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The map label for this gene is coxM [H]

Identifier: 116624665

GI number: 116624665

Start: 7000460

End: 7001245

Strand: Direct

Name: coxM [H]

Synonym: Acid_5589

Alternate gene names: 116624665

Gene position: 7000460-7001245 (Clockwise)

Preceding gene: 116624662

Following gene: 116624666

Centisome position: 70.25

GC content: 59.03

Gene sequence:

>786_bases
ATGCTGCTTGCTCCCGTCGTATGGATACTGACGGCCGTAATCGCGTATTTTTTCGCGGCTAAGACGTGGTGGTTTCCACC
GCCGATTAACGCCCACGGCATTGCTTACGACGAGCAGTTCATGCGGACCCTGGTGGTCACCGGCATCATTTTCGTTCTCG
CCCAATTTGCCCTTGGCTGGGTCATCGTCCGGTCCCGCGACGATGGCCGTCCCGCTACTTACAACCACGGCAACAACCGC
CTCGAGACTGTCTGGACCAGCGCCACCGCGCTGCTCTTCCTCGGCCTCGTCCTCATGGGCACAAAAATCTGGGCCGGCGT
CCACTTCGATGAGCCGCCCGCCGATGCCATCCCCATCGAAGTGCTCGGCAAGCAGTTCGCCTGGAGCTTTCGCTATCCCG
GCGCCGATGGCAAGTTCGGCCGCACCGACCTCAAGTTCGTCAACGATTCCGCCGGCAATCCCTTCGGCCTTGATCCCAAC
GACCCCGCCGGCAAGGACGATCTCGTCTCCGCCTCTCTCAAAATTCCCGCAGGCAAGCCGATCAAACTCATCATGCACTC
CCGCGACGTCATCCACAATTTCTTCGTCCGCGAACTGCGCATGAAGCAGGATATCGTCCCCGGCATGGAGATCCCCCTCA
GTTTCACTGCCGACACAGTCGGCGTCTATGAAGTGCCGTGTTCCGAGCTTTGCGGCCTGGGACACTTTCAGATGCGCACC
ACCATGCAAGTCATGAGCATGGCCGATTTCGAACAATGGAAGATCCAACTACAGGCTCAGAAATGA

Upstream 100 bases:

>100_bases
ACATCGCCGCGCTCCGCTTGCGCTGCGGAAATGACTGTGATAGTGTACGTTCCACATTTGAATCCCAGGAATTTTTCCGG
GACCGCGTAGAGGAGGGCTG

Downstream 100 bases:

>100_bases
TTCCCGTCCGCGAATCCTAGGAGAGATTATGGCCGCCCCTGCCACTCATACGGCGCACCATGCGCCTGAAGGCTTCATCC
GAAGATATATCTTCAGCCTG

Product: cytochrome c oxidase subunit II

Products: NA

Alternate protein names: Alternative cytochrome c oxidase polypeptide II; Cytochrome BB3 subunit 2; Oxidase BB(3) subunit 2 [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MLLAPVVWILTAVIAYFFAAKTWWFPPPINAHGIAYDEQFMRTLVVTGIIFVLAQFALGWVIVRSRDDGRPATYNHGNNR
LETVWTSATALLFLGLVLMGTKIWAGVHFDEPPADAIPIEVLGKQFAWSFRYPGADGKFGRTDLKFVNDSAGNPFGLDPN
DPAGKDDLVSASLKIPAGKPIKLIMHSRDVIHNFFVRELRMKQDIVPGMEIPLSFTADTVGVYEVPCSELCGLGHFQMRT
TMQVMSMADFEQWKIQLQAQK

Sequences:

>Translated_261_residues
MLLAPVVWILTAVIAYFFAAKTWWFPPPINAHGIAYDEQFMRTLVVTGIIFVLAQFALGWVIVRSRDDGRPATYNHGNNR
LETVWTSATALLFLGLVLMGTKIWAGVHFDEPPADAIPIEVLGKQFAWSFRYPGADGKFGRTDLKFVNDSAGNPFGLDPN
DPAGKDDLVSASLKIPAGKPIKLIMHSRDVIHNFFVRELRMKQDIVPGMEIPLSFTADTVGVYEVPCSELCGLGHFQMRT
TMQVMSMADFEQWKIQLQAQK
>Mature_261_residues
MLLAPVVWILTAVIAYFFAAKTWWFPPPINAHGIAYDEQFMRTLVVTGIIFVLAQFALGWVIVRSRDDGRPATYNHGNNR
LETVWTSATALLFLGLVLMGTKIWAGVHFDEPPADAIPIEVLGKQFAWSFRYPGADGKFGRTDLKFVNDSAGNPFGLDPN
DPAGKDDLVSASLKIPAGKPIKLIMHSRDVIHNFFVRELRMKQDIVPGMEIPLSFTADTVGVYEVPCSELCGLGHFQMRT
TMQVMSMADFEQWKIQLQAQK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A ce

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=173, Percent_Identity=29.4797687861272, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6226540, Length=234, Percent_Identity=24.7863247863248, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 29160; Mature: 29160

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00078 COX2 ; PS50857 COX2_CUA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLAPVVWILTAVIAYFFAAKTWWFPPPINAHGIAYDEQFMRTLVVTGIIFVLAQFALGW
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHE
VIVRSRDDGRPATYNHGNNRLETVWTSATALLFLGLVLMGTKIWAGVHFDEPPADAIPIE
EEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
VLGKQFAWSFRYPGADGKFGRTDLKFVNDSAGNPFGLDPNDPAGKDDLVSASLKIPAGKP
HHHHHHEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHEEEEEECCCCCC
IKLIMHSRDVIHNFFVRELRMKQDIVPGMEIPLSFTADTVGVYEVPCSELCGLGHFQMRT
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCHHHHHCCCCHHHHH
TMQVMSMADFEQWKIQLQAQK
HHHHHHHHCCCEEEEEEEECC
>Mature Secondary Structure
MLLAPVVWILTAVIAYFFAAKTWWFPPPINAHGIAYDEQFMRTLVVTGIIFVLAQFALGW
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHE
VIVRSRDDGRPATYNHGNNRLETVWTSATALLFLGLVLMGTKIWAGVHFDEPPADAIPIE
EEEEECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
VLGKQFAWSFRYPGADGKFGRTDLKFVNDSAGNPFGLDPNDPAGKDDLVSASLKIPAGKP
HHHHHHEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHEEEEEECCCCCC
IKLIMHSRDVIHNFFVRELRMKQDIVPGMEIPLSFTADTVGVYEVPCSELCGLGHFQMRT
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCHHHHHCCCCHHHHH
TMQVMSMADFEQWKIQLQAQK
HHHHHHHHCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1444719; 12597275 [H]