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The map label for this gene is coxN [H]

Identifier: 116624666

GI number: 116624666

Start: 7001274

End: 7003049

Strand: Direct

Name: coxN [H]

Synonym: Acid_5590

Alternate gene names: 116624666

Gene position: 7001274-7003049 (Clockwise)

Preceding gene: 116624665

Following gene: 116624667

Centisome position: 70.25

GC content: 60.02

Gene sequence:

>1776_bases
ATGGCCGCCCCTGCCACTCATACGGCGCACCATGCGCCTGAAGGCTTCATCCGAAGATATATCTTCAGCCTGGATCACAA
AGTGATCGGTATTCAGTACTATTTCCTCGGGCTGTTCTCCGTCTTCATCGGGATGGCGCTTTCGCTCCTGATGCGTTTCC
ACATGGTGAACCCGGAAGCCAAGGTCGCCTGGTTCGCCAAACTATGGCCCACCGCCGCCGCCGGCGGCATGATGACGCCG
GAACTCTACCTCTCGCTCATGACCATGCATGGCACCATCATGGTCTTCTTCGTGCTCACCACCGTTCCGCAAAGCGGCTT
CGGCAACTACTTCCTTCCCATCCAGATCGGCGCCGAGGACATGGCCTTCCCGGTCCTCAACATGATGTCCTTCTGGACCA
CCTTCCTCGCCCTCGTCGTCATGGTCTCCGCCTTCTTCGTGCAGGGCGGCGCTCCCCTCGCCGGCTGGACCGGCTATCCG
CCCCTGAGCGGCATCGGCCGCCTCACCGGACCCGGCGAAGGCCTTGGGCAAACGCTCTGGATTCTCAGCATCGCCATCTT
CTGCGGCGCCTCGCTCATGGGCGCCATCAACTTCATCGCCACCACCGTGGACCTGCGCTGCAAGGGCATGAAGCTCATGC
GCATGCCGCTCACTTGCTGGACCTGGCTCGTCACCGCGATTCTCGCGCTGCTAGGTTTCGCCGTCCTGCTTGCGGCCGGC
GTCCTGCTCATCCTCGATCGCTCCGCGGGAACCAGCTTCTTCATTCCCGGCGGGCTCATGGTCAGCGATCAGATCATCTC
CAGTCACAAGGGCGGTTCCCCGCTCCTCTGGCAGCACCTCTTCTGGTTTTTCGGGCACCCCGAGGTTTATATCGCCATCC
TCCCCGGTATGGGCGTCACTTCGCACCTGCTGGCGACCTTCTCCCGCAAGCCCATCTTCGGCTACAAAGCCATGGTCTAC
GCCATTCTCAGCATCGGCTTCCTCGGCTTCCTGGTCTGGGGCCACCACATGTTCATGAGCGGCATGAACCCCTACTCCGC
CATGGCCTTCTCCGTTCTCACGATGTGCATCGGCGTACCCTCCGCCATCAAGACCTTTAACTGGATCGGCACCCTCTGGG
GCGGAAAAATACACTTCGATACCGCGATGATGTTCTCCCTCGGATTCGTCTCCCTCTTCGTCACCGGCGGCATCAGCGGC
ATCTTCCTCGGACAGCCCGCGCTCGATCTCTACTTCCACGACACCTACTTCGTGGTCGGCCACTTCCACATGATCATGGG
TGTCGCAGCGATCTTCGGAATGTTCGCAGGCACCTTCTACTGGTTCCCCAAGATGTTCGGACGCATGATGAATGAGACCC
TCGGCAAGATCCACTTCTATGCCACTTTCATCGGCGTCTACTGCATCTTCACTCCCATGCACTTCGTCGGAATGGCCGGC
AATCCGCGCCGCTATTCGGATTTCAGCAACGTGGAGTACCTCGCCGGCCTCATGCCGGTGCACAAATTCATGACCCACGC
CGCATATTTCACCGCGGCCGTTCAAATCCTGTTCATCATCAATCTGTTCTGGAGCATGTTCAAGGGCCCCAAGGCGCCCA
TGAACCCCTGGCATTCCACGTCGCTCGAATGGACCATTCCTTCGCCGCCGCCCTTCGATAACTTCGCCGGCGTGCACCCG
GTAGTCAATCACGGACCTTACGAATTCAGCGTTCCCGGCGCGCCCAACGACTTCATCATGCAGAGCGACCCGCCCACCGA
GGAAGTCGAAGCCTGA

