSVQVEEYMAAHTEGNGFDIVYDTVGGATLDASFAVVKRYTGHVLSS
LGWGTHALAPLSFRSASYSGVFTLFPMISGEGRAHHGKILTEAAALAEEGKLRPLLHKQCFAIAEIEAAHALVEAGALGK
VVVEV

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=366, Percent_Identity=32.2404371584699, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI194239674, Length=319, Percent_Identity=29.7805642633229, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI13236495, Length=319, Percent_Identity=29.7805642633229, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI194239676, Length=166, Percent_Identity=36.144578313253, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI22538446, Length=324, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI22538444, Length=324, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI24308257, Length=334, Percent_Identity=25.748502994012, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI41872631, Length=259, Percent_Identity=30.1158301158301, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI18379349, Length=207, Percent_Identity=32.8502415458937, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI28557745, Length=232, Percent_Identity=28.8793103448276, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI90669511, Length=221, Percent_Identity=29.8642533936652, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1790485, Length=209, Percent_Identity=33.0143540669856, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71987554, Length=351, Percent_Identity=29.0598290598291, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17507255, Length=336, Percent_Identity=29.1666666666667, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI212642053, Length=249, Percent_Identity=32.5301204819277, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=345, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24581345, Length=282, Percent_Identity=28.7234042553192, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19920632, Length=240, Percent_Identity=27.9166666666667, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330659, Length=240, Percent_Identity=27.9166666666667, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581341, Length=341, Percent_Identity=29.0322580645161, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24581339, Length=341, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 33594; Mature: 33594

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAYLVERVGGEFRKAELARPVAGWNQVLVRIAASGVNPLDTKIRGGKAAHAKQPLPAVL
CCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCHHH
GLDMAGTVEEVGPGVTGFLTGDEVYGAVGGVGGLQGTLAELVAADVDLVAHKPKNLSMRE
CCCCCCCHHHHCCCEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHEECCCCCCCHHH
AAALPLGIITAWEGLVDRAGVHAGQKVLIHGGAGGVGHIAVQVARAFGAEVFATVSPEKK
HHCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCCHH
SVVEGFGAVPIDYRSVQVEEYMAAHTEGNGFDIVYDTVGGATLDASFAVVKRYTGHVLSS
HHHHCCCCCCCCCHHEEHHHHHHHCCCCCCEEEEEECCCCCEECHHHHHHHHHHHHHHHH
LGWGTHALAPLSFRSASYSGVFTLFPMISGEGRAHHGKILTEAAALAEEGKLRPLLHKQC
CCCCCHHCCCEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
FAIAEIEAAHALVEAGALGKVVVEV
HHHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MQAYLVERVGGEFRKAELARPVAGWNQVLVRIAASGVNPLDTKIRGGKAAHAKQPLPAVL
CCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCHHH
GLDMAGTVEEVGPGVTGFLTGDEVYGAVGGVGGLQGTLAELVAADVDLVAHKPKNLSMRE
CCCCCCCHHHHCCCEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHEECCCCCCCHHH
AAALPLGIITAWEGLVDRAGVHAGQKVLIHGGAGGVGHIAVQVARAFGAEVFATVSPEKK
HHCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCEEEEECCCCHH
SVVEGFGAVPIDYRSVQVEEYMAAHTEGNGFDIVYDTVGGATLDASFAVVKRYTGHVLSS
HHHHCCCCCCCCCHHEEHHHHHHHCCCCCCEEEEEECCCCCEECHHHHHHHHHHHHHHHH
LGWGTHALAPLSFRSASYSGVFTLFPMISGEGRAHHGKILTEAAALAEEGKLRPLLHKQC
CCCCCHHCCCEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
FAIAEIEAAHALVEAGALGKVVVEV
HHHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]