Upstream 100 bases:

>100_bases
CGCACCACCATGCAAGTCATGAGCATGGCCGATTTCGAACAATGGAAGATCCAACTACAGGCTCAGAAATGATTCCCGTC
CGCGAATCCTAGGAGAGATT

Downstream 100 bases:

>100_bases
GCGATCCTATGAGTATGGCTGGGTCAGTTTCACAAGACATCATCATCGGTCCTCCCCCTCCGCCGGCCGACGGCGGTTGG
GGCGATGGCGGCGGCAATGG

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Alternative cytochrome c oxidase polypeptide I; Cytochrome BB3 subunit 1; Oxidase BB(3) subunit 1 [H]

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MAAPATHTAHHAPEGFIRRYIFSLDHKVIGIQYYFLGLFSVFIGMALSLLMRFHMVNPEAKVAWFAKLWPTAAAGGMMTP
ELYLSLMTMHGTIMVFFVLTTVPQSGFGNYFLPIQIGAEDMAFPVLNMMSFWTTFLALVVMVSAFFVQGGAPLAGWTGYP
PLSGIGRLTGPGEGLGQTLWILSIAIFCGASLMGAINFIATTVDLRCKGMKLMRMPLTCWTWLVTAILALLGFAVLLAAG
VLLILDRSAGTSFFIPGGLMVSDQIISSHKGGSPLLWQHLFWFFGHPEVYIAILPGMGVTSHLLATFSRKPIFGYKAMVY
AILSIGFLGFLVWGHHMFMSGMNPYSAMAFSVLTMCIGVPSAIKTFNWIGTLWGGKIHFDTAMMFSLGFVSLFVTGGISG
IFLGQPALDLYFHDTYFVVGHFHMIMGVAAIFGMFAGTFYWFPKMFGRMMNETLGKIHFYATFIGVYCIFTPMHFVGMAG
NPRRYSDFSNVEYLAGLMPVHKFMTHAAYFTAAVQILFIINLFWSMFKGPKAPMNPWHSTSLEWTIPSPPPFDNFAGVHP
VVNHGPYEFSVPGAPNDFIMQSDPPTEEVEA

Sequences:

>Translated_591_residues
MAAPATHTAHHAPEGFIRRYIFSLDHKVIGIQYYFLGLFSVFIGMALSLLMRFHMVNPEAKVAWFAKLWPTAAAGGMMTP
ELYLSLMTMHGTIMVFFVLTTVPQSGFGNYFLPIQIGAEDMAFPVLNMMSFWTTFLALVVMVSAFFVQGGAPLAGWTGYP
PLSGIGRLTGPGEGLGQTLWILSIAIFCGASLMGAINFIATTVDLRCKGMKLMRMPLTCWTWLVTAILALLGFAVLLAAG
VLLILDRSAGTSFFIPGGLMVSDQIISSHKGGSPLLWQHLFWFFGHPEVYIAILPGMGVTSHLLATFSRKPIFGYKAMVY
AILSIGFLGFLVWGHHMFMSGMNPYSAMAFSVLTMCIGVPSAIKTFNWIGTLWGGKIHFDTAMMFSLGFVSLFVTGGISG
IFLGQPALDLYFHDTYFVVGHFHMIMGVAAIFGMFAGTFYWFPKMFGRMMNETLGKIHFYATFIGVYCIFTPMHFVGMAG
NPRRYSDFSNVEYLAGLMPVHKFMTHAAYFTAAVQILFIINLFWSMFKGPKAPMNPWHSTSLEWTIPSPPPFDNFAGVHP
VVNHGPYEFSVPGAPNDFIMQSDPPTEEVEA
>Mature_590_residues
AAPATHTAHHAPEGFIRRYIFSLDHKVIGIQYYFLGLFSVFIGMALSLLMRFHMVNPEAKVAWFAKLWPTAAAGGMMTPE
LYLSLMTMHGTIMVFFVLTTVPQSGFGNYFLPIQIGAEDMAFPVLNMMSFWTTFLALVVMVSAFFVQGGAPLAGWTGYPP
LSGIGRLTGPGEGLGQTLWILSIAIFCGASLMGAINFIATTVDLRCKGMKLMRMPLTCWTWLVTAILALLGFAVLLAAGV
LLILDRSAGTSFFIPGGLMVSDQIISSHKGGSPLLWQHLFWFFGHPEVYIAILPGMGVTSHLLATFSRKPIFGYKAMVYA
ILSIGFLGFLVWGHHMFMSGMNPYSAMAFSVLTMCIGVPSAIKTFNWIGTLWGGKIHFDTAMMFSLGFVSLFVTGGISGI
FLGQPALDLYFHDTYFVVGHFHMIMGVAAIFGMFAGTFYWFPKMFGRMMNETLGKIHFYATFIGVYCIFTPMHFVGMAGN
PRRYSDFSNVEYLAGLMPVHKFMTHAAYFTAAVQILFIINLFWSMFKGPKAPMNPWHSTSLEWTIPSPPPFDNFAGVHPV
VNHGPYEFSVPGAPNDFIMQSDPPTEEVEA

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=542, Percent_Identity=38.929889298893, Blast_Score=358, Evalue=7e-99,
Organism=Escherichia coli, GI1786634, Length=545, Percent_Identity=36.1467889908257, Blast_Score=318, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6226519, Length=562, Percent_Identity=39.1459074733096, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6226524, Length=353, Percent_Identity=40.7932011331445, Blast_Score=259, Evalue=8e-70,
Organism=Saccharomyces cerevisiae, GI6226523, Length=280, Percent_Identity=36.4285714285714, Blast_Score=155, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 65271; Mature: 65140

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
6.8 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
AAPATHTAHHAPEGFIRRYIFSLDHKVIGIQYYFLGLFSVFIGMALSLLMRFHMVNPEA
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KVAWFAKLWPTAAAGGMMTPELYLSLMTMHGTIMVFFVLTTVPQSGFGNYFLPIQIGAED
HHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCH
MAFPVLNMMSFWTTFLALVVMVSAFFVQGGAPLAGWTGYPPLSGIGRLTGPGEGLGQTLW
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ILSIAIFCGASLMGAINFIATTVDLRCKGMKLMRMPLTCWTWLVTAILALLGFAVLLAAG
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
VLLILDRSAGTSFFIPGGLMVSDQIISSHKGGSPLLWQHLFWFFGHPEVYIAILPGMGVT
HHEEEECCCCCCEEECCCCEEHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHH
SHLLATFSRKPIFGYKAMVYAILSIGFLGFLVWGHHMFMSGMNPYSAMAFSVLTMCIGVP
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
SAIKTFNWIGTLWGGKIHFDTAMMFSLGFVSLFVTGGISGIFLGQPALDLYFHDTYFVVG
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCHHHHHH
HFHMIMGVAAIFGMFAGTFYWFPKMFGRMMNETLGKIHFYATFIGVYCIFTPMHFVGMAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NPRRYSDFSNVEYLAGLMPVHKFMTHAAYFTAAVQILFIINLFWSMFKGPKAPMNPWHST
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SLEWTIPSPPPFDNFAGVHPVVNHGPYEFSVPGAPNDFIMQSDPPTEEVEA
CEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1444719; 12597275 [H]